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Burden of biliary tract carcinoma in China(1990–2021):Findings from the 2021 Global Burden of Disease Study

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Science Bulletin 2024年第22期69卷 3547-3557页

作者： Wei Zhang Yi-Jun Wang Jiang-Mei liu Xu-Heng Sun Yan Jiang Fang Shen Li-Juan Shen Jing xiang Jun-Feng Zhang lin-hua Yang Wen-Guang Wu Tao Chen Hui Wang min He Li-Guo liu Wen-Qi Tao Yong-Zhi Chen Yong-Bing xiang Mao-Lan Li Mai-Geng zhou Ying-Bin liu Department of Epidemiology Shanghai Cancer InstituteRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200120China Department of Biliary-Pancreatic Surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200120China National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China Department of Medical Affairs Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200120China Department of General Surgery Jiading BranchRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 201800China Shanghai Key Laboratory of Systems Regulation and Clinical Translation for Cancer Shanghai 200127China State Key Laboratory of Systems Medicine for Cancer Shanghai Cancer InstituteShanghai 200127China Shanghai Cancer Institute Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200120China

Biliary tract carcinoma(BTC)is a group of malignant tumors that originate in the digestive system and occurs with a high incidence in *** consistent and comparable assessments of BTC disease burden have been conducted at national or subnational levels,and little is known about the demographic,temporal,and geographic patterns of epidemiological characteristics and disease burden of BTC in *** incidence,mortality,disability-adjusted life-years(DALYs),years of life lost(YLLs)due to premature death and years lived with disability(YLDs)of BTC were comprehensively examined by age,sex,and calendar year in the Chinese population,using the methodological framework and analytical strategies used for the 2021 Global Burden of Disease ***-age incidence increased from 17,077 to 51,720between 1990 and 2021,and the age-standardized incidence rate rose by 13.62%;all-age deaths increased from 17,251 to 37,833,but the age-standardized mortality rate fell by nearly *** DALYs rose by 89.57%while the age-standardized DALY rate fell by 23.24%.Variations of the tendencies in BTC burden were found between sexes and age *** for each provincial region indicate that coastal eastern provincial regions have higher incidence and YLD levels,whereas northern provincial regions have higher mortality,DALY,and YLL *** proportions of DALYs attributable to high body mass index(BMI)illustrate the growing attribution obesity has made,and high BMI usually puts more burden on northern provincial *** results provide evidence to support precise,targeted,and customed public health strategies aimed at enhancing biliary tract health among the Chinese population.

关键词： Biliary tract carcinoma China Global burden of disease study Disability-adjusted life-year Year of life lost due to premature death Year lived with disability

工艺参数对X80管线钢组织和硬度的影响研究

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钢铁研究 2009年第2期37卷 31-33,36页

作者：周民张凯杜林秀刘相华刘佳伟东北大学轧制技术及连轧自动化国家重点实验室辽宁沈阳110004

利用MMS-300热模拟试验机模拟研究了管线钢两阶段轧制的控轧控冷工艺。通过控制不同的终轧温度和终冷温度,并在17℃/s冷却速度下控制冷却,研究其对管线钢显微组织和显微硬度的影响。研究结果表明,在终轧温度810℃、终冷温度540℃时可获... 详细信息

利用MMS-300热模拟试验机模拟研究了管线钢两阶段轧制的控轧控冷工艺。通过控制不同的终轧温度和终冷温度,并在17℃/s冷却速度下控制冷却,研究其对管线钢显微组织和显微硬度的影响。研究结果表明,在终轧温度810℃、终冷温度540℃时可获得以针状铁素体、多边形铁素体以及M/A岛为主的混合组织。

关键词：终轧温度终冷温度显微组织硬度

Phosphate film free of chromate, fluoride and nitrite on AZ31 magnesium alloy and its corrosion resistance

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Transactions of Nonferrous Metals Society of China 2012年第11期22卷 2713-2718页

作者：崔学军刘春海杨瑞嵩李明田林修洲龚敏四川理工学院材料腐蚀与防护四川省重点实验室自贡643000 四川理工学院材料与化学工程学院自贡643000

A phosphate solution free of chromate, fluoride and nitrite was prepared and an environment-friendly film was obtained on AZ31 magnesium alloy surface via the chemical deposition method. The morphology, composition, phase structure and its corrosion resistance were studied. The effects of film-forming temperature and free acid on corrosion resistance, microstructure and electrochemical behavior of the film were discussed. The results indicate that the corrosion resistance of AZ31 with the phosphate film was better than blank AZ31 substrate, which was most attributed to the great inhibitive action on the anodic dissolution and cathodic hydrogen evolution of the film.

