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Ginsenoside Rg1 changes brain-derived neurotrophic factor expression in the facial nucleus of rats after ovariectomy: A semiquantitative analysis

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Neural Regeneration Research 2009年第5期4卷 383-389页

作者： Cuiying zhou Wenlong luo Dong Wang Department of Otolaryngology-Head and Neck Surgery Second Affiliated Hospital Chongqing Medical University Chongqing 400010 China

BACKGROUND： Estrogen is neuroprotective effects such as breast carcinoma, endometria but long-term estrogen treatment can induce side cancer, and stroke. However, phytoestrogen is neuroprotective without these side effects. OBJECTIVE： To study the effects of Ginsenoside Rgl on facial neurons and brain-derived neurotrophic factor （BDNF） expression in the facial nucleus in ovariectomized rats. DESIGN, TIME AND SETTING： The randomized, controlled animal experiments were performed at the Ultrasonic Institute, Second Affiliated Hospital, Chongqing Medical University, China, from September 2007 to September 2008. MATERIALS： Ginsenoside Rgl （Sigma, USA）, rabbit anti-rat BDNF, Bcl-2, Bax antibodies, biotin-labeled goat anti-rabbit IgG （Boster, China）, and a TUNEL kit （Roche, Germany） were used in this study. METHODS： A total of 48 adult Sprague Dawley rats undergoing ovariectomy were randomly assigned into sham operation （n = 8）, model （n = 20）, and Ginsenoside Rgl （n = 20） groups. Facial nerve damage was induced by bilateral clamping of the facial nerve trunk. The bilateral facial nerve trunk was exposed in the sham operation group, with no clamping. Rats in the Ginsenoside Rgl group were intraperitoneally injected with 10 mg/kg per day Ginsenoside Rgl; other groups received 2 mL saline, once a day, for 14 days. MAIN OUTCOME MEASURES： Morphologic changes in neurons of the facial nucleus were observed following hematoxylin-eosin staining. Neuronal apoptosis was detected by TUNEL. Changes in ultrastructure of the facial nerve fibers were observed with a transmission electron microscope. Expression of BDNF, Bcl-2, and Bax protein was quantified by semiquantitative immunohistochemistry. RESULTS： At 3-14 days following facial nerve damage, Ginsenoside Rgl increased BDNF expression and the number of regenerated nerve fibers, and produced thicker myelin sheaths （P 〈 0.05）. Ginsenoside Rgl also gradually increased Bcl-2 protein expression and decreased Bax protein expression （P 〈

关键词： Ginsenoside Rgl facial nerve damage facial nucleus brain-derived neurotrophic factor apoptosis

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Dopamine Switches Affective States Under Acute Sleep Deprivation

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Neuroscience Bulletin 2024年第8期40卷 1205-1208页

作者： zhou-Cai luo Tian-Ming Gao State Key Laboratory of Organ Failure Research Key Laboratory of Mental Health of the Ministry of EducationGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired IntelligenceGuangdong-Hong Kong Joint Laboratory for Psychiatric DisordersGuangdong Province Key Laboratory of Psychiatric DisordersGuangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi DiseasesDepartment of NeurobiologySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China

The transition of affective states manifests affective regulation,wherein individuals adaptively adjust their emotional states to cope with changes in the external environment,reflecting their sensitivity and adaptability to environmental *** process of affective state transition is complex,involving both instantaneous and persistent changes influenced by environmental,behavioral,and pharmacological *** underlying neural mechanisms encompass alterations in neurotransmitter release,neural circuit activity,and the plasticity of brain structures[1].

关键词： alterations Dopamine neural

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Effect of cerium on wettability of mechanically milled Cu-based brazing alloy powder

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Journal of Rare Earths 2018年第11期36卷 1226-1233页

作者： Qiaoping Wu zhou luo Yu Wang Heng Zhao Weijia Zheng Hunan Provincial Key Laboratory of High Efficiency and Precision Machining of Difficult-to-cut Material Hunan University of Science and Technology

CuSn powders and Till2 powders were milled using high energy mechanical milling to prepare Cu-based alloy powders for brazing diamond. And Ce was added to the milled Cu-based alloy powders to improve the wettability. It is found that the wetting angle reaches the minimum value 13.2° and the maximum spreading area 178 mm2 is achieved when the amount of Ce is 0.75 wt%. And Ce remarkably reduces the surface tension of liquid alloy, which improves the climbing height along the diamond and forms a massive support profile. And the results show that Ce can effectively improve the transverse rupture strength （TRS） due to high wettability. The wear characteristics of the diamonds brazed with Cu-based alloy containing 0.75 wt% Ce mainly consist of integrity, micro-fracture, fracture and rubdown, diamonds pull-out can not easily happen.

