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Predicting microbial extracellular electron transfer activity in paddy soils with soil physicochemical properties using machine learning

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Science China(Technological Sciences) 2024年第1期67卷 259-270页

作者： OU JiaJun LUO xiaoshan LIU JunYang HUANG LinYan zhou LiHua YUAN Yong School of Automation Guangdong University of TechnologyGuangzhou 510006China Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control Guangzhou Key Laboratory Environmental Catalysis and Pollution ControlSchool of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China

Soil extracellular electron transfer(EET)is a pivotal biological process within the realm of ***,EET suffers from a lack of predictive ***,an intricately crafted machine learning model has been developed for the purpose of predicting soil EET by using the physicochemical properties of soil as independent input variables and the EET capabilities in terms of current density(j_(max))and Coulombic charge(C_(out))as dependent output *** autoencoder ensemble stacking(AES)model was developed to address the aforementioned issue by integrating support vector machine,multilayer perceptron,extreme gradient boosting,and light gradient boosting machine algorithms as the stacking *** 10-fold crossvalidation,the AES model exhibited notable improvements in predicting j_(max)and C_(out),with average test R^(2)values of 0.83 and 0.84,respectively,surpassing those of single machine learning(ML)models and the basic ensemble *** utilizing partial correlation plots(PDPs),Shapley Additive explanations(SHAP)values,and SHAP decision plots,we quantitatively explained the impact and contribution of the input molecules on the AES model’s predictions of j_(max)and C_(out).In the context of the SHAP method for the AES model,total carbon(TC)was identified as the most correlated descriptor for j_(max),while total organic carbon(TOC)stood out as the most relevant descriptor for C_(out).In the prediction tasks of j_(max)and C_(out)within the AES model,employing a multitask ML approach allowed the model to benefit from the shared information of input variables,thereby enhancing its overall *** study provides a feasible tool for the prediction of soil EET from soil physiochemical properties and an advanced understanding of the relationship between soil physiochemical properties and EET capability.

关键词： extracellular electron transfer paddy soil machine learning prediction autoencoder ensemble stacking model

An engineered DNA aptamer-based PROTAC for precise therapy of p53-R175H hotspot mutant-driven cancer

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Science Bulletin 2024年第13期69卷 2122-2135页

作者： Lingping Kong Fanlu Meng Ping zhou Ruixin Ge xiaoshan Geng Zhihao Yang Guo Li Linlin Zhang Jing Wang Jinfeng Ma Cheng Dong Jun zhou Sijin Wu Diansheng Zhong Songbo Xie Department of Medical Oncology Tianjin Medical University General HospitalTianjin 300052China Center for Cell Structure and Function Collaborative Innovation Center of Cell Biology in Universities of ShandongCollege of Life SciencesShandong Normal UniversityJinan 250014China The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease(Ministry of Education)School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment Lung Cancer InstituteTianjin Medical University General HospitalTianjin 300052China Haihe Laboratory of Cell Ecosystem State Key Laboratory of Medicinal Chemical BiologyCollege of Life SciencesNankai UniversityTianjin 300071China Wisdom Lake Academy of Pharmacy Xi’an Jiaotong-Liverpool UniversitySuzhou 215028China Department of Ophthalmology Tianjin Medical University General HospitalLaboratory of Molecular OphthalmologyTianjin Key Laboratory of Ocular TraumaTianjin Medical UniversityTianjin 300052China

Targeting oncogenic mutant p53 represents an attractive strategy for cancer treatment due to the high frequency of gain-of-function mutations and ectopic expression in various cancer *** extensive efforts,the absence of a druggable active site for small molecules has rendered these mutants therapeutically *** we develop a selective and effective proteolysis-targeting chimera(PROTAC)for p53-R175H,a common hotspot mutant with dominant-negative and oncogenic *** a novel iterative molecular docking-guided post-SELEX(systematic evolution of ligands by exponential enrichment)approach,we rationally engineer a high-performance DNA aptamer with improved affinity and specificity for *** this resulting aptamer as a binder for PROTACs,we successfully developed a selective p53-R175H degrader,named ***53m induces the ubiquitin–protea some-dependent degradation of p53-R175H while sparing wildtype ***,dp53m demonstrates significant antitumor efficacy in p53-R175H-driven cancer cells both in vitro and in vivo,without ***,dp53m significantly and synergistically improves the sensitivity of these cells to cisplatin,a commonly used chemotherapy *** findings provide evidence of the potential therapeutic value of dp53m in p53-R175H-driven cancers.

