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Resolving the developmental mechanisms of cardiac microthrombosis of SARS-CoV-2 based on single-cell transcriptome analysis

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Science China Life Sciences 2025年第1期 103-115页

作者： Xizi Luo Nan Zhang Yuntao Liu Beibei Du xuan Wang Tianxu Zhao Bingqiang Liu Shishun Zhao Jiazhang qiu Guoqing Wang State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Basic MedicineJilin University State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Veterinary MedicineJilin University College of Mathematics Jilin University Bioinformatic Lab School of MathematicsShandong University Department of Cardiology China-Japan Union HospitalJilin University

The coronavirus disease 2019（COVID-19） outbreak caused by the severe acute respiratory syndrome coronavirus-2（SARS-CoV-2） developed into a global health emergency. Systemic microthrombus caused by SARS-CoV-2 infection is a common complication in patients with COVID-19. Cardiac microthrombosis as a complication of SARS-CoV-2 infection is the primary cause of cardiac injury and death in patietns with severe COVID-19. In this study, we performed single-cell sequencing analysis of the right ventricular free wall tissue from healthy donors,patients who died during the hypercoagulable period of characteristic coagulation abnormality（CAC）, and patients who died during the fibrinolytic period of CAC. We collected 61,187 cells enriched in 24 immune cell subsets and 13 cardiac-resident cell subsets. We found that in the course of SARS-CoV-2 infected heart microthrombus, MYO1EhighRASGEF1Bhighmonocyte-derived macrophages promoted hyperactivation of the immune system and initiated the extrinsic coagulation pathway by activating chemokines CCL3, CCL5. This series of events is the main cause of cardiac microthrombi following SARS-CoV-2 infection. In a SARS-CoV-2 infected heart microthrombus, excessive immune activation is accompanied by an increase in cellular iron content, which in turn promotes oxidative stress and intensifies intercellular competition. This induces cells to alter their metabolic environment, resulting in increased sugar uptake via the glycosaminoglycan synthesis pathway. In addition, high levels of reactive oxygen species generated by elevated iron levels promote increased endogenous malondialdehyde synthesis in a subpopulation of cardiac endothelial cells. This exacerbates endothelial cell dysfunction and exacerbates the coagulopathy process.

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凝胶色谱仪的开放使用与管理

分析测试技术与仪器 2015年第3期21卷 184-186页

作者：刘朋周秋璇苏州大学分析测试中心江苏苏州215123

凝胶色谱仪是高分子化学学科日常科研工作的必备仪器.随着高校高分子化学学科的迅猛发展,如何提高该仪器的开放使用和管理维护变得十分重要.总结了管理的经验及体会.

关键词：凝胶色谱仪开放使用管理

配位化合物[Cd(hca)2(H2O)3](H2O)2,[Cu(hca)2(phen)]的合成与表征

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无机化学学报 2008年第7期24卷 1046-1050页

作者：茅嘉原方红新徐庆锋周秋璇路建美张勇江苏省有机合成重点实验室苏州大学化学化工学院苏州215123

配合物1由醋酸镉和Nahca(对羟基肉桂酸钠)在水溶液中反应得到,配合物2由醋酸铜,Hhca和phen在水和乙醇混合溶液中反应得到。配合物1属正交晶系,Pbcn空间群。配合物2属单斜晶系,C2/c空间群。配合物1和2中配体中的羧酸根与金属离子都是螯... 详细信息

配合物1由醋酸镉和Nahca(对羟基肉桂酸钠)在水溶液中反应得到,配合物2由醋酸铜,Hhca和phen在水和乙醇混合溶液中反应得到。配合物1属正交晶系,Pbcn空间群。配合物2属单斜晶系,C2/c空间群。配合物1和2中配体中的羧酸根与金属离子都是螯合配位的,末端羟基没有参与配位。配合物1和2的结构中都包含了丰富的氢键。通过氢键作用,配合物1形成了三维网状超分子结构,配合物2形成了二维层状超分子结构。

关键词：铜(Ⅱ) 镉(Ⅱ) 晶体结构对羟基肉桂酸氢键

二维配位聚合物[Ag(4-pytz)]_∞的水热合成、结构及其发光性能(英文)

