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单次、连续髂筋膜间隙阻滞在老年髋部骨折患者术前的应用对比研究

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四川生理科学杂志 2024年第2期46卷 401-403,410页

作者：谢文飞周志英高佑松于都县第二人民医院麻醉科江西赣州342323

目的:对比单次、连续髂筋膜间隙阻滞(Fascia iliaca compartment block,FICB)在老年髋部骨折(Hip fracture,HF)患者术前的应用价值。方法:选取于都县第二人民医院2020年5月~2022年12月就诊的80例老年HF患者,随机数字表法分为观察组(n=40... 详细信息

目的:对比单次、连续髂筋膜间隙阻滞(Fascia iliaca compartment block,FICB)在老年髋部骨折(Hip fracture,HF)患者术前的应用价值。方法:选取于都县第二人民医院2020年5月~2022年12月就诊的80例老年HF患者,随机数字表法分为观察组(n=40)及对照组(n=40)。对照组术前予以单次FICB,观察组术前予以连续FICB。比较两组阻滞起效情况、不同时间点疼痛程度、手术前后应激反应指标、不良反应。结果:两组股前区及股外侧区感觉阻滞有效率比较,差异无统计学意义(P>0.05);观察组股前区及股外侧区感觉阻滞起效时间均短于对照组(P0.05)。结论:术前连续FICB能缩短老年髋部骨折患者股前区及股外侧区感觉阻滞起效时间,缓解术后疼痛,改善机体应激反应,安全性较高。

关键词：髂筋膜间隙阻滞髋部骨折老年患者疼痛

Spatiotemporal changeof vegetationcoverage recovery and its driving factors in the Wenchuan earthquake-hit areas

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Journal of Mountain Science 2021年第11期18卷 2854-2869页

作者： SUN Xiao-fei YUAN Lin-guo zhou ying-zhi SHAO Huai-yong LI Xian-feng ZHONG Ping Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengdu 611756China College of Earth Science Chengdu University of TechnologyChengdu 610059China Natural Resources and Planning Bureau of Nanchong Nanchong 637000China Department of Geography National University of SingaporeKent Ridge 117570Singapore

Vegetation coverage recovery after the Wenchuan earthquake has important implications for preventing post-seismic geohazards and soil ***,spatiotemporal changes in vegetation coverage recovery and its driving factors have not been sufficiently studied in the quake-hit *** paper aims to analyze vegetation coverage recovery and its driving factors in the quake-hit areas using monadic linear regression,coefficient of variation,and geographical ***,we used Moderate-resolution Imaging Spectroradiometer(MODIS)data to calculate the vegetation coverage from 2008 to 2018 in the quake-hit ***,we assessed the trend and stability of vegetation recovery in the quake-hit areas based on vegetation ***,combined with topography,climate,soil type,vegetation type,and human activities in the quake-hit areas,the driving factors affecting vegetation coverage recovery were *** results showed that the vegetation coverage level in the quake-hit areas recovered about 90%of that before the *** coverage recovery was mainly improved in a stepwise manner:increasing and then stabilizing,then increasing and stabilizing ***,soil type,and road density were the main factors affecting vegetation coverage recovery,and the interaction among all factors positively strengthened their impacts on vegetation coverage *** addition,the results also revealed the categories that were conducive to vegetation coverage recovery among the same environmental factors and can provide a scientific reference for vegetation coverage recovery in the quake-hit areas.

关键词： Wenchuan earthquake Vegetation coverage recovery Geographical detector Driving factors

右美托咪定减轻脂多糖诱导的心肌炎大鼠炎性损伤的机制研究

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局解手术学杂志 2024年第6期33卷 479-485页

作者：蔡迪盛任建光鲁晓梅周志颖儋州市人民医院麻醉手术科海南儋州571700 儋州市人民医院检验科海南儋州571700

目的探讨右美托咪定(Dex)调节腺苷酸激活蛋白激酶(AMPK)/沉默信息调节因子1(SIRT1)/核转录因子-κB(NF-κB)信号通路对脂多糖(LPS)诱导的心肌炎(Myo)大鼠炎性损伤的影响。方法将大鼠随机分为NC组、Myo组、L-Dex组(10μg/kg Dex)、M-Dex... 详细信息

