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Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： yang zhou Yuan-yan Huang Ding-Yue Shang Ying Chen Meng Tian Cheng-Yu Jin Xin lu Bing-Chun yan Han-Qing Pang institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern china for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,china National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 2.0 ingredients have been characterized from EH,inc{2.ding flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a va{2.able herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

Fractionation of Heavy Metals in Sediments from Dianchi Lake,china

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Pedosphere 2007年第2期17卷 265-272页

作者： LI Ren-Ying yanG Hao zhou Zhi-Gao Lü Jun-Jie SHAO Xiao-Hua JIN Feng State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 （China）. College of Geography Science Nanjing Normal University Nanjing 210097 （China） Department of Applied Meteorology Nanjing University of Information Science ＆ Technology Nanjing 210044 （China）

Fractionation of heavy metals in sediments can help in understanding potential hazards of heavy metals. The present study analyzed total concentrations and fractions of selected heavy metals （Cd, Cr, Cu, Pb, and Zn） in surface sediments from Dianchi Lake, Yunnan Province, china, as well as factors that may affect distributions of the various heavy metal fractions. Total concentrations of the heavy metals decreased in the order Zn 〉 Cu 〉 Pb 〉 Cr 〉 Cd. These heavy metals, except Cr, were much higher than their background levels, indicating that Dianchi Lake was polluted by Cd, Zn, Pb, and Cu. Cadmium occurred mainly as the non-residual fraction （sum of the HOAc-soluble, reducible, and oxidizable fractions）（97.6%）, and Zn （55.7%） was also predominantly found in the non-residual fraction. In contrast, most of the Cr （88.5%）, Pb （81.8%）, and Cu （59.2.） occurred in the residual fraction. Correlation analysis showed that total heavy metal concentrations, organic matter and reducible Fe were the main factors affecting the distributions of the various heavy metal fractions. In the Walhai section of Dianchi Lake （comprising 97% of the lake area）, the concentrations of Cd, Zn, Pb, and Cu in the non-residual fraction were significantly lower （P ≤ 0.01 or 0.05） than those of the Caohal section （3% of the lake area）. This indicated that potential heavy metal hazards in the Caohai section were greater than the Waihai section.

关键词： Dianchi Lake heavy metal fractions lake sediment organic matter reducible Fe

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无阀纳米泵中水流的反常堵塞

物理学报 2024年第9期73卷 179-185页

作者：李伟健周晓艳陆杭军浙江师范大学凝聚态物理研究所金华321004

对于颗粒物质,在锥形通道的窄口处容易发生堵塞现象,实验中通常利用机械振动进行疏通.而对于无孔不入的水却不同,即使在纳米尺度的碳纳米管中仍然可以快速通透.本文利用分子动力学模拟研究了由锥形碳纳米管与石墨烯平面构成的无阀纳米泵... 详细信息

对于颗粒物质,在锥形通道的窄口处容易发生堵塞现象,实验中通常利用机械振动进行疏通.而对于无孔不入的水却不同,即使在纳米尺度的碳纳米管中仍然可以快速通透.本文利用分子动力学模拟研究了由锥形碳纳米管与石墨烯平面构成的无阀纳米泵,发现水输运在一定条件下也会出现反常堵塞.与颗粒物质截然不同的是振动方法无法恢复水流,相反,它促使水在纳米水泵的通道窄口处发生堵塞.通过分析堵塞区水的密度分布、氢键寿命、水分子的结构特征,揭示了反常堵塞是由腔体中振动膜的高频振动引发水的结构相变造成的.

