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Recent progress in neurodegenerative disorder research in China

Science China(Life Sciences) 2010年第3期53卷 348-355页

作者： zhou jiawei institute of neuroscience,shanghai institutes for {3. Sciences,chinese academy of Sciences,shanghai,20003. 1. institute of neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

Neurodegenerative disorders,including Alzheimer's disease(AD) and Parkinson's disease(PD),are common disorders of the central nervous system among aging *** the last 10 years insights concerning the etiology,diagnosis and pathogenesis of these diseases have come from research carried out by chinese *** findings include the description of chinese patients with autosomal recessive early-onset PD,the function of the tau protein,molecular mechanisms underlying protein aggregation,and the identification of biomarkers for AD diagnosis and molecules/compounds with potential neuroprotective activities.

关键词： neurodegenerative disorders pathogenesis diagnosis neuroprotection Alzheimer’s disease Parkinson’s disease

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Visual neuroscience research in China

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Science China(Life Sciences) 2010年第3期53卷 363-373页

作者： YAO HaiShan,LU HaiDong & WANG Wei institute of neuroscience,State Key Laboratory of neuroscience,{3. institutes for biological Sciences,chinese academy of Sciences,{3. 20003.,China 1. institute of neuroscience State Key Laboratory of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

Historically,vision research in China was one of a few distinct research programs within the chinese academy of Sciences(CAS).With improved funding opportunities and research environment in neuroscience,vision research at several research {3. within the academy has made significant progress not only in the quantity of publications,but also in the quality of the *** on our own expertise,this review is mainly focused on the findings that have advanced the understanding of visual processing in the central visual pathway,visual perceptual learning,visual development and eye diseases.

关键词： visual cortices contextual modulation feedback feature binding motion processing perceptual learning functional brain imaging eye movement visual development and senescence

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Control of Secretion by Encodes of Action Potentials in Neuronal Cells

Control of Secretion by Encodes of Action Potentials in Neur...

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2003.离子通道、受体与信号转导专题研讨会

作者： Kailai Duan and Zhuan zhou institute of neuroscience, {3. institutes of biological Sciences, chinese academy of Sciences, {3. 20003., China

Action potentials (APs) are principle physiological stimuli of neurotransmitter secretion or synaptic transmis-sion. Most studies on stimulus-secretion-coupling have been performed under voltage clamp using artificial electricstimulations. To investigate the modulation effect of AP code on neural secretion, we introduced a novel method to studyAP-induced secretion in single cells. The action potential pattern is defined by a 4-parameter "encode function" F

关键词： Action Control of Secretion by Encodes of Action Potentials in Neuronal Cells

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Critical Role of TRPC6 Channels in Synaptogenesis

Critical Role of TRPC6 Channels in Synaptogenesis

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2008年全国生物化学与分子生物学学术大会

作者： Jian zhou Yi-zheng Wang (institute of neuroscience,{3. institutes of biological Sciences,State Key Laboratory of neuroscience chinese academy of Science,{3. China.20003.)

The transient receptor potential canonical (TRPC) channels are Ca2+ permeable nonselective cation chan- nels with different biological functions,but their roles in brain are largely *** we report that TRPC6 was locali...

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TORC1 controls the kinetics of CRE-target gene transcription and dendritic growth of developing cortical neurons

TORC1 controls the kinetics of CRE-target gene transcription...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Shuai LI,Yang zhou,Zhi-Qi XIONG institute of neuroscience and Key Laboratory of Neurobiology,{3. institutes for biological Sciences,chinese academy of Sciences,{3. 20003.,China

＜正＞Activity-dependent CREB-target gene transcription is implicated in cortical dendritic ***, the molecular mechanisms regulating CREB-target gene transcription and dendritic morphogenesis are not well understood. We here reported that the CREB coacti vator TORC 1（transducer of regulated CREB 1） controls the kinetics of CREB-target gene transcription and dendritic ***1 is highly expressed in the developing ***～（2+） influx induced persistent CREB phosphorylation,but transient CRE-target gene transcription in cultured developing cortical neurons. The kinetics of CREB-target gene transcription paralleled that of the nuclear translocation of ***-dependent nuclear translocation of TORC 1 activated the transcription of CREB-target genes,including salt-inducible kinase 1（SIK1）. SIK1 could phosphorylate TORC1 and then terminated TORC1-mediated CRE-target gene transcription by driving the nuclear exportation of ***,overexpressing a wild-type form of TORC1 promoted activity-dependent dendritic growth,an effect was further potentiated by down-regulating *** expressing a dominant-negative form, knocking down TORC1,or overexpressing SIK1 blocked activity-dependent dendritic *** observations identify TORC1 as a molecular switch of neuronal activity-dependent CREB target gene transcription and dendritic development.

