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A YAP/TAZ-CD54 axis is required for CXCR2-CD44-tumor-specific neutrophils to suppress gastric cancer

Protein & Cell 2023年第7期14卷 515-533页

作者： Pingping Nie Weihong Zhang Yan Meng Moubin Lin Fenghua Guo Hui Zhang Zhenzhu Tong Meng Wang Fan Chen Liwei An Yang Tang Yi Han Ruixian Yu wenjia Wang Yuanzhi Xu Linxin Wei Zhaocai zhou Shi Jiao CAS Center for Excellence in Molecular Cell Science Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China State Key Laboratory of Genetic Engineering School of Life SciencesZhongshan HospitalFudan UniversityShanghai 200438China Tongji University Cancer Center Department of Medical UltrasoundShanghai Tenth People's HospitalUltrasound Research and Education InstituteTongji University School of MedicineShanghai200072China Postdoctoral Station of Clinical Medicine Shanghai Tenth People's HospitalTongji University School of MedicineShanghai 200072China Tumor Immunology and Gene Therapy Center Shanghai Eastem Hepatobiliary Surgery HospitalShanghai 200438China Department of General Surgery Yangpu HospitalTongji University School of MedicineShanghai 200090China Department of General Surgery Hua'shan HospitalFudan University Shanghai Medical CollegeShanghai 200040China Department of Stomatology Shanghai Tenth People's HospitalTongji University School of MedicineShanghai 200072China Collaborative Innovation Center for Cancer Personalized Medicine School of Public HealthNanjing Medical UniversityNanjing 211166China

As an important part of tumor microenvironment,neutrophils are poorly understood due to their spatiotemporal heterogeneity in *** we defined,at single-cell resolution,CD44-CxCR2-neutrophils as tumor-specific neutrophils(tsNeus)in both mouse and human gastric cancer(GC).We uncovered a Hippo regulon in neutrophils with unique YAP signature genes(e.g.,ICAM1,CD14,EGR1)distinct from those identified in epithelial and/or cancer ***,knockout of YAP/TAz in neutrophils impaired their differentiation into CD54+tsNeus and reduced their antitumor activity,leading to accelerated GC ***,the relative amounts of CD54+tsNeus were found to be negatively associated with GC progression and positively associated with patient ***,GC patients receiving neoadjuvant chemotherapy had increased numbers of CD54+***,pharmacologically enhancing YAP activity selectively activated neutrophils to suppress refractory GC,with no significant inflammation-related side ***,our work characterized tumor-specific neutrophils in GC and revealed an essential role of YAP/TAZ-CD54 axis in tsNeus,opening a new possibility to develop neutrophil-based antitumor therapeutics.

关键词： neutrophils YAP TAZ gastriccancer

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Accurate structure determination of nanocrystals by continuous precession electron diffraction tomography

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Science China Materials 2022年第5期65卷 1417-1420页

作者： Yihan Shen wenjia Sun Yang Liu Zhengyang zhou Junliang Sun State Key Laboratory of Rare Earth Materials Chemistry and Applications College of Chemistry and Molecular EngineeringBNLMSPeking UniversityBeijing 100871China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 201899China ReadCrystal Biotech. Suzhou 215500China

Structures are the cornerstones of structure-function relationship research of *** more than a hundred years of development,single crystal X-ray diffraction(SC-XRD)becomes the most common method to determine structures of ***,the weak interaction between X-ray and matter requires crystals to be larger than 5μm ×5μm × 5μm for normal SC-XRD *** appearances of X-ray free electron lasers(XFEL)and micro-focused synchrotron beamlines allow SC-XRD data collection from micron-sized crystals,but access to these facilities is *** development of three-dimensional(3D)electron diffraction(ED)has provided a powerful tool for scientists to explore the microcosmos,extending the limit of the SC-XRD method[1].