关键词： P53 Aptamer PROTAC Cancer Drug resistance

Specific myeloprotection via multidrug resistance 1 gene controlled by aminopeptidase N myeloid promoter

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Chinese Science Bulletin 2002年第19期47卷 1650-1653页

作者： LIANG Libo MA Yewei zhou xiaoshan YANG Jun LI Yanchun LIU Yuying WANG Zheng ZHAO Qingzheng Cancer Institute Peking Union Medical College and Chinese Academy of Medical SciencesBeiing 100021China Institute of Blood Transfusion Medicine Beijing 100850China

In the treatment of tumor patients introduction of multidrug resistance genes into hematopoietic cells has been reported as an approach for reducing myelotoxicity created by antitumor drugs. However, the nonspecific expression of the genes can also increase the chemoresistance of the tumor cells invaded into bone marrow, which influences seriously the effectiveness of chemotherapy. In this study, a new strategy is described for specific myeloprotection. The recombinant retroviral vector containing multidrug resistance 1 (MDR1) gene regulated by aminopeptidase N (APN) myeloid promoter was constructed and then introduced into myeloblastic cells KGla and tumor cell line BEL7402. The specific transcript of MDR1 was detected in KGla cells transduced with MDR1 gene and rhodamine 123 was effectively extruded by Pgp, the protein of MDR1 gene. The resistance elevated markedly by 10.6, 10.4, 11.2, 4.2 and 14.2 folds in MDR1 gene-transduced KGla cells to chemothera-peutic drugs such as cochicine, VP-16,

关键词： animopeptidase N myelo-specific promoter MDR1 retroviral vector hepatoma cell myeloid cell.

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《布莱希特的情人》:换一个角度看布莱希特

当代外国文学 2005年第1期26卷 99-102页

作者：周小珊南京大学外国语学院

《布莱希特的情人》截取了 2 0世纪德国杰出的戏剧家布莱希特 1948年回归东柏林后的短短几年中的生活片段 ,通过他身边一个身份特殊的美丽女子的目光 ,展现了一个“平民”布莱希特。小说在虚构的故事中糅入了大量的历史事实 ,模糊于真... 详细信息

《布莱希特的情人》截取了 2 0世纪德国杰出的戏剧家布莱希特 1948年回归东柏林后的短短几年中的生活片段 ,通过他身边一个身份特殊的美丽女子的目光 ,展现了一个“平民”布莱希特。小说在虚构的故事中糅入了大量的历史事实 ,模糊于真实与虚构之间。小说的语言特别 ,用大量的名词排列 ,创作出强烈的背景装饰效果 ,再加上舞台剧似的结构 ,给叙述留下了许多空白 ,给人以充分的想象空间。

关键词：布莱希特小说虚构纪德故事叙述空白舞台剧戏剧家实与虚

Ginsenoside rg3 reduces body weight by regulating fat content and browning in obese mice

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Journal of Traditional Chinese Medical Sciences 2021年第1期8卷 65-71页

作者： Qianqian Mu Jiacheng Zuo Dandan Zhao xiaoshan zhou Jing Hua Ying Bai Fangfang Mo Xin Fang Min Fu Sihua Gao Hospital Office Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Department of Endocrinology Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China Research Institute of McGill University Health Center McGill UniversityMontreal H4A 3J1Canada

