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A study of antineutrino spectra from spent nuclear fuel at Daya Bay

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Chinese Physics C 2012年第1期36卷 1-5页

作者： zhou Bin RUAN Xi-Chao NIE Yang-Bo zhou zu-ying AN Feng-Peng CAO Jun Science and Technology on Nuclear Data Laboratory China Institute of Atomic EnergyBeijing 102413China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Northwest Institute of Nuclear Technology Xi’an 710024China

The Daya Bay Reactor Antineutrino Experiment is designed to determine the as yet unknown neutrino mixing angle,θ13,by measuring the disappearance of electron antineutrinos from several nuclear reactor *** projected sensitivity in sin2（2θ13） of better than 0.01 at a 90% CL should be achieved after three years of *** emitted from spent nuclear fuel （SNF） distort the soft part of the energy *** this article,a calculation of the antineutrino spectra from the long-life isotopes in SNF is performed.A non-equilibrium generation of long half-life isotopes during the running time of the reactor is also ***,we show that the antineutrino event rate contribution from SNF,which has been stored in the SNF pool for several years,may be non-negligible.

关键词： spent nuclear fuel antineutrino spectrum non-equilibrium event rate

Inter-chromosomal insertions into wild-type chromosomes induced by SCRaMbLE

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 125-135页

作者： Sijie zhou Junyanrui Li Xichen Cui ying Wang ying-Jin Yuan Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Frontiers Research Institute for Synthetic Biology Tianjin UniversityTianjin 300072China

Genomic rearrangements play a crucial role in shaping biological phenotypic diversity and driving species *** chromosome rearrangement and modification by LoxP-mediated evolution(SCRaMbLE)has been applied to explore large-scale genomic rearrangements,yet it has been observed that these rearrangements occur exclusively in genomic regions containing loxPsym ***,we found that SCRaMbLE of synthetic yeast harboring synthetic chromosome V and X can generate a variety of synthetic segment insertions into wild-type chromosomes,ranging from 1 to 300 ***,it was revealed that the novel insertions impacted the transcriptional level of neighboring regions and affected the production of exemplar pathway of ***,our results improve the understanding of the ability of SCRaMbLE to generate complex structural variations in nonsynthetic regions and provide a potential model to explore genomic transposable events.

关键词： genomic rearrangements synthetic yeast genome SCRaMbLE inter-chromosomal insertions synthetic biology

Structural Engineering of Hierarchical Magnetic/Carbon Nanocomposites via In Situ Growth for High-Efficient Electromagnetic Wave Absorption

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Nano-Micro Letters 2024年第9期16卷 262-278页

作者： Xianyuan Liu Jinman zhou ying Xue Xianyong Lu Key Laboratory of Bio‑Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191People’s Republic of China

Materials exhibiting high-performance electromagnetic wave absorption have garnered considerable scientific and technological attention,yet encounter significant *** new materials and innovative structural design concepts is crucial for expanding the application field of electromagnetic wave ***,hierarchical structure engineering has emerged as a promising approach to enhance the physical and chemical properties of materials,providing immense potential for creating versatile electromagnetic wave absorption ***,an exceptional multi-dimensional hierarchical structure was meticulously devised,unleashing the full microwave attenuation capabilities through in situ growth,selfreduction,and multi-heterogeneous interface *** hierarchical structure features a three-dimensional carbon framework,where magnetic nanoparticles grow in situ on the carbon skeleton,creating a necklace-like ***,magnetic nanosheets assemble within this *** impedance matching was achieved by precisely adjusting component proportions,and intelligent integration of diverse interfaces bolstered dielectric *** obtain Fe_(3)O_(4)-Fe nanoparticles/carbon nanofibers/Al-Fe_(3)O_(4)-Fe nanosheets composites demonstrated outstanding performance with a minimum reflection loss(RLmin)value of−59.3 dB and an effective absorption bandwidth(RL≤−10 dB)extending up to 5.6 GHz at 2.2 *** notable accomplishments offer fresh insights into the precision design of high-efficient electromagnetic wave absorption materials.

