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Rock magnetic properties and palaeomagnetic results of sediments from a stone implement layer in the Bose Basin, Guangxi

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Science China Earth Sciences 2008年第3期51卷 441-450页

作者： YANG XiaoQiang ZHU ZhaoYu ZHANG YiNan LI HuaMei zhou wenjuan YANG Jie Department of Earth Sciences Sun Yat-Sen UniversityGuangzhou 510275China Guangzhou Institute of Geochemistry Chinese Academy of SciencesGuangzhou 510640China School of Environmental Sciences and Engineering Sun Yat-Sen UniversityGuangzhou 510275China Shenzhen Municipal Bureau of Land Resources and Housing Management Shenzhen 518301China

Directional samples were taken to study rock magnetism and palaeomagnetic records from the Dongsheng profile, which is 5 m thick and on the northwest edge of the Bose Basin. Mineralogy and rock magnetism of typical samples indicate that coarse granular titanomagnetite, and fine-grained hematite, superparamagnetic maghemite formed by pedogenesis are in the sediment, which has undergone many transformative processes during different stages of pedogenesis. Parallel samples were taken for thermal demagnetization (TH) (0 to 680°C) and alternating field (AF) demagnetization (0 to 80 mT) respectively. Experimental results of these two kinds of demagnetization illustrate that there are two or more magnetic components in the samples. Intensity of NRM decreases by almost 60% to 90% rapidly when the temperature ranges from 100°C to 350°C, with a steady magnetic component. It is impossible to analyze the magnetic components at high temperature because those fluctuate widely when the temperature is higher than 400°C. Steady magnetic components from 100°C to 350°C indicate that the remanence was mainly carried by fine-grained hematite formed by pedogenesis, reflecting a change in the geomagnetic field while the magnetite was being oxidized into hematite by chemical weathering after deposition. The formative age of the sediments cannot be obtained by magnetic methods in this profile.

关键词： Bose Basin Dongsheng profile palaeomagnetic records

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Identification of the multiple bioactive derivatives and their endogenous molecular targets that may mediate the laxative effect of rhubarb in rats

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Journal of Traditional Chinese Medical Sciences 2020年第2期7卷 210-220页

作者： Lei Xie Ying Wang Gan Luo wenjuan zhou Jiayan Miao Siqi Tang Qin Jiang Yage Guan Xiaoyan Gao School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China

Objective:To determine the mechanism of the laxative effect of rhubarb(Rheum tanguticum *** Balf.)in rats using a combined bioinformatic and in vivo ***:Substances derived from rhubarb that are present in the colorectum were identified using high-performance liquid chromatography,coupled with linear ion-trap quadrupole Orbitrap highresolution mass *** targets with a potential laxative effect were identified from databases and the literature,then used with rhubarb-derived substances in molecular docking *** expression of candidate endogenous target molecules that bound specific components of rhubarb was then measured in constipated rats that had or had not been administered rhubarb by western ***,potentially bioactive compounds were traced back to their prototype ***:We identified 17 anthraquinones and 21 anthrones derived from rhubarb in the colorectum of rats.G-scoring identified three potential mediators of the laxative effect:c-kit,5-hydroxytryptamine receptor 4(5-HT4),and aquaporin-3(AQP3).In addition,10 rhubarb-derived components(aloeemodin,emodin,rhein,chrysophanol,physcion,sennoside A,sennoside C,physcionanthrone,aloeemodinanthrone,and rheinanthrone),which have strong binding affinities for more than one of the three potential targets,were selected as likely active *** extract increased the expression of c-kit and 5-HT4,and reduced the expression of AQP3 in the colon of constipated rats,which might mediate its laxative *** also found that a single prototype component may be metabolized into several active metabolites,and a single active ingredient can also be generated from various prototype ***:The present study demonstrates that various anthraquinones and anthrones present in rhubarb may be metabolized to form bioactive compounds that have additive or synergistic effects to promote defecation via c-kit,5-HT4 and/or AQP3.

关键词： Rhubarb Laxative Anthraquinones Anthrones C-kit Aquaporin-3

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Research of Vision Detection System on PCB

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武汉理工大学学报 2006年第S2期28卷 714-717页

作者： CHENG Songlin zhou Zude HU wenjuan (School of Information Engineering,Wuhan University of Technology,Wuhan 430070,China School of Information Engineering Wuhan University of TechnologyWuhan 430070China

Machine vision is applied in defect detection system on *** whole system structure and the principle of vision detection are introduced,while the detection method including image processing,detection and recognition algorithms are detailed. The simulation results demonstrate that through this method,four types of defects including short circuit,open circuit,protuber- ance and concavity on PCB circuit can be effectively inspected,located and recognized.

