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Directional screening and identification of potential cytotoxic components from Achnatherum inebrians by a combination of surface palsmon resonance and chromatography

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Chinese Herbal Medicines 2023年第2期15卷 329-336页

作者： Wenbin zhou Man Wang Aiqin Zhang Danrong Huang Hua guo Gangyi Shen Key laboratory of Ethnomedicine(Minzu University of China) Ministry of EducationSchool of PharmacyMinzu University of ChinaBeijing 100081China College of life and Environmental Sciences Minzu University of ChinaBeijing 100081China

Objective:To establish a method for directional screening of the cytotoxic components from the medicinal herb of Achnatherum inebrians by a combination of surface plasmon resonance(SPR)biosensor and chromatographic isolation ***:Under the guidance of bioactive assessment based on binding abilities between objects and the a-Mannosidase(a-Man)target,the active components from different solvents extracts,different polar extraction parts and fractions were screened orderly and directionally using *** with a high binding ability to a-Man can be precisely oriented in a narrower fractions range and are easy to *** human cancer cells were used to evaluate the cytotoxic activity of component with the highest affinity to ***:Eight compounds were isolated and identificated from *** for the first *** possessed the highest affinity to a-Man among ***,deoxyvasicinone showed good effects on inhibited proliferation of human hepatoma cells HepG2(IC_(50)=5.7 μmol/l),human breast cancer cells MCF7(IC_(50)=7.21 μmol/l)and human lung cancer cells HCC827(IC_(50)=0.75 μmol/l),*** particular,its inhibitory effect on HCC827 was stronger than the positive drug gefitinib(IC_(50)=1.65 μmol/l).Conclusion:A comprehensive strategy of directional screening potential cytotoxic components from herb based on biomolecular interaction and chromatography was *** as an effective anti-cancer component was initially isolated from *** is expected that this screening strategy could provide new perspectives for rapid screening and identification of active components from natural plants with the complex matrix.

关键词： Achnatherum inebrians(Hance)Keng chromatography cytotoxic components deoxyvasicinone surface plasmon resonance α-Mannosidase

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添加蒲公英对苜蓿青贮品质及抗氧化活性的影响

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草业科学 2024年第9期41卷 2155-2163页

作者：马成艳周小栋马小婧黄帅宁夏大学林业与草业学院宁夏银川750021

将药用蒲公英(Taraxacum officinale)分别以0(对照组,CK)、2%、4%、6%和8%添加至苜蓿(Medicago sativa)中进行青贮,每组4个重复,发酵60 d后测定青贮营养成分、发酵品质及抗氧化活性。结果表明,与CK相比,在营养品质上,4%组的干物质(DM)... 详细信息

将药用蒲公英(Taraxacum officinale)分别以0(对照组,CK)、2%、4%、6%和8%添加至苜蓿(Medicago sativa)中进行青贮,每组4个重复,发酵60 d后测定青贮营养成分、发酵品质及抗氧化活性。结果表明,与CK相比,在营养品质上,4%组的干物质(DM)和粗脂肪(EE)含量显著增加(PlA)含量和乳酸菌(lAB)数量均显著增加,分别为4.85%和7.19 lg(cfu·g^(−1)),且氨态氮(NH_(3)-N)含量显著降低,为2.46%。抗氧化活性上,8%组类黄酮含量显著增加,为1.37%,4%、6%和8%组的总酚和总多糖含量及谷胱甘肽过氧化物酶(GSH-Px)活性均显著提高,6%组青贮的超氧化物歧化酶(SOD)活性显著提高,为241.37 U·mg^(−1),2%和6%组青贮的1,1-二苯基-2-三硝基苯肼(DPPH)清除率均显著提高,且均在90.00%以上;2%、4%和8%组青贮的总抗氧化能力(T-AOC)均显著提高,分别为0.51、0.60和0.43 mmol·l^(−1)。主成分分析和综合得分排名表现为6%组>4%组>2%组>8%组>CK。综上所述,蒲公英添加量为6.0%时对苜蓿青贮的营养品质、发酵品质和抗氧化活性效果最好。

关键词：苜蓿蒲公英营养品质发酵品质抗氧化活性黄酮多糖

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DNA methylation as a mediator of epigenetic regulation in the pathogenesis and precision medicine of osteoarthritis:An updated review

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BIOCEll 2023年第4期47卷 761-772页