关键词： Electromagnetic wave absorption Hierarchical structure In situ growth Self-reduction

Carbon-based nanomaterials cause toxicity by oxidative stress to the liver and brain in Sprague-Dawley rats

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Nuclear Science and Techniques 2024年第6期35卷 54-64页

作者： ying-ying Xu Chan Jin Meng Wu Jian-Ye zhou Hui-Ling Wei Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Institute of Particle and Nuclear Physics College of PhysicsHenan Normal UniversityXinxiang 453007China

Carbon-based nanomaterials have important research significance in various disciplines,such as composite materials,nanoelectronic devices,biosensors,biological imaging,and drug ***,the human and ecological risks associated with carbon-based nanomaterials have received increasing ***,the biological safety of carbon based nanomaterials has not been systematically *** this study,we used different types of carbon materials,namely,graphene oxide(GO),single-walled carbon nanotubes(SWCNTs),and multiwalled carbon nanotubes(MWCNTs),as models to observe their distribution and oxidative damage in *** results of Histopathological and ultrastructural examinations indicated that the liver and lungs were the main accumulation targets of these ***-μ-XRF analysis revealed that SWCNTs and MWCNTs might be present in the *** shows that the three types of carbon-based nanomaterials could cross the gas-blood barrier and eventually reach the liver *** addition,SWCNTs and MWCNTs could cross the blood-brain barrier and accumulate in the cerebral *** increase in ROS and MDA levels and the decrease in GSH,SOD,and CAT levels indicated that the three types of nanomaterials might cause oxidative stress in the *** suggests that direct instillation of these carbon-based nanomaterials into rats could induce ROS *** addition,iron(Fe)contaminants in these nanomaterials were a definite source of free ***,these nanomaterials did not cause obvious damage to the rat brain *** deposition of selenoprotein in the rat brain was found to be related to oxidative stress and Fe *** information may support the development of secure and reasonable applications of the studied carbon-based nanomaterials.

关键词： Carbon-based nanomaterials Oxidative stress Trace element distribution TEM SR-μ-XRF

An initial investigation of the non-isotropic feature of GNSS tropospheric delay

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Satellite Navigation 2024年第1期5卷 155-167页

作者： ying Xu Zaozao Yang Hongzhan zhou Fangzhao Zhang College of Geodesy and Geomatics Shandong University of Science and Technology579 Qianwangang RoadQingdao266590ShandongChina

Tropospheric delay is a significant error source in Global Navigation Satellite Systems(GNSS)*** Path Delay(SPD)is commonly derived by multiplying Zenith Tropospheric Delay(ZTD)with a mapping ***,mapping functions,assuming atmospheric isotropy,restrict the accuracy of derived *** improve the accuracy,a horizontal gradient correction is introduced to account for azimuth-dependent SPD variations,treating the atmosphere as *** study uncovers that,amidst atmospheric dynamics and spatiotemporal changes in moisture content,the SPD deviates from that based on traditional isotropy or anisotropy *** innovatively introduces the concept that SPD exhibits non-isotropy with respect to azimuth *** validation involves assessing SPD accuracy using three mapping functions at five International GNSS Service(IGS)stations,referencing the SPD with the ray-tracing *** subsequently evaluates the SPD accuracy with horizontal gradient correction based on Vienna Mapping Function 3(VMF3)***,the non-isotropic of SPD is analyzed through the ray-tracing *** results indicate the smallest residual(1.1–82.7 mm)between the SPDs with VMF3 and those with the ***,introducing horizontal gradient correction yields no significant improvement of SPD *** potential decimeter-level differences in SPD due to non-isotropic tropospheric delay across azimuth angles,a precise grasp and summary of these variations is pivotal for accurate tropospheric delay *** finding provides vital support for future high-precision tropospheric delay modeling.

关键词： Tropospheric delay GNSS Non-isotropy Mapping function Ray-tracing Horizontal gradient ERA5

Structure-based development of potent and selective type-II kinase inhibitors of RIPK1

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Acta Pharmaceutica Sinica B 2024年第1期14卷 319-334页

作者： ying Qin Dekang Li Chunting Qi Huaijiang Xiang Huyan Meng Jingli Liu Shaoqing zhou Xinyu Gong ying Li Guifang Xu Rui zu Hang Xie Yechun Xu Gang Xu Zheng Zhang Shi Chen Lifeng Pan ying Li Li Tan Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 201210China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Chemical Biology Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Institute of Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People’s Hospitalthe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen 518112China Department of Burn and Plastic Surgery Shenzhen Institute of Translational MedicineShenzhen University Medical SchoolShenzhen Second People’s Hospitalthe First Affiliated Hospital of Shenzhen UniversityShenzhen 518035China

Receptor-interacting serine/threonine-protein kinase 1(RIPK1)functions as a key regulator in inflammation and cell death and is involved in mediating a variety of inflammatory or degenerative diseases.A number of allosteric RIPK1 inhibitors(RIPK1i)have been developed,and some of them have already advanced into clinical ***,selective RIPK1i that interact with both the allosteric pocket and the ATP-binding site of RIPK1 have started to ***,we report the rational development of a new series of type-II RIPK1i based on the rediscovery of a reported but mechanistically atypical *** also describe the structure-guided lead optimization of a potent,selective,and orally bioavailable RIPK1i,62,which exhibits extraordinary efficacies in mouse models of acute or chronic inflammatory ***,62 provides a useful tool for evaluating RIPK1 in animal disease models and a promising lead for further drug development.