关键词： magnesium alloy AZ31 alloy phosphate conversion coating chromate-free film corrosion resistance anodicdissolution cathodic hydrogen evolution

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胃肠道间质瘤肝转移介入治疗疗效分析

介入放射学杂志 2006年第5期15卷 283-285页

作者：林钧华刘鲁明周振华复旦大学附属肿瘤医院肝癌科上海200032

目的观察经肝动脉化疗栓塞(TACE)治疗胃肠道间质瘤(GIST)肝转移的临床疗效。方法对4例胃肠道间质瘤肝转移患者共19个病灶,病灶直径2～5cm,经肝动脉灌注FuDR、CDDP、EPI-ADM,用超液化碘油和明胶海绵作动脉栓塞,每例平均2～4次。结果DSA显... 详细信息

目的观察经肝动脉化疗栓塞(TACE)治疗胃肠道间质瘤(GIST)肝转移的临床疗效。方法对4例胃肠道间质瘤肝转移患者共19个病灶,病灶直径2～5cm,经肝动脉灌注FuDR、CDDP、EPI-ADM,用超液化碘油和明胶海绵作动脉栓塞,每例平均2～4次。结果DSA显示GIST肝转移灶动脉血供丰富,染色明显,经TACE治疗后,肝转移灶未见缩小,碘油较快被清除,4例患者无CR或PR,2例改服伊马替尼有效。结论有限的病例显示TACE治疗胃肠道间质瘤肝转移未见明显疗效。

关键词：胃肠道间质瘤肝转移介入治疗

Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su Sun-Bin ling Qiao-Nan Shan Xu-Yong Wei Rui Wang Chang-Ku Jia Li Zhuang Tian Shen Li-min Ding Zhi-Dan Xu Lai-Bang Luo Li-Bo Sun Guang-ming Li Tai-Shi Fang Nan Jiang Kun Zhang Zhao-Jie Su Zhi-Hai Peng Ren Lang Tao Jiang Qiang He lin-Sen Ye Yang Yang Yu-Ting He Wen-Zhi Guo liu-Gen Lan Xu-Yong Sun Dong Chen Zhi-Shui Chen Da-Wei zhou Shao-Jun Ye Qi-Fa Ye min Tian Jian-hua Shi Bo Wang Jiang liu Qian Lu Wei Rao Jin-Zhen Cai Tao Lv Jia-Yin Yang Pu-Sen Wang lin Zhong Jing-Sheng Ma Qi-Gen Li Sheng-Dong Wu Chang-Jiang Lu Cai-De Lu Dong-hua Zhang Xuan Wang Zi-Qiang Li Mu-Jian Teng Jun-Jie Li Wen-Tao Jiang Jian-hua Li Quan-Bao Zhang Ning-Qi Zhu Zheng-Xin Wang Kang He Qiang Xia Shao-hua Song Zhi-Ren Fu Wei Qiu Guo-Yue Lv Rui-Peng Song Ji-zhou Wang Zheng Wang Jian zhou Gang Chen Ying-Peng Zhao Li Li Ze-min Hu Qi-Jie Luo Zhong-zhou Si Bin Xie Xiao-Shun He Zhi-Yong Guo Shu-Sen Zheng Xiao Xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China Liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic Surgery and Liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma Liver transplantation Conversion

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芦荟凝胶对大鼠多柔比星外渗性损伤的影响

癌症 2009年第4期28卷 356-360页

作者：刘雪花夏红周秀田罗文周建国董琳南华大学附属第一医院肿瘤内科湖南衡阳421001 南华大学肿瘤研究所湖南衡阳421001 湖南环境生物职业技术学院护理学院湖南衡阳421001

背景与目的:芦荟对多种化疗药物外渗性损伤有良好的防护作用。本实验主要研究芦荟凝胶对大鼠多柔比星外渗性损伤的防治作用,初步探讨芦荟凝胶促进大鼠多柔比星外渗性损伤伤口愈合的机制。方法:建立SD大鼠多柔比星外渗性损伤动物模型,将3... 详细信息

背景与目的:芦荟对多种化疗药物外渗性损伤有良好的防护作用。本实验主要研究芦荟凝胶对大鼠多柔比星外渗性损伤的防治作用,初步探讨芦荟凝胶促进大鼠多柔比星外渗性损伤伤口愈合的机制。方法:建立SD大鼠多柔比星外渗性损伤动物模型,将30只SD大鼠采用自身对照法随机分组:对照组(生理盐水)、实验组(芦荟凝胶1g/L)和硫酸镁组(50%硫酸镁湿敷),测量各组大鼠外渗性损伤的面积,观察损伤程度;在治疗后第1、4、7、11、18天各组分别随机取2只大鼠,切除损伤组织,HE染色观察病理形态学改变。另取30只外渗性损伤模型大鼠随机分组,分组同上。于损伤后第5天切除外渗损伤部位的皮肤及皮下组织,间断缝合,术后第7天拆线,观察手术伤口Ⅰ期愈合情况和愈合时间。用免疫组化法检测损伤部位的皮肤及皮下组织中的血管内皮生长因子(vascular endothelial growth factor,VEGF)、表皮生长因子受体(epidermal growth factor receptor,EGFR)的表达情况。结果:芦荟凝胶组和硫酸镁组的外渗性损伤面积及程度明显低于生理盐水组(P<0.01)。对照组、芦荟凝胶组和硫酸镁组的手术伤口Ⅰ期愈合率分别为20.0%、60.0%和66.7%,伤口愈合时间分别为(12.1±2.1)d、(9.6±1.6)d和(9.3±1.4)d,对照组与另外两组之间的差异均有统计学意义(P<0.01)。免疫组化检测结果显示,芦荟凝胶组与生理盐水组比较,VEGF、EGFR的表达呈现上调。结论:芦荟凝胶对大鼠多柔比星外渗性损伤有良好的防治作用,其促进伤口愈合的机制可能与组织中VEGF、EGFR的表达上调有关。

