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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Fan-Tao MENG~1,Yan-Li,WANG~2,Jiang-Ning zhou~(1,*) 1 University of Science and Technology of China(USTC),Hefei,China 2 Anhui Medical University,hefei,China

＜正＞Clinical and epidemiological studies have confirmed that the effect of estrogen replacement therapy（ERT） on the cognition in AD depends on ApoE *** clinical investigation demonstrated that natural menopause age of ApoE4 carrier women delayed significantly compared with other genotype *** data from ApoE transgenic mice showed that hippocampas estrogen level was lower in ApoE4-tg mice while the plasma estrogen level was higher than that of ApoE3.tg mice;The relative activity of aromatase in hippocampus of ApoE4-tg mice was lower too;However,aromatase mRNA transcription level was upregulated in ApoE4-tg mice’s *** ApoE stable transfected C6 cell line model, we found that ERK signal was involved in regulating the aromatase level just in ApoE3.*** conclusion,our data show that ApoE4 have different effects on estrogen biosynthesis in central nervous system and periphery,which may be important with respect to the ERT in AD.

关键词： ApoE genotype estrogen biosynthesis aromatase

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Ginsenoside Rg1 protects against Aβ25-3.-induced eurotoxicity in PC12 cells

Ginsenoside Rg1 protects against Aβ25-35-induced eurotoxici...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Wen-Fang CHEN,Li-Ping zhou,Ke-Li GE,Jun-Xia XIE~* State Key Disciplines:Physiology(in incubation),Department of Physiology,Medical College of Qingdao University, Qingdao,266071,China

Objective In recent years,ginseng has become one of the most commonly used alternative herbal medicines in the *** Rg1 is the major pharmacological active compound of ginseng and has been identified as a potent *** Rg1 has been reported to exert neurotropic and neuroprotective effects both in vivo and in *** in vitro studies,ginsenoside Rg1 has been reported to protect the dopaminergic cells against glutamate,MPP toxicities and rotenone *** present study was designed to investigate the neuroprotective effects of ginsenoside Rg1 against Aβ25-3.-induced neurotoxicity in PC12 cells and the possible *** The PC12 cells were routinely cultured and pretreated with ginsenoside Rg1 to determine the protective effect of Rg1 against Aβ25-3.-induced *** cell viability was observed by MTT *** gene and protein expressions of Bcl-2 and Bax were detected by real time RT-PCR and western blot *** Pretreatment with ginsenoside Rg1 had obvious dosedependent neuroprotective effects on cell viability against Ap25-3.-induced neurotoxicity.Aβ25-3. decreased the gene and protein expressions of *** significant changes were found in the gene and protein expression of *** with Rg1 could attenuate Aβ25-3.-induced decrease in Bcl-2 *** Our results clearly show that ginsenoside Rg1 has neuroprotective effects against A|}25-3.-induced neurotoxicity in PC 12 cells,and its mechanism may be related to its anti-apoptosis effects.

关键词： ginsenoside Rg1 β-amyloid apoptosis,PC12 cell

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The protein interacting with Cαkinase 1(PICK1) modulates periphery nociception through the interaction with ASICs

The protein interacting with Cαkinase 1(PICK1) modulates pe...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Hui FU,Lei WEI,Chao HUANG,Zhuang-Li HU,Xin-Di zhou,You JIN,Fang WANG,Jiang-Guo CHEN~* Department of Pharmacology,Tongji Medical College,Hubei 43.03.,China

Objective The protein interacting with Cαkinase 1(PICK1) is a membrane-bound protein resided in cytoplasm. It interacts with the acid sensing ion channels(ASICs) in primary sensory neurons and is involved in the sensitization and transmission of periphery *** designed experiments to test the effects of PICK1 on periphery nociception through interacting with ASICs by using PICK1 *** The amplitude of ASIC1 current and the[Ca]i increase through ASIC1 were measured by whole-cell patch clamp and Ca image,the expression and localization of ASIC1 and SP were identified by immunofluorescence and western *** We showed that PICK1 mice exhibited more tolerance to inflammation-induced pain *** amplitude of ASIC1 current and the[Ca]i increase through ASIC1 were both reduced in PICK1 *** immunofluorescence and western blotting results showed that the absence of PICK1 could down-regulate the expression and localization of ASIC1 either in normal or in ***1 also modulated the release of substance P(SP).Conclusion PICK1 is essential for inflammation-induced pain hypersensitivity and periphery *** specific blockade of PICK1 may have antinociceptive effect on inflammatory pain.

