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Photonics Research 2024年第7期12卷 1494-1501页

作者： YANBO JIN LINPENG LU SHUN zhou JIE zhou YAO FAN CHAO ZUO Smart Computational Imaging Laboratory(SCILab) School of Electronic and Optical EngineeringNanjing University of Science and TechnologyNanjing 210094China Smart Computational Imaging Research Institute(SCIRI)of Nanjing University of Science and Technology Nanjing 210019China Jiangsu Key Laboratory of Spectral Imaging&Intelligent Sense Nanjing 210094China

The transport-of-intensity equation(TIE) enables quantitative phase imaging(QPI) under partially coherent illumination by measuring the through-focus intensities combined with a linearized inverse reconstruction algorithm. However, overcoming its sensitivity to imaging settings remains a challenging problem because of the difficulty in tuning the optical parameters of the imaging system accurately and because of the instability to long-time measurements. To address these limitations, we propose and experimentally validate a solution called neural-field-assisted transport-of-intensity phase microscopy(NFTPM) by introducing a tunable defocus parameter into neural field. Without weak object approximation, NFTPM incorporates the physical prior of partially coherent image formation to constrain the neural field and learns the continuous representation of phase object without the need for training. Simulation and experimental results of He La cells demonstrate that NFTPM can achieve accurate, partially coherent QPI under unknown defocus distances, providing new possibilities for extending applications in live cell biology.

关键词： field. coherent phase

Preparation of baicalin colon-targeted granules and its intervention effect on ulcerative colitis in rats

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Particuology 2024年第2期85卷 13-21页

作者： Yongqing Huang Yuxin zhou Yao Shen Jin Wang Liangliang zhou Zhenhua Chen Jiangxi Provincial Key Laboratory of Drug Design and Evaluation School of PharmacyJiangxi Science and Technology Normal UniversityNanchang330013China

Baicalin(BA)is a flavonoid extracted from the dried root of Scutellaria baicalensis Georgi with excellent antioxidant and anti-inflammatory biological *** this study,Eudragit S100 was used as the colonic target material to prepare BA colonic targeting granules(EBCGs)based on plasticizer dry powder coating technology to improve the targeting transportation performance of *** vitro studies showed that EBCGs with pH-sensitive properties were successfully prepared by plasticizer dry powder coating,and in vivo animal imaging studies showed that EBCGs could deliver BA to the colon and inhibit the release of BA in the upper gastrointestinal tract(GIT).In vivo studies showed that EBCGs had good therapeutic effects in colitis,which reduced expression levels of tumor necrosis factor alpha(TNF-α)and interleukin-1β(IL-1β)and increased superoxide dismutase(SOD)activities in the colonic tissues of rats with *** conclusion,Eudragit S100 could be used for the preparation of multi-unit oral colon-targeted formulations by plasticizer dry powder coating technology,and our prepared EBCGs had good colon-targeting properties,which could improve the therapeutic effect and provide a potential application for ulcerative colitis(UC).

关键词： Plasticizer dry powder coating Colon-targeted granulesIn vivo imaging Ulcerative colitis

Limit state analysis of rigid retaining structures against seismically induced passive failure in heterogeneous soils

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 1095-1105页

作者： Jianfeng zhou Changbing Qin College of Civil Engineering Huaqiao UniversityXiamen362021China School of Civil Engineering Chongqing UniversityChongqing400045China Key Laboratory of New Technology for Construction of Cities in Mountain Area Chongqing UniversityChongqing400045China National Joint Engineering Research Center of Geohazards Prevention in the Reservoir Areas Chongqing UniversityChongqing400045China

Soils are not necessarily uniform and may present linearly varied or layered characteristics,for example the backfilled soils behind rigid retaining *** the presence of large lateral thrust imposed by arch bridge,passive soil failure is possible.A reliable prediction of passive earth pressure for the design of such wall is challenging in complicated soil strata,when adopting the conventional limit analysis *** order to overcome the challenge for generating a kinematically admissible velocity field and a statically allowable stress field,finite element method is incorporated into limit analysis,forming finiteelement upper-bound(FEUB)and finite-element lower-bound(FELB)***-static,original and modified pseudo-dynamic approaches are adopted to represent seismic acceleration *** generating feasible velocity and stress fields within discretized elements based on specific criteria,FEUB and FELB formulations of seismic passive earth pressure(coefficient K_(P))can be derived from work rate balance equation and stress *** to an interior point algorithm,optimal upper and lower bound solutions are *** proposed FEUB and FELB procedures are well validated by limit equilibrium as well as lower-bound and kinematic *** studies are carried out to investigate the effects of influential factors on seismic K_(P).Notably,true solution of K_(P) is well estimated based on less than 5%difference between FEUB and FELB solutions under such complex scenarios.