关键词： CREB TORC1 dendrite arborization

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Requirement of TORC1 for Late-phase long-term potentiation in the hippocampus

Requirement of TORC1 for Late-phase long-term potentiation i...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Yang zhou.Hao WU.Zhi-Qi XIONG institute of neuroscience and Key Laboratory of Neurobiology,{3. institutes for biological Sciences.chinese academy of Sciences.{3. 20003.,China

＜正＞Late-phase long-term potentiation（L-LTP） and long-term memory depend on the transcription of mRNA of CRE-driven genes and synthesis of ***,how synaptic signals propagate to the nucleus is *** report that the CREB coactivator TORC 1（transducer of regulated CREB activity 1） undergoes neuronal activity-induced translocation from the cytoplasm to the nucleus,a process required for CRE-dependent gene expression and L-LTP. Overexpressing a dominant-negative form of TORC1 or down-regulating TORC 1 expression prevented activity-dependent transcription of CREB target genes in cultured hippocampal neurons,while overexpressing a wild-type form of TORC1 facilitated basal and activity-induced transcription of CREB target ***,overexpressing the dominant- negative form of TORC 1 suppressed the maintenance of L-LTP without affecting early-phase long-term potentiation,while overexpressing the wild-type form of TORC1 facilitated the induction of L-LTP in hippocampal *** results indicate that TORC1 is essential for CRE-driven gene expression and maintenance of long-term synaptic potentiation.

关键词： neuronal excitability TORC1 nuclear translocation CRE target gene transcription L-LTP maintenance

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The Kv4.2 mediates excitatory activity-dependent regulation of neuronal excitability

The Kv4.2 mediates excitatory activity-dependent regulation ...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Bin SHEN,Ke-Chun zhou,Tian-Le XU,Yi-Zheng WANG institute of neuroscience,Key Laboratory of Neurobiology,{3. institutes for biological Sciences,Graduate School,chinese academy of Sciences,{3. 20003.,China

Scaling in neuronal intrinsic excitability cooperates with synaptic transmission to control the information *** regulation of neuronal plasticity can be affected by alterations in neuronal inputs and accomplished by modulation of voltage-dependent ion ***,we report that enhanced excitatory input negatively regulated neuronal *** excitatory input by glutamate,electric field stimulation or high K increased transient outward K current,whereas did not affect the delayed rectifier K current in rat cortical *** increase in the K current density was ascribed to the cytoplasmic membrane translocation of voltage-dependent K channel 4.2,which was mediated by N-methyl-D-aspartate type of glutamate ***,enhanced excitatory input inhibited neuronal *** together,our results suggest that excitatory neurotransmission affects neuronal excitability via regulation of the K channel membrane translocation.

关键词： glutamate Kv4.2 excitability translocation NMDA receptor

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Mushroom bodies modulate salience-based attention-like behavior in Drosophila

Mushroom bodies modulate salience-based attention-like behav...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Wang XI~(1,3.),Yue-Qing PENG~(1,3.),Jian-Zheng GUO~1,Yi-zhou YE~1,Ke ZHANG~(1,3.,Aike GUO~(1,2) 1 institute of neuroscience,Key Laboratory for Neurobiology,{3. institutes for biological Sciences,chinese academy of Sciences,{3. 20003.,China 2 State Key Laboratory of Brain and Cognitive Science,institute of Biophysics,CAS,Beijing 100101,China 3.Graduate school of chinese academy of Sciences,Beijing 10003.,China

＜正＞The mushroom bodies（MBs） are involved in the visual cognitive behavior of Drosophila,such as context generalization and decision-making facing conflicting *** we report that MBs mediate the sahence-based orientation behavior in object fixation-tracking paradigms in the flight simulator that resemble attention behavior in *** found that the fixationtracking ability of flies without MBs was significantly reduced not only at low contrast levels but also in certain noise backgrounds. In the fixation-tracking selection among multiple objects,only wild type flies discriminated the strong contrast stimulus to track, while MB-deficient flies could ***,we also found that the MBs not only inhibit visual background noise,but also inhibit olfactory background noise in salience-based fixation-tracking ***,all flies including the MB mutants showed improved fixation-tracking performance when the visual/olfactory signal was synchronous presented with an olfactory/ visual hint,which suggest that MBs are not involved in crossmodal synergetic integration between olfactory and visual signals in fixation-tracking *** findings suggest that the MBs are the brain center implementing a gating mechanism that pass and amplify the salient signals and filter out background noise or unrelated signals.

