检索结果-南通市图书馆

Meromorphic Solutions to Higher Order Nonlinear Delay Differential Equations

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2024年

作者： Ye-zhou LI ming-yue WU He-qing SUN School of Science Beijing University of Posts and Telecommunications Key Laboratory of Mathematics and Information Networks (Beijing University of Posts and Telecommunications) Ministry of Education Beijing University of Posts and Telecommunications

Let w（z） be non-rational meromorphic solutions with hyper-order less than 1 to a family of higher order nonlinear delay differential equations w（z+1）w（z-1）+a（z）w（k）（z）/w（z）=R(z,w（z）),k∈N+,where a（z） is rational,R(z,w（z）)=P(z,w（z）)/Q(z,w（z）) is an irreducible rational function in w with rational coefficients in *** paper mainly show the relationships of the degree of P(z,w（z）) and Q(z,w（z）) when the above equations exist such solutions w（z）.There are also some examples to show that our results are sharp.

关键词：

Persistent greening against drying in northeast Asian semiarid grasslands:Asymmetrical responses of direct and legacy effects to intensified drought

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Advances in Climate Change Research 2024年第1期15卷 9-20页

作者： Yu-Tong MA Hai-Shan CHEN Yao-ming SONG Bo-Tao zhou Shan-Lei SUN Xin-Guan DU yue SUN Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China School of Atmospheric Sciences Nanjing University of Information Science and TechnologyNanjing 210044China

Despite experiencing a decadal shift towards drought conditions at the end of the 2Oth century,semiarid grasslands in northeast Asia(NEA)exhibited an evident greening trend from 1982 to ***,the mechanism behind this phenomenon remains ***,we analysed the interdecadal changes in vegetation response to drought on the basis of the standardised precipitation evapotranspiration index(SPEI)and Global Inventory Modelling and Mapping Studies LAI4g datasets,with an emphasis on the differences between direct and legacy effects(as measured by resilience),to explore the mechanism of persistent grassland *** revealed that during the post-drought shift period(2000-2020),the sudden decrease in the water content of the intermediate soil layer triggered an intensified vegetation response to ***,although direct effects and resilience were amplified,they exhibited asymmetric *** was stronger than direct effects,and this difference increased with increasing drought(drought recovery)*** combined effects may account for persistent greening against intensified drying in the semiarid grasslands in *** the projected exacerbation of future droughts,this study holds notable importance for comprehending the long-term change dynamics of dryland ecosystems.

关键词： Semiarid grassland Drought decadal shift Direct effect Legacy effect(resilience) Northeast Asia

Manufacturing task data chain-driven production logistics trajectory analysis and optimization decision making method

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Manufacturing 2024年第1期12卷 185-206页

作者： Lin Ling Zhe-ming Song Xi Zhang Peng-zhou Cao Xiao-Qiao Wang Cong-Hu Liu ming-zhou Liu School of Mechanical Engineering Hefei University of TechnologyHefei230009People’s Republic of China Guobo Electronics Co.Ltd. Nanjing211111People’s Republic of China School of Mechanical and Electronic Engineering Suzhou UniversitySuzhou234000AnhuiPeople’s Republic of China Sino-US Global Logistics Institute Shanghai Jiao Tong UniversityShanghai200030People’s Republic of China

Production logistics(PL)is considered as a critical factor that affects the efficiency and cost of production operations in discrete manufacturing *** effectively utilize manufacturing big data to improve PL efficiency and promote job shop floor economic benefits,this study proposes a PL trajectory analysis and optimization decision making method driven by a manufacturing task data chain(MTDC).First,the manufacturing task chain(MTC)is defined to characterize the discrete production process of a *** handle manufacturing big data,the MTC data paradigm is designed,and the MTDC is ***,the logistics trajectory model is presented,where the various types of logistics trajectories are extracted using the MTC as the search engine for the *** on this,a logistics efficiency evaluation indicator system is proposed to support the optimization decision making for the ***,a case study is applied to verify the proposed method,and the method determines the PL optimization decisions for PL efficiency without changing the layout and workshop equipment,which can assist managers in implementing the optimization decisions.

关键词： Production logistics(PL) Logistics trajectory analysis Logistics optimization Data driven Manufacturing task data chain(MTDC)

Dopamine Switches Affective States Under Acute Sleep Deprivation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第8期40卷 1205-1208页

作者： zhou-Cai Luo Tian-ming Gao State Key Laboratory of Organ Failure Research Key Laboratory of Mental Health of the Ministry of EducationGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired IntelligenceGuangdong-Hong Kong Joint Laboratory for Psychiatric DisordersGuangdong Province Key Laboratory of Psychiatric DisordersGuangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi DiseasesDepartment of NeurobiologySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China

The transition of affective states manifests affective regulation,wherein individuals adaptively adjust their emotional states to cope with changes in the external environment,reflecting their sensitivity and adaptability to environmental *** process of affective state transition is complex,involving both instantaneous and persistent changes influenced by environmental,behavioral,and pharmacological *** underlying neural mechanisms encompass alterations in neurotransmitter release,neural circuit activity,and the plasticity of brain structures[1].

