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Chinese Medical Journal 2009年第11期122卷 1342-1345页

作者： CHEN Gong WU Xing YAO Yu zhou Liang-fu mao Ying Department of Neurosurgery Huashan Hospital Fudan University Shanghai 200040 China

O6-Methylguanine-DNA methyltransferase （MGMT） is a cellular DNA repair protein that rapidly reverses alkylation （e.g. methylation） at the O6 position of guanine, thereby neutralizing the cytotoxic effects of alkylating agent therapy such as temozolomide （TMZ） and carmustine. It has been shown that epigenetic silencing of the MGMT gene by promoter methylation shuts down gene transcription and reflects a common alteration in primary human tumors leading to MGMT deficiency. Epigenetic silencing of the MGMT gene has been shown to correlate with improved survival in several studies of glioma patients treated with the alkylating agent therapy and has been substantiated in two clinical trials.

关键词： O6-methylguanine-DNA-methyltransferase real-time PCR methylation-specific PCR glioma drug resistance

Separation of the ionospheric and thermospheric contributions in the data from the Triple Ionosophere Photo Meter onboard the Feng-Yun 3E satellite

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Science China Earth Sciences 2025年第1期68卷 172-184页

作者： Fang JIANG Tian mao Jin-Song WANG Xiu-Qing HU Xiao-Xin ZHANG Liping fu Nan JIA Tianfang WANG National Space Science Center Chinese Academy of Sciences Beijing Key Laboratory of Space Environment Exploration Key Laboratory of Environmental Space Situation Awareness Technology National Satellite Meteorological Center China Meteorological Administration

The Triple Ionosphere Photo Meter （TRIPM） is a far ultraviolet nadir-view photometer that is onboard the secondgeneration,polar-orbiting Chinese meteorological satellite Feng-Yun 3E （FY-3E）,which was launched on July 5,*** has three channels,and each is used to measure different types of emissions:（1） 135.6 nm airglow produced by the recombination of the O+ions and electrons in the absence of sunlight （nighttime channel）;（2） 135.6 nm airglow from the OI when sunlight is present （daytime/dusk-dawn 135.6 nm channel）;and （3） Airglow in the N2LBH of the TRIPM （daytime/dusk-dawn N2LBH channel）.FY-3E is a satellite operating in the early morning ***,the data are mostly distributed on the dawndusk side or at times when the solar zenith angle is relatively *** this study,combined with simulation calculations,the data are *** further explore the application value of the data products,a model is used to separate the ionospheric radiative recombination contribution from the thermosphere photoelectron impact excitation contribution in the data from the daytime/dusk-dawn 135.6 nm *** approach not only improves the accuracy of O/N2derived from the 135.6 nm channel and N2LBH channel but also provides the ionospheric 135.6 nm radiance at the same time as the *** results show that the 135.6 nm radiance originating from the combination of O+and electrons extracted from the measurement data exhibits similar equatorial anomaly peak structure characteristics and seasonal variations as the corresponding GPS total electron content （TEC） *** the other hand,the separated 135.6 nm radiance generated from the thermosphere photoelectron collision excitation does not contain radiative recombination contributions;thus,the ionosphere influence is greatly avoided when the O/N2is obtained.

关键词： Far ultraviolet 135.6 nm emission intensity Photoelectron impact excitation Radiative recombination excitation

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Erzhi pills ameliorates cognitive dysfunction and alter proteomic profiles of hippocampus in ovariectomized Alzheimer disease model rats induced by D-galactose and Aβ1-40 injection

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中国药理学与毒理学杂志 2021年第9期35卷 658-659页

作者： XIE Yong-yan HOU Min zhou mao-fu YAN Bo LIU Chao YAO Li-hua SUN Men-sheng HE Kun FANG Cong CHEN Yao-hui HUANG Li-ping LIU Bo School of Pharmacy Jiangxi University of Traditional Chinese MedicineNanchang 330004China College of traditional Chinese medicine Jiangxi University of Traditional Chinese MedicineNanchang 330004China the Second People′s Hospital of Jingdezhen Jingdezhen 333099China Shandong Qidu Pharmaceutical Co. Ltd.Zibo 255400China Jiangxi Provincial People′s Hospital Affiliated to Nanchang University Nanchang 330006China China Pharmaceutical University Nanjing 211198China School of Life Science Jiangxi Science&Technology Normal UniversityNanchang 330096China 不详

