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Chinese Medicine Plaster as A New Treatment for Surgical Site Infection in Patients with Cesarean Delivery:A Randomized,Double-Blind,Controlled Trial

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Chinese Journal of Integrative Medicine 2023年第6期29卷 483-489页

作者： HAN Guan-ya WU Xiao-li LI Dong-mei CAI Hai-rui zhou jun-jun HE Xiao-bo Department of Obstetrics Ningbo Women and Children's HospitalNingboZhejiang Province(315012)China Department of Medical Intensive Care Unit Ningbo Women and Children's HospitalNingboZhejiang Province(315012)China

Objective To evaluate the efficacy of Chinese plaster containing rhubarb and mirabilite on surgical site infection(SSI)in patients with cesarean delivery(CD)by performing a randomized controlled *** This randomized controlled trial included 560 patients with CD due to fetal head descent enrolled at a tertiary teaching center between December 31,2018 and October 31,*** patients were randomly assigned to a Chinese medicine(CM)group(280 cases)or a placebo group(280 cases)by a random number table,and were treated with CM plaster(made by rhubarb and mirabilite)or a placebo plaster,*** courses of treatment lasted from the day 1 of CD,followed day 2 until *** primary outcome was the total number of patients with superficial,deep and organ/space *** secondary outcome was duration of postoperative hospital stay,antibiotic intake,and unplanned readmission or reoperation due to *** reported efficacy and safety outcomes were confirmed by a central adjudication committee that was unaware of the study-group *** During the recovery process after CD,the rates of localized swelling,redness and heat were significantly lower in the CM group than in the placebo group[7.55%(20/265)vs.17.21%(47/274),P<0.01].The durution of postoperative antibiotic intake was shorter in the CM group than in the placebo group(P<0.01).The duration of postoperative hospital stay was significantly shorter in the CM group than in the placebo group(5.49±2.68 days vs.8.96±2.35 days,P<0.01).The rate of postoperative C-reactive protein elevation(≽100 mg/L)was lower in the CM group than in the placebo group[27.6%(73/265)vs.43.8%(120/274),P<0.01].However,there was no difference in purulent drainage rate from incision and superficial opening of incision between the two *** intestinal reactions and skin allergies were found in the CM *** CM plaster containing rhubarb and mirabilite had an effect on *** is safe for mothers and im

关键词： Chinese medicine plaster rhubarb and mirabilite surgical site infection cesarean delivery randomizedcontrolledtrial

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The composition of magmatic-hydrothermal fluids and their related metal mineralization

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Science China Earth Sciences 2025年第1期68卷 208-225页

作者： Qihai SHU jun DENG State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences and Resources China University of Geosciences Frontiers Science Center for Deep-time Digital Earth China University of Geosciences

Magmatic hydrothermal deposits are important sources of many bulk, precious, and rare metals, and have attracted interest from both academic and industrial communities. However, it is still unclear if the major enrichment of the ore-forming metals occurs in the parental magma source region, during the magma evolution, or after the fluid exsolution. Fluid inclusions trapped in hydrothermal minerals crystallized in the early, high-temperature stage before metal precipitation record information close to that of the initially exsolved magmatic fluids, which are helpful in revealing whether the metals have been already significantly enriched prior to the hydrothermal stage. In this study, available compositional data of such early-stage fluid inclusions from magmatic hydrothermal systems globally have been compiled. The results indicate that the concentrations of Cu,Sn, and W respectively from the Cu-, Sn-, and W-mineralized fluids are significantly higher than the hydrothermal systems that do not produce ores with the corresponding metals. This suggests that Cu, Sn, and W could have already been enriched in the magma source and/or magma evolution stage. The Mo concentrations show no difference between Mo-mineralized and Mobarren fluid systems, indicating no significant pre-enrichment in the source region or during the magma evolution. This also implies that an efficient collection of Mo from a large volume of magmas is required to account for the formation of a large Mo deposit. Almost all the hydrothermal fluids contain high concentrations of Fe and Zn-Pb, but only a few of them eventually form Fe or Zn-Pb deposits, reflecting an important role of the hydrothermal evolution process on the selective metal *** above results indicate that different metals are enriched in different stages of a magmatic hydrothermal system, and that the major roles played in the formation of a deposit vary with the metal types. In addition to the metal concentrations in the o

关键词： Magmatic hydrothermal deposits Fluid inclusions LA-ICP-MS Metal enrichment Mineralization mechanism