Objective:To determine the effects of ginsenoside rg3 on the body weight of C57BL/6J obese mice and to investigate its underlying weight loss mechanisms with a focus on white fat browning-related ***:Eight-week-old C57BL/6J male mice were fed a high-fat diet for 12 successive weeks to construct the obese model.C57BL/6J male mice were fed a standard chow diet to construct normal control *** 8 weeks of intervention with ginsenoside rg3,the food intake,body weight,body fat mass,blood sugar,and lipid profiles of the mice in each group were *** and eosin(HE)staining was used to observe the histological morphology of the adipose ***-time polymerase chain reaction(RT-PCR)and Western blotting(WB)were applied to detect the gene and protein expression levels of peroxisome proliferators-activated receptor gama(PPARg),Peroxisome proliferatoractivated receptor-gamma coactivator-1alpha(PGC-1a),PR domain containing 16(PRDM16),and uncoupling protein 1(UCP-1).Results:Compared to normal control group mice,the body weight,food intake,body fat composition,and blood lipid levels of model group mice increased *** 8 weeks of intervention with ginsenoside rg3,body weight,body fat composition,food intake,and blood lipid profiles *** staining showed that ginsenoside rg3 can improve white adipocyte hypertrophy to a certain *** and WB demonstrated that ginsenoside rg3 can increase the mRNA and protein expression levels of PPARg,PGC-1a,PRDM16,and UCP-1 in the adipose tissues of obese ***:The weight reduction effect of ginsenoside rg3 may be related to the promotion of white fat browning.

关键词： Ginsenoside rg3 White fat Browning Obesity

现代音乐技法在《去年在马里昂巴德》中的视觉化表达

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北京电影学院学报 2020年第2期 109-116页

作者：周晓杉重庆师范大学音乐学院

现代音乐技法通过抛弃稳定的调性与线性的旋律来表达精神世界的瞬息万变,这种技法与阿伦·雷乃探寻时空结构与内心感知的表达观念相契合并影响他的创作方式。文章通过分析现代音乐创作的基本技术与雷乃独特音乐意识的结合,研究雷乃如何... 详细信息

现代音乐技法通过抛弃稳定的调性与线性的旋律来表达精神世界的瞬息万变,这种技法与阿伦·雷乃探寻时空结构与内心感知的表达观念相契合并影响他的创作方式。文章通过分析现代音乐创作的基本技术与雷乃独特音乐意识的结合,研究雷乃如何将现代音乐技法应用于影像表达,深化视听观念多维度的构建,扩展音乐与电影的相关研究领域,探索音乐化视觉表达的多样可能性。

关键词：现代音乐《去年在马里昂巴德》移位音画对位阿伦·雷乃

基于物联网的井下瓦斯泄漏的远程监控平台设计

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现代电子技术 2016年第14期39卷 135-138页

作者：吕欣周晓山华北理工大学现代技术教育中心河北唐山063009 华北理工大学继续教育学院河北唐山063009

由于当前矿井瓦斯事故频繁发生,传统监控系统存在检测精度低和实时性弱的缺陷,设计基于物联网的井下瓦斯泄漏远程监控平台。该监控平台包括井下无线传感器网络、有线通信网和井上监控管理站,分别对应于物联网的感知层、网络层以及应用... 详细信息

由于当前矿井瓦斯事故频繁发生,传统监控系统存在检测精度低和实时性弱的缺陷,设计基于物联网的井下瓦斯泄漏远程监控平台。该监控平台包括井下无线传感器网络、有线通信网和井上监控管理站,分别对应于物联网的感知层、网络层以及应用层。监控平台在井下采用无线传感网络采集和传输瓦斯数据,传感器采用CC2430芯片作为核心处理器,实现瓦斯信息的快速检测,系统网关服务器采用飞凌S3C2440开发板实现网络通信,可将井下瓦斯数据通过网络传递到井上监控管理站。实验结果表明,所设计监控平台监控结果稳定可靠,能够实现瓦斯泄漏点的精确监测。

关键词：物联网瓦斯泄漏远程监控监控平台

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融合选择注意力的小样本知识图谱补全模型

计算机科学与探索 2024年第3期18卷 646-658页

作者：林穗卢超海姜文超林晓珊周蔚林广东工业大学计算机学院广州510006 数安时代科技股份有限公司广东佛山510100

在面对实体对关系复杂或目标邻域稀疏等情况时,现有的小样本知识图谱补全模型普遍存在关系表示学习能力不足以及忽略实体对相对位置和交互作用的问题。基于此,提出一种基于选择注意力机制和交互感知的小样本知识图谱补全模型(SAIA)。首... 详细信息