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无机化学学报 2009年第3期25卷 539-543页

作者：金雪明徐庆锋周秋璇路建美王丽华张勇江苏省有机合成重点实验室苏州大学化学化工学院苏州215123

A silver(Ⅰ) complex has been obtained from reaction of silver salt and 4-Hpytz(4-Hpytz=3,5-di(4-pyridyl)-1,2,4-triazole) by hydrothermal *** crystal structure reveals that it consists of a 2D coordination polymer [Ag(4-pytz)]∞(1)(4-pytz=3,5-di(4-pyridyl)-1,2,4-triazolate),which was crystallized in monoclinic crystal system and space group of P21/c,with a=0.753 64(1) nm,b=1.135 55(2) nm,c=1.291 7(2) nm,β=104.015(4)°,V=1.072 5(3) nm3,Z=*** Ag(Ⅰ) ion has a trigonal coordination geometry which three N atoms from two bridging pytz ligands.4-pytz shows-1 valence which lost its proton located at a triazole ring in final *** title complex exhibits high thermal stability and decomposed at 472 ℃.Furthermore,complex 1 shows obvious luminescence with λem at 547 nm,which is ascribed to MLCT.

关键词：晶体结构银配合物热稳定性发光性能

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常温凝胶色谱仪的使用及维护体会

广州化工 2014年第1期42卷 98-99页

作者：周秋璇陈健英胡丽华唐娟苏州大学分析测试中心江苏苏州215123

介绍了常温凝胶色谱仪日常使用中常见的故障,结合自己的工作经验提出了一些日常维护的体会。分别从贮液系统、运输系统、进样系统、分离系统以及检测系统5个方面进行了总结。我们在测试工作中正确使用仪器,尽量避免仪器或耗材的损耗不... 详细信息

介绍了常温凝胶色谱仪日常使用中常见的故障,结合自己的工作经验提出了一些日常维护的体会。分别从贮液系统、运输系统、进样系统、分离系统以及检测系统5个方面进行了总结。我们在测试工作中正确使用仪器,尽量避免仪器或耗材的损耗不但能节约测试成本,还能延长仪器使用寿命。

关键词：凝胶色谱仪使用维护

Evolution of vortex structure around a wall-mounted rough hemisphere

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Journal of Hydrodynamics 2023年第3期35卷 467-481页

作者： Xiang qiu Hao-xuan Liu Jia-hua Li Yi-zhou Tao Yu-lu Liu School of Science Shanghai Institute of TechnologyShanghai 201418China College of Urban Construction and Safety Engineering Shanghai Institute of TechnologyShanghai 201418China Shanghai Institute of Applied Mathematics and Mechanics Shanghai UniversityShanghai 200072China

In this paper,the large eddy simulation(LES)method is used to calculate Reynolds numbers the range in the range of 3000–30000(based on the diameter of the hemisphere D),and then the statistical analysis method is used to study the influence of Re on the characteristics of the flow field around the rough hemisphere and the evolution law of the tail *** effect of the Reynolds number on the structure of the rough hemisphere flow field and the evolution of vortex structure is studied by vorticity distribution,POD method,and correlation *** can be observed that with the increase of Reynolds number,the shear in the recirculating region of the rough hemisphere is enhanced,the large-scale structure is reduced,the small-scale structure is increased,and the angle between the hairpin vortex and the wall is reduced.λ_(ci)vortex identification and the Q-criterion are used to capture the evolution of a periodic vortex structure.Q-criterion gives the three-dimensional vortex structure behind the hemispherical *** is found that the horseshoe vortex and arch vortex generated by the incoming flow after passing through the hemisphere will interact with the wall surface to form a hairpin vortex,and the hairpin vortex structure will continue to evolve downstream to form a new vortex structure.

关键词： Rough hemisphere large eddy simulation(LES) POD method two-point velocity correlation function

Numerical study on erosion behavior of sliding sleeve ball seat for hydraulic fracturing based on experimental data

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Petroleum Science 2023年第1期20卷 515-525页

作者： xuan-Li zhou Yan-Bao Guo qiu-Ju Xie De-Guo Wang Hyun C.Yoon College of Mechanical and Transportation Engineering China University of PetroleumBeijing102249China Harold Vance Department of Petroleum Engineering Texas A&M UniversityCollege StationTX77843United States Korea Institute of Geoscience and Mineral Resources Daejeon34132South Korea