作者： QIAO zhou JIAN lIU lING XIN YANYAN FANG lEI WAN DAN HUANG JINCHEN guo JIANTING WEN Anhui University of Chinese Medicine Hefei230012China Institute of Rheumatism Prevention and Treatment of Traditional Chinese Medicine Anhui Academy of Chinese Medicine SciencesHefei230031China Department of Rheumatism Immunity The Second Affiliated HospitalAnhui University of Chinese MedicineHefei230061China Department of Rheumatism Immunity The First Affiliated HospitalAnhui University of Chinese MedicineHefei230031China

The pathophysiology of osteoarthritis(OA)is multifactorial,with the primary risk factors being obesity,age,environmental variables,and genetic *** available evidence suggests that genetic diversity does not adequately account for all clinical characteristics and heterogeneity of *** has emerged as a nascent and crucial area of research in *** epigenetic module presents a potential link between genetic and environmental risk factors and the susceptibility and pathogenesis of *** a critical epigenetic alteration,DNA methylation has been shown to have an important role in the etiology of OA and is a viable biomarker for predicting disease progression and medication response,as shown in this *** review aims to update knowledge in the field of DNA methylation associated with OA to better identify the essential features of OA subtypes and pathological conditions,hence accelerating individualized treatment and precision medicine.

关键词： Epigenetics DNA methylation Osteoarthritis Pathogenesis Precision medicine

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Unicentric Castleman disease was misdiagnosed as pancreatic mass:A case report

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World Journal of Clinical Cases 2022年第4期10卷 1278-1285页

作者： Hong-Yan Zhai Xin-Yuan Zhu Gui-Ming zhou li Zhu Dan-Dan guo Hao Zhang Department of Ultrasound Tianjin Medical University General HospitalTianjin 300005China Department of Cardivascular Tianjin Medical University General HospitalTianjin 300005China Department of Cardivascular Surgery Tianjin Medical University General HospitalTianjin 300005China

BACKGROUND Castleman’s disease(CD)is a lymphatic proliferative disorder of unknown cause and is rarely seen *** has been divided into unicentric and multicentric *** CD(UCD)occurs as a solitary enlarged mass and mediastinal lymph nodes are the most common *** excision has proven to be curative for *** CD(MCD)appears as a systemic disease with peripheral *** had a poor response to surgery and monoclonal antibodies with rituximab have become a research *** SUMMARY A 44-year-old woman presented with a pancreatic mass during routine physical *** had no obvious symptoms,such as fever,abdominal pain,abdominal distension,or *** examination indicated a hypoechoic mass between the body of the pancreas,left lobe of the liver and *** had a clear boundary,irregular shape,uneven echo,and no obvious blood flow *** clarify the diagnosis,contrast-enhanced ultrasound examination was performed,which showed a benign pancreatic *** or solid pseudopapillary tumor was a possible *** patient underwent further contrast-enhanced computed tomography and contrastenhanced magnetic resonance imaging,which were suggestive of solid pseudopapillary tumor or neuroendocrine *** the examinations failed to give a definitive diagnosis,and the patient underwent *** final pathological and immunohistochemical results showed that the mass was *** This case highlights when lymphadenopathy is encountered clinically,CD should be considered and a biopsy should be performed.

关键词： Castleman’s disease lymphadenopathy Unicentric Multicentric Contrastenhanced ultrasound Case report

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Ultra-low thermal conductivity of roughened silicon nanowires:Role of phonon-surface bond order imperfection scattering

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Chinese Physics B 2020年第8期29卷 102-107页

作者： Heng-Yu Yang Ya-li Chen Wu-Xing zhou guo-Feng Xie Ning Xu School of Materials Science and Engineering Hunan University of Science and TechnologyXiangtan 411201China Hunan Provincial Key laboratory of Advanced Materials for New Energy Storage and Conversion Xiangtan 411201China School of Physics and Optoelectronics Xiangtan UniversityXiangtan 411105China Deparment of Physics Yancheng Institute of TechnologyYancheng 224051China

The ultra-low thermal conductivity of roughened silicon nanowires(SiNWs)can not be explained by the classical phonon-surface scattering *** there have been several efforts at developing theories of phonon-surface scattering to interpret it,but the underlying reason is still *** consider that the bond order loss and correlative bond hardening on the surface of roughened SiNWs will deeply influence the thermal transport because of their ultra-high surface-to-volume *** combining this mechanism with the phonon Boltzmann transport equation,we explicate that the suppression of high-frequency phonons results in the obvious reduction of thermal conductivity of roughened ***,we verify that the roughness amplitude has more remarkable influence on thermal conductivity of SiNWs than the roughness correlation length,and the surface-to-volume ratio is a nearly universal gauge for thermal conductivity of roughened SiNWs.