关键词： RIPK1 Necroptosis Type-II kinase inhibitors Rational design Lead optimization Structure‒activity relationship Anti-inflammation Preclinical drug discovery

Investigation of MXene nanosheets based radio-frequency electronics by skin depth effect

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Nano Research 2024年第4期17卷 3061-3067页

作者： Rongguo Song Yunfa Si Wei Qian Haoran zu Bilei zhou Qinglei Du Daping He Yongliang Wang Air Force Early Warning Academy Wuhan 430019China Hubei Engineering Research Center of RF-Microwave Technology and Application Wuhan University of TechnologyWuhan 430070China Hainan Research Institute Wuhan University of TechnologySanya 572000China

Various new conductive materials with exceptional properties are utilized for the preparation of electronic *** ultra-high conductivity is crucial to attain excellent electrical ***,there is a lack of systematic research on the impact of conductor material thickness on device ***,we investigate the effect of conductor thickness on power transmission and radiation in radio-frequency(RF)and microwave electronics based on MXene nanosheets material transmission lines and *** MXene transmission line with thickness above the skin depth exhibits a good transmission coefficient of approximately-3 dB,and the realized gain of MXene antennas exceeds 2 ***,the signal transmission strength of MXene antenna with thickness above the skin depth is higher than 5-μm MXene antenna approximately 5.5 *** lines and antennas made from MXene materials with thickness above the skin depth exhibit stable and reliable performance,which has significant implications for obtaining high-performance RF and microwave electronics based on new conductive materials.

关键词： MXene film radiao-frequency electronics antenna transmission line skin depth

Implantable Electrochemical Microsensors for In Vivo Monitoring of Animal Physiological Information

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Nano-Micro Letters 2024年第3期16卷 183-211页

作者： Jin zhou Shenghan zhou Peidi Fan Xunjia Li Yibin ying Jianfeng Ping Yuxiang Pan Laboratory of Agricultural Information Intelligent Sensing College of Biosystems Engineering and Food ScienceZhejiang UniversityHangzhou 310058People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311200People’s Republic of China

In vivo monitoring of animal physiological information plays a crucial role in promptly alerting humans to potential diseases in animals and aiding in the exploration of mechanisms underlying human ***,implantable electrochemical microsensors have emerged as a prominent area of *** microsensors not only fulfill the technical requirements for monitoring animal physiological information but also offer an ideal platform for *** have been extensively studied for their ability to monitor animal physiological information in a minimally invasive manner,characterized by their bloodless,painless features,and exceptional *** development of implantable electrochemical microsensors for in vivo monitoring of animal physiological information has witnessed significant scientific and technological advancements through dedicated *** review commenced with a comprehensive discussion of the construction of microsensors,including the materials utilized and the methods employed for *** this,we proceeded to explore the various implantation technologies employed for electrochemical *** addition,a comprehensive overview was provided of the various applications of implantable electrochemical microsensors,specifically in the monitoring of diseases and the investigation of disease ***,a concise conclusion was conducted on the recent advancements and significant obstacles pertaining to the practical implementation of implantable electrochemical microsensors.

关键词： Electrochemical microsensors Implantable sensors In vivo monitoring Animal physiological information

Cogeneration of Innovative Audio-visual Content: A New Challenge for Computing Art

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Machine Intelligence Research 2024年第1期21卷 4-28页

作者： Mengting Liu ying zhou Yuwei Wu Feng Gao Advanced Institute of Information Technology Peking UniversityHangzhou311215China School of Electronic and Computer Engineering Shenzhen Graduate SchoolPeking UniversityShenzhen 518000China Peng Cheng Laboratory Shenzhen 518000China School of Arts Peking UniversityBeijing 100871China

In recent years,computing art has developed rapidly with the in-depth cross study of artificial intelligence generated con-tent(AIGC)and the main features of ***-visual content generation has gradually been applied to various practical tasks,including video or game score,assisting artists in creation,art education and other aspects,which demonstrates a broad application *** this paper,we introduce innovative achievements in audio-visual content generation from the perspective of visual art genera-tion and auditory art generation based on artificial intelligence(Al).We outline the development tendency of image and music datasets,visual and auditory content modelling,and related automatic generation *** objective and subjective evaluation of generated samples plays an important role in the measurement of algorithm *** provide a cogeneration mechanism of audio-visual content in multimodal tasks from image to music and display the construction of specific stylized *** are still many new op-portunities and challenges in the field of audio-visual synesthesia generation,and we provide a comprehensive discussion on them.

关键词： Artificial intelligence(AI)art audio-visual artificial intelligence generated content(AIGC) multimodal artistic evalu-ation