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Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids

Protein & Cell 2024年第4期15卷 285-304页

作者： Yunuo Mao Wei Wang Jingwei Yang xin zhou Yongqu Lu Junpeng Gao xiao Wang Lu Wen Wei Fu Fuchou Tang School of Life Sciences Biomedical Pioneering Innovation CenterDepartment of General SurgeryThird HospitalPeking UniversityBeijing 100871China Beijing Advanced Innovation Center for Genomics(ICG) Ministry of Education Key Laboratory of Cell Proliferation and DifferentiationBeijing 100871China Peking-Tsinghua Center for Life Sciences Peking UniversityBeijing 100871China Peking University Third Hospital Cancer Center Beijing 100871China The Research Center of Stem Cell and Regenerative Medicine School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China

Colorectal cancer(CRC)is a highly heterogeneous cancer and exploring novel therapeutic options is a pressing issue that needs to be ***,we established human CRC tumor-derived organoids that well represent both morphological and molecular heterogeneities of original *** efficiently identify repurposed drugs for CRC,we developed a robust organoid-based drug screening *** combining the repurposed drug library and computation-based drug prediction,335 drugs were tested and 34 drugs with anti-CRC effects were *** importantly,we conducted a detailed transcriptome analysis of drug responses and divided the drug response signatures into five representative patterns:differentiation induction,growth inhibition,metabolism inhibition,immune response promotion,and cell cycle *** anticancer activities of drug candidates were further validated in the established patient-derived organoids-based xenograft(PDOX)system in *** found that fedratinib,trametinib,and bortezomib exhibited effective anticancer ***,the concordance and discordance of drug response signatures between organoids in vitro and pairwise PDOX in vivo were *** study offers an innovative approach for drug discovery,and the representative transcriptome features of drug responses provide valuable resources for developing novel clinical treatments for CRC.

关键词： colorectal cancer organoids drug repurposing patient-derived organoids-based xenograft mechanism of action

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(Benzimidazolium)_(2)GeI_(4):A layered two-dimensional perovskite with dielectric switching and broadband near-infrared photoluminescence

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Chinese Journal of Structural Chemistry 2024年第6期43卷 45-49页

作者： Xuan Zhu Lin zhou xiao-Yun Huang Yan-Ling Luo xin Deng xin Yan Yan-Juan Wang Yan Qin Yuan-Yuan Tang Ordered Matter Science Research Center Nanchang UniversityNanchang330031People's Republic of China

Two-dimensional(2D)lead halide perovskites have attracted tremendous attention due to their outstanding physical ***,the presence of toxic lead is a major problem for large-scale ***,we report the synthesis,phase transition,dielectric and photoluminescence(PL)properties of a lead-free 2D Ge-based perovskite(BIM)_(2)GeI_(4)(BIM=benzimidazolium)which experiences a phase transition at 405 K accompanied by an order-disorder change of organic ***,the step-like dielectric transition near the phase transition temperature makes it suitable for dielectric ***,(BIM)_(2)GeI_(4)has a direct bandgap of 2.23 eV and broadband emission from 550 to 1000 nm,implying its unique optical property for potential near-infrared lighting and *** work provides a fresh example for the development of lead-free 2D Ge-based perovskite with potential applications in the fields of optoelectronics and high temperature dielectric switching.

关键词： Dielectric switching Photoluminescence Two-dimensional perovskite Lead-free perovskite

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Pluggable multitask diffractive neural networks based on cascaded metasurfaces

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Opto-Electronic Advances 2024年第2期7卷 23-31页

作者： Cong He Dan Zhao Fei Fan Hongqiang zhou xin Li Yao Li Junjie Li Fei Dong Yin-xiao Miao Yongtian Wang Lingling Huang Beijing Engineering Research Center of Mixed Reality and Advanced Display Key Laboratory of Photoelectronic Imaging Technology and System of Ministry of Education of ChinaSchool of Optics and PhotonicsBeijing Institute of TechnologyBeijing 100081China Institute of Modern Optics Tianjin Key Laboratory of Optoelectronic Sensor and Sensing Network TechnologyNankai UniversityTianjin 300350China Department of Physics and Optoelectronics Faculty of ScienceBeijing University of TechnologyBeijing 100124China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100191China Beijing Aerospace Institute for Metrology and Measurement Technology Beijing 100076China

Optical neural networks have significant advantages in terms of power consumption,parallelism,and high computing speed,which has intrigued extensive attention in both academic and engineering *** has been considered as one of the powerful tools in promoting the fields of imaging processing and object ***,the existing optical system architecture cannot be reconstructed to the realization of multi-functional artificial intelligence systems *** push the development of this issue,we propose the pluggable diffractive neural networks(P-DNN),a general paradigm resorting to the cascaded metasurfaces,which can be applied to recognize various tasks by switching internal *** the proof-of-principle,the recognition functions of six types of handwritten digits and six types of fashions are numerical simulated and experimental demonstrated at near-infrared ***,the proposed paradigm not only improves the flexibility of the optical neural networks but paves the new route for achieving high-speed,low-power and versatile artificial intelligence systems.