关键词： thermal conductivity silicon nanowires bond order imperfections phonon-surface scattering

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An electrocatalyst with anti-oxidized capability for overall water splitting

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Nano Research 2018年第6期11卷 3411-3418页

作者： Chang Yu Huawei Huang Si zhou Xiaotong Han Changtai Zhao Juan Yang Shaofeng li Wei guo Bowen An Jijun Zhao Jieshan Qiu State Key lab of Fine Chemicals School of Chemical Engineering Liaoning Key Lab for Energy Materials and Chemical Engineering Dalian University of Technology Dalian 116024 China Key laboratory of Materials Modification by laser Ion and Electron Beams (Ministry of Education) Dalian University of Technology Dalian 116024 China

An anti-oxidized NiS2 electrocatalyst with improved catalytic activity was developed using a Fe-induced conversion strateg3a X-ray photoelectron spectroscopy reveals that betatopic Ni species with high valence states are present within the Fe-NiS2 matrix and relatively less oxidized layers exist on the catalyst＇s surface, indicating its greatly enhanced anti-oxidized capability. Density functional theory calculations reveal that the Ni and Fe sites on the Fe-NiS2 catalyst surface possess strong adsorption capacity toward hydroxyl ions compared with the Ni sites on NiS2. Benefiting from its unique microstructure and modulated electronic structure due to the effects of iron species, the Fe-NiS2 catalyst prepared on carbon fiber delivers a remarkably enhanced catalytic activity and superior long-life durability for overall water splitting. The present results provide an efficient strategy for the design and configuration of anti-oxidation catalysts, especially for energy storage and catalysis.

关键词： anti-oxidized catalysts metal sulfides oxygen evolution hydrogen evolution water splitting

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Discovery of amantadine formate:Toward achieving ultrahigh pyroelectric performances in organics

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The Innovation 2022年第2期3卷 73-78页

作者： Junyan zhou Shifeng Jin Congcong Chai Munan Hao Xin Zhong Tianping Ying Jiangang guo Xiaolong Chen Beijing National laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 101408China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 101408China Materials Research Center for Element Strategy Tokyo Institute of TechnologyYokohama 226-8503Japan Songshan lake Materials laboratory Dongguan 523808China

Pyroelectrics are a class of polar compounds that output electrical signals upon changes in *** the rapid development of flexible electronics,organic pyroelectrics are highly ***,most organics suffer from low pyroelectric coefficients or low working *** date,the realization of superior pyroelectric performance in all-organics has remained a challenge.

关键词： temperature realization electrical

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Multi-scale coupling simulation in directional solidification of superalloy based on cellular automaton-finite difference method

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China Foundry 2017年第5期14卷 398-404页

作者： Zhao guo Jian-xin zhou Ya-jun Yin Dong-qiao Zhang Xiao-yuan Ji Xu Shen State Key laboratory of Materials Processing and Die&Mould Technology Ituazhong Universityof Science and TechnologyWuhan 430074China

Casting microstructure evolution is difficult to describe quantitatively by only a separate simulation of dendrite scale or grain scale, and the numerical simulation of these two scales is difficult to render compatible. A three-dimensional cellular automaton model couplling both dendritic scale and grain scale is developed to simulate the microstructure evolution of the nickel-based single crystal superalloy DD406. Besides, a macro–mesoscopic/microscopic coupling solution algorithm is proposed to improve computational efficiency. The simulation results of dendrite growth and grain growth of the alloy are obtained and compared with the results given in previous reports. The results show that the primary dendritic arm spacing and secondary dendritic arm spacing of the dendritic growth are consistent with the theoretical and experimental results. The mesoscopic grain simulation can be used to obtain results similar to those of microscopic dendrites simulation. It is indicated that the developed model is feasible and effective.

