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Diagnosis,treatment,and prevention of monkeypox in children:an experts'consensus statement

World Journal of Pediatrics 2023年第3期19卷 231-242页

作者： Rong-Meng Jiang Yue-Jie Zheng Lei zhou Lu-Zhao Feng lin Ma Bao-Ping Xu Hong-Mei Xu Wei liu Zheng-De Xie Ji-Kui Deng Li-Juan Xiong Wan-Jun Luo Zhi-Sheng liu Sai-Nan Shu Jian-She Wang Yi Jiang Yun-Xiao Shang Miao liu Li-Wei Gao Zhuang Wei Guang-hua liu Gang liu Wei xiang Yu-Xia Cui Gen Lu min Lu Xiao-Xia Lu Run-ming Jin Yan Bai Le-Ping Ye Dong-Chi Zhao A-Dong Shen xiang Ma Qing-hua Lu Feng-Xia Xue Jian-Bo Shao Tian-You Wang Zheng-Yan Zhao Xing-Wang Li Yong-Hong Yang Kun-ling Shen Diagnosis and Treatment Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Respiratory Shenzhen Children’s HospitalShenzhen 518038China Branch for Emerging Infectious Disease Public Health Emergency CenterChinese Center for Disease Control and PreventionBeijing 102206China School of Population Medicine&Public Health Chinese Academy of Medical Science/Peking Union Medical CollegeBeijing 100730China Department of Dermatology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s Health(Beijing)Beijing 100045China Department of Respiratory Beijing Children’s HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children’s Health(Beijing)Beijing 100045China Department of Infectious Diseases Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Tianjin Children’s Hospital Children’s Hospital of Tianjin UniversityTianjin 300134China Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s Health(Beijing)Beijing 100045China Department of Infectious Diseases Shenzhen Children’s HospitalShenzhen 518038China Department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Ofce of Infection Management Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Neurology Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Pediatrics Tongji

Monkeypox is a zoonotic *** the first human monkeypox case was detected in 1970,it has been prevalent in some countries in central and western *** May 2022,monkeypox cases have been reported in more than 96 non-endemic countries and regions *** of September 14,2022,there have been more than 58,200 human monkeypox cases,and there is community *** cessation of smallpox vaccination in 1980,which had some cross-protection with monkeypox,resulted in a general lack of immunity to monkeypox,which caused global concern and *** of Sep-tember 14,2022,there are four monkeypox cases in China,including three in Taiwan province and one in Hong Kong *** foreign studies have shown that children are vulnerable to monkeypox and are also at high risk for severe disease or *** order to improve pediatricians'understanding of monkeypox and achieve early detection,early diagno-sis,early treatment,and early disposal,we have organized national authoritative experts in pediatric infection,respiratory,dermatology,critical care medicine,infectious diseases,and public health and others to formulate this expert consensus,on the basis of the latest"Clinical management and infection prevention and control for monkeypox"released by The World Health Organization,the"guidelines for diagnosis and treatment of monkeypox(version 2022)"issued by National Health Commission of the People's Republic of China and other relevant *** the development of this consensus,multidisciplinary experts have repeatedly demonstrated the etiology,epidemiology,transmission,clinical manifestations,laboratory examinations,diagnosis,differential diagnosis,treatment,discharge criteria,prevention,disposal process,and key points of prevention and control of suspected and confirmed cases.

关键词： Children Consensus Diagnosis Monkeypox Prevention Treatment

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Effect of Heficobacter pylori Eradication on Reflux Esophagitis Therapy： A Multi-center Randomized Control Study

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Chinese Medical Journal 2015年第8期128卷 995-999页

作者： Yan Xue Li-Ya zhou San-Ren lin Xiao-hua HOU Zhao-Shen Li min-Hu Chen xiu-E Yan ling-Mei Meng Jing Zhang Jing-Jing Lu Department of Gastroenterology Peking University Third Hospital Beijing 100191 China Department of Gastroenterology Wuhan Union Hospital Tongji Medical College Huazhong University of Science and Technology Huhan Hubei 430022 China Department of Gastroenterology Shanghai Changhai Hospital Shanghai 200433 China Department of Gastroenterology The First Affiliated Hospital Sun Yat-Sen University Guangzhou Guangdong 510080 China

