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Altered prosaposin expression in the rat facial nerve nucleus following facial nerve transection and repair

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Neural Regeneration Research 2009年第3期4卷 230-235页

作者： Dong Wang Wenlong Luo Cuiying zhou jingjing Li Department of Otolaryngology-Head and Neck Surgery Second Affiliated Hospital of Chongqing University of Medical Sciences Chongqing400010 China

BACKGROUND： Studies have demonstrated that damaged facial nerves synthesize prosaposin to promote repair of facial neurons. OBJECTIVE： To observe time-course changes of prosaposin expression in the facial nerve nucleus of Sprague Dawley rats following facial nerve transection and repair. DESIGN, TIME AND SETTING： A randomized control neuropathological animal experiment was performed in Chongqing Medical University between March 2007 and September 2008. MATERIALS： A total of 48 adult, male, Sprague Dawley rats were selected and randomly divided into transection and transection ＋ end-to-end anastomosis groups （n =24）. Rabbit anti-rat prosaposin antibody, instant SABC immunohistochemical kit, and antibody dilution solution were purchased from Wuhan Uscn Science Co., Ltd., China. METHODS： In the transection group, the nerve trunk of the distal retroauricular branch of the left facial nerves was ligated in Sprague Dawley rats, and a 5-mm nerve trunk at the distal end of the ligation site was removed. In the transection ＋ end-to-end anastomosis group, epineurial anastomosis was performed immediately following transection of the left facial nerves. The right facial nerves in the two groups served as the normal control group. MAIN OUTCOME MEASURES： The number of prosaposin-positive neurons, as welt as intensity of immunostaining in facial nerve nucleus, following transection and end-to-end anastomosis were determined by immunohistochemistry at 1, 3, 7, 14, 21, and 35 days after injury. RESULTS： Transection group： transection of facial nerves resulted in increased number of prosaposin-positive neurons and immunoreactivity intensity in the facial nucleus on day 1. These values significantly increased by day 3. Expression was greater than in the control side. The peak of the reduction was reached at 7 days post-surgery. Transection ＋ end-to-end anastomosis group： the number of prosaposin-positive neurons and immunoreactivity intensity was reduced in the facial nerve nucleus fo

关键词： facial nucleus: orosaposin: rats: facial nerve

Up-regulation of P2X7 Receptors Contributes to Spinal Microglial Activation and the Development of Pain Induced by BmK-I

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Neuroscience Bulletin 2019年第4期35卷 624-636页

作者： jingjing zhou Xiaoxue Zhang You zhou Bin Wu Zhi-Yong Tan Laboratory of Neuropharmacology and Neurotoxicology Shanghai University Shanghai 200444 China Department of Pharmacology and Toxicology and Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis IN 46202 USA

Previous work has demonstrated that the sensitization of spinal neurons and microglia is important in the development of pain behaviors induced by BmK I,a Na^+ channel activator and a major peptide component of the venom of the scorpion Buthus martensi Karsch(BmK).We found that the expression of P2X7 receptors(P2X7Rs)was up-regulated in the ipsilateral spinal dorsal horn after BmK I injection in rats.P2X7R was selectively localized in microglia but not astrocytes or ***,interleukin 1β(IL-1β)was selectively up-regulated in microglia in the spinal dorsal horn after BmK I *** injection of P2X7R antagonists largely reduced BmK I-induced spontaneous and evoked pain behaviors,and the up-regulation of P2X7R and IL-1β in the spinal *** data suggested that the up-regulation of P2X7Rs mediates microglial activation in the spinal dorsal horn,and therefore contributes to the development of BmK I-induced pain.

关键词： P2X7 receptor BmK I Spinal dorsal horn Interleukin 1β Microglia Brilliant Blue G

The Research of One Novel Cost-Sensitive Classification Algorithm

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Chinese Journal of Electronics 2018年第5期27卷 1015-1024页

作者： zhou jingjing SUN Weifeng HAN Xiaomin LU Ruqiang ZHANG Yuanqi ZHANG Shenwei Zhejiang Gongshang University School of Software Dalian University of Technology

Assuming that misclassification costs between different categories are equal, traditional Graph based semi-supervised classification(GSSC) algorithms pursues high classification accuracy. In many practical problems, especially in the fields of finance and medicine,compared with global classification accuracy, less cost on global misclassification is more likely to be the most significant factor. We propose one novel cost-sensitive classification algorithm based on the local and global consistency, which utilizes the semi-supervised classification algorithms better, and ensures higher classification accuracy on the basis of reducing overall cost. Our improved algorithm may bring some problems due to unbalanced data account, so we introduce synthetic minority oversampling technique algorithm for further optimization. Experimental results of bank loans and medical problems verify the effectiveness of our novel classification algorithm.

