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Molecular Spectrum ofα-andβ-Thalassemia among Young Individuals of Marriageable Age in Guangdong Province,China

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Biomedical and Environmental Sciences 2021年第10期34卷 824-829页

作者： zhou bing yi& WANG Yong Xia XU Shan Shan GU Heng LI Ming Zhen NHC Key Laboratory of Male Reproduction and Genetics Family Planning Research Institute of Guangdong ProvinceGuangzhou 510060GuangdongChina

Thalassemia is a group of genetically heterogeneous diseases characterized by hemolytic *** investigate molecular characteristics ofα-andβ-thalassemia among young individuals of marriageable age in Guangdong Province,24,788 subjects with suspected thalassemia were genetically tested forα-andβ-thalassemia by GapPCR and reverse dot blot during 2018–*** suspected rare thalassemia cases,DNA sequencing was performed to identify rare and unknown thalassemia gene mutations.A total of 14,346 thalassemia carriers were detected,including 7,556 cases ofα-thalassemia with 25 genotypes and 8α-gene mutations identified,5,860 cases ofβ-thalassemia with 18 genotypes and 18β-gene mutations identified,and 930 cases of compoundα/β-*** them,the frequency of--SEA deletion was the highest inα-thalassemia(66.01%),followed by-α3.7(17.98%)and-α.24(8.22%),and the frequency of CD41-42(-TCTT)mutation was the highest inβ-thalassemia(38.38%),followed by IVS-II-654(C>T)(25.67%),-28(A>G)(15.76%),and CD17(10.01%).In addition,5 rare mutations(--THAI and HKαα,CD113,-90,and CD56)were found in the study *** results revealed molecular epidemiological background ofα-andβ-thalassemia in Guangdong Province,which can support optimization of thalassemia prevention and control *** demonstrated that thalassemia is heterogeneous with significant geographical differences and population specificity.

关键词： Guangdong prevention marriage

Effectiveness of Using Mean Corpuscular Volume and Mean Corpuscular Hemoglobin for Beta-thalassemia Carrier Screening in the Guangdong Population of China

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Biomedical and Environmental Sciences 2021年第8期34卷 667-671页

作者： GU Heng WANG Yong Xia DU Meng Xuan XU Shan Shan zhou bing yi LI Ming Zhen NHC Key Laboratory of Male Reproduction and Genetics Family Planning Research Institute of Guangdong ProvineeGuangzhou 510000GuangdongChina Department of Public Health and Preventive Medicine Jinan UniversityGuangzhou 510000GuangdongChina

Beta(β)-thalassemia is one of the most common hemoglobinopathies worldwide,creating major public health problems and social burdens in many *** forβ-thalassemia carriers is crucial for controlling this *** investigate the?effectiveness?of?mean?corpuscular?volume?(MCV)and mean corpuscular hemoglobin(MCH)for screeningβ-thalassemia,retrospective data were analyzed for 6,779β-thalassemia carriers subjected to genetic testing following thalassemia screening in Guangdong province between January 2018 and December 2019.

关键词： Guangdong Population thalassemia

Identification of differentially expressed mRNAs as novel predictive biomarkers for gastric cancer diagnosis and prognosis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1947-1964页

作者： Jian-Wei zhou yi-bing Zhang Zhi-Yang Huang Yu-Ping Yuan Jie Jin Department of Gastroenterology Wenzhou Central HospitalDingli Clinical College of Wenzhou Medical UniversityThe Second Affiliated Hospital of Shanghai UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Gastric cancer(GC)has a high mortality rate *** significant progress in GC diagnosis and treatment,the prognosis for affected patients still remains *** To identify important candidate genes related to the development of GC and iden-tify potential pathogenic mechanisms through comprehensive bioinformatics *** The Gene Expression Omnibus database was used to obtain the GSE183136 dataset,which includes a total of 135 GC *** limma package in R software was employed to identify differentially expressed genes(DEGs).Thereafter,enrichment analyses of Gene Ontology(GO)terms and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways were performed for the gene modules using the clusterProfile package in R *** protein-protein interaction(PPI)networks of target genes were constructed using STRING and visualized by Cytoscape *** common hub genes that emerged in the cohort of DEGs that was retrieved from the GEPIA database were then screened using a Venn *** expression levels of these overlapping genes in stomach adenocarcinoma samples and non-tumor samples and their association with prognosis in GC patients were also obtained from the GEPIA database and Kaplan-Meier ***,real-time quantitative polymerase chain reaction(RT-qPCR)and western blotting were performed to determine the mRNA and protein levels of glutamic-pyruvic transaminase(GPT)in GC and normal immortalized cell *** addition,cell viability,cell cycle distribution,migration and invasion were evaluated by cell counting kit-8,flow cytometry and transwell ***,we also conducted a retrospective analysis on 70 GC patients diagnosed and surgically treated in Wenzhou Central Hospital,Dingli Clinical College of Wenzhou Medical University,The Second Affiliated Hospital of Shanghai University between January 2017 to December *** tumor and adjacent normal samples were collected from the patients to determine the

