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China Geology 2024年第2期7卷 222-236页

作者： Zi-zheng Guo xin-yong zhou Da huang Shi-jie Zhai Bi-xia Tian Guang-ming Li School of Civil and Transportation Engineering Hebei University of TechnologyTianjin 300401China School of Geological Engineering and Geomatics Chang’an UniversityXi’an 710054China Tianjin Municipal Engineering Design&Research Institute(TMEDI) Tianjin 300392China

This study proposed a novel friction law dependent on velocity,displacement and normal stress for kinematic analysis of runout process of rapid *** well-known Yigong landslide occurring in the Tibetan Plateau of China was employed as the case,and the derived dynamic friction formula was included into the numerical simulation based on Particle Flow *** showed that the friction decreased quickly from 0.64(the peak)to 0.1(the stead value)during the 5s-period after the sliding initiation,which explained the behavior of rapid movement of the *** monitored balls set at different sections of the mass showed similar variation characteritics regarding the velocity,namely evident increase at the initial phase of the movement,followed by a fluctuation phase and then a stopping *** peak velocity was more than 100 m/s and most particles had low velocities at 300s after the landslide *** spreading distance of the landslide was calculated at the two-dimension(profile)and three-dimension scale,*** with the simulation result without considering friction weakening effect,our results indicated a max distance of about 10 km from the initial unstable position,which fit better with the actual situation.

关键词： Rapid long-runout landslide PFC Friction weakening Three-dimension Numerical simulation Tibetan Plateau Hydrogeology Engineering Geological hazards survey engineering

The spatial transcriptomic landscape of human gingiva in health and periodontitis

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Science China(Life Sciences) 2024年第4期67卷 720-732页

作者： Zongshan Shen Ran Zhang yunjia huang Jiayao Chen Mengjun yu Chunhua Li Yong Zhang Lingling Chen xin huang Jichen Yang Zhengmei Lin Songlin Wang Bin Cheng Hospital of Stomatology Guangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-sen UniversityGuangzhou 510055China Beijing Laboratory of Oral Health Capital Medical UniversityBeijing 100050China Department of Oral Pathology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100050China Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical SciencesBeijing 100050China BGI-Qingdao BGI-ShenzhenQingdao 266555China

The gingiva is a key oral barrier that protects oral tissues from various stimuli.A loss of gingival tissue homeostasis causes periodontitis,one of the most prevalent inflammatory diseases in *** human gingiva exists as a complex cell network comprising specialized *** understand the tissue-specific pathophysiology of the gingiva,we applied a recently developed spatial enhanced resolution omics-sequencing(Stereo-seq)technique to obtain a spatial transcriptome(ST)atlas of the gingiva in healthy individuals and periodontitis *** utilizing Stereo-seq,we identified the major cell types present in the gingiva,which included epithelial cells,fibroblasts,endothelial cells,and immune cells,as well as subgroups of epithelial cells and immune *** further observed that inflammation-related signalling pathways,such as the JAK-STAT and NF-κB signalling pathways,were significantly upregulated in the endothelial cells of the gingiva of periodontitis patients compared with those of healthy ***,we characterized the spatial distribution of periodontitis risk genes in the gingiva and found that the expression of IFI16 was significantly increased in endothelial cells of inflamed *** conclusion,our Stereo-seq findings may facilitate the development of innovative therapeutic strategies for periodontitis by mapping periodontitis-relevant genes and pathways and effector cells.

关键词： spatial transcriptomics gingiva periodontal disease periodontitis risk genes

Preoperative prediction of hepatocellular carcinoma microvascular invasion based on magnetic resonance imaging feature extraction artificial neural network

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2546-2554页

作者： Jing-Yi Xu yu-Fan Yang Zhong-yue huang xin-Ye Qian Fan-Hua Meng Center of Hepatobiliary Pancreatic Disease Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Department of Surgical Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Department of Anesthesiology Huashan HospitalFudan UniversityShanghai 200040China

BACKGROUND Hepatocellular carcinoma(HCC)recurrence is highly correlated with increased *** invasion(MVI)is indicative of aggressive tumor biology in *** To construct an artificial neural network(ANN)capable of accurately predicting MVI presence in HCC using magnetic resonance *** This study included 255 patients with HCC with tumors<3 *** annotated the tumors on the T1-weighted plain MR ***,a three-layer ANN was constructed using image features as inputs to predict MVI status in patients with *** pathological examination is considered the gold standard for determining *** operating characteristic analysis was used to evaluate the effectiveness of the *** Using the bagging strategy to vote for 50 classifier classification results,a prediction model yielded an area under the curve(AUC)of ***,correlation analysis revealed that alpha-fetoprotein values and tumor volume were not significantly correlated with the occurrence of MVI,whereas tumor sphericity was significantly correlated with MVI(P<0.01).CONCLUSION Analysis of variable correlations regarding MVI in tumors with diameters<3 cm should prioritize tumor *** ANN model demonstrated strong predictive MVI for patients with HCC(AUC=0.79).