关键词：电子衍射连续旋转断层扫描数据收集方法步进式纳米晶微观世界 PEDT

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RuO_(2) nanoparticles supported on Ni and N co-doped carbon nanotubes as an efficient bifunctional electrocatalyst of lithium-oxygen battery

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Science China Materials 2021年第10期64卷 2397-2408页

作者： Chengcheng Xiang wenjia Sheng Pengfang Zhang Shaojian Zhang Juntao Li Yao zhou Ling Huang Shigang Sun State Key Lab of Physical Chemistry of Solid Surface College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China College of Energy Xiamen UniversityXiamen 361005China Shandong Provincial Key Laboratory/Collaborative Innovation Center of Chemical Energy Storage and Novel Cell Technology and School of Chemistry and Chemical EngineeringLiaocheng UniversityLiaocheng 252000China

Li_(2)O_(2),as the discharge product of Li-O_(2) batteries on cathode,is difficult to be electrochemically decomposed,which will lead to short cycling lifespan of the *** this study,the cycling lifespan of Li-O_(2)battery was prolonged significantly by an efficient bifunctional *** Ni and N co-doped carbon nanotubes(Ni NCs)were synthesized firstly,and then RuO_(2) nanoparticles were deposited on Ni NCs by a hydrothermal route to synthesize RuO_(2)/Ni NC *** electron microscopy and X-ray diffraction characterizations demonstrated that part of metallic Ni was converted into NiO and Ni(OH)2 after loading RuO_(2),and the existence of Ni O layer can prevent further oxidation of metallic *** Li-O_(2)battery with RuO_(2)/Ni NC as the cathode catalyst exhibits an overpotential of 0.43 V,which is much lower than the value of 1.03 V measured with the Li-O_(2) battery using Ni NC as the cathode *** a rate of 200 mAg^(-1),the Li-O_(2) battery with the RuO_(2)/Ni NC cathode can maintain a reversible capacity of 500 mAhg^(-1)for 260 cycles,and 117 cycles with a higher reversible capacity of 1000 m A h g^(-1).The superior property of the RuO_(2)/NiNC bifunctional catalyst could be ascribed to the high activity of RuO_(2) and the rich carbon nanotube structure of NiNC for deposition and decomposition of Li_(2)O_(2).

关键词： Li-O_(2)battery bifunctional catalyst RuO_(2) Ni and N co-doping carbon nanotubes

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Advances in applying somatosensory interaction technology in geriatric care:A bibliometric analysis

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International Journal of Nursing Sciences 2024年第5期11卷 571-577,I0003,I0004页

作者： Changle Pei Weibo Lyu Jingxia Liu Yan Wang wenjia Ye zhou zhou Kangyao Cheng School of Nursing Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Nursing Tangzhen Health Community CenterShanghaiChina

Objectives:Somatosensory Interaction Technology(SIT)is used in various aspects of geriatric *** aimed to conduct a bibliometric analysis to summarize relevant publications and visualize publication characteristics,current hotspots,and development trends,thereby inspiring subsequent ***:We searched theWeb of Science Core Collection database for publications on the application of SIT in geriatric *** visualization and clustering analysis were performed using VOSviewer V1.6.18 Software,while keywords burst detection analysis was conducted with CiteSpace 6.1.R6 ***:After screening,a total of 1,019 publications were *** number of publications on SIT in geriatric care is gradually increasing,exhibiting a rapid growth *** United States,Canada,and Australia led in terms of publication *** clustering analysis identified major research hotspots:crisis warning,somatic abilities,rehabilitation training and psychosocial *** studies primarily explored themes such as recovery,movement,systems,and later shifted towards gait analysis,muscle strength,parameters,and home-based *** recently,research themes have evolved to dementia,machine learning,and ***:SIT is innovative for promoting active aging,advancing intelligent healthcare,and elevating the daily quality of life for older adults in clinical and domestic *** of SIT can be categorized into early warning systems for crises,detailed analyses of physical conditions,rehabilitation enhancement,and support for psychosocial *** trends have transitioned from whole-body recognition to precise feedback,from a focus on physical health to mental health,and from technical feasibility to *** research should focus on developing accessible and user-friendly devices,fostering interdisciplinary collaborations for innovation,expanding research to address both the physical and mental health

关键词： Bibliometrics Data visualization Geriatric care Health management Review Somatosensory interaction technology

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Robust Balance Adaptive Control for Quadruped Robots under Lateral Push Disturbance

Robust Balance Adaptive Control for Quadruped Robots under L...