关键词： Retaining wall Passive earth pressure Earthquakes Finite-element limit-analysis methods

SOX2/DRD2 signaling pathway facilitates astrocytic dedifferentiation in cerebral ischemic mice

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神经解剖学杂志 2024年第3期40卷 277-286页

作者： YI Xuyang KANG Enming WANG Yanjin ZHANG Kun LIN Wei WU shengxi WANG Yazhou Department of Neurobiology School of Basic Medicine2.Fifth BrigadeSchool of Basic Medicine3.Department of NeurosurgeryXijing HospitalAir Force Medical UniversityXi’an 710032China

Objective:To explore the effects of dopamine receptor D2(DRD2)on astrocytic dedifferentiation based on SOX2-regulated genes in neural stem cells(NSCs)and ***:Immunofluorescence staining and SOX2-GFP mice were used to examine the lineage differentiation of SOX2-positive cells during the development of cerebral *** NSCs/astrocytes culture,ChIP-seq and Western Blot were adopted to analyze and verify the expression of candidate *** manipulation,neurosphere formation,photochemical ischemia,immunofluorescence staining and behavior tests were adopted to evaluate the effects of activating DRD2 signaling on astrocytic ***:Immunofluorescence staining demonstrated the NSC-astrocyte switch of SOX2-expression in the normal development of cerebral ***-seq revealed enrichment of DRD2 signaling by SOX2-bound enhancers in NSCs and SOX2-bound promoters in *** Blot and immunofluorescence staining verified the expression of DRD2 in NSCs and reactive *** of quinagolide hydrocholoride(QH),an agonist of DRD2,significantly promoted astrocytic dedifferentiation both in vitro and in vivo following *** addition,quinagolide hydrocholoride treatment improved locomotion ***:Activating DRD2 signaling facilitates astrocytic dedifferentiation and may be used to treat ischemic stroke.

关键词： cerebral ischemia astrocyte dedifferentiation SOX2 dopamine D2 receptor(DRD2) mouse

2D all-organic perovskites refine flexible electronics

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Science China Materials 2024年第7期67卷 2365-2366页

作者： Wei zhou Bing Chen College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China

Recent years have witnessed a paradigm shift with the advent of perovskites,a class of materials with a distinct CaTiO_(3)-type crystalline structure that show remarkable promise across a wide array of applications,including photovoltaics,photodetectors,lighting,lasers,and so *** them,the development of two-dimensional(2D)perovskites has garnered significant attention due to their tunable structures(mainly Dion-Jacobson and Ruddlesden-Popper structures)and enhanced stability in comparison with their 3D counterparts[1].Amidst the burgeoning research on perovskites,on the other side,all-organic perovskites stand out as a particularly intriguing subset[2].Unlike traditional perovskites that typically comprise all-inorganic(e.g.,CsPbBr_(3))or organic-inorganic hybrid components(e.g.,(PEA)_(2)PbI_(4)),all-organic perovskites are composed entirely of carbon-or nitrogen-based molecules.

关键词： perovskite inorganic entirely

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The Unprecedented Extreme Anticyclonic Anomaly over Northeast Asia in July 2021 and Its Climatic Impacts

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Advances in Atmospheric Sciences 2024年第4期41卷 608-618页

作者： Xingyan zhou Riyu LU Laboratory for Climate Studies National Climate CenterChina Meteorological AdministrationBeijing 100081China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

This study investigates the evolution of an extreme anomalous anticyclone(AA)event over Northeast Asia,which was one of the dominant circulation systems responsible for the catastrophic extreme precipitation event in July 2021 in Henan,and further explores the significant impact of this AA on surface temperatures beneath *** results indicate that this AA event over Northeast Asia was unprecedented in terms of intensity and *** AA was very persistent and extremely strong for 10 consecutive days from 13 to 22 July *** long-lived and unprecedented AA led to the persistence of warmer surface temperatures beyond the temporal span of the pronounced 500-hPa anticyclonic signature as the surface air temperatures over land in Northeast Asia remained extremely warm through 29 July ***,the sea surface temperatures in the Sea of Japan/East Sea were extremely high for 30 consecutive days from 13 July to 11 August 2021,persisting well after the weakening or departure of this *** results emphasize the extreme nature of this AA over Northeast Asia in July 2021 and its role in multiple extreme climate events,even over remote ***,possible reasons for this long-lasting AA are explored,and it is suggested to be a byproduct of a teleconnection pattern over extratropical Eurasia during the first half of its life cycle,and of the Pacific-Japan teleconnection pattern during the latter half.

