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A glimpse of enzymology within the idea of systems

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Science China(Life Sciences) 2012年第9期55卷 826-833页

作者： LIU ChuanPeng FAN DongJie SHI Yi zhou qiming School of Life Science and Technology Harbin Institute of Technology Harbin 150080 China National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China Center for Stem Cell and Regenerative Medicine Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai 201203 China State Key Laboratory of Mycology Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China

Next year will mark the 100th anniversary of the Michaelis- Menten equation [1], one of the most important and well known models in enzymology. Remarkable progress in en- zymology over the past hundred years has not only provided deep insight into biological processes, but also has dramati- cally changed our lives. However, because of limitations in available techniques, enzymologists primarily investigate the in vitro properties and catalytic mechanisms of individ- ual enzymes. Thus, they often fail to address a fundamental scientific question： how a^e biological processes, most of which are chemical reactions catalyzed by enzymes, coor- dinated in space and time to produce a livin~ organism ｜2]？

关键词：酶学在系统生物过程米氏方程催化机制科学问题化学反应酶催化

A 3-DIMENSIONAL DATA MODEL FOR VISUALIZING CLOVERLEAF JUNCTION IN A CITY MODEL

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Geo-Spatial Information Science 1999年第1期2卷 9-15页

作者： Chen Jun Sun Min zhou qiming National Laboratory for Information Engineering in Surveying Mapping and Remote Sensing WTUSM

The research work has been seldom done about cloverleaf junction expression in a 3-dimensional city model (3DCM). The main reason is that the cloverleaf junction is often in a complex and enormous construction. Its main body is bestraddle in air,and has aerial intersections between its parts. This complex feature made cloverleaf junction quite different from buildings and terrain, therefore, it is difficult to express this kind of spatial objects in the same way as for buildings and terrain. In this paper,authors analyze spatial characteristics of cloverleaf junction, propose an all-constraint points TIN algorithm to partition cloverleaf junction road surface, and develop a method to visualize cloverleaf junction road surface using TIN. In order to manage cloverleaf junction data efficiently, the authors also analyzed the mechanism of 3DCM data management, extended BLOB type in relational database, and combined R-tree index to manage 3D spatial data. Based on this extension, an appropriate data

关键词： 3-dimensional city model (3DCM) GIS cloverleaf junction data structure database

Remnants of the amalgamation of the east and west Cathaysia blocks revealed by a short-period dense nodal array

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Geoscience Frontiers 2023年第1期14卷 207-214页

作者： He Huang Xuzhang Shen Jian Xu Rui Gao Wentian Wang qiming zhou Qiangqiang Huang Guangdong Provincial Key Laboratory of Geodynamics and Geohazards School of Earth Sciences and EngineeringSun Yat-Sen UniversityGuangzhou 510275China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China

The Cathaysia block located at the southeast South China block(SCB)is considered formed by the amalgamation of the east and west Cathaysia blocks along the Gaoyao-Huilai and Zhenghe-Dapu deep faults(here referred as GHF and ZDF,respectively).Although the extension of the ZDF to the northeast,which represents the amalgamation of the two sub-blocks has been confirmed,the development of the GHF to the southwest remains to be *** better constrain the detailed deep structure beneath the southwest Cathaysia,which hold great significance for revealing the evolution of the SCB,a linear seismic array with 331 nodal geophones was deployed across the Sanshui basin(SSB).Combining with the regional 10 permanent stations(PA),we obtained two profiles with teleseismic P-wave receiver function *** most obvious feature in our results is the ascending Moho towards the coastal area,which is consistent with the passive margin continental and extensional tectonic *** stacking profile from the dense nodal array(DNA)shows that the Moho is offset beneath the transition zone of the Nanling orogeny and *** deduce that this offset may be casued by the deep extension of the GHF,which represents the remnants of the amalgamation of the Cathaysia *** the other evidences,we infer that the widespread and early erupted felsic magmas in the SSB may have resulted from lithospheric materials that were squeezed out to the *** relative higher Bouguer gravity and heat flow support the consolidation of magmas and the residual warm state in the shallow crustal scale beneath the *** sporadic basaltic magmas in the middle SSB may have a close relation to deep extension of the GHF,which serves as a channel for upwelling hot materials.

