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World Journal of Gastrointestinal Surgery 2024年第2期16卷 345-356页

作者： ying-Hao Xiang Huan Mou Bo Qu Hui-rong sun Department of General Surgery Lichuan People's HospitalEnshi 445400Hubei ProvinceChina

BACKGrOUND Although accurately evaluating the overall survival(OS)of gastric cancer patients remains difficult,radiomics is considered an important option for studying *** To develop a robust and unbiased biomarker for predicting OS using machine learning and computed tomography(CT)image *** This study included 181 stage II/III gastric cancer patients,141 from Lichuan People's Hospital,and 40 from the Cancer Imaging Archive(TCIA).Primary tumors in the preoperative unenhanced CT images were outlined as regions of interest(rOI),and approximately 1700 radiomics features were extracted from each *** skeletal muscle index(SMI)and skeletal muscle density(SMD)were measured using CT images from the lower margin of the third lumbar *** the least absolute shrinkage and selection operator regression with 5-fold cross-validation,36 radiomics features were identified as important predictors,and the OS-associated CT image radiomics score(OACrS)was cal-culated for each patient using these important *** Patients with a high OACrS had a poorer prognosis than those with a low OACrS score(Priate analyses revealed that OACrS was a risk factor[rr=3.02.(1.896-4.365),PrS outperformed SMI and SMD and could improve OS prediction(Prker based on machine learning and radiomics was developed that exhibited exceptional OS discrimination potential.

关键词： radiomics Machine learning Gastric cancer Skeletal muscle density Skeletal muscle index

Pipeline of New Drug Treatment for Non-alcoholic Fatty Liver Disease/Metabolic Dysfunction-associated Steatotic Liver Disease

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Journal of Clinical and Translational Hepatology 2024年第9期12卷 802-814页

作者： Ye Hu Chao sun ying Chen Yu-Dong Liu Jian-Gao Fan Department of Gastroenterology Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Geriatrics Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Gastroenterology Changxing branch of Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina

Given the global prevalence and rising incidence of metabolic dysfunction-associated steatotic liver disease(MASLD),the absence of licensed medications is striking.A deeper understanding of the heterogeneous nature of MASLD has recently contributed to the discovery of novel groups of agents and the potential repurposing of currently available *** therapies center on four major *** the close relationship between MASLD and type 2.diabetes,the first approach involves antidiabetic medications,including incretins,thiazolidinedione insulin sensitizers,and sodium-glucose cotransporter 2.*** second approach targets hepatic lipid accumulation and the resultant metabolic *** in this group include peroxisome proliferatoractivated receptor agonists(e.g.,pioglitazone,elafibranor,saroglitazar),bile acid-farnesoid X receptor axis regulators(obeticholic acid),de novo lipogenesis inhibitors(aramchol,NDI-010976),and fibroblast growth factor 2./19 *** third approach focuses on targeting oxidative stress,inflammation,and *** in this group include antioxi-dants(vitamin E),tumor necrosis factor a pathway regulators(emricasan,pentoxifylline,ZSP1601),and immune modulators(cenicriviroc,belapectin).The final group targets the gut(IMM-12.e,solithromycin).Combination therapies targeting different pathogenetic pathways may provide an alternative to MASLD treatment with higher efficacy and fewer side *** review aimed to provide an update on these medications.

关键词： NAFLD MASLD Clinical trial Medication Hypoglycemic agents Intermediary metabolism

The Value of Modern Information Technology in Nursing Emergencies

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Health 2024年第9期16卷 849-855页

作者： Xushan zhou ying Li Henglong Xu Chenyan Li Hongling {2. Department of Information Technology Section The First Rehabilitation Hospital of Shandong Linyi China Department of Nursing The First Rehabilitation Hospital of Shandong Linyi China Department of Health Management Center The First Rehabilitation Hospital of Shandong Linyi China Department of Laboratory The Second Affiliated Hospital of Guangxi Medical University Liuzhou Cancer Hospital of Guangxi Liuzhou China

In first aid, traditional information interchange has numerous shortcomings. For example, delayed information and disorganized departmental communication cause patients to miss out on critical rescue time. Information technology is becoming more and more mature, and as a result, its use across numerous industries is now standard. China is still in the early stages of developing its integration of emergency medical services with modern information technology;despite our progress, there are still numerous obstacles and constraints to overcome. Our goal is to integrate information technology into every aspect of emergency patient care, offering robust assistance for both patient rescue and the efforts of medical personnel. Information may be communicated in a fast, multiple, and effective manner by utilizing modern information technology. This study aims to examine the current state of this field’s development, current issues, and the field’s future course of development.