Background： Helicohacterpylori （H. pylori） frequently colonizes the stomach. Gastroesophageal reflux disease （GERD） is a common and costly disease. But the relationship ofH. pylori and GERD is still unclear. This study aimed to explore the effect ofH. *** and its eradication on reflux esophagitis therapy. Methods： Patients diagnosed with reflux esophagitis by endoscopy were enrolled; based on rapid urease test and Warth-Starry stain, they were divided into H. pylori positive and negative groups. H. pylori positive patients were randomly given H. pylori eradication treatment for 10 days, then esomeprazole 20 mg bid for 46 days. The other patients received esomeprazole 20 mg bid therapy for 8 weeks. After treatment, three patient groups were obtained： H. pylori positive eradicated, H. pylori positive uneradicated, and H. pylori negative. Before and after therapy, reflux symptoms were scored and compared. Healing rates were compared among groups. The x2 test and t-test were used, respectively, for enumeration and measurement data. Results： There were 176 H. pylori positive （with 92 eradication cases） and 180 negative cases. Healing rates in the H. pylori positive eradicated and H. pylori positive uneradicated groups reached 80.4% and 79.8% （P = 0.911）, with reflux symptom scores of 0.22 and 0.14 （P = 0.588）. Healing rates of esophagitis in the 14. pylori positive uneradicated and H. pylori negative groups were, respectively, 79.8% and 82.2% （P = 0.848）; reflux symptom scores were 0.14 and 0.21 （P = 0.546）. Conclusions： Based on esomeprazole therapy, H. pylori infection and eradication have no significant effect on reflux esophagitis therapy.

关键词： Gastroesophageal Reflux Disease Helicobacter pylori Reflux Esophagitis Therapy

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黑潮延伸体区域叶绿素季节变化以及中尺度涡对其影响机制研究

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海洋与湖沼 2020年第6期51卷 1370-1378页

作者：胡松李敏华刘必林周相乾余为上海海洋大学海洋科学学院上海201306 国家远洋渔业工程技术研究中心上海201306 上海河口海洋测绘工程技术研究中心上海201306

中尺度涡是影响西北太黑潮延伸体南北海域叶绿素分布的重要因子。通过对2012—2018年NOAA遥感水色卫星数据和法国COPERNICUS流场资料的统计分析,发现中尺度涡对表层叶绿素浓度的影响具有明显的季节性特征。在春季有17%的气旋涡导致中心... 详细信息

中尺度涡是影响西北太黑潮延伸体南北海域叶绿素分布的重要因子。通过对2012—2018年NOAA遥感水色卫星数据和法国COPERNICUS流场资料的统计分析,发现中尺度涡对表层叶绿素浓度的影响具有明显的季节性特征。在春季有17%的气旋涡导致中心叶绿素高值结构且多数向西传播,而其余季节对叶绿素浓度影响较弱。反气旋涡导致环状叶绿素高值结构,在春、秋两季常有发生,在冬夏出现频次少。中尺度涡影响叶绿素能力的季节差异可能与营养盐背景场、光限制、等密线等季节性变化有关,不能只考虑风和流场的垂向输运机制。叶绿素浓度在一定程度上反映浮游植物生物量,对黑潮延伸体海域有重要生态意义。因此,该区域服务渔业的中尺度涡研究应该考虑这种季节特征。

关键词：黑潮延伸体中尺度涡叶绿素生态系统动力学

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Combined acoustic radiation force impulse, aminotransferase to platelet ratio index and Forns index assessment for hepatic fibrosis grading in hepatitis B

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World Journal of Hepatology 2016年第14期8卷 616-624页

作者： Chang-Feng Dong Jia Xiao ling-Bo Shan Han-Ying Li Yong-Jia Xiong Gui-lin Yang Jing liu Si-min Yao Sha-Xi Li Xiao-hua Le Jing Yuan Bo-Ping zhou George L Tipoe Ying-Xia liu Division of Ultrasound Shenzhen Third People’s Hospital National Key Disciplines for Infectious Diseases Shenzhen Third People’s Hospital Department of Immunobiology Institute of Tissue Transplantation and Immunology Jinan University Department of Pathology Shenzhen Third People’s Hospital School of Biomedical Sciences LKS Faculty of Medicine the University of Hong Kong