关键词： machine vision image processing pattern recognition morphology

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Directed evolution of a neutrophilic and mesophilic methanol dehydrogenase based on high-throughput and accurate measurement of formaldehyde

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Synthetic and Systems Biotechnology 2023年第3期8卷 386-395页

作者： Jin Qian Liwen Fan Jinxing Yang Jinhui Feng Ning Gao Guimin Cheng Wei Pu wenjuan zhou Tao Cai Shuang Li Ping Zheng Jibin Sun Depei Wang Yu Wang College of Biotechnology Tianjin University of Science and TechnologyTianjin300222China Haihe Laboratory of Synthetic Biology Tianjin300308China Key Laboratory of Engineering Biology for Low-carbon Manufacturing Tianjin Institute of Industrial BiotechnologyChinese Academy of SciencesTianjin300308China National Technology Innovation Center of Synthetic Biology Tianjin300308China University of Chinese Academy of Sciences Beijing100049China School of Biology and Biological Engineering South China University of TechnologyGuangzhou510006China

Methanol is a promising one-carbon feedstock for biomanufacturing,which can be sustainably produced from carbon dioxide and natural ***,the efficiency of methanol bioconversion is limited by the poor catalytic properties of nicotinamide adenine dinucleotide(NAD^(+))-dependent methanol dehydrogenase(Mdh)that oxidizes methanol to ***,the neutrophilic and mesophilic NAD^(+)-dependent Mdh from Bacillus stearothermophilus DSM 2334(Mdh_(Bs))was subjected to directed evolution for enhancing the catalytic *** combination of formaldehyde biosensor and Nash assay allowed high-throughput and accurate measurement of formaldehyde and facilitated efficient selection of desired ***_(Bs)variants with up to 6.5-fold higher K_(cat)/K_(M)value for methanol were screened from random mutation *** T153 residue that is spatially proximal to the substrate binding pocket has significant influence on enzyme *** beneficial T153P mutation changes the interaction network of this residue and breaks theα-helix important for substrate binding into two shortα-*** the interaction network of T153 with surrounding residues may represent a promising strategy to further improve Mdh_(Bs),and this study provides an efficient strategy for directed evolution of Mdh.

关键词： Methanol dehydrogenase Formaldehyde biosensor Directed evolution C1 bioconversion Methanol oxidation Methylotrophy

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Efficient and Generic Preparation of Diverse Polyelectrolyte Nanogels by Electrostatic Assembly Directed Polymerization

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CCS Chemistry 2020年第6期2卷 1016-1025页

作者： Peng Ding Jianan Huang Cheng Wei Wei Liu wenjuan zhou Jiahua Wang Mingwei Wang Xuhong Guo Martien A.Cohen Stuart Junyou Wang State Key Laboratory of Chemical Engineering and Shanghai Key Laboratory of Multiphase Materials Chemical EngineeringEast China University of Science and TechnologyShanghai 200237

Nanogels hold promise as soft and functional carriers and nanoreactors,but whether they will ever reach the stage of large-scale application depends crucially on efficient production methods,and on what interesting properties and functionalities they can *** particular,nanogels consisting of highly charged polyelectrolyte have not yet been very much ***,the authors present a novel and generic strategy for controlled and efficient synthesis of a large diversity of polyelectrolyte *** method is based on polymerizing an ionic monomer in the presence of an oppositely charged polyion-neutral diblock copolymer as template,while adding a *** growing polymer chains assemble with the template,forming polyion complex micelles,which dissociate upon increasing salt *** separation yields nanogels with well-controlled size and properties,and free template polymers that can be used *** design can be applied generally to a wide range of both cationic and anionic monomers,as well as various ***-up production presents no problems as increasing monomer concentration(hundreds of mM)and reaction volume(up to 1 L)hardly compromise product ***,the obtained nanogels with their well-controlled size,morphology,chemistry,and cross-linking degree perform well as soft nanocarriers and catalytic nanoreactors.

关键词： nanogel polyelectrolyte electrostatic interaction template polymerization scale-up production soft nanocarrier nanoreactor

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文学生产视域下的“图文缝合”运行机制与“期待视域”范式研究

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外语教学 2023年第2期44卷 107-112页

作者：周文娟南通大学外国语学院

“图文缝合”是文学生产视域下基于镜像、语象、形象、意象图文互文效应,实现文本表述与读者接受意识缝合的有机运行机制。“期待视域”是文学接受理论的核心概念,体现了“读者的文学阅读经验构成的思维定向或现在结构”对文学接受的重... 详细信息

“图文缝合”是文学生产视域下基于镜像、语象、形象、意象图文互文效应,实现文本表述与读者接受意识缝合的有机运行机制。“期待视域”是文学接受理论的核心概念,体现了“读者的文学阅读经验构成的思维定向或现在结构”对文学接受的重要作用。文学生产中,“期待视域”需要形成定向的结构图式,作为有机组成部分纳入“图文缝合”的系统运行之中,方能以其科学范式引导读者介入作品的二度创作,实现作品预期的目标效应。将“期待视域”置于文学生产系统视域下,揭示其与“图文缝合”运行机制的相应关系,对其应用范式展开深入探赜,这一命题既是对“图文缝合”运行机制的创新探索,亦是对接受理论读者“期待视域”效应的理论完善。

关键词：图文缝合运行机制期待视域结构图式范式研究

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从“语图互文”到“图文缝合”——文学接受效应的发生逻辑、内在理路与研究价值