目的探讨右美托咪定(Dex)调节腺苷酸激活蛋白激酶(AMPK)/沉默信息调节因子1(SIRT1)/核转录因子-κB(NF-κB)信号通路对脂多糖(LPS)诱导的心肌炎(Myo)大鼠炎性损伤的影响。方法将大鼠随机分为NC组、Myo组、L-Dex组(10μg/kg Dex)、M-Dex组(30μg/kg Dex)、H-Dex组(50μg/kg Dex)、AICAR组(100 mg/kg AMPK/SIRT1/NF-κB信号通路激活剂)、H-Dex+GSK690693组(50μg/kg Dex+0.2μmol/kg AMPK/SIRT1/NF-κB信号通路抑制剂GSK690693),每组10只。用M型超声心动图系统评估大鼠心脏功能;ELISA试剂盒检测大鼠血清白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超氧化物歧化酶(SOD)、丙二醛(MDA)水平;TUNEL染色观察细胞凋亡情况;通过HE染色观察心肌组织病理形态变化;RT-qPCR检测大鼠心肌组织中C-X-C基序配体1(CXCL1)、C-X-C基序配体2(CXCL2)、血管细胞黏附分子1(VCAM-1)mRNA表达;Western blot检测大鼠心肌组织中AMPK/SIRT1/NF-κB通路相关蛋白表达。结果NC组心肌细胞无异常变化,Myo组心肌细胞出现变形、坏死、炎性细胞浸润以及间质充血等现象,L-Dex组、M-Dex组、H-Dex、AICAR组细胞坏死、炎性细胞浸润以及间质充血等现象较Myo组得到了改善,H-Dex组和AICAR组心肌细胞变化与NC组相似,H-Dex+GSK690693组心肌细胞变化与Myo组相似。与NC组相比,Myo组左心室射血分数(LVEF)、左心室缩短分数(LVFS),SOD、p-AMPK/AMPK、p-SIRT1/SIRT1表达水平均显著下降(P0.05);与H-Dex组相比,H-Dex+GSK690693组LVEF、LVFS及SOD、p-AMPK/AMPK、p-SIRT1/SIRT1表达水平均显著下降(P<0.05),LVESV、LVEDV、LVESD、LVEDD,IL-1β、IL-6、TNF-α、MDA水平,心肌细胞凋亡率水平,CXCL1、CXCL2、VCAM-1、p-NF-κB/NF-κB、NF-κB p65蛋白表达均显著升高(P<0.05)。结论Dex可能通过上调AMPK/SIRT1/NF-κB信号通路减轻LPS诱导的Myo大鼠炎性损伤。

关键词：右美托咪定 AMPK/SIRT1/NF-κB信号通路心肌炎炎性损伤

Beamline design for multipurpose muon beams at CSNS EMuS

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Nuclear Science and Techniques 2024年第5期35卷 1-12页

作者： Yang Hong ying-Peng Song Lu-Ping zhou Jing-Yu Tang zhi-Hao zhou Nikolaos Vassilopoulos Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China University of Chinese Academy of Sciences Beijing 100049China Radiotherapy Physics and Technology Center Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China Xi’an Jiaotong University Health Science Center Xi’an 710049China Department of Radiation Oncology First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710049China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China

A new muon beam facility,called the Experimental Muon Source(EMuS),was proposed for construction at the China Spallation Neutron Source(CSNS).The design of the complex muon beamlines for the EMuS baseline scheme,which is based on superconducting solenoids,superferric dipoles and room-temperature magnets,is presented *** muon beams,including surface muons,decay muons and low energy muons,have been developed for multipurpose *** optics design and simulation results of the trunk beamline and branch beamlines are *** a proton beam power of 25 kW at a standalone target station that consists of a conical graphite target and high-field superconducting solenoids,the muon beam intensity in the trunk beamline varies from 10^(7)/s for surface muons to 10^(10)/s for high-momentum decay *** at the endstations,these values vary from 10^(5)/s for surface muons to 10^(8)/s for decay muons.

