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智能版MoCA评估系统在轻度认知功能障碍诊断中的应用价值研究

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中华老年医学杂志 2024年第8期43卷 1019-1024页

作者：汤观秀张秋香刘倩曾晖周可怡颜萍平中南大学湘雅三医院老年病科长沙410013

目的探讨智能版蒙特利尔认知量表(MoCA)评估系统在老年住院患者中识别轻度认知功能障碍(MCI)的价值。方法选取2020年7月至2022年12月期间在中南大学湘雅三医院神经内科和老年病科诊断为MCI的75例患者(MCI组)和195例认知功能正常的患者(... 详细信息

目的探讨智能版蒙特利尔认知量表(MoCA)评估系统在老年住院患者中识别轻度认知功能障碍(MCI)的价值。方法选取2020年7月至2022年12月期间在中南大学湘雅三医院神经内科和老年病科诊断为MCI的75例患者(MCI组)和195例认知功能正常的患者(正常对照组),分别给予智能版MoCA系统评估和简易智能状态检查量表(MMSE)评估,并分析评估结果。结果MCI组MoCA总评分及MMSE总分[(19.73±2.42)分和(24.81±2.33)分]均低于正常对照组[(24.47±2.02)分和(26.50±1.65)分],差异有统计学意义(P<0.01)。智能版MoCA最佳截断值为23.5分,其诊断MCI的灵敏度、特异度、Kappa值(96.0%、82.1%、0.690)均高于MMSE量表(90.0%、62.6%、0.428)。结论智能版对老年MCI具有较高的筛查价值,该系统诊断MCI的敏感性和特异性均高于MMSE。

关键词：轻度认知功能障碍电子化评估蒙特利尔认知评估量表简易智能状态检查量表诊断价值

基于子空间学习的快速自适应局部比值和判别分析

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计算机应用研究 2024年第1期41卷 108-115页

作者：曹传杰王靖赵伟豪周科艺杨晓君广东工业大学信息工程学院广州510006 广东工业大学集成电路学院广州510006

降维是处理高维数据的一项关键技术,其中线性判别分析及其变体算法均为有效的监督算法。然而大多数判别分析算法存在以下缺点:a)无法选择更具判别性的特征;b)忽略原始空间中噪声和冗余特征的干扰;c)更新邻接图的计算复杂度高。为了克服... 详细信息

降维是处理高维数据的一项关键技术,其中线性判别分析及其变体算法均为有效的监督算法。然而大多数判别分析算法存在以下缺点:a)无法选择更具判别性的特征;b)忽略原始空间中噪声和冗余特征的干扰;c)更新邻接图的计算复杂度高。为了克服以上缺点,提出了基于子空间学习的快速自适应局部比值和判别分析算法。首先,提出了统一比值和准则及子空间学习的模型,以在子空间中探索数据的潜在结构,选择出更具判别信息的特征,避免受原始空间中噪声的影响;其次,采用基于锚点的策略构造邻接图来表征数据的局部结构,加速邻接图学习;然后,引入香农熵正则化,以避免平凡解;最后,在多个数据集上进行了对比实验,验证了算法的有效性。

关键词：降维线性判别分析子空间学习比值和

The recirculation flow after different cross-section shaped high-rise buildings with applications to ventilation assessment and drag parameterization

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Building Simulation 2024年第4期17卷 509-524页

作者： keyi Chen Ziwei Mo Jian Hang School of Atmospheric Sciences Sun Yat-sen University&Southern Marine Science and Engineering Guangdong LaboratoryZhuhai519082China Key Laboratory of Tropical Atmosphere-Ocean System Ministry of EducationZhuhai519000China

The building cross-section shape significantly affects the flow characteristics around buildings,especially the recirculation region behind the high-rise *** generic building shapes including square,triangle,octagon,T-shaped,cross-shaped,#-shaped,H-shaped and L-shaped are examined to elucidate their effects on the flow patterns,recirculation length L and areas A using computational fluid dynamics(CFD)simulations with Reynolds-averaged Navier-Stokes(RANS)*** sizes and positions of the vortexes behind the buildings are found to be substantially affected by the building shapes and subsequently changing the recirculation *** recirculation length L is in the range of 1.6b-2.6b with an average of *** maximum L is found for L-shaped building(2.6b)while the shortest behind octagon building(1.6b).The vertical recirculation area Av is in the range of 1.5b^(2)-3.2b^(2)and horizontal area Ah in 0.9b^(2)-2.2b^(2).The L,Av and Ah generally increase with increasing approaching frontal area when the wind direction changes but subject to the dent structures of the#-shaped and cross-shaped *** area-averaged wind velocity ratio(AVR),which is proposed to assess the ventilation performance,is in the range of 0.05 and 0.14,which is around a three-fold difference among the different building *** drag coefficient parameterized by Ah varies significantly,suggesting that previous models without accounting for building shape effect could result in large uncertainty in the drag *** findings provide important reference for improving pedestrian wind environment and shed some light on refining the urban canopy parameterization by considering the building shape effect.