关键词：无阀纳米泵水流堵塞振动氢键网络

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Molecular features of gastroenteropancreatic neuroendocrine carcinoma: A comparative analysis with lung neuroendocrine carcinoma and digestive adenocarcinomas

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Chinese Journal of Cancer Research 2024年第1期36卷 90-102页

作者： Jianwei Zhang Hanxiao Chen Junli Zhang Sha Wang yanfang Guan Wenguang Gu Jie Li Xiaotian Zhang Jian Li Xicheng Wang Zhihao lu Jun {2. Zhi Peng Yu Sun yang Shao Lin Shen Minglei Zhuo Ming lu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Department of Radiation Therapy National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518172China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department I of Thoracic OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Medical Department Nanjing Geneseeq Technology Inc.Nanjing 210061China Geneplus-Beijing Beijing 102200China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of PathologyPeking University Cancer Hospital&InstituteBeijing 100142China

Objective: There is an ongoing debate about whether the management of gastroenteropancreatic(GEP)neuroendocrine carcinoma(NEC) should follow the guidelines of small-cell lung cancer(SCLC). We aim to identify the genetic differences of GEPNEC and its ***: We recruited GEPNEC patients as the main cohort, with lung NEC and digestive adenocarcinomas as comparative cohorts. All patients undergone next-generation sequencing(NGS). Different gene alterations were compared and analyzed between GEPNEC and lung NEC(LNEC), GEPNEC and adenocarcinoma to yield the remarkable ***: We recruited 2.7 patients, including 99 GEPNEC, 57 LNEC, and 101 digestive *** the mutations, KRAS, RB1, TERT, IL7R, and CTNNB1 were found to have different gene alterations between GEPNEC and LNEC samples. Specific genes for each site were revealed: gastric NEC(TERT amplification),colorectal NEC(KRAS mutation), and bile tract NEC(ARID1A mutation). The gene disparities between small-cell NEC(SCNEC) and large-cell NEC(LCNEC) were KEAP1 and CDH1. Digestive adenocarcinoma was also compared with GEPNEC and suggested RB1, APC, and KRAS as significant genes. The TP53/RB1 mutation pattern was associated with first-line effectiveness. Putative targetable genes and biomarkers in GEPNEC were identified in2..2. of the patients, and they had longer progression-free survival(PFS) upon targetable treatment [12.5 months vs. 3.0 months, HR=0.40(0.2.-0.75), P=0.006].Conclusions: This work demonstrated striking gene distinctions in GEPNEC compared with LNEC and adenocarcinoma and their clinical utility.

关键词： Neuroendocrine carcinoma gastroenteropancreatic lung genetic alterations molecular markers

Potassium Fractions in Soils as Affected by Monocalcium Phosphate,Ammonium Sulfate,and Potassium Chloride Application

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Pedosphere 2010年第3期20卷 368-377页

作者： WANG Huo-yan, zhou Jian-Min, DU Chang-Wen and CHEN Xiao-Qin State Key Laboratory of Soil and Sustainable Agriculture, {2. of Soil Science, Chinese Academy of Sciences, nanjing 2.0008 (china) State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 (China)

Soil potassium （K） deficiency has been increasing over recent decades as a result of higher inputs of N and P fertilizers concomitant with lower inputs of K fertilizers in china; however, the effects of interactions between N, P, and K of fertilizers on K status in soils have not been thoroughly investigated for optimizing N, P, and K fertilizer use efficiency. The influence of ammonium sulfate （AS）, monocMcium phosphate （MCP）, and potassium chloride application on K fractions in three typical soils of china was evaluated during 90-d laboratory soil incubation. The presence of AS significantly altered the distribution of native and added K in soils, while addition of MCP did not significantly affected K equilibrium in most cases. Addition of AS significantly increased water-soluble K （WSK）, decreased exchangeable K （EK） in almost all the soils except the paddy soil that contained considerable amounts of 2.1.type clay minerals with K added, retarded the formation of fixed K in the soils with K added, and suppressed the release of fixed K in the three soils without K added. These interactions might be expected to influence the K availability to plants when the soil was fertilized with AS. To improve K fertilizer use efficiency, whether combined application of AS and K was to be recommended or avoided should depend on K status of the soil, soil properties, and cropping systems.