AIM: To investigate the combined diagnostic accuracy of acoustic radiation force impulse(ARFI), aspartate aminotransferase to platelet ratio index(APRI) and Forns index for a non-invasive assessment of liver fibrosis in patients with chronic hepatitis B(CHB). METHODS: In this prospective study, 206 patients had CHB with liver fibrosis stages F0-F4 classified by METAVIR and 40 were healthy volunteers were measured by ARFI, APRI and Forns index separately or combined as indicated. RESULTS: ARFI, APRI or Forns index demonstrated a significant correlation with the histological stage(all P < 0.001). According to the AUROC of ARFI and APRI for evaluating fibrotic stages more than F2, ARFI showed an enhanced diagnostic accuracy than APRI(P < 0.05). The combined measurement of ARFI and APRI exhibited better accuracy than ARFI alone when evaluating ≥ F2 fibrotic stage(Z = 2.77, P = 0.006). Combination of ARFI, APRI and Forns index did not obviously improve the diagnostic accuracy compared to the combination of ARFI and APRI(Z = 0.958, P = 0.338). CONCLUSION: ARFI + APRI showed enhanced diagnostic accuracy than ARFI or APRI alone for significant liver fibrosis and ARFI + APRI + Forns index shows the same effect with ARFI + APRI.

关键词： Acoustic radiation force impulse Aspartate aminotransferase to platelet ratio index Forns index Hepatitis B virus Non-invasive diagnosis

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酸改性对褐煤半焦脱除烟气中元素态汞性能的影响

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中国环境科学 2014年第12期34卷 3056-3061页

作者：王力刘秀丽张林林李敏张华伟山东科技大学化学与环境工程学院山东青岛266590

为减少燃煤烟气中零价汞的排放,利用HCl和HNO3溶液对褐煤半焦改性研制了一种高效、低成本的吸附剂.运用酸碱滴定、Boehm滴定、BET、SEM和FTIR等技术对半焦吸附剂的表面特性进行表征与分析,利用固定床吸附实验装置及烟气测汞仪在线考察... 详细信息

为减少燃煤烟气中零价汞的排放,利用HCl和HNO3溶液对褐煤半焦改性研制了一种高效、低成本的吸附剂.运用酸碱滴定、Boehm滴定、BET、SEM和FTIR等技术对半焦吸附剂的表面特性进行表征与分析,利用固定床吸附实验装置及烟气测汞仪在线考察了半焦吸附剂对气态Hg0的吸附特性.结果表明,酸改性使半焦灰分含量降低,增加了半焦比表面积和羧基、酚羟基等官能团含量.酸改性处理可提高半焦对元素态单质汞的脱除效率,特别是盐酸溶液改性褐煤半焦可使吸附温度为140℃时的脱汞效率显著提高,这与改性半焦表面羧基、酚羟基和C-Cl官能团的含量及性质有关,半焦表面这些官能团能为Hg0的化学吸附提供活性位.

关键词：褐煤半焦 Hg^0 酸改性半焦酸性官能团

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基于核酸侵入反应偶联PCR的粪便样本基因甲基化定量分析方法及用于结直肠癌无创筛查

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分析化学 2018年第10期46卷 1552-1559页

作者：刘琳琳齐谢敏邹秉杰宋沁馨周国华中国药科大学药物质量与安全预警教育部重点实验室南京军区南京总医院药理科

从粪便中检测BMP3基因甲基化水平可实现对结直肠癌的无创筛查,但对检测方法的灵敏度与特异性要求很高。本研究将核酸侵入反应与实时荧光聚合酶链式反应(PCR)偶联,建立了BMP3基因甲基化检测方法,以ACTB基因作为参比基因,通过优化反应体... 详细信息

从粪便中检测BMP3基因甲基化水平可实现对结直肠癌的无创筛查,但对检测方法的灵敏度与特异性要求很高。本研究将核酸侵入反应与实时荧光聚合酶链式反应(PCR)偶联,建立了BMP3基因甲基化检测方法,以ACTB基因作为参比基因,通过优化反应体系中探针浓度、Flap核酸内切酶与Taq酶用量,提高BMP3目标基因与ACTB参比基因的扩增效率至接近100%,实现了利用ΔCT法进行BMP3基因甲基化水平的相对定量,可对低至10 copies的甲基化BMP3基因进行检测,并可从非甲基化模板中准确定量0.01%的甲基化模板,非甲基化模板不产生非特异性信号,表明本方法具有极高的灵敏度与良好的特异性。将本方法用于16例结直肠癌患者、7例结直肠腺瘤患者及19例健康人粪便样本中BMP3基因甲基化检测,结果表明,有5例结直肠癌患者的粪便样本检出BMP3基因甲基化,2例结直肠腺瘤患者的粪便样本检出BMP3甲基化,健康人的粪便样本均没有检出甲基化,表明本方法可用于检测粪便样本中基因的甲基化水平,为临床开展基于粪便中基因甲基化检测的无创结直肠癌筛查提供了新方法。

