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Recent progress in neurodegenerative disorder research in China

Science China(Life sciences) 2010年第3期53卷 348-355页

作者： zhou jiawei institute of neuroscience,shanghai institutes for biological sciences,chinese academy of sciences,shanghai,200031 1. institute of neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

Neurodegenerative disorders,including Alzheimer's disease(AD) and Parkinson's disease(PD),are common disorders of the central nervous system among aging *** the last 10 years insights concerning the etiology,diagnosis and pathogenesis of these diseases have come from research carried out by chinese *** findings include the description of chinese patients with autosomal recessive early-onset PD,the function of the tau protein,molecular mechanisms underlying protein aggregation,and the identification of biomarkers for AD diagnosis and molecules/compounds with potential neuroprotective activities.

关键词： neurodegenerative disorders pathogenesis diagnosis neuroprotection Alzheimer’s disease Parkinson’s disease

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Visual neuroscience research in China

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Science China(Life sciences) 2010年第3期53卷 363-373页

作者： YAO HaiShan,LU HaiDong & WANG Wei institute of neuroscience,State Key Laboratory of neuroscience,shanghai institutes for biological sciences,chinese academy of sciences,shanghai 200031,China 1. institute of neuroscience State Key Laboratory of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

Historically,vision research in China was one of a few distinct research programs within the chinese academy of sciences(CAS).With improved funding opportunities and research environment in neuroscience,vision research at several research institutes within the academy has made significant progress not only in the quantity of publications,but also in the quality of the *** on our own expertise,this review is mainly focused on the findings that have advanced the understanding of visual processing in the central visual pathway,visual perceptual learning,visual development and eye diseases.

关键词： visual cortices contextual modulation feedback feature binding motion processing perceptual learning functional brain imaging eye movement visual development and senescence

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Control of Secretion by Encodes of Action Potentials in Neuronal Cells

Control of Secretion by Encodes of Action Potentials in Neur...

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2003’离子通道、受体与信号转导专题研讨会

作者： Kailai Duan and Zhuan zhou institute of neuroscience, shanghai institutes of biological sciences, chinese academy of sciences, shanghai 200031, China

Action potentials (APs) are principle physiological stimuli of neurotransmitter secretion or synaptic transmis-sion. Most studies on stimulus-secretion-coupling have been performed under voltage clamp using artificial electricstimulations. To investigate the modulation effect of AP code on neural secretion, we introduced a novel method to studyAP-induced secretion in single cells. The action potential pattern is defined by a 4-parameter "encode function" F

关键词： Action Control of Secretion by Encodes of Action Potentials in Neuronal Cells

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TORC1 controls the kinetics of CRE-target gene transcription and dendritic growth of developing cortical neurons

TORC1 controls the kinetics of CRE-target gene transcription...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Shuai LI,Yang zhou,Zhi-Qi XIONG institute of neuroscience and Key Laboratory of Neurobiology,shanghai institutes for biological sciences,chinese academy of sciences,shanghai 200031,China

＜正＞Activity-dependent CREB-target gene transcription is implicated in cortical dendritic ***, the molecular mechanisms regulating CREB-target gene transcription and dendritic morphogenesis are not well understood. We here reported that the CREB coacti vator TORC 1（transducer of regulated CREB 1） controls the kinetics of CREB-target gene transcription and dendritic ***1 is highly expressed in the developing ***～（2+） influx induced persistent CREB phosphorylation,but transient CRE-target gene transcription in cultured developing cortical neurons. The kinetics of CREB-target gene transcription paralleled that of the nuclear translocation of ***-dependent nuclear translocation of TORC 1 activated the transcription of CREB-target genes,including salt-inducible kinase 1（SIK1）. SIK1 could phosphorylate TORC1 and then terminated TORC1-mediated CRE-target gene transcription by driving the nuclear exportation of ***,overexpressing a wild-type form of TORC1 promoted activity-dependent dendritic growth,an effect was further potentiated by down-regulating *** expressing a dominant-negative form, knocking down TORC1,or overexpressing SIK1 blocked activity-dependent dendritic *** observations identify TORC1 as a molecular switch of neuronal activity-dependent CREB target gene transcription and dendritic development.

关键词： CREB TORC1 dendrite arborization

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Critical Role of TRPC6 Channels in Synaptogenesis

Critical Role of TRPC6 Channels in Synaptogenesis

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2008年全国生物化学与分子生物学学术大会

作者： Jian zhou Yi-zheng Wang (institute of neuroscience,shanghai institutes of biological sciences,State Key Laboratory of neuroscience chinese academy of Science,shanghai China.200031)

The transient receptor potential canonical (TRPC) channels are Ca2+ permeable nonselective cation chan- nels with different biological functions,but their roles in brain are largely *** we report that TRPC6 was locali...

