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Satellite cell proliferation and myofiber cross-section area increase after electrical stimulation following sciatic nerve crush injury in rats

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Chinese Medical Journal 2020年第16期133卷 1952-1960页

作者： Hua-Yi Xing Nan Liu mou-wang zhou Department of Rehabilitation Medicine Peking University Third HospitalBeijing 100191China

Background:Electrical stimulation has been recommended as an effective therapy to prevent muscle atrophy after nerve ***,the effect of electrical stimulation on the proliferation of satellite cells in denervated muscles has not yet been fully *** study was aimed to evaluate the changes in satellite cell proliferation after electrical stimulation in nerve injury and to determine whether these changes are related to the restoration of myofiber cross-section area(CSA).Methods:Sciatic nerve crush injury was performed in 48 male Sprague-Dawley *** half(24/48)of the rats,the gastrocnemius was electrically stimulated transcutaneously on a daily basis after injury,while the other half were not *** group of 24 male Sprague-Dawley rats were used as sham operation controls without injury or *** rats were euthanized 2,4,and 6 weeks *** 5-bromo-2’-deoxyuridine(BrdU)labeling,the gastrocnemia were harvested for the detection of paired box protein 7(Pax7),BrdU,myofiber CSA,and myonuclei number per *** data were analyzed using two-way analysis of variance and Bonferroni post-hoc ***:The percentages of Pax7-positive nuclei(10.81±0.56%)and BrdU-positive nuclei(34.29±3.87%)in stimulated muscles were significantly higher compared to those in non-stimulated muscles(2.58±0.33%and 1.30±0.09%,respectively,Bonferroni t=15.91 and 18.14,P<0.05).The numbers of myonuclei per fiber(2.19±0.24)and myofiber CSA(1906.86±116.51 mm2)were also increased in the stimulated muscles(Bonferroni t=3.57 and 2.73,P<0.05),and both were positively correlated with the Pax7-positive satellite cell content(R2=0.52 and 0.60,P<0.01).There was no significant difference in the ratio of myofiber CSA/myonuclei number per fiber among the three ***:Our results indicate that satellite cell proliferation is promoted by electrical stimulation after nerve injury,which may be correlated with an increase in myonuclei number and myofiber CS

关键词： Skeletal muscle satellite cells Peripheral nerve injuries Electric stimulation therapy Pax7 transcription factor Cell proliferation

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Co/carbon nanofiber with adjustable size and content of Co nanoparticles for tunable microwave absorption and thermal conductivity

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Journal of Materiomics 2024年第1期10卷 124-133页

作者： Shaohua Shi Pengpeng mou Dao wang Xiangying Li Shengjie Teng Maofan zhou Xiaolong Yu Zhen Deng Gengping Wan Guizhen wang State Key Laboratory of Marine Resource Utilization in South China Sea School of Materials Science and EngineeringHainan UniversityHaikouHainan570228China Department of Radiology Central South University Xiangya School of Medicine Affiliated Haikou HospitalHaikou570208China College of Science Qiongtai Normal UniversityHaikouHainan571127China Sanya Nanfan Research Institute of Hainan University Hainan Yazhou Bay Seed LaboratorySanya572025China

Electromagnetic pollution and heat dissipation problems are becoming increasingly worthy of attention due to the rapid development of electronic devices,which puts forward an urgent demand for microwave absorbers with excellent thermal management ***,high-performance Co/carbon nanofiber(Co/CNF)microwave absorbers with high thermal conductivity were fabricated by facile step-by-step *** microwave absorption properties can be readily tuned by adjusting the content and size of Co nanoparticles through concentration gradient *** from the formation of dielectric and magnetic coupling network,Co/CNF composites possess intensive dipole polarization,interface polarization,and magnetic *** optimal Co/CNF composites exhibit outstanding microwave absorption performance with a minimum reflection loss(RL)of−53.0 dB at 11.44 GHz,and a maximum effective absorption bandwidth(EAB)of 5.5 *** addition,the thermal conductivities of the Co/CNF-natural rubber(Co/CNF-NR)composites are significantly *** work may inspire the exploration of high-efficiency heat-conduction microwave absorbers based on CNF.

