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Study on asymmetric synthesis of steroids——XIV. New synthesis of two optically active steroid CD synthons

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Chinese Journal of Chemistry 1986年第2期4卷 187-188页

作者： DAI wei-Min zhou wei-shan*, shanghai Institute of Organic Chemistry, Academia sinica, shanghai shanghai Institute of Organic Chemistry Academia sinica Shanghai

1a and 2a are important optically active steroid CD ring synthons used for total synthesisof 19-nor *** now wish to report herein a new synthesis of two optically active

关键词： New synthesis of two optically active steroid CD synthons Study on asymmetric synthesis of steroids XIV CD

Asymmetric epoxidation of gibberellates by the modified Sharpless reagent

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Chinese Journal of Chemistry 1990年第1期8卷 84-88页

作者： WANG,Zhi-Min zhou,wei-shan shanghai Institute of Organic Chemistry,Academia Sinica.shanghai 200032 shanghai Institute of Organic Chemistry Academia Sinica Shanghai 200032

Asymmetric epoxidation of methyl gibberellate by the modified Sharpless reagent at various temperature is *** 8 and 9 can be used as the key intermediates for the syntheses of the polyhydroxygibberellins.

关键词： Asymmetric epoxidation of gibberellates by the modified Sharpless reagent

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Studies on the structures and syntheses of arteannuin and related compounds——ⅩⅥ.Synthesis of arteannuin E and epoxy fission reaction of methyl a-epoxy arteannuinate

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Chinese Journal of Chemistry 1985年第2期3卷 158-166页

作者： zhou wei-shan ZHANG Lian XU Xing-Xiang shanghai Institute of Organic Chemistry,Acadamia Sinica,shanghai shanghai Institute of Organic Chemistry Acadamia Sinica Shanghai

Arteannuin E was synthesized from methyl β-epoxy arteannuinate by treatment withformic acid followed by hydrolysis and *** a-epoxy arteannuinate or methyl α-epoxy dihydroarteannuinate treated with formic acid did no... 详细信息

关键词： Studies on the structures and syntheses of arteannuin and related compounds Synthesis of arteannuin E and epoxy fission reaction of methyl a-epoxy arteannuinate

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Study on asymmetric syntheses of steroids ⅩⅢ. Synthesis of two new (±)-3-oxa-A-nor steroids 1a and 1b

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Chinese Journal of Chemistry 1986年第3期 230-238页

作者： zhou wei-shan DAI wei-Min shanghai Institute of Organic Chemistry, Academia Sinica, shanghai

This paper deals with the synthesis of two new (±)-3-oxa-A-nor steroids 1a and 1 *** conjugated addition of 5'-methylfurandithane anion 8b to the CD-ring synthon 9 in HMPA-THFafforded 9, 10-seco-3-oxa-A-nor steroid 22. The intramolecular cyclization of 22 in acidic mediumgave 23, which underwent hydrolytic desulfurization at elevated temperature in acidic medium togive 1b. The desulfurization of 23 over Raney nickel gave 1a.

关键词： oxa-A-nor steroids 1a and 1b Study on asymmetric syntheses of steroids

Studies on steroidal plant growth regulator——*** construction of the side chain of brassinosteroid by employing a separated dialkylation and a tandem dialkylation of the pyranone moiety

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Chinese Journal of Chemistry 1993年第4期11卷 376-384页

作者： zhou,wei-shan shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,shanghai 200032SUN,Li-Qiang PAN,Xin-Fu Department of Chemistry Lanzhou University,Laahou 730000 1shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 2000322Department of Chemistry 'Lanzhou University Laahou 730000

A stereocontrolled construction of the side chain of brassinosteroid was developed via the separated dialkylation and the tandem dialkylation of the pyranone moiety as the key step.

关键词： Studies on steroidal plant growth regulator Stereoselective construction of the side chain of brassinosteroid by employing a separated dialkylation and a tandem dialkylation of the pyranone moiety

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Studies on the identification and syntheses of insect pheromones *** of(7R,8S)-(+)-sex pheromone of gypsy moth through the kinetic resolution of(±)allylic alcohol by Sharpless asymmetric epoxidation

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Chinese Journal of Chemistry 1985年第3期3卷 257-261页

作者： LIN Guo-Qiang JIANG Yan-Ying zhou wei-shan shanghai Institute of Organic Chemistry,Academia Sinica,shanghai shanghai University of Science and Technology. shanghai Institute of Organic Chemistry Academia Sinica Shanghai

The chiral epoxy alcohol 3 was synthesized in 92％ e.e through the kinetic resolutionof(±)-1-tridecen-3-ol 2 by Sharpless asymmetric epoxidation.3 was then transformed to(7R,8S)-1a,the sex pheromone of gypsy moth,in ... 详细信息

关键词： sex pheromone of gypsy moth through the kinetic resolution of HPLC allylic alcohol by Sharpless asymmetric epoxidation

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： shan Ping Yu Emily Choi Michael QJiang Ling wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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Studies on the structure and synthesis of arteannuin and its related compounds——Ⅹ.The stereocontrolled synthesis of arteannuin and deoxyarteannuin from arteannuinic acid

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Chinese Journal of Chemistry 1983年第1期 98-99页

作者： XU Xing-xiang ZHU Jie HUANG Da-zhong zhou wei-shan(CHOU wei-shan) shanghai Institute of Organic Chemistry,Academia Sinica

Arteannuin(1)is a new sesquiterpene lactone containing a peroxide group and is anantimalarial principle isolated from Artemisia annua ***(2)occurs inthe same plant and was isolated as a metabolite from the urine of patients treated with *** now report the first stereocontrolled synthesis of these two naturally occurringsesquiterpene lactones starting from arteannuinic acid by the reaction sequence shown inScheme 2.

关键词： Studies on the structure and synthesis of arteannuin and its related compounds The stereocontrolled synthesis of arteannuin and deoxyarteannuin from arteannuinic acid

The total syntheses of optically active 7α and 7β,18-dimethyl-19-nor-testosterone

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Chinese Journal of Chemistry 1985年第4期 384-386页

作者： ZHUANG Zhi-Ping zhou wei-shan shanghai Institute of Organic Chemistry,Academia Sinica,shanghai

Introduction of 7-methyl group into the steroid molecule usually causes enhancementand/or modification of parent hormonal *** example,7α,17α-dimethyl-19-nor-testosterone 1 has significant contragestative activity and is lack of *** paperconcerned with the total synthesis of these 7-methyl steroids seems dealing only with thesynthesis of 7-methyl aromatic steroids 2 by using the optically active indanone derivative3 as starting material.

关键词： dimethyl-19-nor-testosterone and 7 The total syntheses of optically active 7