OBJECTIVE Erzhi pills is a clas⁃sic prescription of Chinese medicine originated from fu Shou Jing Fang in Ming dynasty,with the effects of nourishing kidney-Yin and hemosta⁃sis,black hair,strengthening muscles and *** a classical prescription for nourishing kidney-Yin,Erzhi pills has been used to treat senile dementia in China for many ***,our study aimed to investigate the protective effects of Erzhi pills in rat models of Alzheimer disease(AD)induced by ovariectomy as well as D-galactose and Aβ1-40 injection and to explore its potential *** The model of AD rats was established by ovariectomy com⁃bined with D-galactose and Aβ1-40 *** rats were randomly divided into four groups:model group,estradiol valerate(0.80 mg·kg-1)group,Erzhi pills high(1.50 mg·kg-1)and low(0.75 mg·kg-1)doses *** addition,rats of sham operation were selected as the sham operated *** for the sham oper⁃ated group,rats were injected intraperitoneally with D-galactose(100 mg·kg-1 per day,for 49 d)on the 8th day,then they were given intracerebro⁃ventricular injection of Aβ1-40(10μg per rat,1 g·L-1)on the 36th day,while the corresponding drugs were given by gastrointestinal administra⁃tion on the 22nd *** our study,Morris water maze test was used to evaluate the learning and memory abilities,while ELISA kit was used to an⁃alyze serum estrogen *** morphology of hippocampal neuron cells was observed by HE staining,and Nissl staining was utilized to ob⁃serve the Nissl body in ***,the ex⁃pression of ERβpositive cells and hippocampal Aβ1-40 and p-Tau404 proteins was determined by *** order to further explore the molecular mechanism of Erzhi pills preven⁃tion and treatment of AD,proteomics was used to find potential targets and related pathways,Western blotting was used to verify the expres⁃sion of candidate differential *** to the results of proteomics in our experiment,Western blotting w

关键词： Erzhi pills Alzheimer disease hip⁃pocampal neurons proteomics estrogen aging memory PI3K/Akt signaling pathway

Modular assembly of Co4-thiacalix[4]arene units and Keggin-type SiW12O40 for visible-light photothermal conversion

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Tungsten 2025年第1期7卷 112-119页

作者： Jia-Hui Li Qing Zhao Dong-Ao mao Kun zhou Bao-Kuan Chen Yan-Feng Bi School of Petrochemical Engineering Liaoning Petrochemical University

The construction of metal-organic coordination clusters（MCCs） using modular secondary building units is an important method for preparing functional *** this study,two new MCCs modularly assembled from Keggin-type {SiW12O40}H4TC4A=p-tert-Butylthiacalix[4]arene(SiW12) units and thiacalixarene-supported Co4-thiacalix[4]arene(Co4-TC4A polynuclear second-building units（PSBUs,H4TC4A=p-tert-Butylthiacalix[4]arene） are *** two MCCs,abbreviated as Co4-SiW12and Co8-SiW12,were structurally characterized by single-crystal X-ray *** Co4-SiW12is a supramolecular structure involving cation-anion interactions between Co4-TC4A PSBUs and ***8-SiW12features "barbell-like" shapes with two Co4-TC4A coordinatively linked to a Keggin-type SiW12unit on opposite via W-O_t-Co *** coordination of Co4-TC4A to SiW12in Co8-SiW12resulted in significantly improved photothermal conversion performances compared with Co4-SiW12and pure SiW12or ***-gap determination and photophysical analysis combined with density functional theory calculations indicated the binding mode between Co4-TC4A PSBUs and SiW12,which considerably influences the way of electron transport and the conversion ability of visible light to heat.

关键词： Modular construction Photothermal conversion Polyoxometalate Thiacalixarene

有限切开锁定钢板内固定治疗胫骨Pilon骨折的临床效果观察

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中国当代医药 2014年第19期21卷 151-153页

作者：周福茂湖南省怀化市辰溪县中医医院骨科湖南辰溪419500

目的探讨应用有限切开锁定钢板内固定治疗胫骨Pilon骨折的临床效果。方法选取本院2011年1月~2013年1月收治的胫骨Pilon骨折患者50例,均给予有限切开内固定治疗,随机分为观察组和对照组各25例,观察组给予锁定钢板内固定,对照组给予解剖... 详细信息

目的探讨应用有限切开锁定钢板内固定治疗胫骨Pilon骨折的临床效果。方法选取本院2011年1月~2013年1月收治的胫骨Pilon骨折患者50例,均给予有限切开内固定治疗,随机分为观察组和对照组各25例,观察组给予锁定钢板内固定,对照组给予解剖钢板内固定,比较两组的疗效。结果观察组骨折愈合时间明显短于对照组[（12.6±3.4）周vs（19.7±3.6）周],并发症发生率明显低于对照组（8.0%vs 24.0%）,治疗优良率明显高于对照组（88.0%vs 68.0%）,差异有统计学意义（P〈0.05）。结论有限切开锁定钢板内固定治疗胫骨Pilon骨折效果显著,值得临床推广。

关键词： Pilon骨折有限切开锁定钢板内固定

Review of precipitation strengthening in ultrahigh-strength martensitic steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 256-269页