关键词： Dense short-period nodal array Teleseismic receiver function Cathaysia block Offset Moho High V_(p)/V_(s)ratio

Analysis of spatio-temporal pattern and driving force of land cover change using multi-temporal remote sensing images

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Science China(Technological Sciences) 2010年第S1期53卷 111-119页

作者： zhou qiming & SUN Bo Department of Geography,Hong Kong Baptist University,Hong Kong,China Department of Geography Hong Kong Baptist University Hong Kong China

Landuse and land cover change is regarded as a good indicator that represents the impact of human activities on earth’s *** the large collection of multi-temporal satellite images has become available,it is possible to study a long-term historical process of land cover *** study aims to investigate the spatio-temporal pattern and driving force of land cover change in the Pearl River Delta region in southern China,where the rapid development has been witnessed since *** fast economic growth has been associated with an accelerated expansion of urban landuse,which has been recorded by historical remote sensing *** paper reports the method and outcome of the research that attempts to model spatio-temporal pattern of land cover change using multi-temporal satellite *** classified satellite images were compared to detect the change from various landuse types to built-up *** trajectories of land cover change have then been established based on the time-series of the classified land cover *** correlation between the expansion of built-up areas and selected economic data has also been analysed for better understanding on the driving force of the rapid urbanisation *** result shows that,since early 1990s,the dominant trend of land cover change has been from farmland to urban *** relationship between economic growth indicator(measured by GDP)and built-up area can well fit into a linear regression model with correlation coefficients greater than *** is quite clear that cities or towns have been sprawling in general,demonstrating two growth models that were closely related to the economic development stages.

关键词： remote sensing change detection multi-temporal image processing spatio-temporal analysis land cover change Pearl River Delta urban expansion

Logical and Innovative Construction of Digital Twin City

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Journal of Geodesy and Geoinformation Science 2021年第4期4卷 113-120页

作者： Xinchang ZHANG Shaoying LI qiming zhou Ying SUN School of Geography and Remote Sensing Guangzhou UniversityGuangzhou 510006China Department of Geography Hong Kong Baptist UniversityHongKong 046000China

This paper first introduces the background and basic concept of digital twin city,then analyzes the relationship between digital twin city and smart ***,it introduces the primary supporting technologies for the construction of a digital twin city,and finally summarizes the current application status and development trends regarding digital twin *** authors argue that digital twin technology will face challenges in regards to data,basic knowledge base,system integration,and talent issues if it is to be more widely applied in the construction of the smart ***,the authors propose institutional and technical suggestions for solving these problems at the macro and micro levels.

关键词： smart city digital twin Internet of Things(IoT) artificial intelligence(AI)

Estimation of Endocarpon pusillum Hedwig carbon budget in the Tengger Desert based on its photosynthetic rate

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Science China(Life Sciences) 2013年第8期56卷 848-855页

作者： DING LiPing zhou qiming WEI JiangChun State Key Laboratory of Mycology Institute of Microbiology Chinese Academy of Sciences University of Chinese Academy of Sciences

This study investigated the photosynthetic rate of the lichen Endocarpon pusillum at the Chinese Academy of Sciences Shapotou Desert Research Station and estimated its annual contribution to the carbon budget in the ecosystem. The software SigmaPlot 10.0 with "Macro-Area below curves" was used to calculate the carbon fixation capacity of the lichen. The total carbon budget (ΣC) of the lichen was obtained by subtracting the respiratory carbon loss (ΣDR) from the photosynthetic carbon gain (ΣNP). Because water from precipitation plays an important role in photosynthesis in this ecosystem, the annual carbon budget of E. pusillum at the station was estimated based on the three-year average precipitation data from 2009 to 2011. Our results indicate that the lichen fixes 14.6 g Cm-2 annually. The results suggest that artificial inoculation of the crust lichen in the Tengger Desert could not only help reduce the sand and dust storms but also offer a significant carbon sink, fixing a total of 438000 t of carbon over the 30000 km2 of the Tengger Desert. The carbon sink could potentially help mitigate the atmospheric greenhouse effect. Our study suggests that the carpet-like lichen E. pusillum is an excellent candidate for "Bio-carpet Engineering" of arid and semi-arid regions.

