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The Optical Variability Properties of TeV Blazars

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Research in Astronomy and Astrophysics 2024年第9期24卷 68-77页

作者： Zi-An Su Wen-Xin Yang xiang-Tao Zeng Le-Jian Ou Ze-Lin Li jiang-He Yang Jun-Hui Fan Department of Physics School of Physics and Electronics Hunan Normal University Center for Astrophysics Guangzhou University Greater Bay Brand Center of the National Astronomical Data Center Astronomy Science and Technology Research Laboratory of Department of Education of Guangdong Province College of Microelectronics Feicuihu Campus of Hefei University of Technology College of Mathematics and Physics Science Hunan University of Arts and Science

Variability is one of the typical observational properties of blazars and the spectral changes are usually associated with variability,although this kind of association is unclear *** this work,we used data from the Steward Observatory blazar monitoring program to investigate the optical variability properties including the short-term timescale,the brightness-dependent spectral property,the correlation between the the brightness variation and the polarization,and then estimate the Doppler factors based on the obtained short timescale to study the polarization property for a sample of 20 TeV *** analyses arrive at the following results:（1） The largest variation amplitude in R-band,ΔRM,covers a range fromΔRM=0.29 mag （1ES 2344+514） toΔRM=4.66 mag （3C 279）.（2） Intra-day variability was found from five sources with timescales from 0.14 day for S5 0716+714 to 0.98 day for PKS 2155–*** sources show spectra that are bluer when they become brighter,suggesting a common bluer-when-brighter property.（3） The plot of the polarization versus estimated Doppler factor is consistent with the Doppler factor dependent formula of polarization.（4） The largest polarization is correlated with the largest optical variation,suggesting that the high polarization and high amplitude variation are both the indicator of beaming effect.

关键词： galaxies: active galaxies: jets radiation mechanisms: non-thermal

Interplay between mesenchymal stem cells and macrophages:Promoting bone tissue repair

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World Journal of Stem Cells 2024年第4期16卷 375-388页

作者： Fei-Fan Zhang Yang Hao Kuai-xiang Zhang jiang-Jia Yang Zhi-Qiang Zhao Hong-Jian Liu Ji-Tian Li Molecular Biology Lab Henan Luoyang Orthopedic Hospital(Henan Provincial Orthopedic Hospital)Zhengzhou 450000Henan ProvinceChina Graduate School Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Graduate School Henan University of Chinese MedicineZhengzhou 450046Henan ProvinceChina Department of Orthopaedics The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

The repair of bone tissue damage is a complex process that is well-orchestrated in time and space,a focus and difficulty in orthopedic *** recent years,the success of mesenchymal stem cells(MSCs)-mediated bone repair in clinical trials of large-area bone defects and bone necrosis has made it a candidate in bone tissue repair engineering and regenerative *** are closely related to *** one hand,MSCs regulate the immune regulatory function by influencing macrophages proliferation,infiltration,and phenotype polarization,while also affecting the osteoclasts differentiation of *** the other hand,macrophages activate MSCs and mediate the multilineage differentiation of MSCs by regulating the immune *** cross-talk between MSCs and macrophages plays a crucial role in regulating the immune system and in promoting tissue *** full use of the relationship between MSCs and macrophages will enhance the efficacy of MSCs therapy in bone tissue repair,and will also provide a reference for further application of MSCs in other diseases.

关键词： Bone tissue damage Inflammation Macrophages Mesenchymal stem cells Tissue regeneration

Clinical characteristics of peripapillary hyperreflective ovoid mass-like structures in myopic children

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1292-1299页

作者： Lu Zhang Zuo-Hui-Zi Yi Xuan jiang Gong-Peng Sun Fang Zhao Li Zhang Yi xiang Chang-Zheng Chen Department of Ophthalmology the Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014Hubei ProvinceChina Eye Center Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

