检索结果-南通市图书馆

Superlubricitive engineering—Future industry nearly getting rid of wear and frictional energy consumption

在线全文

学校读者我要写书评

暂无评论

Friction 2020年第4期8卷 643-665页

作者： Jianbin LUO xiang zhou State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China

Superlubricity has been developing very rapidly in recent years as a new and important area in tribology. Many new phenomena and materials, as well as some new mechanisms in both liquid and solid superlubricity have been obtained. In liquid superlubricity, tens of new kinds of liquids with superlubricity have been found (e.g., water-based liquids, oil-based lubricants, and liquids combined with additives of two-dimensional (2D) materials that exhibit very good superlubricity properties under high pressure). In the field of solid superlubricity, more materials with superlubricity have been observed, including graphene-to-graphene surfaces, highly oriented pyrolytic graphite to graphene surfaces, and heterostructure surfaces where a friction coefficient as low as 0.00004 has been obtained. However, superlubricity is still under laboratory research. What is the future of superlubricity? What is the barrier restricting superlubricity from industrial applications? How do we transfer superlubricity from scientific research to industrial application? These questions and application fields of superlubricity in near future have been analyzed, and the concept of"superlubricitive engineering"has been proposed in the present work.

关键词： superlubricitive engineering superlubricity liquid superlubricity solid superlubricity two-dimensional(2D)material lubrication

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第01期 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang Xie Qian Hao xiang zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

关键词：

Novel schemes to generate multi-level modulation formats for ultra-capacity coherent detection transmission systems

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Optics Letters 2010年第9期8卷 823-830页

作者： Jianjun Yu xiang zhou ZTE USA Inc. Iselin NJ 08830 USA and also with ZTE Inc. Beijing 100876 China AT&T Labs-Research Middletown NJ 07748 USA

We summarize several novel schemes to generate multi-level modulation formats for high capacity transmission system with high spectral efficiency. We show that multi-level 8QAM, 16QAM, 32QAM, and 64QAM （QAM： quatlrature amplitude modulation） optical signals can be generated by commercial optical and electrical devices. Employing these multilevel modulation formats, we have realized PDM-8QAM （PDM： polarization division multiplexing） 32 Tb/s and PDM-36QAM 64-Tb/s signals transmission over 580-and 320-km fibers, respectively.

关键词： Spectrum analyzers

The emerging role of long noncoding RNA RMRP in cancer development and targeted therapy

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2022年第2期19卷 140-146页

作者： Qian Hao xiang zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)Institutes of Biomedical SciencesFudan UniversityShanghai 200032China

The RNA component of mitochondrial RNA-processing endoribonuclease(RMRP)was first described as an entity that cleaved mitochondrial RNA at a priming site of mitochondrial DNA *** long noncoding RNA(lncRNA)was encoded by an evolutionarily conserved nuclear gene that has been characterized in many species,including human,mouse,cattle,zebrafish,toad,and *** was soon learned that RMRP as a component of the RNase MRP complex was also located in the nucleus,and was critical for ribosomal RNA(rRNA)processing,particularly the biosynthesis of 5.8S *** 2001,the first evidence of the role of RMRP in the pathogenesis of human disorders was reported,involving mutations in the RMRP gene,which caused cartilage-hair hypoplasia(CHH)1,a recessively inherited developmental disorder characterized by short stature,hypoplastic anemia,defective immunity,and predisposition to several cancers.

关键词： immunity anemia pathogenesis

Energy and carbon performance of urban buildings using metamodeling variable importance techniques

在线全文

学校读者我要写书评

暂无评论

Building Simulation 2021年第3期14卷 535-547页

作者： Yunliang Liu Wei Tian xiang zhou School of Mechanical Engineering Tongji UniversityShanghai 200092China Tianjin Key Laboratory of Integrated Design and On-line Monitoring for Light Industry&Food Machinery and Equipment College of Mechanical EngineeringTianjin University of Science and TechnologyTianjin 300222China Tianjin International Joint Research and Development Center of Low-Carbon Green Process Equipment Tianjin 300222China

Global urbanization causes more environmental stresses in cities and energy efficiency is one of major concerns for urban *** variable importance techniques have been widely used in building energy analysis to determine key factors influencing building energy *** of these applications,however,use only one type of variable importance ***,this paper proposes a procedure of conducting two types of variable importance analysis(predictive and variance-based)to determine robust and effective energy saving measures in urban *** two variable importance methods belong to metamodeling techniques,which can significantly reduce computational cost of building energy simulation models for urban *** predictive importance analysis is based on the prediction errors of metamodels to obtain importance rankings of inputs,while the variance-based variable importance can explore non-linear effects and interactions among input variables based on variance *** campus buildings are used to demonstrate the application of the method proposed to explore characteristic of heating energy,cooling energy,electricity,and carbon emissions of *** results indicate that the combination of two types of metamodeling variable importance analysis can provide fast and robust analysis to improve energy efficiency of urban *** carbon emissions can be reduced approximately 30%after using a few of effective energy efficiency measures and more aggressive measures can lead to the 60%of reduction of carbon ***,this research demonstrates the application of parallel computing to expedite building energy analysis in urban environment since more multi-core computers become increasingly available.