作者： Zhihao Tian Chunlei Shang Chaolei Zhang Xiaoye zhou Honghui Wu Shuize Wang Guilin Wu Junheng Gao Jiaming Zhu Xinping mao Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China Institute of Steel Sustainable Technology Liaoning Academy of MaterialsShenyang 110004China Department of Materials Science and Engineering Shenzhen MSU-BIT UniversityShenzhen 518172China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China School of Civil Engineering Shandong UniversityJinan 250061China

Martensite is an important microstructure in ultrahigh-strength steels,and enhancing the strength of martensitic steels often involves the introduction of precipitated phases within the martensitic *** considerable research efforts devoted to this area,a systematic summary of these advancements is *** review focuses on the precipitates prevalent in ultrahigh-strength martensitic steel,primarily carbides(e.g.,MC,M_(2)C,and M_(3)C)and intermetallic compounds(e.g.,Ni Al,Ni_(3)X,and Fe_(2)Mo).The precipitation-strengthening effect of these precipitates on ultrahigh-strength martensitic steel is discussed from the aspects of heat treatment processes,microstructure of precipitate-strengthened martensite matrix,and mechanical ***,a perspective on the development of precipitation-strengthened martensitic steel is presented to contribute to the advancement of ultrahigh-strength martensitic *** review highlights significant findings,ongoing challenges,and opportunities in the development of ultrahigh-strength martensitic steel.

关键词： ultrahigh-strength martensitic steel precipitation strengthening mechanical property carbide intermetallic compound

110kV主变经受短路冲击后的绕组变形综合诊断分析

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变压器 2016年第10期53卷 66-68页

作者：周旋毛欣付斌夏维建国网重庆市电力公司永川供电分公司重庆402160

介绍了一起110k V变压器经受短路冲击后的故障情况。在油色谱、直流电阻和变比数据正常的情况下,运用频率响应法、电容量测试及低电压短路阻抗法对绕组变形情况进行了判断,给出了解决方法。

关键词：变压器绕组分析

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《伤寒论》第29条救误启迪

江西中医学院学报 2009年第6期21卷 10-11页

作者：周茂福江西中医学院南昌330006

《伤寒论》第29条实为仲景明示救治坏病治则之典型范例。读仲景之书,重要的是要学会辨证思维的方法,临床失误时,要善于分析不同的致误原因,总结教训,明确救误的原则、步骤,积极应对,果断处理,以提高临床疗效,更好地为患者服务。

关键词：张仲景伤寒论救误体会

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伍炳彩治杂病验案撷英

江西中医药 2006年第3期37卷 7-8页

作者：周茂福江西中医学院南昌330006

伍炳彩教授,擅长治疗各种疑难杂症,笔者师承伍炳彩教授,现将其治疗杂病验案二则整理如下.例1.猪苓汤治头昏失眠:吴某某,女,35岁,农民.1978年6月21日初诊.患者头昏失眠2个月余,头昏厉害时伴视物旋转,但不呕吐,走路需人搀扶,胆小易惊,不... 详细信息

伍炳彩教授,擅长治疗各种疑难杂症,笔者师承伍炳彩教授,现将其治疗杂病验案二则整理如下.例1.猪苓汤治头昏失眠:吴某某,女,35岁,农民.1978年6月21日初诊.患者头昏失眠2个月余,头昏厉害时伴视物旋转,但不呕吐,走路需人搀扶,胆小易惊,不敢过马路,失眠多梦,口渴不欲多饮.

关键词：伍炳彩杂病猪苓汤温胆汤

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液体晃荡自由液面波高的相似关系的实验研究

船舶力学 2020年第3期24卷 282-293页

作者：卫志军申利敏王梓名周茂夫阮诗伦岳前进大连理工大学海岸和近海工程国家重点实验室大连116023 大连理工大学工业装备结构分析国家重点实验室大连116023

采用模型实验进行液体晃荡问题研究时,相似关系是模型实验设计及结果分析中的一个关键问题,目前尚没有系统的针对不同比尺下液舱晃荡波高的相似关系研究。本文采用三个不同比尺的二维GTT八边形液舱,对比分析了不同比尺的模型液舱在单次... 详细信息

采用模型实验进行液体晃荡问题研究时,相似关系是模型实验设计及结果分析中的一个关键问题,目前尚没有系统的针对不同比尺下液舱晃荡波高的相似关系研究。本文采用三个不同比尺的二维GTT八边形液舱,对比分析了不同比尺的模型液舱在单次激励下液体晃荡冲击的完整过程。结合波高幅值和高速视频研究波高,结果表明液舱晃荡波高均具有双峰形式,三个比尺的液舱整体流场形式相似,但晃荡冲击的物理现象存在差异。在相同实验介质下,大比尺液舱中晃荡冲击现象复杂,而小比尺液舱中晃荡冲击平缓,分析认为粘性是造成该差异的重要原因。此外,晃荡波高的相似关系与比尺有关。

关键词：晃荡模型实验波高相似关系