The sleeve sealing ball seat is one of the important components in the multistage fracturing process of horizontal *** erosion and wear of the surface will decrease the sealing performance of the fracturing ball and the ball *** leads to pressure leakage during the fracturing process and fracturing *** this paper,combined with the actual ball seat materials and working conditions during the fracturing process,the erosion tests of ductile iron and tungsten carbide materials under different erosion speeds,angles,and mortar concentrations are carried *** the erosion test results were analyzed by mathematical fitting,and a set of erosion models suitable for sliding sleeve setting ball seat materials were innovatively *** the first time,this paper combines the erosion model obtained from the experiment and the computational fluid dynamics(CFD)with Fluent software to simulate the erosion of the ball *** on the simulation results,the morphology of the sliding sleeve seat ball after erosion is *** analysis of the test and simulation results,it is showed that the erosion rate of tungsten carbide material is lower and the wear resistance is better under the condition of small angle *** research can offer a strong basis for fracturing site selection,surface treatment methods,and prediction of failure time of ball seats.

关键词： Multistage fracturing Sliding sleeve ball seat Erosion wear Erosion model Fluent simulation

Effect of Complex Parameters of Porous Media on Desalination Performance in Air-Gap Diffusion Distillation Based on Multiple Regression Analysis

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Journal of Thermal Science 2022年第6期31卷 2329-2345页

作者： CHEN Lele WANG Ping ZHANG xuan qiu Qinggang Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education School of Energy and Power EngineeringDalian University of TechnologyDalian 116024China

Air-Gap Diffusion Distillation(AGDD) is a new technology aiming at solving the problem of the safety of drinking water for residents in remote areas that uses a super hydrophilic porous medium as the hot channel and evaporation surface. In the experiment, it was found that the parameters of porous media have a significant influence on the desalination(evaporation) efficiency of AGDD. Although porous media are widely used as evaporation components, the factors affecting their evaporation efficiency are not fully understood. The evaporation process in super hydrophilic porous media is rarely discussed. A large number of experiments have been carried out based on AGDD. The introduction of statistical methods solves the problem that experiments cannot distinguish the contribution of complex parameters of porous media to evaporation efficiency. Stepwise regression analysis is used to reduce the dimensionality of the independent variables and construct regression equations(coefficient of determination R~2 reached 81.3%-96.8%). Evaporation flux correlations and dimensionless mass transfer correlations are established based on porous media parameters. We found that the surface evaporation of super hydrophilic porous media can be divided into three stages: diffusion evaporation, capillary evaporation, and thermal evaporation. The evaporation efficiency of these three stages is controlled by the vapor diffusion process resistance, capillary force, and energy supply. At low saturation, evaporation efficiency is limited by the resistance of the vapor diffusion process. The evaporation efficiency of the porous media is affected predominantly by the pore size, the specific surface area, porosity and the characteristic length. At high saturation, the evaporation efficiency becomes influenced primarily by the permeability. A small thickness and a high hydrophilicity also improve the evaporation efficiency.

关键词： Air-Gap Diffusion Distillation(AGDD) stepwise regression analysis evaporation super hydrophilic porous media desalination

Reversible Mechanochemistry Enabled Autonomous Sustaining of Robustness of Polymers—An Example of Next Generation Self-healing Strategy

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Chinese Journal of Polymer Science 2021年第5期39卷 545-553,I0005页

作者： Ming-xuan Li Min-Zhi Rong Ming-qiu Zhang Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education Guangdong Provincial Key Laboratory of High Performance Polymer CompositesSchool of ChemistrySun Yat-Sen UniversityGuangzhou 510275China

Even under low external force,a few macromolecules of a polymer have to be much more highly stressed and fractured first due to the inherent heterogeneous *** the materials keep on working under loading,as is often the case,the minor damages would add up,endangering the safety of *** we show an innovative solution based on mechanochemically initiated reversible cascading variation of metal-ligand *** loading,crosslinking density of the proof-of-concept metallopolymer networks autonomously increases,and recovers after ***,the stress-induced tiny fracture precursors are blocked to grow and then *** entire processes reversibly proceed free of manual intervention and *** proposed molecular-level internal equilibrium prevention mechanisms fundamentally enhance durability of polymers in service.

关键词： Metal-ligand complexations Polyurethane Mechanochemistry Mechanical properties Robustness