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第43届中国控制会议

作者： Chang Chen Jian Guo Chuan zhou wenjia Deng Huning He Bo Su School of Automation Nanjing University of Science and Technology

In this paper, a control strategy is proposed for the balance recovery problem of a quadruped robot under lateral push disturbance, which integrates the robot's step time and position of footfall point. First, the trot motion of the quadruped robot is abstracted into a linear inverted pendulum model(LIPM) by virtual leg mapping. Next, the corresponding control strategy of the footfall and step time is designed by using Divergent Component of Motion(DCM) of LIPM. This strategy dynamically adjusts the robot's step time to better adapt to external pushing forces and improve robustness. Finally, a series of lateral pushing experiments are carried out in Webots simulation software to verify the effectiveness of the designed control strategy and the robot's ability to withstand lateral pushing.

关键词： Quadruped robot lateral disturbance divergent component of motion gait planning virtual model control

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临界条件(0℃)下溶液蒸发冷冻过程中的传质规律

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化工学报 2013年第9期64卷 3206-3212页

作者：高蓬辉衡文佳周兴业倪丹周国庆中国矿业大学深部岩土力学与地下工程国家重点实验室江苏徐州221116 中国矿业大学力学与建筑工程学院江苏徐州221116

通过对相际间力学特性的分析,结合湍流的流动特征,考虑了冰体存在孔隙和毛细作用,给出了临界条件(0℃)湿度差驱动下溶液蒸发冷冻过程中的质扩散分析模型,并对溶液在不同状态下(液态、液固共存和固态)气流界面间的质扩散变化规律进行了研... 详细信息

通过对相际间力学特性的分析,结合湍流的流动特征,考虑了冰体存在孔隙和毛细作用,给出了临界条件(0℃)湿度差驱动下溶液蒸发冷冻过程中的质扩散分析模型,并对溶液在不同状态下(液态、液固共存和固态)气流界面间的质扩散变化规律进行了研究,结果表明,随着溶液从液态向固态的转变,其表面质扩散系数逐渐减小,即表面质扩散能力逐渐减弱,因此,对于溶液自身蒸发冻结过程而言,为了强化溶液表面的质传递和冻结,应控制冻结过程中溶液表面的结冰状况。这一研究结果为蒸发冷冻传质的研究以及强化蒸发冻结的工程应用提供了理论指导和参考。

关键词：蒸发冷冻传质毛细作用

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介孔硅负载Keggin型钨磷酸催化环己烯环氧化(英文)

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催化学报 2013年第1期34卷 193-199页

作者：蔡雯佳周琰包任烈岳斌贺鹤勇复旦大学化学系上海市分子催化和功能材料重点实验室上海200433

采用共合成法制备了一系列不同硅氨基含量的介孔氧化硅SBA-15,在其孔道中引入Keggin型钨磷酸,且其含量随硅氨基含量的增加而增加. 考察了不同处理温度下杂多酸的热稳定性,发现焙烧后钨物种能在SBA-15孔道内高度分散. 以H2O2为氧化剂,研... 详细信息

采用共合成法制备了一系列不同硅氨基含量的介孔氧化硅SBA-15,在其孔道中引入Keggin型钨磷酸,且其含量随硅氨基含量的增加而增加. 考察了不同处理温度下杂多酸的热稳定性,发现焙烧后钨物种能在SBA-15孔道内高度分散. 以H2O2为氧化剂,研究了该催化剂在环己烯环氧化反应中的催化活性,考察了杂多酸负载量和焙烧温度对催化活性的影响. 结果表明,400 C处理后的钨磷酸催化剂具有高的反应活性和重复使用性能.

关键词： 12-磷钨酸硅氨基化 SBA-15 环氧化环己烯

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Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma

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Signal Transduction and Targeted Therapy 2022年第3期7卷 896-908页

作者： Yiyi Xi Yuan Lin wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng zhou Jianzhong Su Chen Wu Dongxin Lin Department of Etiology and Carcinogenesis National Cancer Center/National Clinical Research Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Beijing Advanced Innovation Center for Genomics Biomedical Pioneering Innovation CenterPeking UniversityBeijing 100871China Cancer Institute Affiliated Cancer Hospital of Xinjiang Medical UniversityUrumqi 830000China School of Biomedical Engineering School of Ophthalmology and Optometry and Eye HospitalWenzhou Medical UniversityWenzhou 325011China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325000China Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjing 211166China CAMS Key Laboratory of Genetics and Genomic Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhou 510060China

This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival *** genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns.