关键词： recirculation region cross-section shape ventilation assessment drag parameterization computational fluid dynamics

Copper/Photoredox-Catalyzed Regioselective 1,4-Addition to 1,3-Enynes: A Convenient Access to Perfluoroalkylated Allenes

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Chinese Journal of Chemistry 2024年第17期42卷 2023-2028页

作者： Ya Chen Quanyuan Wang keyi Peng Lilei Cheng Ziyi She Guo-Jun Deng Key Laboratory for Green Organic Synthesis and Application of Hunan Province Key Laboratory of EnvironmentallyFriendly Chemistry andApplication of Ministryof EducationCollege of ChemistryXiangtan UniversityXiangtanHunan 411105China Department School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiangHenan 453007China

A general and broadly applicable copper and photoredox dual-catalyzed multicomponent 1,4-perfluoroalkylcyanation of 1,3-enynes has been *** protocol enjoys success with high regioselectivity,mild reaction conditions,and excellent functional-group tolerance,allowing the facile synthesis of structurally diverse perfluoroalkylated allenes from readily available fluoroalkyl halides,1,3-enynes and TMscN in a one-pot manner.A reasonable mechanism has been proposed according to a series of control experiments.

关键词： Fluorinated allenes 1 3-Enynes Photoredox Fluoroalkylation Multicomponent reactions Difunctionalization Radicals Regioselectivity

Transcriptomic analysis on cucumber tendril reveals GLRs play important roles in thigmotropism and thigmomorphogenesis

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Horticultural Plant Journal 2024年第5期10卷 1177-1186页

作者： Mengzhuo Zhang Bowen Wang Shenhao Wang Tongxu Xin keyi Ye Sanwen Huang Xueyong Yang State Key Laboratory of Vegetable Biobreeding Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 100081China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518120China College of Horticulture Northwest A&F UniversityYanglingShaanxi 712100China

Thigmotropism and thigmomorphogenesis are two related and pervasive processes that play crucial roles in plant adaptation to the ***,there have been few investigations into the molecular regulatory mechanisms of these ***(Cucumis sativus L.)tendrils are ideal material for studying thigmotropism and thigmomorphogenesis because they display a combination of the two ***,we generated the transcriptome profiles of cucumber tendrils at the young,stretch,and coiling *** related to receptor proteins,transmembrane transport,and ion transport were significantly enriched among those differentially expressed between *** assays illustrated that three GLUTAMATE RECEPTOR(GLR)genes might play a vital function in perceiving or transducing touch stimulation *** the transcriptomes of tendrils and roots after touch stimulation,we found that genes related to extracellular stimulus and xyloglucan metabolism might have conserved functions in the regulation of *** transcriptome atlas of thigmotropism and thigmomorphogenesis of cucumber tendrils constructed in this study will help further elucidate the molecular mechanisms behind these processes.

关键词： Cucumber Thigmotropism Thigmomorphogenesis Transcriptome Tendril GLUTAMATE RECEPTOR

Carboniferous integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 1071-1106页

作者： keyi HU Xiangdong WANG Wenqi WANG Yingfan SONG Xunyan YE Lu LI Yukun SHI Sunrong YANG Ying LI State Key Laboratory for Mineral Deposits Research School of Earth Sciences and Engineering and Frontiers Science Center for Critical Earth Material CyclingNanjing UniversityNanjing 210023China

During the Carboniferous Period,the Qinghai-Tibetan Plateau and its surrounding areas were located in quite different paleogeographic positions with various sedimentary and biological *** is important to systematically compile and summarize the Carboniferous strata and biotas of the Qinghai-Tibetan Plateau and its surrounding areas,to establish an integrated stratigraphic framework for correlation,and to reconstruct the paleogeography for correctly understanding the breakup of the Gondwana Continent and the evolution of the Paleo-Tethys Ocean in the Late *** Carboniferous of the Qinghai-Tibetan Plateau and its surrounding areas can be subdivided into the Gondwanan,Cimmerian,and Tethyan *** Gondwanan-type Carboniferous are distributed in the North Himalayan,Kangmar-Lhunze,and Zanda-Zumba regions of the South Tibet Subprovince and northern India-Pakistan Area,where only the Mississippian is developed and the biota is of Gondwanan *** Cimmerian-type Carboniferous,which are found in the Baoshan,Tengchong,Coqen-Xainza,LhasaZayu,Nagqu-Biru,and South Qiangtang regions,as well as Shan-Thai and South Afghanistan-Pamir areas,also represent only the Mississippian strata,but their biota is characterized by mixed characters of European,South China,Australian,and North American *** Tethyan-type Carboniferous are distributed in the Tanggula Mountains,Hoh Xil-Bayanhar,ChamdoHengduanshan,Tiekelike,West Kunlun,Karakorum,East Kunlun-Central Qinling,and Qilian regions,where the Carboniferous succession is well developed,and the biota is of warm-water Tethyan *** biostratigraphical correlation of the Gondwanan-type and Cimmerian-type Carboniferous is based mainly on conodonts and additionally on brachiopods and rugose *** Mississippian of the Tethyan-type Carboniferous is correlated mainly by using rugose corals and brachiopods,whereas in the Pennsylvanian foraminifera(fusuline)and conodonts are regarded as primary fossil groups,subord