关键词： PICK1 ASICs inflammatory pain TG neurons

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Decreased rapid eye movement sleep and altered circadian sleep regulation in vasoactive intestinal polypeptide deficient mice

Decreased rapid eye movement sleep and altered circadian sle...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Wang-Ping HU~(1,*),Qun-Yong zhou~2 1 Department of Pharmacology,Xianning College,Xianning 43.100,China 2 Department of Pharmacology,University of California,Irvine,CA 92697 U.S.A.

Objective Vasoactive intestinal peptide(VIP),a 28-amino acid peptide,has been shown to increase rapid eye movement(REM) sleep in normal and insomniac animals,while the administration of anti-VIP antibodies or an antagonist of VIP receptors decreases REM *** addition,recently,mice lacking the VIP gene(VIP) have been shown to display significantly disrupted rhythmicity for a variety of circadian physiological and behavioral *** investigated the role of VIP in sleep regulation using VIP mice in the present *** EEG/EMG sleep-wake patterns were recorded in VIP mice and their wild-type littermate controls under baseline,constant darkness and sleep deprivation ***(1) VIP mice exhibited reduced REM sleep time over the 24h light-dark *** reduced REM sleep time in VIP"’" mice occurred entirely during the light period and was attributed to a short duration of REM sleep bouts. (2) After sleep deprivation,compensatory rebound in NREM sleep and REM sleep was attenuated in VIP mice.(3. The lack of VIP altered the distribution of sleep and exhibited smaller circadian amplitude for total sleep,NREM sleep and REM sleep under light-dark and constant darkness *** These results indicate that VIP appears to play roles in REM sleep and circadian sleep regulation.

关键词： sleep vasoactive intestinal peptide rapid eye movement circadian rhythm

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Erratum to： Questions about NgAgo

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Protein & Cell 2017年第1期8卷 77-77页

作者： Shawn Burgess Linzhao Cheng Feng Gu Junjiu Huang Zhiwei Huang Shuo Lin Jinsong Li Wei Li Wei Qin Yujie Sun zhou Songyang wensheng Wei Qiang Wu Haoyi Wang Xiaoqun Wang Jing-Wei Xiong Jianzhong Xi Hui Yang Bin zhou Bo Zhang National Human Genome Research institute NIH Bethesda MD USA Division of Hematology in Department of Medicine Johns Hopkins University School of Medicine Baltimore MD 21205 USA Stem Cell Program in the institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA Center for Vision Research Eye Hospital Wenzhou Medical University Wenzhou 325035 China Stem Cell and Functional Genomics Laboratory School of Life Sciences Sun Yat-sen University Guangzhou 510275 China HIT Center of Life Sciences Harbin Institute of Technology Harbin 150080 China Department of Molecular Cell and Developmental Biology University of California Los Angeles Los Angeles CA 90095 USA institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China State Key Laboratory of Stem cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China College of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School Shenzhen 518055 China PKU BIOPIC Beijing 100871 China BIOPIC ICG CLS and School of Life Sciences Peking University Beijing 100871 China Center for Comparative Biomedicine Institute of Systems Biomedicine Shanghai Jiao Tong University Shanghai 200240 China institute of Biophysics Chinese Academy of Sciences Beijing 100101 China institute of Molecular Medicine Peking University Beijing 100871 China College of Engineering Peking University Beijing 106871 China Laboratory of Disease Models in Non-Human Primates Institute of Neuroscience Shanghai Chinese Academy of Sciences Shanghai 200031 China College of Life Sciences Peking University Beijing 100871 China

In the original publication of this article the Figure 1E legend has been incorrectly published.