关键词： Carbon nanofiber Co nanoparticle Microwave absorption Heat conductivity

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Origin and tectonic setting of low-Si alkaline magma

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Science China Earth Sciences 2024年第5期67卷 1417-1435页

作者： Qiushi zhou Rui wang State Key Laboratory of Geological Processes and Mineral Resources and Institute of Earth SciencesChina University of GeosciencesBeijing 100083China Frontiers Science Center for Deep-time Digital Earth China University of Geosciences(Beijing)Beijing 100083China

Despite of the relatively rare occurrence of alkaline igneous rocks on Earth, they are the most diverse group of igneous rocks due to variations in their mineral assemblages and geochemical compositions. Alkaline igneous rocks are generally characterized by Si undersaturation, and K-Na(and in some cases C) enrichment. Although there is no unified alkaline igneous rock classification scheme, diagrams such as total alkalis-SiO_(2) or K_(2)O-SiO_(2) can be used to classify alkaline igneous rocks. The origins of silica-saturated alkaline rocks(SiO_(2)>52 wt.%) are relatively complex because multiple episodes of magmatism are often involved, therefore most studies have focused on the origins of silica-undersaturated alkaline *** experimental petrological studies have been conducted in the past few decades. Initially, it was considered that enrichment of trace elements was only achieved by low-degree partial melting of mantle peridotite, but the experimental melts could not reproduce the geochemical composition of natural alkaline igneous rocks. Subsequent studies have focused on carbonate-bearing eclogites that represent the average component of subducted oceanic crust. Although experimental studies indicate that silica-undersaturated and alkali-oversaturated melts can be generated from eclogites, some studies have considered that natural silica-undersaturated alkaline igneous rocks are the result of multi-stage source enrichment by incompatible elements. Low-degree partial melts of the mantle can be emplaced in the lithospheric mantle, forming veins consisting of phlogopite, amphibole, and pyroxene. Melting experiments including these components show that the produced melts better reproduce the naturally occurring silica-undersaturated alkaline magmas. Silica-deficient alkaline igneous rocks occur in various tectonic settings. Those in intraplate and divergent settings(i.e., mainly continental rifts) normally involve contributions from recycled components su

关键词： Alkaline igneous rock Tectonic setting Petrogenesis Big data

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Physical mechanism of the rapid increase in intense and long-lived extreme heatwaves in the Northern Hemisphere since 1980

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Science China Earth Sciences 2024年第7期67卷 2103-2121页

作者： Yuqing wang Wen zhou Chunzai wang Key Laboratory of Polar Atmosphere-ocean-ice System for Weather and Climate of the MOE Department of Atmospheric and Oceanic Sciences&Institute of Atmospheric SciencesFudan UniversityShanghai 200438China Key Laboratory for Polar Science of the MNR Polar Research Institute of ChinaShanghai 201209China State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Global Ocean and Climate Research Center South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China

Since 1980,both the intensity and duration of summer heatwaves in the middle and high latitudes of the Northern Hemisphere have significantly increased,leading this region to become a critical area for a significant increase in the frequency of intense and long-lived extreme *** found that stronger and more persistent high-pressure systems and lower soil moisture before the events were the main drivers of intense and long-lived extreme heatwaves in western Europe and the middle and high latitudes of North ***,in eastern Europe and Siberia,lower cloud cover before events is also a main driver of this type of extreme heatwave,in addition to the above *** factors are coupled with each other and can change heatwave intensity and duration by influencing surface radiation processes during *** the self-organizing map classification method,we found that 6 weather patterns with increased frequency,intensity,and duration were the main dynamic reasons leading to the increase in intense and long-lived extreme heatwaves after *** addition,the decrease in summer average soil moisture in most areas of the mid-high latitudes of the Northern Hemisphere and the decrease in average cloud cover in eastern Europe and Siberia are found to be the main thermodynamic reasons leading to the increase in these extreme heatwaves.