关键词： esophageal squamous diagnosis

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多色标记免疫组织化学染色和免疫荧光染色在肺癌免疫治疗中的研究进展

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中国肺癌杂志 2021年第1期24卷 36-42页

作者：孙文佳周建娅周建英浙江大学医学院附属第一医院呼吸与危重症医学科杭州310000

肺癌是目前临床上最常见的恶性肿瘤,严重威胁着患者的生命健康及生活质量。程序性细胞死亡受体1(programmed cell death receptor 1, PD-1)及其配体(programmed cell death ligand 1, PD-L1)抑制剂为非小细胞肺癌(non-small cell lung c... 详细信息

肺癌是目前临床上最常见的恶性肿瘤,严重威胁着患者的生命健康及生活质量。程序性细胞死亡受体1(programmed cell death receptor 1, PD-1)及其配体(programmed cell death ligand 1, PD-L1)抑制剂为非小细胞肺癌(non-small cell lung cancer, NSCLC)患者提供了新的治疗策略。现有的生物标志物检测对准确选择免疫治疗受益的患者均有一定的价值,但都存在着局限性。多标记免疫组织化学/免疫荧光(multiplex immunohistochemistry/immunofluorescence,mIHC/IF)技术允许在单一组织切片上同时检测多个抗体,并对细胞组成、细胞功能和细胞-细胞相互作用进行全面研究。国内外已有大量研究使用mIHC/IF技术对肿瘤免疫微环境(tumor immune microenvironment, TIME)下特异性免疫细胞群进行了探索,发现其有助于肺癌患者临床预后判断及疗效预测。肺癌免疫治疗时代,这项技术在转化研究和临床实践中均具有良好的应用前景。本文就mIHC/IF检测方法在肺癌免疫治疗中的研究进展进行了总结和展望。

关键词：肺肿瘤多色标记免疫组织化学免疫荧光免疫治疗

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Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19

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Protein & Cell 2022年第1期13卷 72-77页

作者： Lunzhi Yuan Huachen Zhu Ming zhou Jian Ma Rirong Chen Liuqin Yu wenjia Chen Wenshan Hong Jia Wang Yao Chen Kun Wu Wangheng Hou Yali Zhang Shengxiang Ge Yixin Chen Quan Yuan Qiyi Tang Tong Cheng Yi Guan Ningshao Xia State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious DiseasesSchool of Life SciencesSchool of Public HealthXiamen UniversityXiamen 361000China State Key Laboratory of Emerging Infectious Diseases The University of Hong KongHong KongChina Joint Institute of Virology(Shantou University and The University of Hong Kong) Guangdong-Hongkong Joint Laboratory of Emerging Infectious DiseasesShantou UniversityShantou 515063China Department of Microbiology Howard University College of MedicineWashingtonDC 20059USA Research Unit of Frontier Technology of Structural Vaccinology Chinese Academy of Medical SciencesXiamen 361102China

Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has infected more than 200 million people,causing coronavirus disease 2019(COVID-19)*** are the primary target organ of SARS-CoV-2 *** mild COVID-19 cases develop symptoms of fever,fatigue,muscle weakness,chest pain,headache and cough(Chen et al.,2020;Wang et al.,2020;Zhu et al.,2020),while severe COIVD-19 cases might have pneumonia,breathing difficulties,multiple organ failure and death(Chen et al.,2020;Wang et al.,2020;Zhu et al.,2020).Both the clinicians and researchers have largely focused on the acute phase of COVID-19,but the long-term health consequences of the COVID-19 patients after clinical recovery remain less *** clinical cohorts demonstrated that some patients discharged from hospital still experience symptoms including fatigue,muscle weakness,chest pain,cough and breathing difficulties(Carfi et al.,2020;Lim et al.,2020;Huang et al.,2021).Moreover,severely impaired pulmonary diffusion capacities and abnormal chest imaging manifestations were observed in some convalescent patients(Huang et al.,2021).Surprisingly,residual virus(An et al.,2020;Yao et al.,2020;Kim et al.,2021)were detected in some convalescent patients.

关键词： acute impaired pathogenesis

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