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Intravitreal conbercept injection with panretinal photocoagulation for high-risk proliferative diabetic retinopathy with vitreous hemorrhage

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1066-1072页

作者： yao Xu Qing Ye Wei Shen Department of Ophthalmology the Fourth Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Ophthalmology Suzhou Kowloon HospitalShanghai Jiao Tong University School of MedcineSuzhou 215000Jiangsu ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

AIM:To assess the clinical efficacy and safety of combining panretinal photocoagulation(PRP)with intravitreal conbercept(IVC)injections for patients with high-risk proliferative diabetic retinopathy(HR-PDR)complicated by mild or moderate vitreous hemorrhage(VH),with or without diabetic macular edema(DME).METHODS:Patients diagnosed with VH with/without DME secondary to HR-PDR and received PRP combined with IVC injections were recruited in this retrospective *** establishing the patient’s diagnosis,an initial IVC was performed,followed by prompt administration of *** cases who significant bleeding persisted and impeded the laser operation,IVC was sustained before supplementing with *** the completion of PRP,patients were meticulously monitored for a minimum of six *** therapy and IVC injections were judiciously adjusted based on fundus fluorescein angiography(FFA)*** effect and the incidence of adverse events were ***:Out of 42 patients(74 eyes),29 were male and 13 were female,with a mean age of 59.17±12.74y(33-84y).The diabetic history was between 1wk and 26y,and the interval between the onset of visual symptoms and diagnosis of HR-PDR was *** affected eye received 2.59±1.87(1-10)IVC injections and underwent 5.5±1.02(4-8)sessions of *** these,68 eyes received PRP following 1 IVC injection,5 eyes after 2 IVC injections,and 1 eye after 3 IVC *** absorption of VH was observed in all 74 eyes 5-50wk after initial treatment,with resolution of DME in 51 eyes 3-48wk after initial treatment.A newly developed epiretinal membrane was noted in one *** acuity significantly improved in 25 *** complications such as glaucoma,retinal detachment,or endophthalmitis were ***:The study suggests that the combination of PRP with IVC injections is an effective and safe modality for treating diabetic VH in patients with HR-PDR.

关键词： conbercept panretinal photocoagulation high-risk proliferative diabetic retinopathy vitreous hemorrhage

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ANovel Non-Isolated Cubic DC-DC Converter with High Voltage Gain for Renewable Energy Power Generation System

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Energy Engineering 2024年第1期121卷 221-241页

作者： Qin yao Yida Zeng Qingui Jia School of Electrical Engineering Southwest Jiaotong UniversityChengdu610036China

In recent years,switched inductor(SL)technology,switched capacitor(SC)technology,and switched inductor-capacitor(SL-SC)technology have been widely applied to optimize and improve DC-DC boost converters,which can effectively enhance voltage gain and reduce device *** address the issue of low output voltage in current renewable energy power generation systems,this study proposes a novel non-isolated cubic high-gain DC-DC converter based on the traditional quadratic DC-DC boost converter by incorporating a SC and a SL-SC ***,the proposed converter’s details are elaborated,including its topology structure,operating mode,voltage gain,device stress,and power ***,a comparative analysis is conducted on the voltage gain and device stress between the proposed converter and other high-gain ***,a closed-loop simulation system is constructed to obtain simulation waveforms of various devices and explore the dynamic ***,an experimental prototype is built,experimental waveforms are obtained,and the experimental dynamic performance and conversion efficiency are *** theoretical analysis’s correctness is verified through simulation and experimental *** proposed converter has advantages such as high voltage gain,low device stress,high conversion efficiency,simple control,and wide input voltage range,achieving a good balance between voltage gain,device stress,and power *** proposed converter is well-suited for renewable energy systems and holds theoretical significance and practical value in renewable energy *** provides an effective solution to the issue of low output voltage in renewable energy power generation systems.