关键词： High intensity Long duration Extreme heatwaves High pressure system Soil moisture Cloud cover

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Adaptive state-constrained/model-free iterative sliding mode control for aerial robot trajectory tracking

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 603-618页

作者： Chen AN Jiaxi zhou Kai wang College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082China Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHong KongChina

This paper develops a novel hierarchical control strategy for improving the trajectory tracking capability of aerial robots under parameter *** hierarchical control strategy is composed of an adaptive sliding mode controller and a model-free iterative sliding mode controller(MFISMC).A position controller is designed based on adaptive sliding mode control(SMC)to safely drive the aerial robot and ensure fast state convergence under external ***,the MFISMC acts as an attitude controller to estimate the unmodeled dynamics without detailed knowledge of aerial ***,the adaption laws are derived with the Lyapunov theory to guarantee the asymptotic tracking of the system ***,to demonstrate the performance and robustness of the proposed control strategy,numerical simulations are carried out,which are also compared with other conventional strategies,such as proportional-integralderivative(PID),backstepping(BS),and *** simulation results indicate that the proposed hierarchical control strategy can fulfill zero steady-state error and achieve faster convergence compared with conventional strategies.

关键词： aerial robot hierarchical control strategy model-free iterative sliding mode controller(MFISMC) trajectory tracking reinforcement learning

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Inverse aerodynamic design for distributed propulsion wing with expected circulation distribution

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Chinese Journal of Aeronautics 2024年第9期37卷 206-223页

作者： Pengbo SUN zhou zhou Xu LI Kelei wang School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China

Distributed Propulsion Wing(DPW)technology offers significant advantages in terms of flight energy savings,but the strong aerodynamic coupling between the propulsive internal flow and aerodynamic external flow brings significant design *** the primary DPW profile design is of great significance,this paper proposes a hybrid method to solve the inverse problem mainly based on the formula relationship between the required aerodynamic loads and the profile shape,which is more direct and instructive compared with traditional parametric iterative *** aerodynamic characteristics are described by the circulation distribution in the Fourier series form,then the mean camber line of the profile is solved through the re-derived airfoil theory considering disk's *** CFD correction methods are also *** validate the effectiveness and feasibility of the proposed hybrid inverse method,several DPW profile design tests are then ***,the relationship between 2D and realistic 3D unit shape is also *** results show that the proposed inverse design method has great accuracy and convergence speed in the design tests,and shows good robustness against changes of the design *** 2D profile shape and the actual 3D shape of DPW unit can establish an aerodynamic-propulsion equivalent relationship based on the same internal mass fluxes.

关键词： Propulsion Inverse problem Aerodynamic load Fourier series Flux

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Deep-reinforcement-learning-based UAV autonomous navigation and collision avoidance in unknown environments

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Chinese Journal of Aeronautics 2024年第3期37卷 237-257页

作者： Fei wang Xiaoping ZHU zhou zhou Yang TANG School of Astronautics Northwestern Polytechnical UniversityXi’an 710072China School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China

In some military application scenarios,Unmanned Aerial Vehicles(UAVs)need to perform missions with the assistance of on-board cameras when radar is not available and communication is interrupted,which brings challenges for UAV autonomous navigation and collision *** this paper,an improved deep-reinforcement-learning algorithm,Deep Q-Network with a Faster R-CNN model and a Data Deposit Mechanism(FRDDM-DQN),is proposed.A Faster R-CNN model(FR)is introduced and optimized to obtain the ability to extract obstacle information from images,and a new replay memory Data Deposit Mechanism(DDM)is designed to train an agent with a better *** training,a two-part training approach is used to reduce the time spent on training as well as retraining when the scenario *** order to verify the performance of the proposed method,a series of experiments,including training experiments,test experiments,and typical episodes experiments,is conducted in a 3D simulation *** results show that the agent trained by the proposed FRDDM-DQN has the ability to navigate autonomously and avoid collisions,and performs better compared to the FRDQN,FR-DDQN,FR-Dueling DQN,YOLO-based YDDM-DQN,and original FR outputbased FR-ODQN.