关键词： optical neural networks diffractive deep neural networks cascaded metasurfaces

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非对称波形激光驱动的氢原子高次谐波频移及控制

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物理学报 2022年第7期71卷 91-98页

作者：魏博宁焦志宏周效信西北师范大学物理与电子工程学院兰州730070

提出了一种利用非对称波形激光脉冲与原子相互作用在隧穿区发射高次谐波谱的大频移方案.通过数值求解偶极近似下的三维含时薛定谔方程,研究了该激光驱动氢原子发射的高次谐波特性.结果表明,利用上升沿与下降沿不同的非对称激光驱动氢原... 详细信息

提出了一种利用非对称波形激光脉冲与原子相互作用在隧穿区发射高次谐波谱的大频移方案.通过数值求解偶极近似下的三维含时薛定谔方程,研究了该激光驱动氢原子发射的高次谐波特性.结果表明,利用上升沿与下降沿不同的非对称激光驱动氢原子所发射的高次谐波在截止位置附近发生了大的频率红移和蓝移,通过改变激光脉冲的上升沿或下降沿,能调控谐波的频移量.产生频移的原因是激光脉冲上升沿或下降沿对谐波贡献的不同所致,当下降沿发射谐波的贡献大于上升沿的贡献时,谐波发生红移,反之则发生蓝移.通过改变激光脉冲波形,在隧穿电离区能够调控截止位置附近原子发射的高次谐波频率,对于给定的某一阶谐波,调控的范围可从奇次阶到邻近偶次阶之间的任意频率处.

关键词：非对称激光波形高次谐波红移蓝移

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The variation of microbiological characteristics in surface waters during persistent precipitation

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Frontiers of Environmental Science & Engineering 2024年第9期18卷 67-78页

作者： xinyan xiao Chenlan Chen Haoran Li Lihua Li xin Yu College of the Environment&Ecology Xiamen UniversityXiamen 361102China Fujian Key Laboratory of Coastal Pollution Prevention and Control Xiamen UniversityXiamen 361102China

Climate change leads to an increase in both the frequency and intensity of extreme *** runoff generated by extreme precipitation has a significant impact on ***,the impact of persistent precipitation on surface water quality is easy to neglect,due to its prolonged duration and lower-intensity *** study established eight sampling points within selected surface waters to observe the variation of microbial characteristics in a typical persistence precipitation *** primary difference between Furong Lake(FL)and Chengqian Reservoir(CR)was:the concentrations of dissolved organic carbon(DOC)were 21.3±0.7 and 8.3±1.5 mg/L in FL and CR,*** concentrations of R2A culturable bacteria and coliforms were 10^(4.57)and 10^(1.58)colony-forming units(CFU)/mL in FL,and were 10^(5.46)and 10^(2.64)CFU/mL in CR,*** precipitation,the maximum increase concentrations of R2A,NA culturable bacteria,and coliforms were 10^(0.75),10^(1.30),and 10^(2.27)CFU/mL in FL,***,microbial concentration and rainfall did not increase simultaneously,and a delay phenomenon was observed in the increasing microbial *** analyzing the concentration change trends and correlation of various water quality indicators during persistent precipitation,the significant correlation between the DOC concentration and the changes in the dominant species of microbial community structure was found in this study(p<0.05).For example,as the DOC concentration declined,the abundance of hgcl_clade and CL500-29_marine_group ***,although persistent precipitation might not obviously alter the water quality visibly,it could still pose potential microbial risks.

关键词： Rainfall Dissolved organic carbon Culturable bacteria Water quality Microbial community structure Climate change

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温度对激光场中N_2、O_2分子取向的影响

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物理化学学报 2006年第8期22卷 932-936页

作者：杨增强周效信西北师范大学物理与电子工程学院兰州730070 兰州重离子加速器国家重点实验室原子核理论研究中心兰州730000

由刚性转子(rigidrotors)模型出发,利用伪谱方法求解了含时薛定谔方程,从理论上研究了双原子N2分子和O2分子在激光场中的取向(alignment)行为,讨论了分子与飞秒(fs)激光脉冲作用后,在无外场情况下出现的周期性取向现象.计算结果表明,随... 详细信息

由刚性转子(rigidrotors)模型出发,利用伪谱方法求解了含时薛定谔方程,从理论上研究了双原子N2分子和O2分子在激光场中的取向(alignment)行为,讨论了分子与飞秒(fs)激光脉冲作用后,在无外场情况下出现的周期性取向现象.计算结果表明,随着温度的升高,分子的最大取向程度不断地减小;在低温时,随温度减小较快,当温度升高时,最大取向程度随温度的变化比较缓慢.并通过计算角动量分布探讨了产生这种变化的原因.