关键词： urban buildings variable importance metamodeling energy performance carbon emissions

N^(6)-methyladenosine and Its Implications in Viruses

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2023年第4期21卷 695-706页

作者： Yafen Wang xiang zhou College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072China School of Public Health Wuhan UniversityWuhan 430071China

N6-methyladenine(m^(6)A)is the most abundant RNA modification in mammalian messenger RNAs(mRNAs),which participates in and regulates many important biological activities,such as tissue development and stem cell *** to an improved understanding of m^(6)A,researchers have discovered that the biological function of m^(6)A can be linked to many stages of mRNA metabolism and that m^(6)A can regulate a variety of complex biological *** addition to its location on mammalian mRNAs,m^(6)A has been identified on viral transcripts.m^(6)A also plays important roles in the life cycle of many viruses and in viral replication in host *** this review,we briefly introduce the detection methods of m^(6)A,the m^(6)A-related proteins,and the functions of m^(6)*** also summarize the effects of m^(6)A-related proteins on viral replication and *** hope that this review provides researchers with some insights for elucidating the complex mechanisms of the epitranscriptome related to viruses,and provides information for further study of the mechanisms of other modified nucleobases acting on processes such as viral *** also anticipate that this review can stimulate collaborative research from different fields,such as chemistry,biology,and medicine,and promote the development of antiviral drugs and vaccines.

关键词： m^(6)A Writer protein Reader protein Eraser protein Virus

STING-mediated DNA sensing in cancer immunotherapy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2017年第6期60卷 563-574页

作者： xiang zhou Zhengfan Jiang Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education State Key Laboratory of Protein and Plant Gene ResearchSchool of Life SciencesPeking UniversityBeijing 100871China Peking-Tsinghua Center for Life Sciences Peking UniversityBeijing 100871China

While STING(STimulator of INterferon Genes) has been shown to be essential for cytosolic DNA-triggered innate immune activation, accumulated evidence obtained from various studies suggested that an intrinsic relevance of STING-associated signaling in tumorigenesis can be observed. Also, several clinical trials using immunostimulatory adjuvants, particularly agonistic as well as non-agonistic ligands for STING, have revealed their therapeutic potential not only as vaccine adjuvants but also as anti-tumor agents. However, cases have also been reported where the involvement of STING shows a protective role in tumor growth. Here we summarize recent findings that have pointed towards the STING pathway as an innate immune sensing mechanism driving type I interferon production in the tumor context. Better understanding of this pathway can guide further development of novel immunotherapeutic strategies in the treatment of cancer.

关键词： cancer immunotherapy cGAS innate immunity STING tumorigenesis type I interferon

Hybrid Continuous-Time MILP Model for Crude Oil Scheduling under the Influence of High Tides

在线全文

学校读者我要写书评

暂无评论

China Petroleum Processing & Petrochemical Technology 2021年第3期23卷 76-89页

作者： zhou Zhiju zhou xiang zhou Han SINOPEC Research Institute of Petroleum Processing Beijing 100083

Vessels,especially very large or ultra large crude carriers(VLCCs or ULCCs),often can only dock and leave the berth during high tide periods to prevent being ***,the current crude scheduling models do not take into account tidal conditions,which will seriously affect the feasibility of crude *** we first focus on the docking and leaving operations under the tidal actions,and establish a new hybrid continuous-time mixed integer linear programming(MILP)model which incorporates global event based formulation and unit-specific event based *** considering that the multiple blending of crude oil can easily cause the production fluctuating,there are some reasonable assumptions that storage tanks can only store pure crude,and charging tanks just can be refilled after being emptied,which helps us obtain a simple MILP model without composition discrepancy caused by crude *** cases are used to demonstrate the efficacy of proposed scheduling *** results show that the optimization schedule can minimize the demurrage of the vessels and the number of feeding changeovers of crude oil distillation units(CDUs).

关键词： crude scheduling tide continuous-time representation mixed integer linear programming

Miniaturized power detection module operating in millimeter wave band

在线全文

学校读者我要写书评

暂无评论

Journal of Electronic Science and Technology 2024年第2期22卷 69-76页

作者： xiang zhou Zhi-Yong Zhong School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China

The miniaturized broadband detection module can be embedded into the microwave application system such as the front end of the transmitter to detect the power or other parameters in real *** is highly prospective in military and scientific *** this paper,a broadband power detection module operating at 26.5 GHz-40.0 GHz is designed by using low-barrier Schottky diode as the detector and a comparator for threshold *** module can dynamically detect the power range between-10 dBm and 10 dBm with the detection accuracy of 0.1 ***,the temperature compensation circuit is also applied to improve the measurement *** a result,the resulted error low to±1 dB in the temperature range of -55℃ to +85℃ is *** designed module is encapsulated by a Kovar alloy with a small volume of 9 mm×6 mm×3 *** endows the designed module the advantages of small size,easy integration,and low cost,and even it is applicable to high-reliability environments such as satellites.

关键词： Diode Miniaturization Power detection Temperature compensation