关键词： Erratum Questions NgAgo

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Structural and functional changes of rat retinal synapses after acute high intraocular pressure

Structural and functional changes of rat retinal synapses af...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Dan CHEN Hui WANG Jian-Bin TONG Li-Hong zhou Ju-Fang HUANG~* Xue-Gang LUO Department of Anatomy and Neurobiology Xiangya School of Medicine Central South University Changsha 410013.China

＜正＞Objective To investigate the structural and functional changes of rat retinal synapses following acute high intraocular pressure（HIOP）.Methods The intraocular pressure of all left eyes of the SD rats was increased until b wave of flash electroretinogragh（fERG）disappeared and such pressure maintained for 60 *** right eyes served as normal *** were sacrificed at 0,3.6,12 hours and 1,3.7,14 days following operation *** and Western blot were used to detect the expression of synaptophysin（SYN）,one of the markers of synaptic *** microscopy was carried out to show the ultra-structural changes of ***（1） SYN expression was upregulated shown by Western blot at 0,3.6,12 hours after HIOP.（2） Although with dramatical thinning of the inner plexiform layer,SYN remained high expression level at 1,3.7 days after *** distribution of SYN was found within the outer plexiform and nuclear layer,which was accompanied with bouton-like vesicle containing structures found by electron microscopy;（3. Fourteen days after HIOP,the distribution of SYN in the outer plexiform layer reverted to normal *** this time,the total retinal expression level of SYN was under normal because of the structural loss of the inner plexiform *** The results suggested that retinal synapses underwent structural and functional changes following HIOP,which may need to be paid more attention to for better recovery of retina following injury such as HIOP.

关键词： acute high intraocular pressure synapse synaptophsin plasticity rat

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Mechanistic insights into lung cancer metastasis elicited by LKB1 loss

Mechanistic insights into lung cancer metastasis elicited by...

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华东六省一市生物化学与分子生物学学会-2011年学术交流会

作者： Yan Feng Ye Wang Yang zhou Zhaoyuan Fang Tian Xiao Yijun Gao Xiaolong Liu Qiwei Zhai Yihua Sun Nabeel Bardeesy Kwok-kin Wong Haiquan Chen Zhiqi Xiong Hongbin Ji Laboratory of Molecular Cell Biology Institute of Biochemistry and Cell Biology institute of neuroscience and State Key Laboratory of neuroscience Key Laboratory of Nutrition and Metabolism Institute for Nutritional SciencesShanghai Institutes for Biological SciencesChinese Academy of Sciences Department of Thoracic Surgery Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical CollegeFudan University Department of Medicine Massachusetts General Hospital Cancer CenterHarvard Medical School Department of Medical Oncology Dana-Farber Cancer InstituteHarvard Medical School

LKB1 loss-of-function mutations,observed in approximate 3.%of human lung adenocarcinomas,contribute significantly to lung cancer malignancy ***,we define the cytoplasmic scaffold protein,NEDD9/HEF1/CAS-L,as a central mediator of NSCLC metastasis induced by LKB1 *** demonstrate that NEDD9 is negatively regulated by LKB1 in both human and murine lung ***1

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The mechanisms underlying that injury of skin afferents does not produce neuropathic pain:the role of BDNF

The mechanisms underlying that injury of skin afferents does...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Li-Jun zhou Wen-Jie REN Yi ZHONG Tao YANG Xian-Guo LIU~(1 *) Pain Research Center and Department of Physiology Zhongshan Medicine School of Sun Yat-sen University Guangzhou 510089 China

＜正＞Objective Although a large body of evidence has shown that peripheral nerve injury usually induces neuropathic pain,there are also clinical studies demonstrating that injury of the sural nerve,which mainly innervates skin,fails to do *** underlying mechanism,however,is largely ***-derived neurotrophic factor（BDNF）,which is essential for late-phase LTP（L-LTP） in hippocampus,plays an important role in sensory neurotransmission in nociceptive pathways at both spinal and supraspinal *** recent work has demonstrated that BDNF is critical for spinal L-LTP of C-fiber evoked field *** the present study,we investigated whether electrical stimulation or injury of the tibial nerve,innervating both muscle and skin or the sural nerve,innervating mainly skin has different effects on producing neuropathic pain and on inducing LTP of C-fiber-evoked field potentials in spinal dorsal *** role of BDNF in the spinal LTP induced by electrical stimulation of the tibial nerve or the sural nerve was *** Pain behavior test,field potential recorded by electrophysiological in vivo and with immunohistochemistry by injection of Fluorogold. Results In the present work we found that injury of the tibial nerve innervating both muscle and skin but not of the sural nerve produced a lasting mechanical allodynia in adult rats;High frequency stimulation（HFS） or injury of the tibial nerve induced L-LTP of C-fiber evoked field potentials in spinal dorsal horn,lasting for more than 5 h,while HFS or injury of the sural nerve only induced early-phase LTP（E-LTP）,lasting less than 3.***,HFS of the tibial nerve induced L-LTP of C-fiber responses evoked by stimulation of the sural nerve and the heterosynaptic L-LTP was completely prevented by spinal application of TrkB-Fc（a BDNF scavenger）.Spinal application of BDNF at a dose as low as 10 pg/ml enabled HFS of the sural nerve to produce homosynaptic ***,our immunohistochemical results re