关键词： Mushroom bodies attention salience flight simulator tracking Drosophila

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Activation of PI-Linked Dl-Like receptor modulates FGF-2 expression in astrocytes via IP3.dependent Ca2+ signaling

Activation of PI-Linked Dl-Like receptor modulates FGF-2 exp...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Xin-Hua ZHANG~(1,2,4),Zheng zhou~2,Da-Kui WANG~(2,3.,Ai-Qun LI~1,Yan-Qing YIN~2,Xiao-Song GU~3.Fei DING~3.Xue-Chu ZHEN~(5,*),Jia-Wei zhou~(2,*) 1 Laboratory of Molecular Cell Biology,institute of Biochemistry and Cell Biology 2 institute of neuroscience,State Key Laboratory of neuroscience,shanghai institutes for biological Sciences,chinese academy of Sciences,shanghai,20003.,China 3.Jiangsu Key Laboratory of Neuroregeneration,Nantong University School of Medicine,Nantong,226001,China 4 Department of Anatomy,Nantong University School of Medicine,Nantong,226001,China 5 State Key Laboratory of Drug Research,shanghai institute of Materia Medica,shanghai institutes for biological Sciences,chinese academy of Sciences,shanghai,201203.China

FGF-2 is predominantly synthesized and secreted by astrocytes in adult *** previous study showed that activation of classical dopamine receptor D1 or D2 elicits FGF-2 biosynthesis and secretion in ***,we report that astrocytic FGF-2 expression is also regulated by phosphatidylinositol(PI)-linked D1-like ***83.59,a selective Pi-linked D1-like receptor agonist,upregulates the levels of FGF-2 protein in striatal astrocyte cultures in classical dopamine D1 and D2 receptor-independent *** conditional medium derived from SKF83.59-activated astrocytes promoted the number of TH+ neurons in *** of astrocytes with SKF83.59 increased intracellular calcium in two *** of intracellular calcium oscillation by inositol 1,4,5-triphosphate(TP3. inhibitors blocked the SKF83.59-induced increase in FGF-2 ***,intraperitoneal administration of SKF83.59 reversed MPTP-induced reduction in FGF-2 expression in both the striatum and ventral midbrain and resulted in marked protection of dopaminergic neurons from MPTP-induced *** results indicate that IP3.Ca/calmodulin-dependent protein kinase(CaMK) is an uncharted intracellular signaling pathway that is crucial for the regulation of FGF-2 synthesis in ***-linked Dl-like receptor plays an important role in the regulation of astrocytic FGF-2 expression and neuroprotection which may provide a potential target for the drug discovery in Parkinson’s disease.

关键词： striatum neurotrophic factor Parkinson’s disease signal transduction astrocyte FGF-2

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Cloning and Characterization of a Novel Glial Cell Line-derived Neurotrophic Factor Receptor α-like Gene

Cloning and Characterization of a Novel Glial Cell Line-deri...

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华东六省一市生物化学与分子生物学会2003.学术交流会

作者： Zhihua Li, Bingwei Wang, Xuefei Wa, Min Yin, Lei Xu, jiawei zhou ( Key Laboratory of Proteomics, institute of Biochemistry and Cell biology, {3. institutes for biological Sciences, chinese academy of Sciences, {3. 20003., China

Members of the glial cell line-derived neurotrophic factor(GDNF)family comprising GDNF, neurturin, perse-phin and enovin/artemin, are crucial for the development and maintenance of distinct sets of central and peripheralneurons. All ligands signal through the RET which is activated only if the ligand is first bound to GDNF family re-ceptor-α(GFBα) receptors, which are linked to the plasma membrane by a GPI anchor. Four different GFRαre-ceptors have been identified(GFRα1-4), which determine the ligand specificity of the GFRα-RET complex. Herewe described the cloning of a novel gene that may be related to the GFRαreceptor *** bioinformaticstools and RACE (Rapid Amplification of cDNA Ends), a full-length cDNA (2123.bp)was cloned from mousebrain. DNA sequence analysis showed moderate homology of this gene to GFRαreceptor. The gene contained a pu-tative signal peptide at its N-terminus and shares conserved spacing of cystine residues which are also present in the

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