关键词： alterations Dopamine neural

Plexin domain-containing 1 may be a biomarker of poor prognosis in hepatocellular carcinoma patients,may mediate immune evasion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第5期16卷 2091-2112页

作者： ming-yue Tang Xue Shen Run-Sheng Yuan Hui-Yuan Li Xin-Wei Li Yi-ming Jing yue Zhang Hong-Hong Shen Zi-Shu Wang Lei zhou Yun-Chuan Yang He-Xin Wen Fang Su Department of Medical Oncology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Otolaryngology and Head and Neck Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Neurology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina

BACKGROUND For the first time,we investigated the oncological role of plexin domain-containing 1(PLXDC1),also known as tumor endothelial marker 7(TEM7),in hepatocellular carcinoma(HCC).AIM To investigate the oncological profile of PLXDC1 in *** Based on The Cancer Genome Atlas database,we analyzed the expression of PLXDC1 in *** immunohistochemistry,quantitative real-time polymerase chain reaction(qRT-PCR),and Western blotting,we validated our *** prognostic value of PLXDC1 in HCC was analyzed by assessing its correlation with clinicopathological features,such as patient survival,methylation level,tumor immune microenvironment features,and immune cell surface checkpoint ***,to assess the immune evasion potential of PLXDC1 in HCC,we used the tumor immune dysfunction and exclusion(TIDE)website and immunohistochemical staining *** Based on immunohistochemistry,qRT-PCR,and Western blot assays,overexpression of PLXDC1 in HCC was associated with poor *** and multivariate Cox analyses indicated that PLXDC1 might be an independent prognostic *** HCC patients with high methylation levels,the prognosis was worse than in patients with low methylation *** enrichment analysis of HCC tissues indicated that genes upregulated in the high-PLXDC1 subgroup were enriched in mesenchymal and immune activation signaling,and TIDE assessment showed that the risk of immune evasion was significantly higher in the high-PLXDC1 subgroup compared to the low-PLXDC1 *** high-risk group had a significantly lower immune evasion rate as well as a poor prognosis,and PLXDC1-related risk scores were also associated with a poor *** As a result of this study analyzing PLXDC1 from multiple biological perspectives,it was revealed that it is a biomarker of poor prognosis for HCC patients,and that it plays a role in determining immune evasion status.

关键词： Plexin domain-containing 1 Biomarker Immune evasion Prognosis Immunotherapy Hepatocellular carcinoma

A PET probe targeting polyamine transport system for precise tumor diagnosis and therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 146-159页

作者： ming zhou Xiaoqin Yin Bei Chen Shuo Hu Wenhu zhou Department of Nuclear Medicine Xiangya HospitalCentral South UniversityChangsha 410008China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410008China National Clinical Research Center for Geriatric Disorders(Xiangya) Changsha 410008China

Polyamine metabolism dysregulation is a hallmark of many cancers,offering a promising avenue for early tumor *** study presents the development of a nuclear probe derived from spermidine(SPM)for dual-purpose tumor PET imaging and internal radiation *** probe,radiolabeled with either[68Ga]Ga for diagnostic applications or[177Lu]Lu for therapeutic use,was synthesized with exceptional purity,stability,and specific *** testing involving 12 different tumor cell lines revealed remarkable specificity towards B16 melanoma cells,showcasing outstanding tumor localization and target-to-non-target *** investigations employing polyamines,non-labeled precursor,and polyamine transport system(PTS)inhibitor,consistently affirmed the probe?s targetability through recognition of the ***,while previous reports indicated PTS upregulation in various tumor types for targeted therapy,this study observed no positive signals,highlighting a concentration-dependent discrepancy between targeting for therapy and ***,when labeled with[177Lu],the probe demonstrated its therapeutic potential by effectively controlling tumor growth and extending mouse *** into biodistribution,excretion,and biosafety in healthy humans laid a robust foundation for clinical *** study introduces a versatile SPM-based nuclear probe with applications in precise tumor theranostics,offering promising prospects for clinical implementation.