关键词： Graph-based semi-supervised classification(GSSC) Cost-sensitive Rescale

A composite PEO electrolyte with amide-based polymer matrix for suppressing lithium dendrite growth in all-solid-state lithium battery

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Chinese Chemical Letters 2022年第8期33卷 3894-3898页

作者： Menghan Ge Xiaoyu zhou Yinping Qin Yang Liu jingjing zhou Xiaolei Wang Bingkun Guo Materials Genome Institute Shanghai UniversityShanghai 200444China Department of Chemical and Materials Engineering University of AlbertaEdmontonAlberta T6G 2R3Canada

The lithium dendrite growth is still a serious challenge and impeding the realistic applications of all-solid-state lithium *** view of the amide containing sediment layer can be stable on lithium/cathodes,a composite polymer electrolyte with amide-based matrix is in-situ built on porous *** the introduction of amide,the polymer electrolyte presents excellent ability to inhibit lithium dendrite growth and makes the Li/Li symmetric battery stably work for 500 h with a good ionic conductivity of 4.25×10^(-5)S/cm at 40℃.The solid electrolyte also shows a wide electrochemical stable window and good interface contact with the porous *** this composite polymer electrolyte,the all-solid-state Li/LiFePO_(4) battery shows an initial discharge capacity of 146.5 mA h/g at 0.1 C under 40℃ and remains 81.4%in 100 *** polymer electrolyte also can present better properties after *** results demonstrate that the presented PA-based composite polymer electrolyte could be served as a good electrolyte candidate for all-solid-state lithium-ion batteries.

关键词： Composite Amide Lithium dendrite Solid state electrolyte Li metal battery

Rapid health estimation of in-service battery packs based on limited labels and domain adaptation

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Journal of Energy Chemistry 2024年第2期89卷 345-354,I0009页

作者： Zhongwei Deng Le Xu Hongao Liu Xiaosong Hu Bing Wang jingjing zhou School of Mechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina School of Sustainability Stanford UniversityStanfordCA 94305USA College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China China Automotive Engineering Research Institute Co.Ltd. Chongqing 401122China

For large-scale in-service electric vehicles(EVs)that undergo potential maintenance,second-hand transactions,and retirement,it is crucial to rapidly evaluate the health status of their battery ***,existing methods often rely on lengthy battery charging/discharging data or extensive training samples,which hinders their implementation in practical *** address this issue,a rapid health estimation method based on short-time charging data and limited labels for in-service battery packs is proposed in this ***,a digital twin of battery pack is established to emulate its dynamic behavior across various aging levels and inconsistency ***,increment capacity sequences(△Q)within a short voltage span are extracted from charging process to indicate battery ***,data-driven models based on deep convolutional neural network(DCNN)are constructed to estimate battery state of health(SOH),where the synthetic data is employed to pre-train the models,and transfer learning strategies by using fine-tuning and domain adaptation are utilized to enhance the model ***,field data of 10 EVs exhibiting different SOHs are used to verify the proposed *** using the△Q with 100 m V voltage change,the SOH of battery packs can be accurately estimated with an error around 3.2%.

关键词： Lithium-ion battery Electric vehicles Health estimation Feature extraction Convolutional neural network Domain adapatation

First-principles study of lithium intercalated bilayer graphene

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Science China(Physics,Mechanics & Astronomy) 2012年第8期55卷 1376-1382页

作者： zhou jingjing zhou WeiWei GUAN ChunMei SHEN JingQin OUYANG ChuYing LEI MinSheng SHI SiQi TANG WeiHua Department of Physics Center for Optoelectronics Materials and Devices Zhejiang Sci- Tech University Hangzhou 310018 China Department of Physics Jiangxi Normal University Nanchang 330022 China

Litbium intercalated bilayer graphene has been investigated using first-principles density functional theory calculations. Re- sults show that there exist AB and AA stacking sequences for bilayer graphene in which the latter is more favorable for the Li storage and the former will evolve into the latter with the intercalation of Li ions. The relationship between the interlayer dis- tance of two graphene sheets and the intercalated capacity of Li ions is discussed, It is found that structural defect is identified to store Li ions more favorably than pristine bilayer graphene and an isolated C atom vacancy in bilayer graphene can capture three Li ions between two graphene sheets.

关键词： bilayer grapheme lithium ion battery defect first-principles calculation

State-of-health estimation for fast-charging lithium-ion batteries based on a short charge curve using graph convolutional and long short-term memory networks

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Journal of Energy Chemistry 2024年第11期98卷 1-11页

作者： Yvxin He Zhongwei Deng Jue Chen Weihan Li jingjing zhou Fei Xiang Xiaosong Hu School of Mechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China Chair for Electrochemical Energy Conversion and Storage Systems Institute for Power Electronics and Electrical Drives(ISEA)RWTH Aachen UniversityAachen 52074Germany Center for Ageing Reliability and Lifetime Prediction of Electrochemical and Power Electronic Systems(CARL)RWTH Aachen UniversityAachen 52074Germany China Automotive Engineering Research Institute Co.Ltd. Chongqing 401122China