关键词： Surface muons Decay muons Muon beamline Superconducting solenoids Multi-channel electrostatic separator

Effects of dietary intervention on human diseases:molecular mechanisms and therapeutic potential

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1389-1422页

作者： Yu-Ling Xiao Yue Gong ying-Jia Qi zhi-Ming Shao Yi-zhou Jiang Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudanUniversityShanghai200032China

Diet,serving as a vital source of nutrients,exerts a profound influence on human health and disease ***,dietary interventions have emerged as promising adjunctive treatment strategies not only for cancer but also for neurodegenerative diseases,autoimmune diseases,cardiovascular diseases,and metabolic *** interventions have demonstrated substantial potential in modulating metabolism,disease trajectory,and therapeutic *** reprogramming is a hallmark of malignant progression,and a deeper understanding of this phenomenon in tumors and its effects on immune regulation is a significant challenge that impedes cancer *** intake,as a key environmental factor,can influence tumor *** evidence indicates that dietary interventions might affect the nutrient availability in tumors,thereby increasing the efficacy of cancer ***,the intricate interplay between dietary interventions and the pathogenesis of cancer and other diseases is *** encouraging results,the mechanisms underlying diet-based therapeutic strategies remain largely unexplored,often resulting in underutilization in disease *** this review,we aim to illuminate the potential effects of various dietary interventions,including calorie restriction,fasting-mimicking diet,ketogenic diet,protein restriction diet,high-salt diet,high-fat diet,and high-fiber diet,on cancer and the aforementioned *** explore the multifaceted impacts of these dietary interventions,encompassing their immunomodulatory effects,other biological impacts,and underlying molecular *** review offers valuable insights into the potential application of these dietary interventions as adjunctive therapies in disease management.

关键词： diseases metabolism potential

完美球本质——论分布系统软件开发技术(英文)

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软件学报 2005年第12期16卷 2166-2171页

作者：周之英清华大学计算机科学与技术系北京100084

软件开发实践中存在的隐含成分和无法回避的“不够完美”,就是现实软件开发项目中的无法控制或未知部分,这违反现存的大部分软件开发方法的基础,如一致性.完美球却是基于二重性,把微观世界的一些成分和复杂系统相映射.这是探索先进的西... 详细信息

软件开发实践中存在的隐含成分和无法回避的“不够完美”,就是现实软件开发项目中的无法控制或未知部分,这违反现存的大部分软件开发方法的基础,如一致性.完美球却是基于二重性,把微观世界的一些成分和复杂系统相映射.这是探索先进的西方科学技术和古代东方哲学的产物.分析由“陈述”,“思想”和“客观事实”组成的三角形,以说明完美点相区别的三角形.分布系统的测不准关系阐明:代码(代表可用产品)和目标(代表软件产品的性能)不能同时确定.在解释软件系统与人体间的联系中表明在气功哲学概念和软件开发概念之间可建立的某种映射关系.在完美球范畴下的软件开发强调生动活跃的学习行为,而不仅看重的自动机行为.用完美球替代特定目标点或动态可修改的目标点.系统复杂性日益增加,逐步减少概率论和预定计划影响.列举完美球少许应用.

关键词：软件开发方法分布系统完美目标测不准关系古代东方哲学

Gene therapy for monogenic disorders: challenges, strategies, and perspectives

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Journal of Genetics and Genomics 2024年第2期51卷 133-143页

作者： Yi Zhang zhi-ying Wu Department of Medical Genetics and Center for Rare Diseases Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Key Laboratory of Medical Neurobiology of Zhejiang Province HangzhouZhejiang 310009China

Monogenic disorders refer to a group of human diseases caused by mutations in single genes. While disease-modifying therapies have offered some relief from symptoms and delayed progression for some monogenic diseases, most of these diseases still lack effective treatments. In recent decades, gene therapy has emerged as a promising therapeutic strategy for genetic disorders. Researchers have developed various gene manipulation tools and gene delivery systems to treat monogenic diseases. Despite this progress, concerns about inefficient delivery, persistent expression, immunogenicity, toxicity, capacity limitation, genomic integration, and limited tissue specificity still need to be addressed. This review gives an overview of commonly used gene therapy and delivery tools, along with the challenges they face and potential strategies to counter them.