关键词： PET imaging Polyamine metabolism Spermine Radiopharmaceutical Melanoma

Investigating the mechanisms of isochorismate synthase:An approach to improve salicylic acid synthesis and increase resistance to Fusarium head blight in wheat

在线全文

学校读者我要写书评

暂无评论

The Crop Journal 2024年第4期12卷 1054-1063页

作者： Ya-zhou Zhang Jie Man Dan Xu Lan Wen Yinghui Li Mei Deng Qian-Tao Jiang Qiang Xu Guo-yue Chen Yu-ming Wei State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130SichuanChina Triticeae Research Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina

Salicylic acid(SA),a vital endogenous hormone,plays a crucial role in plant growth and the response to abiotic and biotic *** synthase(ICS)and phenylalanine ammonia lyase(PAL)are critical rate-limiting enzymes for SA *** head blight(FHB)seriously threatens the safety of wheat production,but increasing the content of SA can enhance FHB ***,the pathway of SA synthesis and regulation in wheat remains *** this study,three wheat ICS(TaICSA,TaICSB,and TaICSD)were identified,and their functions were validated in vitro for isomerizing chorismate to *** mutation of one or two homoeoalleles of TaICSA,TaICSB,and TaICSD in the wheat variety‘Cadenza’reduced SA levels under ultraviolet treatment and Fusarium graminearum infection,further enhancing sensitivity to *** of TaICSA can significantly enhance SA levels and resistance to *** further study SA synthesis pathways in wheat and avoid interference with pathogenicity related genes,the leaves of wild-type Cadenza and different TaICS mutant lines were subjected to ultraviolet treatment for transcriptomic *** results showed that 37 PALs might be involved in endogenous SA synthesis,and 82 WRKY and MYB family transcription factors may regulate the expression of ICS and *** results were further confirmed by *** conclusion,this study expands our knowledge of SA biosynthesis and identifies TaICSA,as well as several additional candidate genes that encode transcription factors for regulating endogenous SA levels,as part of an efficient strategy for enhancing FHB resistance in wheat.

关键词： Salicylic acid Chorismate Isochorismate RNA-seq Phenylalamine ammonia lyase

Monitoring of Cell Membrane Microenvironment Based on DNA Nanodevices

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2024年第2期40卷 255-267页

作者： NAN Hexin CAI ming KUANG Shi NIE zhou State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan Provincial Key Laboratory of Biomacromolecular Chemical BiologyHunan UniversityChangsha410082P.R.China

The cell membrane is a critical barrier for cellular homeostasis,integral to signaling and intercellular communication,and vital for understanding cellular functions and disease *** its microenvironment is crucial for uncovering the molecular basis of physiological and pathological processes associated with the cell membrane,driving the development of bioanalytical toolkits capable of dynamically monitoring the cell surface *** the continuous advancement of functional nucleic acids and dynamic DNA nanotechnology,DNA nanodevices with controllable nanosized geometry,specific molecular recognition,and selective membrane-localization properties offer a versatile platform for probing the cell membrane *** this review,we summarize the current biosensing and membrane-anchoring mechanisms of DNA nanodevices and highlight their use in studying key cell membrane events,including membrane lipid dynamics,transmembrane transport,receptor dimerization,and signal ***,we discuss the challenges and potential future applications of DNA nanodevices in advancing cell membrane biology research and biomedical applications.

关键词： DNA nanodevice Cell membrane Cellular micro-environment Monitoring

Local environment regulation of transition metal dichalcogenide-based single-atom catalysts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第9期43卷 4019-4037页

作者： ming-Hui Li Jing Li Xiao-Yu Zheng Yao zhou Advanced Research Institute of Multidisciplinary Science and School of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing 100081China Laser Micro/Nano Fabrication Laboratory School of Mechanical EngineeringBeijing Institute of TechnologyBeijing 100081China

Single-atom catalysts have risen significant attention in the realm of green electrocatalytic energy conversion to address energy and environmental sustainability *** metal dichalcogenide(TMD)-based single-atom catalysts are considered highly effective in electrocatalysis due to the TMDs'notable specific surface area,tunable elemental species and efficient utilization of single *** order to enhance electrocatalytic performance,it is imperative to elaborately engineer the local environment surrounding the active sites of single atoms within *** this review,we initially explore the effects of synthesis methods on single-atom active sites and the influence of loading of single atoms on catalytic performance for *** modulation strategies of the local environment surrounding single-atom sites in TMDs are elaborated,including substitution engineering,surface adsorption,vacancies,spatial confinement and dual-atom site *** each modulation strategy,the effects of diverse local environments on various electrocatalytic applications are presented,such as the oxygen evolution reaction,oxygen reduction reaction,nitrogen reduction reaction,CO_(2)reduction reaction and CO ***,this study presents a comprehensive overview of the challenges encountered and the potential directions for the advancement of single-atom catalysts based on TMDs in the realm of electrocatalysis.

关键词： Single-atom catalysts Transition metal dichalcogenide Local environment Electrocatalysis