关键词： Cubic DC-DC converter high voltage gain low device stress high efficiency renewable energy

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Green hydrogen production by intermediate-temperature protonic solid oxide electrolysis cells:Advances,challenges,and perspectives

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InfoMat 2024年第3期6卷 22-65页

作者： Chunmei Tang yao yao Ning Wang Xiaohan Zhang Fangyuan Zheng Lei Du Dongxiang Luo Yoshitaka Aoki Siyu Ye Huangpu Hydrogen Energy Innovation Center School of Chemistry and Chemical EngineeringGuangzhou UniversityGuangzhouthe People's Republic of China Beijing Institute of Metrology Beijingthe People's republic of China Faculty of Engineering Hokkaido UniversitySapporoJapan

Protonic solid oxide electrolysis cells(P-SOECs)operating at intermediate temperatures,which have low costs,low environmental impact,and high theoretical electrolysis efficiency,are considered promising next-generation energy conversion devices for green hydrogen ***,the developments and applications of P-SOECs are restricted by numerous material-and interface-related issues,including carrier mismatch between the anode and electrolyte,current leakage in the electrolyte,poor interfacial contact,and chemical *** the past few decades,considerable attempts have been made to address these issues by improving the properties of *** review comprehensively explores the recent advances in the mechanisms governing steam electrolysis in P-SOECs,optimization strategies,specially designed components,electrochemical performance,and *** particular,given that the lack of suitable anode materials has significantly impeded P-SOEC development,the relationships between the transferred carriers and the cell performance,reaction models,and surface decoration approaches are meticulously ***,the challenges hindering P-SOEC development are discussed and recommendations for future research directions,including theoretical calculations and simulations,structural modification approaches,and large-scale single-cell fabrication,are proposed to stimulate research on P-SOECs and thereby realize efficient electricity-to-hydrogen conversion.

关键词： designed components electrochemical performance hydrogen production key materials protonic solid oxide electrolysis cells

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The Ca^(2+)/CaN/ACC and cAMP/PKA/HK signal pathways are required for PBAN-mediated sex pheromone biosynthesis in Conogethes punctiferalis

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Journal of Integrative Agriculture 2024年第8期23卷 2735-2751页

作者： yao Zhang Zelong She Ruolan He Shuangyan yao Xiang Li Xiaoguang Liu Xinming Yin Jizhen Wei Mengfang Du Shiheng An State Key Laboratory of Wheat and Maize Crop Science/Henan International Laboratory for Green Pest Control/College of Plant Protection Henan Agricultural UniversityZhengzhou 450046China

Conogethes punctiferalis is a crop and fruit pest that has caused serious economic losses to agricultural *** pest relies heavily on its sex pheromone to ensure sexual encounters and subsequent mating ***,the molecular mechanism underlying sex pheromone biosynthesis in this species remains *** present study investigated the detailed mechanism underlying PBAN-regulated sex pheromone biosynthesis in *** by transcriptome sequencing of the *** pheromone glands(PGs)and subsequent functional identification of the target *** results showed that female mating started from the first scotophase,and peaked at the second to fifth scotophases in accordance with the release of sex *** regulated sex pheromone biosynthesis by employing Ca^(2+)and cAMP as secondary messengers,as demonstrated by RNA interference(RNAi),pharmacological inhibitors,and behavioral *** investigation revealed that calcineurin(CaN)and acetyl-CoA carboxylase(ACC)were activated by PBAN/Ca^(2+)signaling,and the RNAimediated knockdown of CaN and ACC transcripts significantly reduced sex pheromone production,ultimately leading to a significantly reduced ability of females to attract ***,hexokinase(HK)was found to regulate sex pheromone biosynthesis in response to the PBAN/cAMP/PKA signaling pathway,as demonstrated by RNAi,enzyme activity,and pharmacological inhibitor ***,Far2 and Desaturase1 were found to participate in PBAN-regulated sex pheromone ***,our findings revealed that PBAN regulates sex pheromone biosynthesis through the PBANR/Ca^(2+)/CaN/ACC and PBANR/cAMP/PKA/HK pathways in ***,which enriches our comprehension of the details of sex pheromone biosynthesis in moths.