AIM:To describe the characteristics of peripapillary hyperreflective ovoid mass-like structure(PHOMS)in myopic children and to investigate factors associated with ***:This retrospective observational study included 101 eyes of 101 children(age≤17y)with *** included patients underwent comprehensive clinical *** nerve canal parameters,including disc diameter,optic nerve head(ONH)tilt angle,and border tissue angle were measured using serial enhanced-depth imaging spectral-domain optical coherence tomography(EDI-OCT).Based on the optic disc drusen consortium’s definition of PHOMS,eyes were classified as PHOMS group and non-PHOMS *** was categorized according to ***:Sixty-seven(66.3%)eyes were found with *** PHOMS could only be detected by optical coherence tomography(OCT).Medium PHOMS could be seen with blurred optic disc borders corresponding to *** most frequent location of PHOMS was at the nasosuperior(91%,61 of 67 eyes)to ONH *** axial length and spherical equivalent were more myopic in the PHOMS group than in the non-PHOMS group(both P<0.001).ONH tilt angle was also significantly greater in PHOMS group than in non-PHOMS group[8.90(7.16-10.54)vs 3.93(3.09-5.25),P<0.001].Border tissue angle was significantly smaller in PHOMS group than in non-PHOMS group[29.70(20.90-43.81)vs 45.62(35.18-60.45),P<0.001].In the multivariable analysis,spherical equivalent(OR=3.246,95%CI=1.209-8.718,P=0.019)and ONH tilt angle(OR=3.275,95%CI=1.422-7.542,P=0.005)were significantly correlated with *** was no disc diameter associated with *** the linear regression analysis,border tissue angle was negatively associated with PHOMS height(β=-2.227,P<0.001).CONCLUSION:PHOMS is associated with optic disc tilt and optic disc nasal shift in *** diameter is not a risk factor for *** changes in ONH caused by axial elongation facilitated an understanding of the mechanism of PHOMS.

关键词： peripapillary hyperreflective ovoid masslike structure myopia optic disc edema enhanced-depth imaging spectral-domain optical coherence tomography

Unraveling magnetic properties and martensitic transformation in Mn-rich Ni-Mn-Sn alloys:first-principles calculations and experiments

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Rare Metals 2024年第4期43卷 1769-1785页

作者： Yu Zhang Jing Bai Ke-Liang Guo Jia-Xin Xu jiang-Long Gu Nicola Morley Qui-Zhi Gao Yu-Dong Zhang Claude Esling xiang Zhao Liang Zuo Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Material Science and EngineeringNortheastern UniversityShenyang110819China Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province School of Resources and MaterialsNortheastern University at QinhuangdaoQinhuangdao066004China Department of Material Science and Engineering University of SheffieldSheffieldS13JDUK State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao066004China Laboratoire d’Étude des Microstructures Et de Mécanique des Matériaux University of Lorraine57045MetzFrance

We have investigated the phase stability,magnetic properties,and martensitic transformation thermodynamics/kinetics of the Ni_(24-x)Mn_(18+x+y)Sn_(6-y)(x,y=0,1,2)system by combining the first-principles calculations and *** calculation results show that the optimized lattice parameters are consistent with the experimental ***,we obtain the relation equation for the austenite formation energy(E_(form-A))and Mn content(X_(Mn)):E_(form-A)=507.358X_(Mn)-274.126,as well as for the six-layer modulated(6M)martensite formation energy(E_(form-6M))and Ni content(X_(Ni)):E_(form-6M)=-728.484X_(Ni)+*** ternary phase diagram of the total magnetic moment was *** excess Mn will reduce the total magnetic moment of 6M(Mag6M)and non-modulated(NM)(MagNM)martensites,with the following equations relating the total magnetic moment and Mn content:Mag_(6M)=-15.905X_(Mn)+7.902and Mag_(NM)=-14.781X_(Mn)+7.411,while the effect on austenite is *** variation of total magnetic moment is mainly dominated by the Mn atomic magnetic *** 3d electrons of Mn_(Sn)(Mn at Sn sublattice)play an important role in magnetic properties from the perspective of the electronic density of *** on the thermodynamics of martensitic transformation,the alloys will likely undergo austenite?6M?NM transformation *** the thermodynamic and kinetic results,the martensitic transformation temperature decreases with x increasing and increases with y *** results are expected to provide reference for predicting the phase stability and magnetic properties of NiMn-Sn alloys.

关键词： Ni-Mn-Sn First-principles calculations Martensitic transformation Magnetic property Kinetics

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Enhancing immunotherapy efficacy against MHC-I deficient triple-negative breast cancer using LCL161-loaded macrophage membranedecorated nanoparticles

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3218-3231页

作者： Wen Zhang Yihui Zhai Ying Cai xiang Gong Yunxuan jiang Rong Rong Chao Zheng Binyu Zhu Helen He Zhu Hao Wang Yaping Li Pengcheng Zhang China State Institute of Pharmaceutical Industry Shanghai 201203China State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Biomedical Engineering&State Key Laboratory of Advanced Medical Materials and Devices ShanghaiTech UniversityShanghai 201210China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China Yantai Institute of Materia Medica Shandong 264000China State Key Laboratory of Oncogenes and Related Genes Renji-Med-X Stem Cell Research CenterDepartment of UrologyRen Ji HospitalSchool of Medicine and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200127China University of Chinese Academy of Sciences Beijing 100049China