关键词：激光场分子取向转动波包

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强激光场中模型氢原子和真实氢原子的高次谐波与电离特性研究

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物理学报 2006年第8期55卷 4078-4085页

作者：赵松峰周效信金成西北师范大学物理与电子工程学院兰州730070

利用数值方法求解含时薛定谔方程,研究了一维、二维模型氢原子和真实的三维氢原子在强激光场中产生的高次谐波和电离特性.结果表明,在多光子电离区域和过垒电离区域,模型氢原子与真实的氢原子产生的高次谐波和电离概率差别很小;在隧道... 详细信息

利用数值方法求解含时薛定谔方程,研究了一维、二维模型氢原子和真实的三维氢原子在强激光场中产生的高次谐波和电离特性.结果表明,在多光子电离区域和过垒电离区域,模型氢原子与真实的氢原子产生的高次谐波和电离概率差别很小;在隧道电离区域,它们产生的高次谐波的平台特征和截止位置相似,电离概率随时间变化的趋势相近,但其数值有明显的差异.对产生这种差异的原因进行了分析.

关键词：强激光场高次谐波电离概率

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红外激光场中共振结构原子对极紫外光脉冲的压缩效应

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物理学报 2016年第10期65卷 67-75页

作者：唐蓉王国利李小勇周效信西北师范大学物理与电子工程学院兰州730070 西北民族大学实验中心兰州730030

通过数值求解一维原子的含时薛定谔方程,研究了具有共振结构的原子在双色场(红外激光(IR)+极紫外光(XUV))驱动下发射高次谐波的特征.研究结果表明,具有共振结构的原子所发射的高次谐波与无共振结构原子(简称为一般原子)发射的高次谐波... 详细信息

通过数值求解一维原子的含时薛定谔方程,研究了具有共振结构的原子在双色场(红外激光(IR)+极紫外光(XUV))驱动下发射高次谐波的特征.研究结果表明,具有共振结构的原子所发射的高次谐波与无共振结构原子(简称为一般原子)发射的高次谐波有明显不同,共振结构的原子除了在某一能量附近(原子的共振能量+电离能)高次谐波的强度有很大提高外,它还对XUV光的响应较一般原子表现得更为敏感,即使XUV光的强度较弱,也能够明显提高XUV光脉冲中心频率附近的谐波强度,更重要的是通过调节双色场的时间延迟,能使输入的XUV光的脉宽得到明显的压缩,通过时间-频率分析给出了发生这种现象的原因.由此提出了通过滤波-连续反馈的方式可使XUV光的脉冲从200 as压缩至120 as左右.

关键词：共振结构原子高次谐波阿秒脉冲极紫外光脉冲压缩

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Quantitative method for calculating spatial release region for laser-guided bomb

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Journal of Systems Engineering and Electronics 2024年第4期35卷 1053-1062页

作者： YANG Ping xiao Bing CHEN xin HAO Yuntao Air Force Early Warning Academy Wuhan 430019China Unit 93175 of the PLA Changchun 136000China

The laser-guided bomb(LGB)is an air-to-ground pre-cision-guided weapon that offers high hit rates,great power,and ease of *** are guided by semi-active laser ground-seek-ing technology,which means that atmospheric conditions can affect their *** spatial release region(SRR)of LGBs is difficult to calculate precisely,especially when there is a poor field of *** can result in a lower real hit *** increase the hit probability of LGBs in tough atmospheric situa-tions,a novel method for calculating the SRR has been *** method is based on the transmittance model of the 1.06μm laser in atmospheric species and the laser diffuse reflection model of the target surface to determine the capture target time of the laser ***,it calculates the boundary ballistic space starting position by ballistic model and gets the spatial scope of the spatial release *** method can determine the release region of LGBs based on flight test data such as instantaneous velocity,altitude,off-axis angle,and atmospheric *** more effectively employing aircraft release conditions,atmospheric visibility and other factors,the SRR calculation method can improve LGB hit probabi-lity by 9.2%.

关键词： laser-guided bombs(LGBs) hit probability atmo-spheric transmittance spatial release region(SRR)boundary ballistic

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Heterogeneous information fusion recognition method based on belief rule structure

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Journal of Systems Engineering and Electronics 2024年第4期35卷 955-964页

作者： WANG Haibin GUAN xin YI xiao SUN Guidong Naval Aviation University Yantai 264001China Unit 32801 of the PLA Beijing 100082China

To solve the problem that the existing situation awareness research focuses on multi-sensor data fusion,but the expert knowledge is not fully utilized,a heterogeneous informa-tion fusion recognition method based on belief rule structure is *** defining the continuous probabilistic hesitation fuzzy linguistic term sets(CPHFLTS)and establishing CPHFLTS distance measure,the belief rule base of the relationship between feature space and category space is constructed through information integration,and the evidence reasoning of the input samples is carried *** experimental results show that the proposed method can make full use of sensor data and expert knowledge for *** with the other methods,the proposed method has a higher correct recognition rate under different noise levels.

关键词： belief rule heterogeneous information intention recognition hesitation fuzzy linguistic

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