关键词： Faster R-CNN model Replay memory Data Deposit Mechanism(DDM) Two-part training approach Image-based Autonomous Navigation and Collision Avoidance(ANCA) Unmanned Aerial Vehicle(UAV)

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A Transformer-Based Ensemble Framework for the Prediction of Protein-Protein Interaction Sites

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Research 2024年第2期2023卷 703-718页

作者： Minjie mou Ziqi Pan Zhimeng zhou Lingyan Zheng Hanyu Zhang Shuiyang Shi Fengcheng Li Xiuna Sun Feng Zhu College of Pharmaceutical Sciences The Second Affliated HospitalZhejiang University School of MedicineNational Key Laboratory of Advanced Drug Delivery and Release SystemsZhejiang UniversityHangzhou 310058China Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University Alibaba-Zhejiang University Joint Research Center of Future Digital HealthcareHangzhou 330110China

The identification of protein-protein interaction (PPI) sites is essential in the research of protein function and the discovery of new drugs. So far, a variety of computational tools based on machine learning have been developed to accelerate the identification of PPI sites. However, existing methods suffer from the low predictive accuracy or the limited scope of application. Specifically, some methods learned only global or local sequential features, leading to low predictive accuracy, while others achieved improved performance by extracting residue interactions from structures but were limited in their application scope for the serious dependence on precise structure information. There is an urgent need to develop a method that integrates comprehensive information to realize proteome-wide accurate profiling of PPI sites. Herein, a novel ensemble framework for PPI sites prediction, EnsemPPIS, was therefore proposed based on transformer and gated convolutional networks. EnsemPPIS can effectively capture not only global and local patterns but also residue interactions. Specifically, EnsemPPIS was unique in (a) extracting residue interactions from protein sequences with transformer and (b) further integrating global and local sequential features with the ensemble learning strategy. Compared with various existing methods, EnsemPPIS exhibited either superior performance or broader applicability on multiple PPI sites prediction tasks. Moreover, pattern analysis based on the interpretability of EnsemPPIS demonstrated that EnsemPPIS was fully capable of learning residue interactions within the local structure of PPI sites using only sequence information. The web server of EnsemPPIS is freely available at http://***/ensemppis.

关键词： residue extracting ensemble

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An intelligent DNA nanodevice for precision thrombus therapy

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Science China Chemistry 2024年第10期67卷 3195-3197页

作者： Yihao zhou Qiangbin wang CAS Key Laboratory of Nano-Bio Interface Division of Nanobiomedicine and i-LabSuzhou Instiute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China

Obstruction of blood vessels(thrombosis)due to blood clots is one of the main causes of death worldwide and is associated with many cardiovascular diseases,such as myocardial infarction,ischemic stroke,and pulmonary embolism[1].Thrombolytic therapy is currently the preferred treatment for acute thrombosis and is administered intravenously with thrombolytic drugs,such as tissue plasminogen activator(tPA)[2].

关键词： drugs cardiovascular acute

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Multi-Robot Collaborative Hunting in Cluttered Environments With Obstacle-Avoiding Voronoi Cells

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1643-1655页

作者： Meng zhou Zihao wang Jing wang Zhengcai Cao the School of Electrical and Control Engineering North China University of TechnologyBeijing 100144China IEEE the College of Information Science and Technology Beijing University of Chemical TechnologyBeijing 100029China

This work proposes an online collaborative hunting strategy for multi-robot systems based on obstacle-avoiding Voronoi cells in a complex dynamic environment. This involves firstly designing the construction method using a support vector machine(SVM) based on the definition of buffered Voronoi cells(BVCs). Based on the safe collision-free region of the robots, the boundary weights between the robots and the obstacles are dynamically updated such that the robots are tangent to the buffered Voronoi safety areas without intersecting with the obstacles. Then, the robots are controlled to move within their own buffered Voronoi safety area to achieve collision-avoidance with other robots and obstacles. The next step involves proposing a hunting method that optimizes collaboration between the pursuers and evaders. Some hunting points are generated and distributed evenly around a circle. Next, the pursuers are assigned to match the optimal points based on the Hungarian ***, a hunting controller is designed to improve the containment capability and minimize containment time based on collision risk. Finally, simulation results have demonstrated that the proposed cooperative hunting method is more competitive in terms of time and travel distance.

关键词： Dynamic obstacle avoidance multi-robot collaborative hunting obstacle-avoiding Voronoi cells task allocation

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