关键词： Modern Information Technology Nursing First Aid Critical Care

Circr-ZC3HC1 mediates Mir-384-5p/SIrT1 axis to promote neuronal autophagy and relieves ischemic stroke

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BIOCELL 2024年第3期48卷 491-499页

作者： MIN SHEN XIAOMAN XU GUANGLING sun LIANGZHU WANG TAO ying HANG SU WEI WANG QINGHUA CAO ZHEZHE sun Department of Neurology The First Affiliated Hospital of Ningbo UniversityNingbo315010China School of Medicine Ningbo UniversityNingbo315211China

Objective:Circular rNAs(circrNAs)have been shown to involve in pathological processes of ischemic stroke(IS),including *** study was designed to explore the effect of circr-ZC3HC1 on neuronal autophagy in IS and the related ***:Expression of circr-ZC3HC1 in blood samples of IS patients and healthy controls was *** neurons were treated with oxygen and glucose deprivation(OGD)to establish IS in vitro *** expression of LC3 and p62.and the number of autophagosomes were examined to evaluate the autophagy level of OGD induced neurons using western blotting and transmission electron *** apoptosis rate and the expression of cleaved caspase-3,Bax,and Bcl-2.were assessed byﬂow cytometry and western *** binding relationships among circr-ZC3HC1,mir-384-5p,and SIrT1 were predicted and veriﬁ***:Low expression of circr-ZC3HC1 was found in blood samples of IS patients and OGD-treated *** circr-ZC3HC1 or inhibited mir-384-5p expression promoted autophagy and inhibited apoptosis of OGD-treated neurons,which could be reversed by further 3-MA ***,circr-ZC3HC1 targeted mir-384-5p to mediate SIrT1 ***-384-5p overexpression or SIrT1 knockdown in the presence of circr-ZC3HC1 overexpression in OGD-treated neurons lead to reduced autophagy and enhanced ***:Collectively,circr-ZC3HC1 promoted neuronal autophagy to attenuate IS via mir-384-5p/SIrT1 axis.

关键词： Ischemic stroke circr-ZC3HC1 mir-384-5p SIrT1 Autophagy

Ultra-high-rate Bi anode encapsulated in 3D lignin-derived carbon framework for sodium-ion hybrid capacitors

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rare Metals 2024年第3期43卷 1037-1047页

作者： Ze-Hua Lin Xue-Qing Qiu Xi-Hong Zu Xiao-Shan Zhang Lei Zhong Shi-rong sun Shu-Hua Hao ying-Juan sun Wen-Li Zhang School of Chemical Engineering and Light Industry Guangdong University of Technology(GDUT)Guangzhou510006China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(rongjiang Laboratory) Jieyang515200China School of Advanced Manufacturing Institute of Green Chemistry and Advanced MaterialsGuangdong University of TechnologyJieyang515200China

Bismuth(Bi),as an alloy-based anode material,has attracted much atte ntion in the developme nt of sodiumion hybrid capacitors(SIHCs)due to its high theoretical ***,the volume expansion of the Bi-based anode during the sodiation/desodiation process results in limited rate *** the present work,a porous Bi-based composite was constructed by a one-step hydrothermal method,and Bi was encapsulated in ligninderived nitrogen-doped porous carbon(Bi@LNPC)after *** obtained Bi nanoparticles could effectively adapt to the strain and shorten the diffusion distance of Na^(+).In addition,porous carbon skeleton provides a rigid conductive network for electronic ***,the assembled sodium-ion half-cell with Bi@LNPC anode shows ultra-high-rate *** the current density was enhanced from 0.1 to 50 A·g^(-1),the specific capacity decreased slightly from 351.5 to 342.8 mAh·g^(-1).Even at an extremely high current density of 2.0 A·g^(-1),it retains 81.3%capacity retention when compared to a current density of 1 A·g^(-1).The SIHCs assembled by Bi@LNPC show a high energy density of 63 Wh·kg^(-1).This work provides an effective method for developing high-rate Bi anode materials for sodium-ion hybrid capacitors(SIHCs)and sodium-ion batteries(SIBs).