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Blockade of 4-1BB/4-1BB ligand interactions prevents acute rejection in rat liver transplantation

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Chinese Medical Journal 2010年第2期123卷 212-215页

作者： QIN Lei GUAN Hong-geng zhou Xiao-jun YIN jun LAN Jing QIAN Hai-xin Department of General Surgery the First Affiliated Hospital of Suzhou University Suzhou Jiangsu 215006. China

Background Blocking the 4-1BB/4-1BB ligand （4-1BBL） signal may modulate the secretion of Th1/Th2 cytokines and prolong the survival of the grafts, which play a key role in organ transplantation tolerance. The aim of this study was to investigate the role of blockade of the 4-1BB/4-1BBL co-stimulatory pathway with 4-1BBL monoclonal antibody （mAB） in acute rejection of rat orthotopic liver transplantation. Methods The orthotopic liver transplantation model was set up, while male Lewis rats were used as liver donors and Brown-Norway rats as recipients. The recipient rats were intravenously injected with anti 4-1BBL mAB or isotype control antibody. Groups were monitored for graft survival after transplantation. Plasma chemistry, including aspartate transaminase （AST）, alanine aminotransferase （ALT）, and bilirubin （BIL）, was assayed. The concentrations of interleukin （IL）-2, IL-10 and interferon （IFN）-γ in plasma were also measured by enzyme-linked immunosorbent assay. Allograft histology images were collected under light microscope and electron microscope. Results Isotype antibody treated recipients exhibited elevated plasma levels of liver injury markers including AST, ALT and BIL, progressive portal and venous inflammation and cellular infiltration of the liver ailografts, and a mean graft survival time （MST） of 10.9 days. Administration of anti 4-1BBL mAB resulted in a decrease in plasma levels of liver injury markers and the concentrations of IL-2, IL-10 and IFN-γ. The histological grade of rejection on day 7 decreased and MST （17.3 days） increased substantially. Conclusions These results demonstrate that attenuation of acute rejection follows the blockade of the 4-1BB/4-1BBL co-stimulatory pathway with 4-1BBL monoclonal antibody and strongly suggest it is a promising strategy to prevent progression of graft rejection by suppressing T cell-mediated immunity.

关键词： liver transplantation, rat, 4-1BB ligand acute rejection

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First Passage Probability of Structures under Non-Gaussian Stochastic Behavior

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Journal of Shanghai Jiaotong university(Science) 2008年第4期13卷 400-403页

作者：何军周拥军寇新建 Department of Civil Engineering School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiaotong University

An analytical moment-based method was proposed for calculating first passage probability of structures under non-Gaussian stochastic behaviour. In the method, the third-moment standardization that con- stants can be obtained from first three-order response moments was used to map a non-Gaussian structural response into a standard Gaussian process; then the mean up-crossing rates, the mean clump size and the initial passage probability of some critical barrier level by the original structural response were estimated. Finally, the formula for calculating first passage probability was established on the assumption that the corrected up-crossing rates are independent. By a nonlinear single-degree-of-freedom system excited by a stationary Gaussian load, it is demonstrated how the procedure can be used for the type of structures considered. Further, comparisons between the results from the present procedure and those from Monte-Carlo simulation are performed.

关键词： first passage probability stochastic process non-Gaussian structures third-moment standardization

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一种丙烯酰胺凝胶的新型光聚合法

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生物化学与生物物理进展 1998年第2期25卷 167-170页

作者：周军贤周筠梅中国科学院生物物理研究所生物大分子国家重点实验室

以亚甲基蓝为引发剂，甲苯亚磺酸钠为还原剂，二苯氯化碘为氧化剂的丙烯酰胺凝胶光聚合方法，具有试剂配制简单，适用范围广，方法稳定性和重现性好，且聚合速度快，操作易于控制等特点，是一种不同于最为广泛使用的过硫酸铵／四甲基乙... 详细信息

以亚甲基蓝为引发剂，甲苯亚磺酸钠为还原剂，二苯氯化碘为氧化剂的丙烯酰胺凝胶光聚合方法，具有试剂配制简单，适用范围广，方法稳定性和重现性好，且聚合速度快，操作易于控制等特点，是一种不同于最为广泛使用的过硫酸铵／四甲基乙二胺和核黄素／四甲基乙二胺法的新型光聚合法．用这一方法做了ＳＤＳ和在酸性缓冲体系中的尿素变性梯度胶电泳。