关键词：芦荟凝胶多柔比星外渗性损伤 VEGF EGFR 大鼠

Paired quasi-periodic pulsations of hard X-ray emission in a solar flare

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Science China(Physics,Mechanics & Astronomy) 2023年第5期66卷 195-206页

作者： Hai-Sheng Zhao Dong Li Shao-lin Xiong Yan-Qiu Zhang Yang Su Wei Chen Yi Zhao Xiao-Bo Li Jia-Cong liu Wen-Xi Peng Rui Qiao Xin-Qiao Li xiang-Yang Wen Li-ming Song Shi-Jie Zheng Xin-Ying Song Xiao-Yun Zhao Yue huang Shuang-Nan Zhang Shuo Xiao Ce Cai Zheng-hua An Can Chen Gang Chen Wei Chen Yan-Qi du min Gao Ke Gong Dong-Ya Guo Zhi-Wei Guo Jian-Jian He Bin Li Chao Li Chao-Yang Li Gang Li Jian-Hui Li Lu Li Qing-Xin Li Yan-Guo Li Jing Liang Xiao-hua Liang Jin-Yuan Liao Xiao-Jing liu Ya-Qing liu Qi Luo xiang Ma Bin Meng Ge Ou Dong-Li Shi Jing-Yan Shi Gong-Xing Sun Xi-Lei Sun You-Li Tuo Chen-Wei Wang Hui Wang Jin Wang Jin-zhou Wang Ping Wang Wen-Shuai Wang Hong Wu Sheng-Lun Xie Yan-Bing Xu Yu-Peng Xu Wang-Chen Xue Sheng Yang min Yao Jian-Ying Ye Qi-Bin Yi Chao-Yue Zhang Da-Li Zhang Fan Zhang Fei Zhang Hong-Mei Zhang Kai Zhang Peng Zhang Xiao-Lu Zhang Zhen Zhang Guo-Ying Zhao Shi-Yi Zhao Chao Zheng Xing zhou Yue Zhu Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China Physics and Space Science College China West Normal UniversityNanchong 637002China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Institute of Astrophysics Central China Normal UniversityWuhan 430079China School of Physics Changchun University of Science and TechnologyChangchun 130022China College of Physics and Engineering Qufu Normal UniversityQufu 273165China College of Physics Sciences&Technology Hebei UniversityBaoding 071002China

We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 *** subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak *** subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive *** periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence *** paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our *** precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.

关键词： solar flare QPPs loop coalescence circular-ribbon flare

近垒能区^(32)S+^(90,96)Zr势垒分布的研究

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高能物理与核物理 2006年第2期30卷 105-107页

作者：吴秀坤林承键杨峰刘祖华张焕乔张春雷周平中国原子能科学研究院北京102413

精确测量了32S+90,96Zr两系统的背角准弹散射激发函数,总体误差小于1％,从中分别抽取了它们的势垒分布,对比观测到32S+96Zr的势垒结构扁平且向低能区展宽,这种势垒可导致在垒下能区该体系的熔合截面的大大增强．32S+96Zr与32S+90Zr相比... 详细信息

精确测量了32S+90,96Zr两系统的背角准弹散射激发函数,总体误差小于1％,从中分别抽取了它们的势垒分布,对比观测到32S+96Zr的势垒结构扁平且向低能区展宽,这种势垒可导致在垒下能区该体系的熔合截面的大大增强．32S+96Zr与32S+90Zr相比存在较强的中子转移反应,且转移Q值为正． 32S+96Zr势垒的扁平结构可能是中子转移道耦合所致,这会导致32S+96Zr垒下熔合截面大的增强．

关键词：准弹激发函数势垒分布中子转移

The RARS-MAD1L1 Fusion Gene Induces Cancer Stem Cell-like Properties and Therapeutic Resistance in Nasopharyngeal Carcinoma

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The RARS-MAD1L1 Fusion Gene Induces Cancer Stem Cell-like Pr...