关键词： Hepatocellular carcinoma Microvascular invasion Artificial neural network Magnetic resonance imaging Tumor sphericity Area under the curve

Effect of proppant sizes and injection modes on proppant transportation and distribution in the tortuous fracture model

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Particuology 2024年第1期84卷 261-280页

作者： Jun Li Xu Han Siyuan He Mingyi Wu xin huang Nianyin Li State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500China Chongqing Industry Polytechnic College Chongqing401120China Sichuan Particles Energy and Technology Co. LtdChengdu611630China Engineering Technology Research Institute of PetroChina Southwest Oil and Gas Field Company Chengdu610017China

Particle-fluid transport and placement mechanism in tortuous fracture played a crucial role in uncon-ventional ***,most studies focused on mono-size proppant with fluid transport pro-cesses in tortuous ***,the mixture-size proppant with fluid movement mechanism in tortuous fracture was still ***,this study designed and applied a series of experiments with a physical analog model of a tortuous fracture with 120°and 90°-angled bends and combined high-speed camera-based *** experimental system was used to track different-mixture-sized proppant particle motion trajectories for a series of proppant injection schemes;The following conclu-sions were drawn from this study:*** pile-up processes mechanism in all investigated schemes were similar and could be reduced to four main *** packing structure at both sides of the fracture wall had different variation rates,which were controlled by the mix ratio(change from 1∶1-1∶5)of proppant *** new packing patterns,such as Zebra Stripe,had occurred,controlled by the different proppant injection ***-sized mono-proppant(30/50 mesh)had the highest transport efficiency in the tortuous fracture,followed by the mixed-sized multi-proppant(10/20 mesh:30/50 mesh),large-sized proppant(10/20 mesh)was the *** optimized alternating in-jection mode was recommended as injecting small-sized proppant first(30/50 mesh)and followed by mixed-sized multi-proppant(10/20 mesh:30/50 mesh),which could contribute to obtaining the optimal both proppant packing height and travel distance in tortuous *** correlations were devel-oped for predicting the proppant packing height and transportation distance.

关键词： Tortuous fracture model Mixed-sized proppant Multi-sized proppant injection mode Proppant motion and distribution Packing mechanism

Laminar Flame Instability of n-Hexane,n-Octane,and n-Decane in Spherical Expanding Flames

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Journal of Thermal Science 2024年第3期33卷 1189-1199页

作者： YIN Geyuan HU Erjiang LI Xiaotian LV xin huang Zuohua State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an710049China United Automotive Electronic Systems Co. LtdShanghai201206China Chongqing Changan Automobile Co. Ltd.Chongqing401120China

This paper focuses on the laminar flame instability of three high molecular weight n-alkanes,namely n-hexane,n-octane,and *** experiment was carried out in a constant volume combustion bomb to get the flame *** critical radius under different conditions was extracted using the image processing *** with the existing critical Peclet number theory,the dominant factors of flame instability under current conditions for three n-alkanes can be figured ***,the average cell size(equivalent cell radius,R_(cell))was extracted to provide quantitative analysis of the flame cellular structure,based on the method developed in this *** theoretical R_(cell)were also calculated and compared with the experimental results to validate the proposed method.

关键词： cellular instability equivalent cell radius critical Peclet number spherical flame

High-throughput screening system of citrus bacterial cankerassociated transcription factors and its application to the regulation of citrus canker resistance

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Journal of Integrative Agriculture 2024年第1期23卷 155-165页

作者： Jia Fu Jie Fan Chenxi Zhang Yongyao Fu Baohang Xian Qiyuan yu xin huang Wen Yang Shanchun Chen Yongrui He Qiang Li Integrative Science Center of Germplasm Creation in Western China(Chongqing)Science City Citrus Research InstituteSouthwest UniversityChongqing 400712China School of Advanced Agriculture and Bioengineering Yangtze Normal UniversityChongqing 408100China National Citrus Engineering Research Center Chongqing 400712China