Current cytotoxic T lymphocyte(CTL)activating immunotherapy requires a major histocompatibility complex I(MHC-I)-mediated presentation of tumor-associated antigens,which malfunctions in around half of patients with triple-negative breast cancer(TNBC).Here,we create a LCL161-loaded macrophage membrane decorated nanoparticle(LMN)for immunotherapy of MHC-I-deficient *** on the macrophage membrane helps LMNs recognize CD47-expressing cancer cells for targeted delivery of LCL161,which induces the release of high mobility group protein 1 and proinflammatory cytokines from cancer *** released cytokines and high mobility group protein 1 activate antitumor immunity by increasing the intratumoral density of the phagocytic macrophage subtype by 15 times and elevating the intratumoral concentration of CTL lymphotoxin by 4.6 *** also block CD47-mediated phagocytosis *** inhibit the growth of MHC-I-deficient TNBC tumors,as well as those resistant to combined therapy of anti-PDL1 antibody and albumin-bound paclitaxel,and prolong the survival of animals,during which process CTLs also play important *** macrophage membrane-decorated nanoparticle presents a generalizable platform for increasing macrophagemediated antitumor immunity for effective immunotherapy of MHC-I-deficient cancers.

关键词： MHC-I deficiency Macrophage CD47 Immunotherapy Triple-negative breast cancer Phagocytosis Immune checkpoint Innate immunity

GATA binding protein 2 mediated ankyrin repeat domain containing 26 high expression in myeloid-derived cell lines

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World Journal of Stem Cells 2024年第5期16卷 538-550页

作者： Yang-zhou jiang Lan-Yue Hu Mao-Shan Chen Xiao-Jie Wang Cheng-Ning Tan Pei-Pei Xue Teng Yu Xiao-Yan He Li-Xin xiang Yan-Ni Xiao Xiao-Liang Li Qian Ran Zhong-Jun Li Li Chen Laboratory of Radiation Biology Department of Blood TransfusionLaboratory Medicine CenterThe Second Affiliated HospitalThird Military Medical UniversityChongqing 400037China Hematopoietic Acute Radiation Syndrome Medical and Pharmaceutical Basic Research Innovation Center Ministry of Education of the People’s Republic of ChinaChongqing 400037China

BACKGROUND Thrombocytopenia 2,an autosomal dominant inherited disease characterized by moderate thrombocytopenia,predisposition to myeloid malignancies and normal platelet size and function,can be caused by 5’-untranslated region(UTR)point mutations in ankyrin repeat domain containing 26(ANKRD26).Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1)have been identified as negative regulators of ***,the positive regulators of ANKRD26 are still *** To prove the positive regulatory effect of GATA binding protein 2(GATA2)on ANKRD26 *** Human induced pluripotent stem cells derived from bone marrow(hiPSC-BM)INTRODUCTION Ankyrin repeat domain containing protein 26(ANKRD26)acts as a regulator of adipogenesis and is involved in the regulation of feeding behavior[1-3].The ANKRD26 gene is located on chromosome 10 and shares regions of homology with the primate-specific gene family *** to the Human Protein Atlas database,the ANKRD26 protein is localized to the Golgi apparatus and vesicles,and its expression can be detected in nearly all human tissues[4].Moreover,UniProt annotation revealed that ANKRD26 is localized in the centrosome and contains coiled-coil domains formed by spectrin helices and ankyrin repeats[5,6].The most common disease related to ANKRD26 is thrombocytopenia 2(THC2),which is a rare autosomal dominant inherited disease characterized by lifelong mild-to-moderate thrombocytopenia and mild bleeding[7-9].Caused by the variants in the 5’-untranslated region(UTR)of ANKRD26,THC2 is defined by a decrease in the number of platelets in circulating blood and results in increased bleeding and decreased clotting ability[8,10].Due to the point mutations that occur in the 5’-UTR of ANKRD26,its negative transcription factors(TFs),Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1),lose their repression effect[11].The persistent expression of ANKRD26 increases the activi

关键词： Ankyrin repeat domain containing 26 GATA binding protein 2 Thrombocytopenia 2 Transcriptional regulation Myeloid-derived cell lines

Graphene oxide/Al_(2)O_(3)-based diffusive memristor cells:enabling robust crossbar arrays for multidisciplinary applications

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Rare Metals 2024年第8期43卷 3997-4005页

作者： Chen Liu Jun-Cheng Jin Yi-Ke Xiao Xin-Xin Wang Ping-Yuan Yan Yan-Qiang Cao Li-Yong jiang Chuan-xiang Sheng Ye-Feng Yu School of Microelectronics Nanjing University of Science and TechnologyNanjing 210094China School of Science Nanjing University of Science and TechnologyNanjing210094China School of Information Science and Technology Fudan UniversityShanghai 200433China

A memristor crossbar array (MCA) has emerged as a cutting-edge platform for advanced memory and neuromorphic computing hardware,offering unrivaled bit-level storage density.A diffusive memristor cell (DMC) is particularly well-suited for MCA integration due to its inherent threshold switching characteristics as a selector,effectively addressing current sneak path *** DMC's potential is acknowledged,it necessitates furtherexploration of their practical applicability.