关键词： Gastric cancer Differentially expressed genes Bioinformatics Hub genes Prognosis

In-situ defect passivation assisted three-step printing of efficient and stable formamidine-lead bromide solar cells

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Journal of Energy Chemistry 2024年第9期96卷 396-405页

作者： Hang Yang Tao zhou Haoyu Cai Wenjian Shen Hao Chen Yongjun Liu Juan Zhao yi-bing Cheng Jie Zhong State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070HubeiChina Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Foshan 528216GuangdongChina School of Automobile Engineering Wuhan University of TechnologyWuhan 430070HubeiChina

Perovskite solar cells(PSCs)emerge as the most promising photovoltaics(PV)for their high performance and potential convenient cost-effective production routes comparing to the sophomore PV *** printed PSCs with simplified device architecture and fabrication procedures could further enhance the competitive strength of PSC *** this work,we present an in-situ defect passivation(ISDP)assisted full-printing of high performance formamidine-lead bromide(FAPbBr_(3))*** three rapid printing steps are involved for electron transporting layer(ETL),perovskite and carbon to form a complete solar cell on the low-cost fluorine-doped tin oxide(FTO)***-chain polymer monomethyl ether polyethylene glycol is particularly utilized as the ISDP passivator,leading to conformal coating on the rough FTO and defect passivation for both ETL and perovskite during printing.A high efficiency of 10.85%(certified 10.14%)and a high V_(oc)up to 1.57 V are achieved for the printed *** unencapsulated PSCs maintain above 90%of the initial efficiency after continuously heating at 85℃for 1000 h and over 80%of the efficiency after the maximum power point tracking for 3500 *** fully printed semitransparent PSCs with carbon grids(CGs)show average visible light transmittance over 33%and an efficiency of 8.81%.

关键词： Formamidinium lead bromide Fully printed Lowcosts Carbon electrode Semitransparent

Andrias davidianus bone peptides alleviates hyperuricemia-induced kidney damage in vitro and in vivo

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Food Science and Human Wellness 2024年第4期13卷 1886-1905页

作者： Wei Li Haihong Chen Hongliang Chen Ziyin Li Wei Hu Qinxuan zhou bing Xu yi Wang Xinhui Xing Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 440300China Key Laboratory for Industrial Biocatalysis Ministry of EducationInstitute of Biochemical EngineeringDepartment of Chemical EngineeringBeijing 100084China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China Affiliated Dongguan Hospital Southern Medical University(Dongguan People’s Hospital)Dongguan 523059China

Hyperuricemia(HUA)is a vital risk factor for chronic kidney diseases(CKD)and development of functional foods capable of protecting CKD is of *** paper aimed to explore the amelioration effects and mechanism of Andrias davidianus bone peptides(ADBP)on HUA-induced kidney *** the present study,we generated the standard ADBP which contained high hydrophobic amino acid and low molecular peptide *** vitro results found that ADBP protected uric acid(UA)-induced HK-2 cells from damage by modulating urate transporters and antioxidant *** vivo results indicated that ADBP effectively ameliorated renal injury in HUA-induced CKD mice,evidenced by a remarkable decrease in serum UA,creatinine and blood urea nitrogen,improving kidney UA excretion,antioxidant defense and histological kidney *** analysis highlighted 14 metabolites that could be selected as potential biomarkers and attributed to the amelioration effects of ADBP on CKD mice kidney ***,ADBP restored the gut microbiome homeostasis in CKD mice,especially with respect to the elevated helpful microbial abundance,and the decreased harmful bacterial *** study demonstrated that ADBP displayed great nephroprotective effects,and has great promise as a food or functional food ingredient for the prevention and treatment of HUA-induced CKD.