关键词： DNA甲基化实时荧光聚合酶链式反应核酸侵入反应结直肠癌粪便DNA

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Low RASSF6 expression in pancreatic ductal adenocarcinoma is associated with poor survival

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World Journal of Gastroenterology 2015年第21期21卷 6621-6630页

作者： Hui-lin Ye Dou-Dou Li Qing lin Yu zhou Quan-Bo zhou Bing Zeng Zhi-Qiang Fu Wen-Chao Gao Yi-min liu Rui-Wan Chen Zhi-hua Li Ru-Fu Chen Department of Hepatobiliary Surgery Sun Yat-sen Memorial HospitalSun Yat-sen University Department of Radiotherapy Sun Yat-sen Memorial HospitalSun Yat-sen University Department of Radiotherapy the First Affiliated Hospital of Sun Yat-sen University Department of Medical Oncology Sun Yat-sen Memorial HospitalSun Yat-sen University

AIM:To analyze RASSF6 expression in pancreatic ductal adenocarcinoma(PDAC) and to determine whether RASSF6 has an independent prognostic value in ***:We studied RASSF6 expression in 96 histologically confirmed PDAC samples and 20 chronic pancreatitis specimens using immunohistochemistry and real-time quantitative reverse *** issues were then classified as RASSF6 strongly positive,weakly positive or ***6 mR NA and protein expression in PDAC samples with strong positive staining was further evaluated using real-time PCR and Western blot ***,correlations between RASSF6 staining and patients' clinicopathological variables and outcomes were ***:RASSF6 was negatively expressed in 51(53.1%) PDAC samples,weakly positively expressed in 29(30.2%) and strongly positively expressed in16(16.7%),while its expression was much higher in para-tumor tissues and chronic pancreatitis *** relationships between RASSF6 expression and T-stage(P = 0.047) and perineural invasion(P = 0.026) were *** median survival time of strongly and weakly positive and negative RASSF6 staining groups was 33 mo,15 mo and 11 mo,*** multivariate analysis indicated that RASSF6 was an independent prognostic indicator of overall survival in patients with PDAC.A survival curve analysis revealed that increased RASSF6 expression was correlated with better overall survival(P = 0.009).CONCLUSION:RASSF6 expression is an independent biomarker of an unfavorable prognosis in patients with PDAC.

关键词： Pancreatic cancer Pancreatic ductaladenocarcinoma Prognostic marker RASSF6 K-ras Immunohistochemistry Survival analysis

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Detection and classification of breast lesions using multiple information on contrast-enhanced mammography by a multiprocess deep-learning system: A multicenter study

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Chinese Journal of Cancer Research 2023年第4期35卷 408-423页

作者： Yuqian Chen Zhen hua Fan lin Tiantian Zheng Heng zhou Shijie Zhang Jing Gao Zhongyi Wang huafei Shao Wenjuan Li Fengjie liu Simin Wang Yan Zhang Feng Zhao Hao liu Haizhu Xie Heng Ma Haicheng Zhang Ning Mao School of Information and Electronic Engineering Shandong Technology and Business UniversityYantai 264005China Department of Radiology Yantai Yuhuangding HospitalAffiliated Hospital of Qingdao UniversityYantai 264000China School of Medical Imaging Binzhou Medical UniversityYantai 264003China Department of Radiology Fudan University Cancer CenterShanghai 200433China Department of Radiology Guangdong Maternal and Child Health HospitalGuangzhou 510010China School of Computer Science and Technology Shandong Technology and Business UniversityYantai 264005China Yizhun Medical AI Co.Ltd. Beijing 100080China Big Data and Artificial Intelligence Laboratory Yantai Yuhuangding HospitalAffiliated Hospital of Qingdao UniversityYantai 264000China