在面对实体对关系复杂或目标邻域稀疏等情况时,现有的小样本知识图谱补全模型普遍存在关系表示学习能力不足以及忽略实体对相对位置和交互作用的问题。基于此,提出一种基于选择注意力机制和交互感知的小样本知识图谱补全模型(SAIA)。首先,通过在聚合邻域信息过程中引入选择注意机制,帮助邻域编码器聚焦更重要的邻居以减少噪声邻居的不良影响;其次,在关系表示学习阶段,利用背景知识图谱中与任务关系相关的信息学习更加准确的关系表示;最后,为了挖掘知识图谱实体之间的交互信息和位置信息,设计了一个实体对公共交互率指标(CIR)来衡量实体对三阶路径内的关联程度,然后结合实体语义信息共同预测新的事实。实验结果表明该方法优于目前最先进的小样本知识图谱补全模型。与基准模型最优的结果相比,SAIA在NELL-one和Wiki-one数据集上的5-shot链接预测中,平均倒数排名(MRR)、Hits@10、Hits@5以及Hits@1等性能评价指标分别提高了0.038、0.011、0.028和0.052以及0.034、0.037、0.029和0.027,验证了所提模型的有效性和可行性。

关键词：知识图谱知识图谱补全表示学习小样本关系注意力机制

基于MRI影像组学鉴别卵巢卵泡膜细胞瘤与阔韧带肌瘤

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中国医学影像学杂志 2022年第2期30卷 145-152页

作者：夏旭东李铭王海彬王功夏王亚龙周小山河南省安阳市肿瘤医院医学影像科河南安阳455001

目的探讨基于MRI影像组学对卵巢卵泡膜细胞瘤(OTCA)与阔韧带肌瘤(BLM)的鉴别诊断价值。资料与方法回顾性分析安阳市肿瘤医院2016年1月—2021年3月经病理证实的76例OTCA和58例BLM的MRI图像,比较两组疾病的MRI特征。于肿瘤最大层面勾画感... 详细信息

目的探讨基于MRI影像组学对卵巢卵泡膜细胞瘤(OTCA)与阔韧带肌瘤(BLM)的鉴别诊断价值。资料与方法回顾性分析安阳市肿瘤医院2016年1月—2021年3月经病理证实的76例OTCA和58例BLM的MRI图像,比较两组疾病的MRI特征。于肿瘤最大层面勾画感兴趣区提取T2WI脂肪抑制序列图像纹理特征,采用分层抽样方式按照7∶3分为训练组104例和测试组30例,根据病理结果分为OTCA亚组和BLM亚组。基于训练组,使用最小绝对收缩和选择算子回归分析筛选关键特征,根据回归模型中变量的回归系数,建立线性方程计算影像组学标签评分。采用受试者工作特征(ROC)曲线评价基于MRI图像特征、影像组学及其组合区分两种疾病的能力。结果共4个MRI特征为鉴别两组疾病的独立特征,包括同侧卵巢可见性(χ^(2)=5.503,P<0.05)、外周囊性区(χ^(2)=7.693,P<0.05)、动脉期强化程度(P<0.05)及表观扩散系数(t=3.310,P<0.05);训练组和测试组OTCA、BLM亚组的影像组学标签评分比较,差异均有统计学意义(P<0.05)。联合MRI图像特征和影像组学标签评分诊断效能最高,在训练组和验证组中的ROC曲线下面积分别为0.900和0.891,敏感度分别为95.8%和99.8%,特异度分别为82.6%和75.0%,准确度分别为83.8%和80.1%。与传统MRI特征(训练组和验证组ROC曲线下面积分别为0.800、0.767,敏感度分别为66.0%、68.8%,特异度分别为84.2%、75.0%,准确度分别为76.9%、71.1%)相比,联合MRI图像特征和影像组学标签评分训练组和测试组诊断效能均有提高(P<0.05)。结论基于MRI影像组学可以提高MRI鉴别OTCA与BLM的能力。

关键词：卵巢肿瘤肌瘤阔韧带磁共振成像影像组学病理学,外科诊断,鉴别

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