A fast-charging policy is widely employed to alleviate the inconvenience caused by the extended charging time of electric vehicles. However, fast charging exacerbates battery degradation and shortens battery lifespan. In addition, there is still a lack of tailored health estimations for fast-charging batteries;most existing methods are applicable at lower charging rates. This paper proposes a novel method for estimating the health of lithium-ion batteries, which is tailored for multi-stage constant current-constant voltage fast-charging policies. Initially, short charging segments are extracted by monitoring current switches,followed by deriving voltage sequences using interpolation techniques. Subsequently, a graph generation layer is used to transform the voltage sequence into graphical data. Furthermore, the integration of a graph convolution network with a long short-term memory network enables the extraction of information related to inter-node message transmission, capturing the key local and temporal features during the battery degradation process. Finally, this method is confirmed by utilizing aging data from 185 cells and 81 distinct fast-charging policies. The 4-minute charging duration achieves a balance between high accuracy in estimating battery state of health and low data requirements, with mean absolute errors and root mean square errors of 0.34% and 0.66%, respectively.

关键词： Lithium-ion battery State of health estimation Feature extraction Graph convolutional network Long short-term memory network

Distributions of typical contaminant species in urban short-term storm runoff and their fates during rain events:A case of Xiamen City

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Journal of Environmental Sciences 2010年第4期22卷 533-539页

作者： Qunshan Wei Gefu Zhu Peng Wu Li Cui Kaisong Zhang jingjing zhou Wenru Zhang Key Laboratory of Urban Environment and Health Institute of Urban Environment Chinese Academy of Sciences Xiamen 361021 China. Jinyun Environmental Protection and Monitoring Station Lishui 321400 China

The pollutants in urban storm runoff, which lead to an non-point source contamination of water environment around cities, are of great concems. The distributions of typical contaminants and the variations of their species in short term storm runoff from different land surfaces in Xiamen City were investigated. The concentrations of various contaminants, including organic matter, nutrients （i.e., N and P） and heavy metals, were significantly higher in parking lot and road runoff than those in roof and lawn runoff. The early runoff samples from traffic road and parking lot contained much high total nitrogen （TN 6-19 mg/L） and total phosphorus （TP 1-3 mg/L）. A large proportion （around 60%） of TN existed as total dissolved nitrogen （TDN） species in most runoff. The percentage of TDN and the percentage of total dissolved phosphorus remained relatively stable during the rain events and did not decrease as dramatically as TN and TP. In addition, only parking lot and road runoff were contaminated by heavy metals, and both Pb （25-120 μg/L） and Zn （0.1-1.2 mg/L） were major heavy metals contaminating both runoff. Soluble Pb and Zn were predominantly existed as labile complex species （50%-99%）, which may be adsorbed onto the surfaces of suspended particles and could be easily released out when pH decreased. This would have the great impact to the environment.

关键词： urban runoff storm water contamination nutrient heavy metal

Design and evaluation of chitosan-amino acid thermosensitive hydrogel

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Marine Life Science & Technology 2022年第1期4卷 74-87页

作者： Jianan Tong Huiyun zhou jingjing zhou Yawei Chen Jing Shi Jieke Zhang Xinyu Liang Tianyuan Du Chemical Engineering and Pharmaceutics College Henan University of Science and TechnologyLuoyang471023China College of Pharmacy(Engineering Research Center for Medicine) Harbin University of CommerceHarbin150000China

Chitosan/glycerophosphate thermosensitive hydrogel crosslinked physically was a potential drug delivery carrier;however, long gelation time limits its application. Here, chitosan-amino acid (AA) thermosensitive hydrogels were prepared from chitosan (CS), αβ-glycerophosphate (GP), and L-lysine (Lys) or L-glutamic acid (Glu). The prepared CS-Lys/GP and CS-Glu/GP hydrogel showed good thermosensitivity and could form gels in a short time. The optimal parameters of CS-Lys/GP hydrogel were that the concentration of CS-Lys was 2.5%, the ratio of CS/Lys was 3.5/1.0, the ratio of CS-Lys/GP was 4.5/1.0. The optimal parameters of CS-Glu/GP hydrogel were that the concentration of CS-Glu was 3.0%, the ratio of CS/Glu was 2.0/1.0, and the ratio of CS-Glu/GP was 4.0/1.5. Chitosan-amino acid (CS-AA) thermosensitive hydrogel had a three-dimensional network structure. The addition of model drug tinidazole (TNZ) had no obvious effect on the structure of hydrogel. The results of infrared spectroscopy showed that there were hydrogen bonds between amino acids and chitosan. In vitro release results showed that CS-Lys/GP and CS-Glu/GP thermosensitive hydrogels had sustained release effects. Thus, the chitosan-amino acid thermosensitive hydrogels hold great potential as a sustained release drug delivery system.

关键词： Chitosan L-Lysine L-Glutamic acid αβ-Glycerophosphate Thermosensitive hydrogel In vitro release