One of the main diseases that adversely impacts the global citrus industry is citrus bacterial canker(CBC),caused by the bacteria Xanthomonas citri ***(Xcc).Response to CBC is a complex process,with both proteinDNA as well as protein–protein interactions for the regulatory *** detect such interactions in CBC resistant regulation,a citrus high-throughput screening system with 203 CBC-inducible transcription factors(TFs),were *** the upstream regulators of target by yeast-one hybrid(Y1H)methods was also performed.A regulatory module of CBC resistance was identified based on this *** TF(CsDOF5.8)was explored due to its interactions with the 1-kb promoter fragment of CsPrx25,a resistant gene of CBC involved in reactive oxygen species(ROS)homeostasis *** mobility shift assay(EMSA),dual-LUC assays,as well as transient overexpression of CsDOF5.8,further validated the interactions and transcriptional *** CsDOF5.8–CsPrx25 promoter interaction revealed a complex pathway that governs the regulation of CBC resistance via *** high-throughput Y1H/Y2H screening system could be an efficient tool for studying regulatory pathways or network of CBC resistance *** addition,it could highlight the potential of these candidate genes as targets for efforts to breed CBC-resistant citrus varieties.

关键词： citrus bacterial canker(CBC) high-throughput screening system transcription factor(TF) yeast-one hybrid(Y1H) CsPrx25

Copper Metabolism and Cuproptosis:Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases

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Current Medical Science 2024年第1期44卷 28-50页

作者： Xiao-xia BAN Hao WAN xin-xing WAN Ya-ting TAN Xi-min HU Hong-xia BAN xin-yu CHEN Kun huang Qi ZHANG Kun XIONG Department of Human Anatomy and Neurobiology School of Basic Medical ScienceCentral South UniversityChangsha 430013China Department of Endocrinology Third Xiangya HospitalCentral South UniversityChangsha 430013China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 430013China Affiliated Hospital Inner Mongolia Medical UniversityHohhot 010050China Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikou 571199China Hunan Key Laboratory of Ophthalmology Changsha 430013China

Copper is an essential trace element,and plays a vital role in numerous physiological processes within the human *** normal metabolism,the human body maintains copper *** deficiency or excess can adversely affect cellular ***,copper homeostasis is stringently *** studies suggest that copper can trigger a specific form of cell death,namely,cuproptosis,which is triggered by excessive levels of intracellular *** induces the aggregation of mitochondrial lipoylated proteins,and the loss of iron-sulfur cluster *** neurodegenerative diseases,the pathogenesis and progression of neurological disorders are linked to copper *** review summarizes the advances in copper homeostasis and cuproptosis in the nervous system and neurodegenerative *** offers research perspectives that provide new insights into the targeted treatment of neurodegenerative diseases based on cuproptosis.

关键词： cuproptosis copper metabolism copper homeostasis neurodegeneration neurodegenerativedisease

Species-level Microbiota of Biting Midges and Ticks from Poyang Lake

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Biomedical and Environmental Sciences 2024年第3期37卷 266-277,I0001-I0003页

作者： GONG Jian WANG Fei Fei LIU Yang Qing PU Ji DONG Ling Zhi ZHANG Si Hui huang Zhen zhou huang yu yuan LI Ya Ben YANG Cai xin TAO yuan Meihui ZHAO Li Jun JIN Dong LIU Li yun YANG Jing LU Shan Department of Epidemiology School of Public HealthShanxi Medical UniversityTaiyuan 030001ShanxiChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Jiangxi Provincial Key Laboratory of Animal-Origin and Vector-Borne Diseases Nanchang Center for Disease Control and PreventionNanchang 330038JiangxiChina Research Units of Discovery of Unknown Bacteria and Function Chinese Academy of Medical SciencesBeijing 100730China

Objective The purpose of this study was to investigate the bacterial communities of biting midges and ticks collected from three sites in the Poyang Lake area,namely,Qunlu Practice Base,Peach Blossom Garden,and huangtong Animal Husbandry,and whether vectors carry any bacterial pathogens that may cause diseases to humans,to provide scientific basis for prospective pathogen discovery and disease prevention and *** Using a metataxonomics approach in concert with full-length 16S rRNA gene sequencing and operational phylogenetic unit(OPU)analysis,we characterized the species-level microbial community structure of two important vector species,biting midges and ticks,including 33 arthropod samples comprising 3,885 individuals,collected around Poyang *** A total of 662 OPUs were classified in biting midges,including 195 known species and 373 potentially new species,and 618 OPUs were classified in ticks,including 217 known species and 326 potentially new ***,OPUs with potentially pathogenicity were detected in both arthropod vectors,with 66 known species of biting midges reported to carry potential pathogens,including Asaia lannensis and Rickettsia bellii,compared to 50 in ticks,such as Acinetobacter lwoffii and Staphylococcus *** found that Proteobacteria was the most dominant group in both midges and ***,the outcomes demonstrated that the microbiota of midges and ticks tend to be governed by a few highly abundant *** sp7 was predominant in biting midges,while Coxiella sp1 was enriched in ***,Coxiella spp.,which may be essential for the survival of Haemaphysalis longicornis Neumann,were detected in all tick *** identification of dominant species and pathogens of biting midges and ticks in this study serves to broaden our knowledge associated to microbes of arthropod *** Biting midges and ticks carry large numbers of known and potentially novel bacteria,and carry a wide