关键词： multi-scale coupling dendritic growth grain growth directional solidification cellular automata numerical simulation

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Tensile Properties and Deformation Behavior of Several Cast Ni-Based Superalloys Fabricated by Different Solidification Ways

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Acta Metallurgica Sinica(English letters) 2017年第3期30卷 280-288页

作者： Hai-Tao li Yong-Chun liang Wan-li Zhong Xue-Zhi Qin Jian-Ting guo lan-Zhang zhou Wei-li Ren South China University of Technology Guangzhou 510641China Guangdong Power Grid Co. ltd Guangzhou 510600 China Electric Power Research Institute of Guangdong Power Grid Corporation Guangzhou 510080 China Institute of Metal Research Chinese Academy of SciencesShenyang 110016 China Shanghai University Shanghai 200072 China

The tensile properties and deformation behavior of several cast Ni-based superalloys, respectively, in the equiaxed, columnar-crystal and single-crystal styles are comparatively studied. The effects of solidification way, heat treatment and strain rate on the tensile properties are discussed in detail. It is found that the reduction of grain boundaries by the feasible solidification ways offers cast Ni-based superalloys the potential capability of improving the mechanical properties, the ultimate achievement of which is also confirmed to lie on the appropriate modifications of chemical composition and heat treatment. The prolongation of solid solution facilitates the precipitation of fine secondary γ＇ phase, whereas the extension of high-temperature aging leads to the coarsening of secondary γ＇ phase. The combination of these two aspects has a crucial influence on the tensile properties. Under tensile applied stress, the surface grains of DZ-A alloy deform slightly, while the inner grains deform heavily. This deformation inhomogeneity is ascribed to the occurrence of cracks or oblique grains near the surface of specimens and the sliding or decohesion of grain boundaries between the surface and inner grains. Regardless of strain rate, the IlTDM （intermediate-low-temperature ductility minimum） phe- nomenon always happens in the temperature range from 400 to 600 ℃ in all the investigated alloys, the occurrence of which is closely related to the strong strain-hardening behavior in the deformation process. Finally, the interaction of slip bands which are the main deformation mode below 600 ℃ is established to be the essential reason for the strain hardening.

关键词： Ni-based superalloy Tensile property Intermediate-low-temperature ductility minimum(IlTDM) Solidification way Strain rate Deformation inhomogeneity

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土地利用方式对豫西丘陵区土壤团聚体稳定性及其化学计量特征的影响

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河南科技大学学报（自然科学版） 2024年第3期45卷 88-95页

作者：郭大勇刘海燕杜鹃曾祥王翔宇周子琪刘雪涛寇太记陈鲜妮河南科技大学农学院河南洛阳471023 洛阳市植物营养与环境生态重点实验室河南洛阳471023 洛阳市农业技术推广服务中心河南洛阳471000 西北农林科技大学资源环境学院陕西杨凌712100

为探究不同土地利用方式对土壤团聚体组成和碳、氮、磷化学计量特征的影响,以豫西丘陵区相同冲积母质土壤为研究对象,对果园、林地、草地和农田等4种土地利用方式的土壤团聚体稳定性、碳含量、氮含量、磷含量及化学计量特征进行了测定... 详细信息

为探究不同土地利用方式对土壤团聚体组成和碳、氮、磷化学计量特征的影响,以豫西丘陵区相同冲积母质土壤为研究对象,对果园、林地、草地和农田等4种土地利用方式的土壤团聚体稳定性、碳含量、氮含量、磷含量及化学计量特征进行了测定分析。结果表明:4种土地利用方式土壤均表现出以0.25~2 mm粒级为优势团聚体分布的特征,以农田土壤最高,质量分数为58.49%~66.11%,土壤团聚体稳定性农田>林地>草地和果园。全碳含量(以质量比表示)随团聚体粒级的下降呈现减少趋势,果园在4个粒级上的全碳含量均显著地高于其他3种土地利用方式,在农田>林地>草地。果园C/N和C/P均显著地高于林地、草地和农田,林地在<2 mm的3个土壤团聚体粒级上的C/N均显著低于草地和农田,但在<2 mm土壤团聚体粒级上的C/P和N/P均显著高于草地。土地利用方式对土壤团聚体稳定性和化学计量特征有显著影响。豫西丘陵区的农田团聚体稳定度最高,果园显示出高的有机输入特征,林地主要受磷限制,草地主要受氮限制。

关键词：土地利用方式土壤团聚体化学计量学丘陵区

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