关键词：亚甲基蓝光聚合聚丙烯酰胺凝胶电泳

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Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu Chen Xue-jun Li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

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Approach from the laboratory to the field: New strategies in the control of mosquito-borne infectious diseases

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Science China Life Sciences 2025年第1期68卷 303-305页

作者： Ziqian Xu Lianpan Dai jun Liu National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID) National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences

Vector-borne viruses, transmitted among humans and animal hosts through bites of vectors such as mosquitoes and ticks,pose a great and ongoing threat to public health and biosafety(Yang et al., 2022).Among them, dengue virus-induced epidemics, have dramatically increased worldwide in recent decades. The report released by the World Health Organization(WHO) at the end of 2023 showed that dengue epidemic globally surged in2023, with the number of reported cases nearing a historical peak.

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局部进展期直肠癌的全程新辅助治疗模式

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解放军医学杂志 2024年第1期49卷 17-22页

作者：周荻周珺珺胡斌陈海燕上海交通大学医学院附属仁济医院放射诊疗科上海200127

局部进展期直肠癌(LARC)目前公认的治疗模式为多学科综合治疗。标准术前同步放化疗可明显降低LARC的局部复发率,但不影响其远处转移发生率和总生存率,而全程新辅助治疗(TNT)通过提高化疗强度、延长放疗至手术的时间,从而提高肿瘤缓解率... 详细信息

局部进展期直肠癌(LARC)目前公认的治疗模式为多学科综合治疗。标准术前同步放化疗可明显降低LARC的局部复发率,但不影响其远处转移发生率和总生存率,而全程新辅助治疗(TNT)通过提高化疗强度、延长放疗至手术的时间,从而提高肿瘤缓解率,可明显改善无病生存率和无转移生存率。TNT模式可明显提高患者的依从性,使全身化疗完成度更高,能带来最大程度的肿瘤退缩,不但能改善远期生存,也能增加器官功能保留的机会。对于远处转移风险高或器官功能保留意愿强的LARC患者,TNT是一种极具潜力的治疗模式。随着免疫治疗在TNT领域的应用,TNT模式不断拓展;同时,疗效预测标志物的探索将为个体化治疗奠定基础。

关键词：局部进展期直肠癌全程新辅助治疗新辅助放化疗无病生存器官保留

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The ECRH Transmission System for HL-2A Tokamak

Southwestern Institute of Physics Annual Report

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Southwestern Institute of Physics Annual Report 2005年第1期 54-55页

作者： zhou jun RAO jun CHEN Gangyu ZHANG Jinsong SONG Shaodong LU Zhihong LEI Jianxin HUANG Mei

Electron cyclotron resonance heating and electron cyclotron current drive （ ECRH/ECCD ） have been developed significantly in recent years in many devices such as Tore Supra, JT-60U, Heliotron J. It has many advantages over other means of heating and current drive. The EC power can be injected as narrow gaussian beams, giving rise to so highly localized power deposition as to make ECRH an ideal candidate for local MHD control.

关键词： ECRH Transmission system

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电石渣催化煤燃烧特性的影响因素分析

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燃料化学学报 2004年第1期32卷 37-42页

作者：程军周俊虎刘建忠周志军曹欣玉岑可法浙江大学能源洁净利用与环境工程教育部重点实验室浙江杭州310027

用热重法研究了不同条件下电石渣的催化煤燃烧特性,发现电石渣对晋城煤的着火温度和固定碳燃尽率都具有一定的促进作用,而且随添加量的增加助燃作用增强。采用干法混合方式添加0 5%电石渣的助燃作用很小,而采用浆状混合方式则具有较为... 详细信息

用热重法研究了不同条件下电石渣的催化煤燃烧特性,发现电石渣对晋城煤的着火温度和固定碳燃尽率都具有一定的促进作用,而且随添加量的增加助燃作用增强。采用干法混合方式添加0 5%电石渣的助燃作用很小,而采用浆状混合方式则具有较为明显的助燃效果。添加0 5%电石渣能使晋城无烟煤的着火温度由582℃降低到576℃,使潞安贫煤的固定碳燃尽率由89 41%提高到94 84%,而对长广高灰烟煤的着火和燃尽特性都影响很小。

关键词：煤燃烧催化电石渣着火温度燃尽率

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