关键词： Cu-based alloy powder Ce Wettability Spreading area Climbing height Wear characteristics

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A STUDY ON TRANSIENT FLUID FLOW OF HORIZONTAL WELLS IN DUAL-PERMEABILITY MEDIA

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Journal of Hydrodynamics 2010年第1期22卷 44-50页

作者： WANG Xiao-dong zhou Ying-fang luo Wan-jing School of Energy Resources China University of Geosciences Beijing 100083 China

To adopt horizontal wells in dual media reservoirs, a good understanding of the related fluid flows is necessary. Most of the recent studies focus on dual porosity media instead of dual permeability media. In this article, through both integral transformation and sink-source superposition, a new Laplace-domain solution is obtained for the slightly-compressible fluid flow in the 3-D dual-permeability media in which the horizontal well is operating in a constant rate of production. Major asymptotic characteristics of diagnosis curves of dimensionless downhole pressure are analyzed by the limited analysis. Effects of parameters of dual-permeability media including mobility ratio k, storativity ratio ω and inter-porosity flow parameter k on the downhote pressure are studied by using the Laplace numerical inversion. The new solution obtained in this article includes and improves the previous results and then can be used as a basis for either pressure transient analysis or formation behavior evaluation for the typical reservoir with horizontal wells.

关键词： horizontal well dual-permeability media fluid flow in 3-D porous media transient pressure analysis Laplacetransformation

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Study on characteristics of long-term gravity changes at Wuhan station

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Chinese Science Bulletin 2008年第13期53卷 2033-2040页

作者： XU JianQiao zhou JiangCun luo ShaoCong SUN HePing Key Laboratory of Dynamic Geodesy Institute of Geodesy and Geophysics Chinese Academy of Sciences Wuhan 430077 China

We consider the characteristics of long-term changes in non-tidal gravity and their implication to the local perturbations in barometric pressure and water storage and to the local vertical crustal movement using the long-term continuous gravity observations from a superconducting gravimeter (SG) at Wu-han station,together with the co-site measurements from a Global Positioning System (GPS) receiver and an absolute gravimeter FG5. The observation results indicate that there are obvious seasonal variations in the long-term gravity changes measured with the SG. About 70 percent of the whole sea-sonal changes come from the contribution of the local disturbances in air pressure and water storage,while over 95 percent of the annual changes are attributed to the loading effects of these environmental perturbations. Due to the absence of direct measurements of the local water storage,especially those of the underground water,the global assimilating models of land water LaD (Land Dynamics) and GLDAS (Global Land Data Assimilation System) cannot virtually describe the real hydrologic distur-bances around the station. The resulting gravity changes,which are simulated theoretically by means of convolution integration of the loading Green’s functions and water models LaD and GLDAS,show significantly time delay of about 55 days from those measured with the SG. Compared with the meas-urements of the absolute gravity with the FG5,the long-term drift rate of the SG is determined as about 17.13 nms-2/a. From the co-site GPS measurements,it is found that the local crust is slowly subsiding at a rate of 3.71±0.16 mm/a,and the related gravity variation is estimated as 13.88±0.22 nms-2/a. In other words,the ratio of the changes in gravity and altitude related to the local vertical crustal movement is about -37.41 nms-2/cm. It implies that a considerable mass adjustment may be associated with the local vertical crustal movement,and its dynamic mechanism should be investigated further.

关键词：超导重力计潮汐引力气压水储存量

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FrepJoin:an efficient partition-based algorithm for edit similarity join

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Frontiers of Information Technology & Electronic Engineering 2017年第10期18卷 1499-1510页

作者： Ji-zhou luo Sheng-fei SHI Hong-zhi WANG Jian-zhong LI School of Computer Science and Technology Harbin Institute of Technology Guangdong Key Laboratory of Popular High Performance Computers Key Laboratory of Service Computing and Application

String similarity join(SSJ) is essential for many applications where near-duplicate objects need to be found. This paper targets SSJ with edit distance constraints. The existing algorithms usually adopt the filter-andrefine framework. They cannot catch the dissimilarity between string subsets, and do not fully exploit the statistics such as the frequencies of characters. We investigate to develop a partition-based algorithm by using such *** frequency vectors are used to partition datasets into data chunks with dissimilarity between them being caught easily. A novel algorithm is designed to accelerate SSJ via the partitioned data. A new filter is proposed to leverage the statistics to avoid computing edit distances for a noticeable proportion of candidate pairs which survive the existing filters. Our algorithm outperforms alternative methods notably on real datasets.