关键词： crossbar arrays offering

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ZYX promotes invasion and metastasis of gastric cancer cells via WNK1/SNAI1axis

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Genes & Diseases 2024年第2期11卷 564-567页

作者： Yi jiang Dongfang xiang Xianmei Wen Mingmin He Yan Qin Xiaoxue Yao Zexuan Yan Xiuli Geng Yong Ren Xiongwei Cai Youhong Cui Yan Wang Institute of Pathology and Southwest Cancer Center Southwest HospitalArmy Medical University (Third Military Medical University)Chongqing 400038China Department of Pathology General Hospital of Central Theater Command of PLAWuhanHubei 430070China Department of Obstetrics and Gynecology Southwest HospitalArmy Medical University (Third Military Medical University)Chongqing 400038China Department of Pharmacy The Hospital of 83rd Group of PLAXinxiangHenan 453000China Department of Gynecology Chongqing Health Center for Women and ChildrenWomen and Children's Hospital of Chongqing Medical UniversityChongqing 400013China

Gastric cancer(GC)is the third most common cause of cancer death globally and a large portion of patients are diagnosed at advanced stages with cancer invasion and metastasis1,***,the mechanisms underlying the invasion and metastasis of GC remain to be *** plays critical roles in cell mobility via cytoskeleton regulation in various cell types.3 In this study,we further reported that ZYX promoted migration,invasion,and metastasis of GC ***,ZYX promoted WNK1 activation and SNAl1 up-regulation,inducing epithelial-mesenchymal transition(EMT)to enhance the mobility of GC *** of WNK1 impaired the mobility of GC ***,ZYX/WNK1 could be potential therapeutic targets for GC treatment.

关键词： WNK1 invasion metastasis

Synthesis of NO by rotating sliding arc discharge reactor with conical-spiral electrodes

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Plasma Science and Technology 2024年第9期26卷 97-108页

作者： Bingyan CHEN Qi LIU Xu LI Chunyang ZHANG xiangbin GUO Qingzhou YU Zhicheng TANG xiang HE Wei SU Yongfeng jiang College of Mechanics and Engineering Science Hohai UniversityNanjing 211100People’s Republic of China College of Mechanical and Electrical Engineering Hohai UniversityChangzhou 213200People’s Republic of China College of Materials Science and Engineering Hohai UniversityChangzhou 213200People’s Republic of China College of Information Science and Engineering Hohai UniversityChangzhou 213200People’s Republic of China

The present work investigates the potential applications of nitrogen oxides(NO_(x)),particularly nitric oxide(NO)and nitrogen dioxide(NO2),generated through discharge plasma in diverse sectors such as medicine,nitrogen fixation,energy,and environmental *** this study,a rotating sliding arc discharge reactor was initially employed to produce high concentrations of gaseous NO_(x),followed by the utilization of a molybdenum wire redox reactor for NO2-to-NO *** outcomes reveal that the discharge states and generations of NO_(x) are affected by varying parameters,including the applied energies,frequencies and airflow states(1.3-2.6 m/s are the laminar flow,2.6-5.2 m/s are the transition state,5.2-6.5 m/s are the turbulent flow),and the concentrations of NO_(x) within the arc discharge are higher than that in the spark ***,the concentrations of NO,NO2 and NO_(x) gradually increased,and the concentration ratios of NO/NO2 and NO_(x)/NO2 decreased with increasing the applied energy for one cycle from 14.8 mJ to 24.3 ***,the concentrations of NO,NO2 and NO_(x) gradually decreased,and the concentration ratios of NO/NO2 and NO_(x)/NO2 first decreased and then increased with increasing the applied frequencies from 5.0 kHz to 9.0 ***,the concentrations of NO,NO2 and NO_(x) gradually decreased,and the concentration ratios of NO/NO2 and NO_(x)/NO2 first increased and then decreased with increasing the air flow speeds from 1.3 m/s to 6.5 m/***,the concentrations of NO increased and NO2 decreased with increasing temperature from 25°C to 400°C using molybdenum *** findings provide experimental support for the application of plasma in the fields of medicine,nitrogen fixation,energy and environmental protection.

关键词： rotating sliding arc discharge NO_(x) synthesis of NO redox reaction

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