关键词： Andrias davidianus bone peptides Hyperuricemia Uric acid Chronic kidney disease Gut microbiota

Regulation of solvation structure and the cooperation environment of potassium bonds for wider-temperature adaptive potassium storage

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Rare Metals 2024年第4期43卷 1610-1621页

作者： bing-bing Liu yi-Hui Liu You-Bin Zhang Zhen-Guo Qi Guo-Hui Qin State Key Laboratory Base for Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao266042China Shandong Synergetic Innovation Center of Ecological and Chemical Engineering Qingdao266042China

Antimony selenide(Sb_(2)Se_(3))is one of the perspective candidates for potassium-ion batteries due to its advanced virtues stem including featured high capacity,fertile reserves and the relative narrow band *** the unique advantages,it is still plagued by the unstable interface compatibility and poor wider-temperature *** optimization of microstructure and the construction of inorganic-organic hybrids with a low desolvation barrier and rapid kinetics behaviors are efficient to address these *** Sb_(2)Se_(3)nanorods enclosed by the S-doped carbon layer(SC),further crosslinked by the poly(N-isopropylacrylamide)(PM)film(PM@Sb_(2)Se_(3)@SC),were artificially fabricated,and it displays the enrichment ion aggregated model as well as contacted ion pair state,the well-tailored cooperation environment of potassium bonds,assuring a homogeneous potassium deposition and an excellent widertemperature *** complicated experimental studies and theoretical calculations authenticate the synergistic effects of geometric conformation and compositional design for the tremendously enhanced potassium ***,the full device over PM@Sb_(2)Se_(3)@SC anode and the potassium Prussian blue cathode manifests impressively durable cycling life and wider-temperature adaptability,verifying the glorious contribution from the finely manipulation in solvation structure and potassium bonds to enhancing the potassium storage behaviors.

关键词： Anode Sb_(2)Se_(3) rods Interface compatibility Inorganic-organic electrode Potassium ion battery

Refining the targeted population and achieving better for colorectal cancer screening

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World Journal of Gastroenterology 2024年第25期30卷 3140-3142页

作者： Nuo-Ya zhou yi-Xiu Lin Liu-Xiang Chen Lian-Song Ye bing Hu Department of Gastroenterology and Hepatology/Medical Engineering Integration Laboratory of Digestive Endoscopy West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

This editorial comments on the article entitled“Stage at diagnosis of colorectal cancer through diagnostic route:Who should be screened?”by Agatsuma et al,who conducted a retrospective study aiming at clarifying the stage at colorectal cancer(CRC)diagnosis based on different diagnostic *** share our opinion about CRC screening *** current situation suggests the need for a more specific and targeted population for CRC screening.

关键词： Colorectal cancer Screening Early diagnosis Technology Cost-effectiveness

Advances and challenges in artificial intelligence text generation

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Frontiers of Information Technology & Electronic Engineering 2024年第1期25卷 64-83页

作者： bing LI Peng YANG Yuankang SUN Zhongjian HU Meng yi School of Computer Science and Engineering Southeast UniversityNanjing 210000China Key Laboratory of Computer Network and Information Integration Ministry of EducationSoutheast UniversityNanjing 210000China

Text generation is an essential research area in artificial intelligence(AI)technology and natural language processing and provides key technical support for the rapid development of AI-generated content(AIGC).It is based on technologies such as natural language processing,machine learning,and deep learning,which enable learning language rules through training models to automatically generate text that meets grammatical and semantic *** this paper,we sort and systematically summarize the main research progress in text generation and review recent text generation papers,focusing on presenting a detailed understanding of the technical *** addition,several typical text generation application systems are ***,we address some challenges and future directions in AI text *** conclude that improving the quality,quantity,interactivity,and adaptability of generated text can help fundamentally advance AI text generation development.

关键词： AI text generation Natural language processing Machine learning Deep learning

Homologous heterostructure of MoS_(2) and MoO_(2) coupled with carbon layers as cathode catalyst for rechargeable lithium-oxygen batteries

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Rare Metals 2024年第7期43卷 3383-3390页

作者： yi-Ming Zhang Zhao-Rui zhou Lan-Ling Zhao Ye-bing Li Rui-Feng Li Ya zhou Sana Shoukat Abulgasim-Ahmed-Abbaker Adam Jun Wang Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) Shandong UniversityJinan 250061China Shenzhen Research Institute of Shandong University Shenzhen 518063China School of Physics Shandong UniversityShenzhen 518063China

Lithium-oxygen batteries tend to experience high overpotentials because of the sluggish oxygen reduction reaction and oxygen evolution reaction during cycling.A potential solution to address this issue is to develop a... 详细信息

关键词： lithium process. kinetics

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