关键词： Bismuth Lignin Sodium-ion batteries Sodium-ion hybrid capacitors rate Porous carbon

Genus-specific secondary metabolome in Allokutzneria and Kibdelosporangium

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Synthetic and Systems Biotechnology 2024年第3期9卷 381-390页

作者： Man-Jing Ma Wen-Chao Yu Huai-ying sun Bing-Cheng Dong Gang-Ao Hu Zhen-Yi {2. Yi Hua Buddha Bahadur Basnet Yan-Lei Yu Hong Wang Bin Wei College of Pharmaceutical Science&Collaborative Innovation Center of Yangtze river Delta region Green Pharmaceuticals Zhejiang Key Laboratory of GreenLow-Carbonand Efficient Development of Marine Fishery ResourcesZhejiang University of TechnologyHangzhou 310014China Central Department of Biotechnology Trihuvan UniversityKathmanduNepal

rare actinomycete genera are highly recognized as a promising source of structurally diverse and bioactive natural *** these genera,Allokutzneria and Kibdelosporangium are two phylogenetically closely related and have been reported to encode some valuable biosynthetic enzymes and secondary ***,there is currently no relevant systematic research available to outline the linkage of genomic and metabolomics for specific secondary metabolites in these two promising *** this study,we first investi-gated the genus-specific secondary metabolic potential in Allokutzneria and Kibdelosporangium by comparing the diversity and novelty of their secondary metabolite biosynthetic gene clusters(BGCs).The specific secondary metabolites produced by two representative strains of these genera were comprehensively investigated using untargeted metabolomics *** findings unveiled that the majority(95.4%)of the gene cluster families(GCFs)encoded by Allokutzneria and Kibdelosporangium were genus-specific,including NrPS GCFs encoding *** untargeted metabolomics analysis revealed that the metabolic profiles of two representative strains exhibit extensive specificity,with the culture medium having a big impact on the metabolic ***,an MS-cluster featuring a series of hydroxamate-type siderophores was identified from Allokutzneria albata JCM 9917,with two of them,including a novel one(N-deoxy arthrobactin A),being experimentally *** present study offers valuable insights for the targeted discovery of genus-specific natural products from microorganisms.

关键词： Genus-specific secondary metabolism Allokutzneria Kibdelosporangium Genome mining Untargeted metabolomics Siderophore

An amorphous FeMoO_(4) nanorod array enabled high-efficiency oxygen evolution electrocatalysis in alkaline seawater

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Nano research 2024年第4期17卷 2270-2275页

作者： Jie Tang Shengjun sun Xun He Hui Zhang Chaoxin Yang Min Zhang Meng Yue Hefeng Wang Yuntong sun Yonglan Luo Sulaiman Alfaifi Asmaa Farouk Mohamed S.Hamdy Xuping sun Huiqing Wang Binwu ying Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu 610041China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinan 250014China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Chemistry Department Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Chemistry College of ScienceKing Khalid UniversityAbha 61413Saudi Arabia Medical Simulation Centre West China Second University HospitalSichuan UniversityChengdu 610041China

The development of highly efficient and durable oxygen evolution reaction(OEr)catalysts for seawater electrolysis is of great importance for ***,an amorphous FeMoO_(4) nanorod array on Ni foam is reported as a highly active OEr electrocatalyst in alkaline seawater,requiring only overpotentials of 303 and 332.mV to achieve 100 and 300 mA·cm^(-2.,***,it shows strong long-term electrochemical durability for at least 50 h.

关键词： amorphous material FeMoO_(4) nanorod array electrocatalyst seawater electrolysis oxygen evolution reaction

Validating the use of rOS-scavenging bacteria as probiotics to increase coral resilience to thermal stress

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Journal of Oceanology and Limnology 2024年第4期42卷 1242-1260页

作者： Xiaoyu TANG Qingsong YANG ying ZHANG Hanzhang WANG Juan LING Haiyan sun Junde DONG Yanying ZHANG CAS Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of Oceanology(SCSIO)Guangzhou 510301China Ocean School Yantai UniversityYantai 264005China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China Sanya National Marine Ecosystem research Station and Key Laboratory of Tropical Marine Biotechnology of Hainan Province Sanya Institute of OceanologySCSIOSanya 572000China Institute of Deep-sea Science and Engineering Chinese Academy of SciencesSanya 572000China univ.r.ity of Chinese Academy of Sciences Beijing 100049China