关键词： Conogethes punctiferalis sex pheromone cAMP/PKA calcineurin acetyl-CoA carboxylase hexokinase

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Research on Data Tampering Prevention Method for ATC Network Based on Zero Trust

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Computers, Materials & Continua 2024年第3期78卷 4363-4377页

作者： Xiaoyan Zhu Ruchun Jia Tingrui Zhang Song yao School of Computer Science Hefei University of TechnologyHefei230000China College of Computer Science Sichuan UniversityChengdu610065China Sichuan University-Pittsburgh Institute Sichuan UniversityChengdu610065China School of Information and Business Management Chengdu Neusoft UniversityChengdu610065China

The traditional air traffic control information sharing data has weak security characteristics of personal privacy data and poor effect,which is easy to leads to the problem that the data is *** from the application of the ATC(automatic train control)network,this paper focuses on the zero trust and zero trust access strategy and the tamper-proof method of information-sharing network *** the improvement of ATC’s zero trust physical layer authentication and network data distributed feature differentiation calculation,this paper reconstructs the personal privacy scope authentication structure and designs a tamper-proof method of ATC’s information sharing on the *** the single management authority to the unified management of data units,the systematic algorithm improvement of shared network data tamper prevention method is realized,and RDTP(Reliable Data Transfer Protocol)is selected in the network data of information sharing resources to realize the effectiveness of tamper prevention of air traffic control data during *** results show that this method can reasonably avoid the tampering of information sharing on the Internet,maintain the security factors of air traffic control information sharing on the Internet,and the Central Processing Unit(CPU)utilization rate is only 4.64%,which effectively increases the performance of air traffic control data comprehensive security protection system.

关键词： Zero trust access policy air traffic information sharing network privacy data tam-per-proof certification features

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Current Loop Disturbance Suppression for Dual Three Phase Permanent Magnet Synchronous Generators Based on Modified Linear Active Disturbance Rejection Control

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Chinese Journal of Electrical Engineering 2024年第1期10卷 101-113页

作者： Dezhi Xu Hu yao Yang He Wenxiang Zhao School of Electrical and Information Engineering Jiangsu UniversityZhenjiang 212013China

A modified four-dimensional linear active disturbance rejection control(LADRC)strategy is proposed for a dual three-phase permanent magnet synchronous generator(DTP-PMSG)system to reduce cross-coupling between the d and q axis currents in the d-q subspace and harmonic currents in the x-y *** the d-q subspace,the proposed strategy uses a model-based LADRC to enhance the decoupling effect between the d and q axes and the disturbance rejection ability against parameter *** the x-y subspace,the 5th and 7th harmonic current suppression abilities are improved by using quasi-resonant units parallel to the extended state observer of the traditional *** proposed modified LADRC strategy improved both the steady-state performance and dynamic response of the DTP-PMSG *** experimental results demonstrate that the proposed strategy is both feasible and effective.

关键词： Dual three-phase permanent magnet synchronous generator current loop decoupling control harmonic suppression linear active disturbance rejection control

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Facile and effective synthesis strategy for terbium-doped hydroxyapatite toward photoelectric devices and flexible functional fibers

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Rare Metals 2024年第4期43卷 1713-1723页

作者： Xiao-Dong Zhang Kun Nie Zi-yao Hu Ran-Ran Zhou Xiu-Qiang Duan Wu-Bin Dai Song-Song Nie Song-Jun yao Luo-Xin Wang Le-Fu Mei Hua Wang Yi-Yi yao Xiao-Xue Ma Hubei Key Laboratory for New Textile Materials and Applications and State Key Laboratory of New Textile Materials and Advanced Processing Technology School of Materials Science and EngineeringWuhan Textile UniversityWuhan430200China Key Laboratory of Testing and Tracing of Rare Earth Products for State Market Regulation Jiangxi University of Science and TechnologyGanzhou341000China Hubei Key Laboratory of Plasma Chemistry and Advanced Materials and Key Laboratory of Green Chemical Engineering Process of Ministry of Education Wuhan Institute of TechnologyWuhan430205China