关键词： fertilizers K availability K fixation K release

A naturally derived small molecule compound suppresses tumor growth and metastasis in mice by relieving p53-dependent repression of CDK2.Rb signaling and the Snail-driven EMT

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Chinese Journal of Natural Medicines 2024年第2期22卷 112-126页

作者： REN Boxue LI yang DI Lei CHENG Ranran LIU Lijuan LI Hongmei LI Yi TANG Zhangrui yan Yongming {2. Tao FU Rong CHENG Yongxian WU Zhaoqiu State Key Laboratory of Natural Medicines Department of PharmacologySchool of PharmacyChina Pharmaceutical UniversityNanjing 211198China institute for Inheritance-Based Innovation of Chinese Medicine School of Pharmaceutical SciencesShenzhen University Health Science CenterShenzhen 518060China

The tumor suppressor protein p53 is central to cancer biology,with its pathway reactivation emerging as a promising therapeutic strategy in *** study introduced LZ2.,a novel compound that selectively inhibits the growth,migration,and metastasis of tumor cells expressing wild-type p53,demonstrating ineffectiveness in cells devoid of p53 or those expressing mutant ***2.’s mechanism of action involves a high-affinity interaction with the histidine-96 pocket of the MDM2.*** interaction disrupted the MDM2.p53 binding,consequently stabilizing p53 by shielding it from proteasomal ***2. impeded cell cycle progression and diminished cell proliferation by reinstating the p53-dependent suppression of the CDK2.Rb signaling ***,LZ2. alleviated the p53-dependent repression of Snail transcription factor expression and its consequent EMT,effectively reducing tumor cell migration and distal ***,LZ2. administration in tumor-bearing mice did not manifest notable side *** findings position LZ2. as a structurally unique reactivator of p53,offering therapeutic promise for the management of human cancers with wild-type TP53.

关键词： LZ2. Wild-type p53 p53 Reactivator Snail-driven EMT Tumor growth and metastasis

Epidemic threshold influenced by non-pharmaceutical interventions in residential university environments

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Chinese Physics B 2024年第2期33卷 551-556页

作者：卢泽超赵生妹束华中巩龙延 institute of Signal Processing and Transmission Nanjing University of Posts and TelecommunicationsNanjing 210003China College of Science Nanjing University of Posts and TelecommunicationsNanjing 210003China

The control of highly contagious disease spreading in campuses is a critical *** residential universities,students attend classes according to a curriculum schedule,and mainly pack into classrooms,dining halls and *** move from one place to *** simulate such environments,we propose an agent-based susceptible–infected–recovered model with time-varying heterogeneous contact *** close environments,maintaining physical distancing is the most widely recommended and encouraged non-pharmaceutical *** can be easily realized by using larger classrooms,adopting staggered dining hours,decreasing the number of students per dorm and so *** real-world influence remains *** numerical simulations,we obtain epidemic *** effect of such countermeasures on reducing the number of disease cases is also quantitatively evaluated.

关键词： epidemic threshold susceptible-infected-recovered model non-pharmaceutical interventions time-varying heterogeneous contact networks

What Can Topology Bring to Chemistry?

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CCS Chemistry 2024年第9期6卷 2084-2109页

作者： Wei Wang Songtao zhou Xiujun Yu Qing-Hui Guo yanhang Ma Jie Song Liang Zhang Xuzhou yan lu Han Qing Liao Xiaopeng Li Wen-Bin Zhang Yiyong Mai Shaodong Zhang Shunai Che Hai-Bo yang Xuefeng Fu Mei-Xiang Wang School of Chemistry and Molecular Engineering East China Normal UniversityShanghai 200062 Hangzhou institute of Medicine Chinese Academy of SciencesHangzhou 310022Zhejiang College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060Guangdong MOE Key Laboratory of Bioorganic Phosphorous and Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084 School of Physical Science and Technology and Shanghai Key Laboratory of High-Resolution Electron Microscopy ShanghaiTech UniversityShanghai 201210 School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesState Key Laboratory of Composite MaterialsShanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai 200240 School of Chemical Science and Engineering Tongji UniversityShanghai 200092 Beijing Key Laboratory for Optical Materials and Photonic Devices Department of ChemistryCapital Normal UniversityBeijing 100048 Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCenter for Soft Matter Science and EngineeringCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871 Department of Chemical Sciences National Natural Science Foundation of ChinaBeijing 10085