关键词： Biting midge Tick Microbiota Pantoea Coxiella

A Gaussian Noise-Based Algorithm for Enhancing Backdoor Attacks

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Computers, Materials & Continua 2024年第7期80卷 361-387页

作者： Hong huang yunfei Wang Guotao yuan xin Li School of Computer Science and Engineering Sichuan University of Science&EngineeringYibin644000China

Deep Neural Networks(DNNs)are integral to various aspects of modern life,enhancing work ***-less,their susceptibility to diverse attack methods,including backdoor attacks,raises security *** aim to investigate backdoor attack methods for image categorization tasks,to promote the development of DNN towards higher *** on backdoor attacks currently faces significant challenges due to the distinct and abnormal data patterns of malicious samples,and the meticulous data screening by developers,hindering practical attack *** overcome these challenges,this study proposes a Gaussian Noise-Targeted Universal Adversarial Perturbation(GN-TUAP)*** approach restricts the direction of perturbations and normalizes abnormal pixel values,ensuring that perturbations progress as much as possible in a direction perpendicular to the decision hyperplane in linear *** limits anomalies within the perturbations improves their visual stealthiness,and makes them more challenging for defense methods to *** verify the effectiveness,stealthiness,and robustness of GN-TUAP,we proposed a comprehensive threat *** on this model,extensive experiments were conducted using the CIFAR-10,CIFAR-100,GTSRB,and MNIST datasets,comparing our method with existing state-of-the-art attack *** also tested our perturbation triggers using various defense methods and further experimented on the robustness of the triggers against noise filtering *** experimental outcomes demonstrate that backdoor attacks leveraging perturbations generated via our algorithm exhibit cross-model attack effectiveness and superior ***,they possess robust anti-detection capabilities and maintain commendable performance when subjected to noise-filtering methods.

关键词： Image classification model backdoor attack gaussian distribution Artificial Intelligence(AI)security

Differential diagnosis of Crohn’s disease and intestinal tuberculosis based on ATR-FTIR spectroscopy combined with machine learning

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World Journal of Gastroenterology 2024年第10期30卷 1377-1392页

作者： yuan-Peng Li Tian-yu Lu Fu-Rong huang Wei-Min Zhang Zhen-Qiang Chen Pei-Wen Guang Liang-yu Deng xin-Hao Yang College of Physical Science and Technology Guangxi Normal UniversityGuilinGuangxi 541004China Department of Gastroenterology The Affiliated Hospital of South University of Science and TechnologyShenzhen 518000Guangdong ProvinceChina Department of Optoelectronic Engineering Jinan UniversityGuangzhou 510632Guangdong ProvinceChina Department of Gastroenterology Integrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510632Guangdong ProvinceChina

BACKGROUND Crohn’s disease(CD)is often misdiagnosed as intestinal tuberculosis(ITB).However,the treatment and prognosis of these two diseases are dramatically ***,it is important to develop a method to identify CD and ITB with high accuracy,specificity,and *** To develop a method to identify CD and ITB with high accuracy,specificity,and *** A total of 72 paraffin wax-embedded tissue sections were pathologically and clinically diagnosed as CD or *** wax-embedded tissue sections were attached to a metal coating and measured using attenuated total reflectance fourier transform infrared spectroscopy at mid-infrared wavelengths combined with XGBoost for differential *** The results showed that the paraffin wax-embedded specimens of CD and ITB were significantly different in their spectral signals at 1074 cm^(-1) and 1234 cm^(-1) bands,and the differential diagnosis model based on spectral characteristics combined with machine learning showed accuracy,specificity,and sensitivity of 91.84%,92.59%,and 90.90%,respectively,for the differential diagnosis of CD and *** Information on the mid-infrared region can reveal the different histological components of CD and ITB at the molecular level,and spectral analysis combined with machine learning to establish a diagnostic model is expected to become a new method for the differential diagnosis of CD and ITB.

关键词： Infrared spectroscopy Machine learning Intestinal tuberculosis Crohn’s disease Differential diagnosis Inflammatory bowel disease