Thermal stress causes the overproduction and toxic accumulation of reactive oxygen species(rOS),which seems to be correlated with coral bleaching and,ultimately,*** reduction of rOS concentration within the coral holobiont could minimize the effects of thermal stress and support efforts to reduce coral decline *** the current study,we explored the physiological responses of Pocillopora damicornis to rOS-scavenging bacteria inoculation as well as the microbiome restructuring that correlates with ***’s resilience to thermal stress after probiotic *** of corals with rOS-scavenging bacteria enhanced coral health and reduced rOS ***,the enhanced coral thermal resistance promoted by rOS-scavenging bacteria was also correlated with an overall coral microbiome *** addition,the complex network relationships between bacteria and Symbiodiniaceae in corals after rOS-scavenging bacteria inoculation contributed to corals’resilience to high ***,coral heat tolerance bacterial biomarkers,such as Myxococcota,were enriched in corals with added rOS-scavenging ***,our findings validate the selected rOS-scavenging bacteria as coral probiotics that could help corals resist thermal stress on a short ***,our data contribute to our understanding of the potential interactions between different members of the coral holobiont and the use of probiotics as tools to aid coral restoration efforts.

关键词： coral beneficial microorganisms for corals(BMCs) Symbiodiniaceae thermal stress coral bleaching

In vivo imaging of the neuronal response to spinal cord injury:a narrative review

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Neural regeneration research 2024年第4期19卷 811-817页

作者： Junhao Deng Chang sun ying Zheng Jianpeng Gao Xiang Cui Yu Wang Licheng Zhang Peifu Tang Department of Orthopedics The Fourth Medical Center of Chinese PLA General Hospital National Clinical research Center for Orthopedics Sports Medicine and Rehabilitation School of Life Sciences Tsinghua University Department of Orthopedics Air Force Medical CenterPLA Medical School of Chinese PLA Institute of Orthopedics The First Medical CenterChinese PLA General Hospital Key Lab of regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma and War Injuries PLA

Deciphering the neuronal response to injury in the spinal cord is essential for exploring treatment strategies for spinal cord injury(SCI).However,this subject has been neglected in part because appropriate tools are *** in vivo imaging and labeling methods offer great potential for observing dynamic neural processes in the central nervous system in conditions of health and *** review first discusses in vivo imaging of the mouse spinal cord with a focus on the latest imaging techniques,and then analyzes the dynamic biological response of spinal cord sensory and motor neurons to *** then summarize and compare the techniques behind these studies and clarify the advantages of in vivo imaging compared with traditional neuroscience ***,we identify the challenges and possible solutions for spinal cord neuron imaging.

关键词： anterior horn neurons calcium imaging central nervous system dorsal horn neurons dorsal root ganglion in vivo imaging neuronal response spinal cord injury spinal cord two-photon microscopy

Tailored ionically conductive graphene oxide-encased metal ions for ultrasensitive cadaverine sensor

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Chinese Chemical Letters 2024年第8期35卷 508-513页

作者： ying Chen Li Li Junyao Zhang Tongrui sun Xuan Zhang Shiqi Zhang Jia Huang Yidong Zou School of Materials Science and Engineering Tongji UniversityShanghai 201804China Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation Translational Research Institute of Brain and Brain-Like IntelligenceShanghai Fourth People’s Hospital Affiliated to Tongji UniversityTongji UniversityShanghai 200434China School of Mechanical Engineering Nantong UniversityNantong 226019China

Intelligent chemical sensors have been extensively used in food safety and environmental assessment,while limited sensitivity and homogeneity bring about huge obstacles to their practical ***,novel ionically conductive sensitive materials were elaborately designed based on metal ion decorated graphene oxide(GO)via a facile and general in-situ spin-coating strategy,where the abundant functional groups(-OH and-COOH)of GO layer could provide natural binding sites for various bivalent metal cations(such as Cu^(2.),Ni^(2.),Zn^(2.),Co^(2.),and Mg^(2.))through coordination and electrostatic *** intercalated metal cations on the layered GO nanosheets can be regarded as charge carriers and complexation with targeted gas(cadaverine,Cad),which is a typical metabolites production and food *** contrast,the designed GO@Cu(Ⅱ)sensor exhibited the optimal sensing performance toward Cad molecules at room temperature,including ultra-low detection limit(ca.3 nL),excellent sensitivity,and rapid low concentration detection rate(only 16 s).Interestingly,the sensor exhibited an irreversible and specific response toward Cad,while it showed a transient and reversible response to other interfering gases,implying its outstanding *** addition,the GO@Cu(Ⅱ)sensor enabled real-time monitoring of the decay progression of cheese,and it exhibited great potential for large-scale production via its excellent *** provides an efficient approach to tailoring intelligent chemical sensors for real-time food safety monitoring and human health warning.

关键词： Graphene oxide Cadaverine monitoring Chemical sensor Ionically conductive Homogeneity