关键词： Gene therapy Monogenic diseases Geneediting Genedelivery Challenges

Role of serum angiopoietin-2 level in screening for esophageal squamous cell cancer and its precursors

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Chinese Medical Journal 2007年第14期120卷 1216-1219页

作者： zhou ying-zhi FANG Xue-qiang LI Hao DIAO Yu-tao YANG Yan-fang ZHAO De-li WU Kan LI Hui-qing School of Public Health Shandong University Jinan 250012 China Qilu Hospital of Shandong University Jinan 250012 China Institute of Basic Medicine Shandong Academy of Medical Sciences Jinan 250062 China People＇s Hospital of Feicheng City Feicheng 271600 China

Background Angiopoietin-2 （Ang-2） is one of the critical regulators of tumor angiogenesis. Studies have shown a significant correlation of Ang-2 expression to tumor invasion and metastasis in various human cancers, but little is known about the serum Ang-2 （sAng-2） levels in esophageal squamous cell cancer （ESCC） and its precursors. In this study, we aimed to investigate its role in screening for ESCC and its precursors. Methods We carried out a free endoscopic screening in Feicheng City, a high ESCC incidence area in Shandong Province of China. Serum samples were collected as follows： 91 from normal subjects, 44 from patients with esophagitis, 85 from patients with hyperplasia, and 13 from patients with early ESCC. In addition, 28 serum samples were obtained from patients with invasive ESCC undergoing surgery in People＇s Hospital of Feicheng City. All the subjects of the five groups were diagnosed by histopathology. The sang-2 levels were tested and compared, and the diagnostic power in early or/and invasive ESCC was calculated in terms of sensitivity and other parameters. Results The sAng-2 levels were （22.0±5.5）, （21.3±3.2）, （20.5±3.3）, （24.0±5.0）, and （29.8±5.0） U/ml in normal, esophagitis, hyperplasia, early ESCC, and invasive ESCC groups respectively. It was significantly higher in early ESCC than inhyperplasia group （P=-0.009）. The invasive ESCC group showed the highest Ang-2 level among all groups （all P=-0.000）. The sensitivities of sAng-2 to early and invasive ESCC were 23.1% and 78.6% respectively. Conclusion sang-2 level is related to carcinogenesis and progression of ESCC, but it can not be used to screen for early ESCC.

关键词： angiopoietin-2 esophageal neoplasms serum sensitivity diagnosis

Chinese patients with adult onset leukodystrophy caused by CST3 variants

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Journal of Genetics and Genomics 2024年第7期51卷 778-780页

作者： Yi Zhang zhi-ying Wu Department of Medical Genetics and Center for Rare Diseases Zhejiang Key Laboratory of Rare Diseases for Precision Medicine and Clinical TranslationSecond Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Nanhu Brain-computer Interface Institute HangzhouZhejiang 314050China Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China MOE Frontier Science Center for Brain Science and Brain-machine Integration School of Brain Science and Brain MedicineZhejiang UniversityHangzhouZhejiang 310012China

Leukodystrophies represent a group of cerebral white matter disorders that mainly affect axon-glia *** disorders are clinically diverse and display significant genetic *** is challenging to differentiate hereditary leukodystrophies,particularly those that present in adulthood,from acquired leukodystrophies and other genetic disorders,such as multiple sclerosis(MS)or hereditary spastic paraplegia(HSP)(Wei et al.,2021).Over the past few decades,a series of causative genes associated with leukodystrophies have been identified(Kohler et al.,2018).Nevertheless,a significant proportion of patients still lack a precise molecular diagnosis.

关键词： al. patients Kohler