The unique mathematical perspectives and principal concepts of topology have not only promoted the development of other branches of mathematics but have also deeply influenced other subjects,particularly physics and *** minireview aims to elucidate the substantial influence of topology on chemistry by critically examining both the contributions of topology to current chemical science and its potential future *** will discuss the topology of molecular structures and assemblies across various scales—from small molecules and mechanically interlocked molecules to polymers,biomacromolecules,and supramolecular *** discussion will include an exploration of cutting-edge techniques for characterizing topological features,underscoring the role of topology as a novel paradigm for the design and synthesis of new molecular ***,a critical analysis of topology’s role in the development of functional materials—such as photonic materials,polymers,biomacromolecules,and chiral materials—will demonstrate its emerging significance as a crucial parameter in unveiling novel properties and *** topology’s formidable potential,it is anticipated to be used increasingly to address pivotal challenges within chemistry and adjacent disciplines.

关键词： chemical topology topological invariants molecular graphs links and knots structureproperty relationship

Efficacy and Safety of Bufei Jiedu Granules in Treating Multidrug-Resistant Pulmonary Tuberculosis:A Multi-center,Double-Blinded and Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第7期30卷 579-587页

作者： ZHANG Shao-yan QIU Lei ZHANG Shun-xian XIAO He-ping CHU Nai-hui ZHANG Xia ZHANG Hui-qiang ZHENG Pei-yong ZHANG Hui-yong lu Zhen-hui institute of Respiratory Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China Clinical Research Center Shanghai University of Traditional Chinese MedicineShanghai200032China Department of Tuberculosis Shanghai Pulmonary HospitalTongji UniversityShanghai200433China Department of Tuberculosis Beijing Chest HospitalCapital Medical UniversityBeijing101100China Department of Tuberculosis the Second Hospital of NanjingNanjing210003China Department of Tuberculosis the First Hospital Affiliated to Xinxiang Medical CollegeXinxiangHenan Province453100China

Objective: To assess the efficacy and safety of Bufei Jiedu(BFJD) Granules as adjuvant therapy for patients with multidrug-resistant pulmonary tuberculosis(MDR-PTB). Methods: A large-scale, multi-center, double-blinded, and randomized controlled trial was conducted in 18 sentinel hospitals in china from December 2.1. to December 2.1.. A total of 312.MDR-PTB patients were randomly assigned to BFJD Granules or placebo groups(1:1) using a stratified randomization method, which both received the long-course chemotherapy regimen for 18 months(6 Am-Lfx-P-Z-Pto, 12.Lfx-P-Z-Pto). Meanwhile, patients in both groups also received BFJD Granules or placebo twice a day for a total of 18 months, respectively. The primary outcome was cure rate. The secondary outcomes included time to sputum-culture conversion, changes in lung cavities and quality of life(QoL) of patients. Adverse reactions were monitored during and after the trial. Results: A total of 2.6 cases completed the trial, 111 in the BFJD Granules group and 105 in the placebo group. BFJD Granules, as adjuvant treatment, increased the cure rate by 13.6% at the end of treatment, compared with the placebo(58.4% vs. 44.8%, P=0.02., and accelerated the median time to sputum-culture conversion(5 months vs. 11 months). The cavity closure rate of the BFJD Granules group(50.6%, 43/85) was higher than that of the placebo group(32.1., 2./81;P=0.02. in patients who completed the treatment. At the end of the intensive treatment, according to the 36-item Short Form, the BFJD Granules significantly improved physical functioning, general health, and vitality of patients relative to the placebo group(all P2.6%(4/156) in the placebo group. Conclusions: Supplementing BFJD Granules with the long-course chemotherapy regimen significantly increased the cure rate and cavity closure rate, and rapidly improved QoL of pati

关键词： alternative medicine Chinese herbal formula Bufei Jiedu Granules multidrug-resistant tuberculosis long-course chemotherapy regimen randomized controlled trial