关键词： sural nerve brain-derived neurotrophic factor neuropathic pain long-term potentiation spinal dorsal horn

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Hypoxia-induced catecholamine secretion in rat hippocampus in vivo

Hypoxia-induced catecholamine secretion in rat hippocampus i...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Mu JIN~(1,2),Lei ZHANG~(1,2),Yu MU~(1,2) Xin-Jiang KANG~1,Shi-Rong WANG~1,Wei YAO~1,Jing LV~1,Hai-Qian DOU~1,Jin-Li GU~1, Qian LEI~(1,2),Pan-Li ZUO~1,Xiao-Yu ZHANG~1,Juan FAN~1,Hua-Dong XU~1,Claire Xi ZHANG~1,Li-Huan LI~2,Zhuan zhou~(1,*) 1 institute of Molecule Medicine,Peking University,Beijing 100871,China 2 Fuwai Hospital,Peking Union Medical College,Beijing 100005,China

＜正＞The brain of anesthesia patients is often damaged by stroke-induced hypoxia during surgeries aided with artificial *** present there is no way to real-time report the oxygen/hypoxia status in the brain during the anesthesia *** we report that dopamine signaling measured by electrochemical amperometry is a sensitive indicator in rat brain under *** full anesthesia,hypoxia triggered reproducible amperometric signals in both hippocampus and ***,a blocker of dopamine transporter,potentiated the amperometric signals,indicating that hypoxia-induced catecholamine secretion（HICS） is responsible for at least part of the amperometric *** signals were dramatically blocked simply by lowering temperature from 3.℃to 3.℃,suggesting hypothermal treatment may effectively protect brain from severe hypoxia during anesthesia and surgical *** the other hand,the popular anesthetics propofol decreased the amplitude of HICS,while ketamine was no effect,suggesting propofol may have a nature of partially brain *** contrast,hypertension enhanced HICS signals significantly,implicating hypertension may deteriorate the brain damage induced by *** conclusion,amperometric recording of HICS might be a novel method to monitor hypoxia/oxygen status during anesthesia and surgical operation.

关键词： Hypoxia catecholamine release in vivo hippocampus

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Distinct severity stages of obstructive sleep apnea are correlated with unique dyslipidaemia:large-scale observational study

Distinct severity stages of obstructive sleep apnea are corr...

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中国睡眠研究会第九届学术年会

作者： Jian Guan Hongliang Yi Jianyin Zou Lili Meng Xulan Tang Huaming Zhu Dongzhen Yu Huiqun zhou Kaiming Su Mingpo Yang Haoyan Chen Yongyong Shi Yue Wang Jian Wang Shankai Yin Department of Otolaryngology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Therapy Center for Obstructive Sleep Apnea Otolaryngology Institute of Shanghai Jiao Tong University lnstitute of neuroscience Shanghai Institutes for Biological SciencesChinese Academy of Sciences Department of Gastroenterology and Hepatology Renji HospitalSchool of MedicineShanghai Jiao Tong University Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Bio-X InstitutesMinistry of EducationShanghai Jiao Tong University The Center for Disease Control and Prevention of China School of Human Communication Disorders Dalhousie University

＜正＞Background Dyslipidaemia is an intermediary exacerbation factor for various diseases but the impact of obstructive sleep apnea（OSA）on dyslipidaemia remains *** A total of 3.582 OSA suspect subjects consecutively admitted to our hospital sleep center were screened and 2,983.2,422 with OSA）were included in the shanghai Sleep Health *** severity was quantified using the apnea-hypopnea index（AHI）,the oxygen desaturation index and

关键词： Sleep apnoea lipids and lipoproteins cardiovascular diseases

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