关键词： crust organisms carpet-like lichen carbon income carbon loss carbon sink

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广西越城岭地区香炉山铷矿矿石特征及铷的赋存状态研究

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矿产与地质 2024年第1期38卷 98-105页

作者：李莉夏瑜周奇明同锐灵周丽君陈永琳冯吉福中国有色桂林矿产地质研究院有限公司广西桂林541004 广西壮族自治区区域地质调查研究院广西桂林541003

铷(Rb)是稀有金属,其资源分布特征和开发利用一直是国内外重点关注对象。本文以广西越城岭地区香炉山铷矿床为研究对象,利用化学分析、光学显微镜鉴定、TIMA以及LA-ICP-MS等微区分析手段查明了矿床中不同类型矿石的矿物组成和化学成分特... 详细信息

铷(Rb)是稀有金属,其资源分布特征和开发利用一直是国内外重点关注对象。本文以广西越城岭地区香炉山铷矿床为研究对象,利用化学分析、光学显微镜鉴定、TIMA以及LA-ICP-MS等微区分析手段查明了矿床中不同类型矿石的矿物组成和化学成分特征,并在此基础上,对不同类型矿石的物质组成特征及其中铷的赋存状态进行了详细研究。研究结果表明,香炉山矿石中含铷矿物为白云母、钾长石和斜长石,其中Rb含量由高到低为白云母>钾长石>斜长石,钾长石是Rb的主要载体矿物,Rb在钾长石中不均匀分布;二长花岗岩和中细粒二长岩的钾长石中Rb占比均大于80%,表明香炉山铷矿床属于长石型铷资源。

关键词：香炉山铷矿矿石特征赋存状态 LA-ICP-MS 广西越城岭

GLP-1 receptor agonists and myocardial metabolism in atrial fibrillation

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Journal of Pharmaceutical Analysis 2024年第5期14卷 653-665页

作者： Jiani Zhong Hang Chen qiming Liu Shenghua zhou Zhenguo Liu Yichao Xiao Department of Cardiovascular Medicine Second Xiangya HospitalCentral South UniversityChangsha410011China Xiangya School of Medicine Central South UniversityChangsha410008China Center for Precision Medicine and Division of Cardiovascular Medicine Department of MedicineSchool of MedicineUniversity of MissouriColumbiaMO65211USA

Atrial fibrillation(AF)is the most common cardiac *** medical conditions,including hypertension,diabetes,obesity,sleep apnea,and heart failure(HF),increase the risk for *** have unique metabolic characteristics to maintain adenosine triphosphate *** changes occur in myocardial metabolism in ***-like peptide-1 receptor agonists(GLP-1RAs)have been used to control blood glucose fluctuations and weight in the treatment of type 2 diabetes mellitus(T2DM)and ***-1RAs have also been shown to reduce oxidative stress,inflammation,autonomic nervous system modulation,and mitochondrial *** article reviews the changes in metabolic characteristics in cardiomyocytes in *** the clinical trial outcomes are unsatisfactory,the findings demonstrate that GLP-1 RAs can improve myocardial metabolism in the presence of various risk factors,lowering the incidence of AF.

关键词： Atrial fibrillation Glucagon-like peptide-1 receptor agonists Metabolism

A Preliminary Review on Three-Dimensional City Model

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Geo-Spatial Information Science 2004年第2期7卷 79-88页

作者： zhou qiming Department of Geography ,Hong Kong Baptist University,KowloonTong HongKong. ZHANG Wenjiang Department of Geography Hong Kong Baptist University

In this paper a review on current research on 3DCM is presented, and an alternative approach by integrating the concepts and techniques of object\|oriented method and Computer Aided Design (CAD) is suggested. Through the approach urban spatial entities as objects are extracted, which are represented with primary 3D elements (node, edge, face and body) and their combinations. In the light of the concept of object, the method supports the multiple representation of Level of Details (LOD). More importantly, topological relationships between objects are described so that 3D topological operations can be implemented.

关键词： spatial data model urban GIS 3D city model object-oriented GIS