Objective: Accurate detection and classification of breast lesions in early stage is crucial to timely formulate effective treatments for patients. We aim to develop a fully automatic system to detect and classify breast lesions using multiple contrast-enhanced mammography(CEM) ***: In this study, a total of 1,903 females who underwent CEM examination from three hospitals were enrolled as the training set, internal testing set, pooled external testing set and prospective testing set. Here we developed a CEM-based multiprocess detection and classification system(MDCS) to perform the task of detection and classification of breast lesions. In this system, we introduced an innovative auxiliary feature fusion(AFF)algorithm that could intelligently incorporates multiple types of information from CEM images. The average freeresponse receiver operating characteristic score(AFROC-Score) was presented to validate system’s detection performance, and the performance of classification was evaluated by area under the receiver operating characteristic curve(AUC). Furthermore, we assessed the diagnostic value of MDCS through visual analysis of disputed cases,comparing its performance and efficiency with that of radiologists and exploring whether it could augment radiologists’ ***: On the pooled external and prospective testing sets, MDCS always maintained a high standalone performance, with AFROC-Scores of 0.953 and 0.963 for detection task, and AUCs for classification were 0.909[95% confidence interval(95% CI): 0.822-0.996] and 0.912(95% CI: 0.840-0.985), respectively. It also achieved higher sensitivity than all senior radiologists and higher specificity than all junior radiologists on pooled external and prospective testing sets. Moreover, MDCS performed superior diagnostic efficiency with an average reading time of 5 seconds, compared to the radiologists’ average reading time of 3.2 min. The average performance of all radiologists was also improved to

关键词： Deep learning contrast-enhanced mammography breast lesions detection classification

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两种酸处理对褐煤半焦表面性质及其脱汞性能的影响

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功能材料 2014年第11期45卷 11046-11050页

作者：王力刘秀丽张林林李敏张华伟山东科技大学化学与环境工程学院山东青岛266590

分别用浓度为25%HNO3和25%H2SO4溶液制备改性半焦,并在固定床吸附装置上以氮气作为载气携带汞蒸气,对比研究了半焦的脱汞性能,分析了半焦脱汞影响因素。利用酸碱滴定、Boehm滴定、SEM、BET、FT-IR、XRD等方法对改性前后半焦的物化性质... 详细信息

分别用浓度为25%HNO3和25%H2SO4溶液制备改性半焦,并在固定床吸附装置上以氮气作为载气携带汞蒸气,对比研究了半焦的脱汞性能,分析了半焦脱汞影响因素。利用酸碱滴定、Boehm滴定、SEM、BET、FT-IR、XRD等方法对改性前后半焦的物化性质进行了表征。结果表明,硝酸和硫酸氧化降低了半焦的灰分含量,提高了改性半焦含氧、含氮和磺酸基团的含量。在吸附温度为30和140℃时,硝酸改性半焦对气态单质汞的脱除效率均提高;而硫酸改性后,只能提高吸附温度为140℃时的除汞效率,这与改性半焦表面性质及其酸性官能团含量有关。

关键词：褐煤半焦气态单质汞酸改性半焦酸性官能团

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异步轧制对硅钢极薄带三次再结晶的影响

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材料科学与工艺 2005年第4期13卷 384-386页

作者：高秀华齐克敏叶何舟邱春林东北大学轧制技术及连轧自动化国家重点实验室辽宁沈阳110004

分别采用同步和异步轧制将成品工业取向硅钢板冷轧到0.045—0.10mm,然后在纯氢气热处理炉中进行三次再结晶高温退火,研究轧制工艺参数对取向硅钢极薄带织构和磁性能的影响,探索异步轧制对硅钢极薄带三次再结晶行为影响机理.结果表明,采... 详细信息

分别采用同步和异步轧制将成品工业取向硅钢板冷轧到0.045—0.10mm,然后在纯氢气热处理炉中进行三次再结晶高温退火,研究轧制工艺参数对取向硅钢极薄带织构和磁性能的影响,探索异步轧制对硅钢极薄带三次再结晶行为影响机理.结果表明,采用异步轧制取向硅钢极薄带的磁性能优于同步轧制的;硅钢极薄带厚度愈薄,磁性能愈好,三次再结晶发展得越完善.

关键词：异步轧制硅钢极薄带三次再结晶织构磁性能

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