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河南大学学报（社会科学版） 2022年第3期62卷 78-83,154页

作者：周文娟南通大学外国语学院江苏南通226019

“图文缝合”作为文学生产与接受的基本方法论,是以提升文学接受效度为目标的理论探索。文章立足于系统科学认识观,以接受美学思想为理论框架,探究从“语图互文”“期待视域”到“图文缝合”这一文学生产与接受系统效应的发生逻辑、内... 详细信息

“图文缝合”作为文学生产与接受的基本方法论,是以提升文学接受效度为目标的理论探索。文章立足于系统科学认识观,以接受美学思想为理论框架,探究从“语图互文”“期待视域”到“图文缝合”这一文学生产与接受系统效应的发生逻辑、内在理路与研究价值。本文意在突破单一学科逻辑囿限,对文学接受展开跨学科的理论推绎,以期获得更为宽阔的时代研究视野,引发更多有益于促进当代文学与时俱进的理论创新。

关键词：语图互文图文缝合期待视域文学接受内在理路

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由“期待视域”到“图文缝合”——当代文学接受理论的再探绎

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求索 2022年第1期 73-80页

作者：周文娟南通大学外国语学院江苏南通226019

文学接受理论又称之为"接受美学",自20世纪60年代中期诞生迄今已经半个多世纪。然而在半个多世纪的研究中,由于对"期待视野"研究尚欠深入,因此还未能将其研究范式有效地建立起来。实际上,"期待视域"是基于读者先验结构与文本体验建构互... 详细信息

文学接受理论又称之为"接受美学",自20世纪60年代中期诞生迄今已经半个多世纪。然而在半个多世纪的研究中,由于对"期待视野"研究尚欠深入,因此还未能将其研究范式有效地建立起来。实际上,"期待视域"是基于读者先验结构与文本体验建构互动生成的阅读"召唤结构"。"期待视域"基于"图文缝合"运行机制的结构图式,弥合了当下与过去之间的历史间距,将读者带入一种特定的情感态度中,为实现文学接受提供了一个统一的审美方向和主客体融合的交流平台。"期待视域"效应取决于结构图式定位的准确程度,在于"期待视域"结构图式与"图文缝合"运行机制的有机协调关系。

关键词：期待视域图文缝合文学接受结构图式

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福克纳作品异质空间叙事解读

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当代外国文学 2013年第3期34卷 5-13页

作者：周文娟南通大学外国语学院

威廉·福克纳被评为"现代主义作家"。然而,在他的文学文本中存在着大量差异性、异质性空间的后现代叙事手法。他的思想与作品穿越了真实和想象、中心与边缘,处在一种时间与空间、历史和未来的交融之中。本文借助于福柯异质空间权力和空... 详细信息

威廉·福克纳被评为"现代主义作家"。然而,在他的文学文本中存在着大量差异性、异质性空间的后现代叙事手法。他的思想与作品穿越了真实和想象、中心与边缘,处在一种时间与空间、历史和未来的交融之中。本文借助于福柯异质空间权力和空间隐喻理论对福克纳典型文本进行分析,归纳其异质空间书写的主要形态和表征意义,以期深入理解福克纳对既有空间、权力的社会性批判。

关键词：威廉·福克纳异质空间表意功能解读

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Clinical and serological characterization of autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation

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Chinese Medical Journal 2014年第7期127卷 1235-1238页

作者： Yang Zhen Wu Bangzhao zhou Youning Wang wenjuan Chen Suning Sun Aining Wu Depei Xu Yang Jiangsu Institute of Hematology Key laboratory of Thrombosis and Hemostasis Ministry of Health The First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China

Background Autoimmune hemolytic anemia （AIHA） is an uncommon complication of allogeneic hematopoietic stem cell transplantation （allo-HSCT） which has only been reported in a few *** here aimed to explore its *** We retrospectively analyzed 296 patients who underwent allo-HSCT in our center from July 2010 to July *** manifestations were carefully reviewed and the response to currently available treatment approaches were *** survival and risk factors of AIHA patients after allo-HSCT were further *** Twelve patients were diagnosed with AIHA at a median time of 100 days （15-720 days） after *** incidence of AIHA after allo-HSCT was 4.1％.IgG antibody were detected in ten patients and IgM antibody in two *** two cold antibody AIHA patients had a better response to steroid corticoid only treatment and the ten warm antibody AIHA patients responded to corticosteroid treatment and adjustment of immunosuppressant *** was shown to be effective for AIHA patients who failed conventional *** analysis showed that the combination of AIHA in allo-HSCT patients hinted at poor *** （CMV） infection,graft-versus-host disease （GVHD） and histocompatibility leukocyte antigen （HLA） mismatch seemed to increase the risk of developing *** Patients who develop AIHA after allo-HSCT have poor survival compared to non-AIHA *** risk factors of AIHA are CMV infection,GVHD,and HLA *** is likely to be the effective treatment choice for the refractory patients.

关键词： autoimmune hemolytic anemia allogeneic hematopoietic stem cell transplantation graft-versus-host disease

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