关键词： String similarity join Edit distance Filter and refine Data partition Combined frequency vectors

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Improvement and upgrade of mine fire simulation program MFIRE

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Journal of Coal Science & Engineering(China) 2011年第3期17卷 275-280页

作者： zhou Li-hong luo Yi Department of Mining Engineering West Virginia University Morgantown WV26505 USA

MFIRE, an underground mine fire simulation program developed in 1980＇s, is a tool that can be used to simulate the impacts of a mine fire event to a mine ventilation network. However, the lack of the abilities to simulate some of the important mine fire phenomena realistically hindered its wide applications. This research carried out to improve and upgrade the MFIRE 2.20 program to MFIRE 2.30. The new additions of MFIRE 2.30 including a time dependent fire model, smoke rollback prediction, the incorporation of a moving fire source, and a rewriting of MFIRE in Microsoft Visual C＋＋ were interpreted.

关键词： mine fire simulation MFIRE t-square fire smoke rollback conveyor belt fire

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Tempering Process to Improve Hardness Uniformity of Plastic Mould Steel

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Journal of Iron and Steel Research International 2012年第12期19卷 53-58页

作者： MIN Yong-an zhou Quan luo Yi LI Dan WU Xiao-chun School of Materials Science and Engineering Shanghai University Shanghai 200072 China

A new design of copper-bearing non-quenched plastic mold steel is presented and explained. Two kinds of microstrueture can be obtained from this new type copper-bearing steel via cooling with different cooling rates, bain- ite and a mixed microstructure consisting of ferrite and bainite. It is found that, after proper tempering process, the hardness will be increased. Moreover, the hardness difference between different microstructures will be reduced. For further investigation, the samples tempered at different temperatures were examined by XRD and 3PAP （three di- mensional atom probe） analysis. Results show that the improvement is contributed mainly by the precipitation of Cu phase and transformation of residual austenite.

关键词： plastic mould steel tempering process Cu precipitation residual austenite

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O2iJoin： An Efficient Index-Based Algorithm for Overlap Interval Join

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Journal of Computer Science & Technology 2018年第5期33卷 1023-1038页

作者： Ji-zhou luo Sheng-Fei Shi Guang Yang Hong-Zhi Wang Jian-Zhong Li School of Computer Science and Technology Harbin Institute of Technology Harbin 150001 China Guangdong Key Laboratory of Popular High Performance Computers Key Laboratory of Service Computing and Application Shenzhen 518000 China

Time intervals are often associated with tuples to represent their valid time in temporal relations, where overlap join is crucial for various kinds of queries. Many existing overlap join algorithms use indices based on tree structures such as quad-tree, B＋-tree and interval tree. These algorithms usually have high CPU cost since deep path traversals are unavoidable, which makes them not so competitive as data-partition or plane-sweep based algorithms. This paper proposes an efficient overlap join algorithm based on a new two-layer flat index named as Overlap Interval Inverted Index （i.e., O2i Index）. It uses an array to record the end points of intervals and approximates the nesting structures of intervals via two functions in the first layer, and the second layer uses inverted lists to trace all intervals satisfying the approximated nesting structures. With the help of the new index, the join algorithm only visits the must-be-scanned lists and skips all others. Analyses and experiments on both real and synthetic datasets show that the proposed algorithm is as competitive as the state-of-the-art algorithms.

关键词： overlap interval join temporal relation overlap inverted index join algorithm

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Isolation of three cyanins from Lonicera caerulea L. fruits and its anticancer activity

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Journal of Central South University 2017年第7期24卷 1573-1581页

作者： luo zhou-fei YANG Yuan WANG Liang-sheng LI Hai-pu Center for Environment and Water Resources College of Chemistry and Chemical EngineeringCentral South University Key Laboratory of Plant Resources Beijing Botanical GardenInstitute of BotanyChinese Academy of Sciences

Lonicera caerulea *** is an excellent source of bioactive *** efficient separation method of cyanins is important for the development of many value-added products and functional food ***-speed counter-current chromatography(HSCCC) was applied to isolate cyanins from Lonicera caerulea fruits with a biphasic solvent system composed of methyl tert-butyl ether/n-butanol/acetonitrile/water/trifluoroacetic acid(2:2:1:5:0.01,volume ratio).1.41 mg of cyanidin 3,5-O-diglucoside,1.08 mg of cyanidin 3-O-rutinoside and 6.38 mg of cyanidin 3-O-glucoside were obtained from 40 mg of crude *** purities of these compounds were 95.8%,92.4% and 97.6%,respectively,as identified by high-performance liquid chromatography–diode array detection(HPLC-DAD) and high-performance liquid chromatography-electrospray ionization mass spectrometryn(HPLC-ESI/MSn).In addition,the dominant anthocyanin,cyanidin 3-O-glucoside was demonstrated cytotoxic response of human hepatocarcinoma SMMC-7721 cells,inducing live cancer cell apoptotic by flow cytometric analysis.

关键词： cyanins cyanidin 3-O-glucoside isolation anticancer HSCCC HPLC-ESI-MSn

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