关键词： anomalous anticyclone Northeast Asia surface air temperatures sea surface temperatures

A coupled thermo-mechanical peridynamic model for fracture behavior of granite subjected to heating and water-cooling processes

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2006-2018页

作者： Luming zhou Zhende Zhu Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing210098China Jiangsu Research Center for Geotechnical Engineering Technology Hohai UniversityNanjing210098China

Thermal damage and thermal fracture of rocks are two important indicators in geothermal mining *** paper investigates the effects of heating and water-cooling on granite specimens at various *** laboratory uniaxial compression experiments were also ***,a coupled thermo-mechanical ordinary state-based peridynamic(OSB-PD)model and corresponding numerical scheme were developed to simulate the damage of rocks after the heating and cooling processes,and the change of crack evolution process was *** results demonstrate that elevated heating temperatures exacerbate the thermal damage to the specimens,resulting in a decrease in peak strength and an increase in ductility of *** escalating occurrence of thermal-induced cracks significantly affects the crack evolution process during the loading *** numerical results accurately reproduce the damage and fracture characteristics of the granite under different final heating temperatures(FHTs),which are consistent with the test results in terms of strength,crack evolution process,and failure mode.

关键词： Peridynamics(PD) Granite Heating and cooling Damage and fracture Uniaxial compression

Optimal Timing of Business Conversion for Solvency Improvement

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 744-757页

作者： Peng LI Ming zhou School of Finance Nanjing University of Finance and EconomicsNanjing 210023China Center for Applied Statistics and School of Statistics Renmin University of ChinaBeijing 100872China

In this paper,we study the optimal timing to convert the risk of business for an insurance company in order to improve its *** cash flow of company evolves according to a jump-diffusion *** conversion option offers the company an opportunity to transfer the jump risk business *** exchange for this option,the company needs to pay both fixed and proportional transaction *** proportional cost can also be seen as the profit loading of the jump risk *** formulated this problem as an optimal stopping *** solving this stopping problem,we find that the optimal timing of business conversion mainly depends on the profit loading of the jump risk business.A larger profit loading would make the conversion option *** fixed cost,however,only delays the optimal timing of business *** the end,numerical results are provided to illustrate the impacts of transaction costs and environmental parameters to the optimal strategies.

关键词： optimal stopping jump-diffusion process conversion option

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Small Cycles Property of Some Cremer Rational Maps and Polynomials

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 123-136页

作者： Rong FU Ji zhou Faculty of Science Yibin UniversityYibin 644000SichuanChina Department of Mathematical Sciences Sichuan Normal UniversityChengdu 610066China

This paper concerns the linearization problem on rational maps of degree d≥2 and polynomials of degree d>2 from the perspective of *** authors introduce a set l_(∞) of irrational numbers and show that if α∈l_(∞),then any rational map is not linearizable and has infinitely many cycles in every neighborhood of the fixed point with multiplier λ=e^(2πiα),Adding more constraints to cubic polynomials,they discuss the above problems by polynomial-like *** the family of polynomials,with the help of Yoccoz's method,they obtain its maximum dimension of the set in which the polynomials are non-linearizable.

关键词： Irrationally indifferent fixed point Linearization problem Small cycles property

Manipulating submolecular-scale phototautomerization

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Science China Materials 2024年第6期67卷 2048-2050页

作者： Ping zhou Hongliang Chen Stoddart Institute of Molecular Science Department of ChemistryZhejiang UniversityHangzhou 310058China Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials ZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 311215China

A recent study on the submolecular-scale control of phototautomerization methods and the underlying reaction mechanisms was reported in Nature Nanotechnology by Guillaume and co-workers[1],elucidating how the field confinement effect generated by the scanning tunneling microscope(STM)tip precisely triggers the phototautomerization of a free-base phthalocyanine at the submolecular level and demonstrating that the reaction process can be finely controlled by adjusting either the laser excitation wavelength or the position of the tip.

关键词： tunneling excitation phthalocyanine