关键词： Qinghai-Tibetan Plateau Carboniferous Lithostratigraphy Biota Stratigraphic correlation

十八胺在碳钢表面吸附和成膜的分子动力学研究

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核动力工程 2023年第2期44卷 203-209页

作者：李超黄军林王露周克毅东南大学能源热转换及其过程测控教育部重点实验室南京210096 中国电力工程顾问集团华东电力设计院有限公司上海200063

华龙一号机组主给水系统大量使用P280GH碳钢管道,并应用十八胺(ODA)在管道内壁吸附形成缓蚀膜,ODA可高效抑制腐蚀,避免管道失效和蒸汽发生器(SG)严重结垢。但ODA在碳钢表面的吸附和成膜机理目前仍不明确,严重制约了ODA的性能优化和推广... 详细信息

华龙一号机组主给水系统大量使用P280GH碳钢管道,并应用十八胺(ODA)在管道内壁吸附形成缓蚀膜,ODA可高效抑制腐蚀,避免管道失效和蒸汽发生器(SG)严重结垢。但ODA在碳钢表面的吸附和成膜机理目前仍不明确,严重制约了ODA的性能优化和推广应用,针对该问题,采用分子动力学(MD)模拟开展研究。结果表明,ODA分子头部的氮原子与碳钢表面铁原子形成配位键,促使ODA分子吸附“锚定”。所形成缓蚀膜的微观构型与ODA浓度相关。浓度较低时,缓蚀膜呈ODA分子尾链间交织较差的单层构型,随着浓度增加,缓蚀膜逐渐演变为ODA分子尾链间紧密交织的复杂双层构型。在ODA浓度超过一定阈值后,缓蚀膜的构型不再显著变化,未吸附成膜的ODA分子最终积聚形成胶体微团。

关键词：十八胺(ODA) 分子动力学(MD)模拟 P280GH碳钢缓蚀膜蒸汽发生器(SG)

汽轮机中间分隔轴封漏汽对热耗率影响的分析与计算

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中国电机工程学报 2012年第26期32卷 10-17,140页

作者：张赟胥建群李刚周克毅东南大学能源热转换及其过程测控教育部重点实验室江苏省南京市210096 苏州热工研究院江苏省苏州市215004

利用小偏差理论,分析了汽轮机定主蒸汽流量时,中间分隔轴封漏汽量变化对汽轮机各缸做功量、过再热吸热量以及热耗率的影响。结果表明,当中间分隔轴封漏汽量变化时,汽轮机高压缸做功量与再热吸热量变化较大,中低压缸做功量变化较小。同时... 详细信息

利用小偏差理论,分析了汽轮机定主蒸汽流量时,中间分隔轴封漏汽量变化对汽轮机各缸做功量、过再热吸热量以及热耗率的影响。结果表明,当中间分隔轴封漏汽量变化时,汽轮机高压缸做功量与再热吸热量变化较大,中低压缸做功量变化较小。同时,对某台超临界660 MW机组进行了变工况计算。结果显示,当中间分隔轴封漏汽量增加时,汽轮机各段做功量、再热吸热量及热耗率近似线性变化,各部分的变化情况与理论分析结果一致,漏汽主要是通过影响高压缸做功和再热吸热量来改变热耗率,但由于低压缸做功量占汽轮机总功量的比例较大,其变化对热耗率的影响也不可忽视。

关键词：超临界660 MW汽轮机中间分隔轴封漏汽线性变工况热耗率

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B型舱VLEC设计关键技术研究

中国造船 2024年第1期65卷 97-108页

作者：周清华胡可一上海交通大学船舶海洋与建筑工程学院上海200240 江南造船(集团)有限责任公司上海201913

以全球首艘设有IMO B型液货舱的99 000 m^(3) VLEC为研究对象,对其研发设计中的若干关键技术进行分析。对VLEC货物围护系统进行选型,运用CFD仿真和模型试验完成液货舱与船体匹配的VS-BOW线型开发,采用有限元分析技术完成液舱支撑系统受... 详细信息

以全球首艘设有IMO B型液货舱的99 000 m^(3) VLEC为研究对象,对其研发设计中的若干关键技术进行分析。对VLEC货物围护系统进行选型,运用CFD仿真和模型试验完成液货舱与船体匹配的VS-BOW线型开发,采用有限元分析技术完成液舱支撑系统受力分析和强度评估,应用水动力分析方法在频域上求解液舱晃荡与船体运动耦合效应,运用“先漏后破”设计理念和自主研发的泄漏计算程序评估液舱疲劳裂纹扩展与泄漏量,形成了具有自主知识产权的IMO B型舱BrilliancE货物围护系统,其安全性、可靠性和经济性已得到VLEC实船营运的验证。

关键词： VLEC B型舱线型开发液舱晃荡疲劳裂纹扩展泄漏分析