As a material with good biocompatibility,hydroxyapatite(HAP)can have optical properties after doping with various rare earth *** a biocompatible fluorescent material,doped HAP could have broad applications in biological probes,drug delivery,optoelectronic materials,fluorescence anti-counterfeiting,and other *** this paper,we put forward the preparation of HAP doped with terbium(Ⅲ)ions(Tb^(3+))by hydrothermal *** controlling the Tb^(3+)doping content in reaction and the reaction time,the changes in HAP's structure,morphology,and luminescence properties under different conditions were *** the doping amount of Tb^(3+)reached an optimal value,the dipole-quadrupole would occur and the concentration would be *** control experiment showed that the optimal Tb3+content was 7.5×10^(-5)mol,which showed the best fluorescence ***,a non-luminous material,was rarely used in the field of fluorescent anti-counterfeiting and photoelectric *** proposed to prepare a luminescent aramid/polyphenylene sulfide(ACFs/PPS)fiber paper and a new light-emitting diode(LED)using the Tb-doped HAP *** composite sample exhibited an excellent stability and fluorescence performance,which also demonstrated a possibility of HAP applications in anticounterfeiting and *** introduction of Tb3+dopant HAP was done to give HAP optical properties and broaden the application range of HAP.

关键词： Hydroxyapatite Rare earth luminescence Photoelectric device Aramid Polyphenylene sulfide fiber paper Luminescent fiber

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A Galaxy Image Augmentation Method Based on Few-shot Learning and Generative Adversarial Networks

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Research in Astronomy and Astrophysics 2024年第3期24卷 180-193页

作者： Yiqi yao Jinqu Zhang Ping Du Shuyu Dong School of Artificial Intelligence South China Normal UniversityFoshan 528225China School of Computer Science South China Normal UniversityGuangzhou 510631China Guangdong Construction Vocational Technology Institute Guangzhou 511500China

Galaxy morphology classifications based on machine learning are a typical technique to handle enormous amounts of astronomical observation data,but the key challenge is how to provide enough training data for the machine learning *** this article proposes an image data augmentation method that combines few-shot learning and generative adversarial *** Galaxy10 DECaLs data set is selected for the experiments with consistency,variance,and augmentation effects being *** popular networks,including AlexNet,VGG,and ResNet,are used as examples to study the effectiveness of different augmentation methods on galaxy morphology *** results show that the proposed method can generate galaxy images and can be used for expanding the classification model’s training *** to comparative studies,the best enhancement effect on model performance is obtained by generating a data set that is 0.5–1 time larger than the original data ***,different augmentation strategies have considerably varied effects on different types of ***-GAN achieved the best classification performance on the ResNet network for In-between Round Smooth Galaxies and Unbarred Loose Spiral Galaxies,with F1 Scores of 89.54%and 63.18%,*** comparison reveals that various data augmentation techniques have varied effects on different categories of galaxy morphology and machine learning ***,the best augmentation strategies for each galaxy category are suggested.

关键词： techniques image processing-galaxies structure-galaxies general

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Global output feedback regulation of time-varying nonlinear systems via the dual-gain method

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Science China(Information Sciences) 2024年第5期67卷 333-334页

作者： Xian-Long YIN Zong-yao SUN Changyun WEN Institute of Automation Qufu Normal University School of Electrical and Electronic Engineering Nanyang Technological University

Notably, owing to the limited information available, the problem of output feedback stabilization/regulation for nonlinear systems has been explored based on state *** addition, the sensors accounting for state measurement could fail to detect the system states accurately due to the limitations of manufacturing techniques and instruments.

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Early monitoring values of oncogenic signalling molecules for hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2350-2361页

作者： Min yao Rong-Fei Fang Qun Xie Min Xu Wen-Li Sai Deng-Fu yao Department of Immunology Medical School of Nantong University and Research Center of Clinical MedicineThe Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Gastroenterology The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Infectious Diseases Haian People’s HospitalHaian 226600Jiangsu ProvinceChina Research Center of Clinical Medicine The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

The prevention and early diagnosis of liver cancer remains a global medical *** the malignant transformation of hepatocytes,a variety of oncogenic cellular signalling molecules,such as novel high mobility group-Box 3,angiopoietin-2,Golgi protein 73,glypican-3,Wnt3a(a signalling molecule in the Wnt/β-catenin pathway),and secretory clusterin,can be expressed and secreted into the *** signalling molecules are derived from different signalling pathways and may not only participate in the malignant transformation of hepatocytes but also become early diagnostic indicators of hepatocarcinogenesis or specific targeted molecules for hepatocellular carcinoma *** article reviews recent progress in the study of several signalling molecules as sensitive biomarkers for monitoring hepatocarcinogenesis.

关键词： Hepatocarcinogenesis Cell signals Specific biomarkers Early diagnosis

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