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Requirement of TORC1 for Late-phase long-term potentiation in the hippocampus

Requirement of TORC1 for Late-phase long-term potentiation i...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Yang zhou.Hao WU.Zhi-Qi XIONG institute of neuroscience and Key Laboratory of Neurobiology,shanghai institutes for biological sciences.chinese academy of sciences.shanghai 200031,China

＜正＞Late-phase long-term potentiation（L-LTP） and long-term memory depend on the transcription of mRNA of CRE-driven genes and synthesis of ***,how synaptic signals propagate to the nucleus is *** report that the CREB coactivator TORC 1（transducer of regulated CREB activity 1） undergoes neuronal activity-induced translocation from the cytoplasm to the nucleus,a process required for CRE-dependent gene expression and L-LTP. Overexpressing a dominant-negative form of TORC1 or down-regulating TORC 1 expression prevented activity-dependent transcription of CREB target genes in cultured hippocampal neurons,while overexpressing a wild-type form of TORC1 facilitated basal and activity-induced transcription of CREB target ***,overexpressing the dominant- negative form of TORC 1 suppressed the maintenance of L-LTP without affecting early-phase long-term potentiation,while overexpressing the wild-type form of TORC1 facilitated the induction of L-LTP in hippocampal *** results indicate that TORC1 is essential for CRE-driven gene expression and maintenance of long-term synaptic potentiation.

关键词： neuronal excitability TORC1 nuclear translocation CRE target gene transcription L-LTP maintenance

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The Kv4.2 mediates excitatory activity-dependent regulation of neuronal excitability

The Kv4.2 mediates excitatory activity-dependent regulation ...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Bin SHEN,Ke-Chun zhou,Tian-Le XU,Yi-Zheng WANG institute of neuroscience,Key Laboratory of Neurobiology,shanghai institutes for biological sciences,Graduate School,chinese academy of sciences,shanghai 200031,China

Scaling in neuronal intrinsic excitability cooperates with synaptic transmission to control the information *** regulation of neuronal plasticity can be affected by alterations in neuronal inputs and accomplished by modulation of voltage-dependent ion ***,we report that enhanced excitatory input negatively regulated neuronal *** excitatory input by glutamate,electric field stimulation or high K increased transient outward K current,whereas did not affect the delayed rectifier K current in rat cortical *** increase in the K current density was ascribed to the cytoplasmic membrane translocation of voltage-dependent K channel 4.2,which was mediated by N-methyl-D-aspartate type of glutamate ***,enhanced excitatory input inhibited neuronal *** together,our results suggest that excitatory neurotransmission affects neuronal excitability via regulation of the K channel membrane translocation.

关键词： glutamate Kv4.2 excitability translocation NMDA receptor

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Cloning and Characterization of a Novel Glial Cell Line-derived Neurotrophic Factor Receptor α-like Gene

Cloning and Characterization of a Novel Glial Cell Line-deri...

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华东六省一市生物化学与分子生物学会2003年学术交流会

作者： Zhihua Li, Bingwei Wang, Xuefei Wa, Min Yin, Lei Xu, jiawei zhou ( Key Laboratory of Proteomics, institute of Biochemistry and Cell biology, shanghai institutes for biological sciences, chinese academy of sciences, shanghai 200031, China

Members of the glial cell line-derived neurotrophic factor(GDNF)family comprising GDNF, neurturin, perse-phin and enovin/artemin, are crucial for the development and maintenance of distinct sets of central and peripheralneurons. All ligands signal through the RET which is activated only if the ligand is first bound to GDNF family re-ceptor-α(GFBα) receptors, which are linked to the plasma membrane by a GPI anchor. Four different GFRαre-ceptors have been identified(GFRα1-4), which determine the ligand specificity of the GFRα-RET complex. Herewe described the cloning of a novel gene that may be related to the GFRαreceptor *** bioinformaticstools and RACE (Rapid Amplification of cDNA Ends), a full-length cDNA (2123 bp)was cloned from mousebrain. DNA sequence analysis showed moderate homology of this gene to GFRαreceptor. The gene contained a pu-tative signal peptide at its N-terminus and shares conserved spacing of cystine residues which are also present in the

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Molecular Cloning of Rat Bystin Gene and Identification of Reactive Astrocytes in the Adult Brain Following Injury

Molecular Cloning of Rat Bystin Gene and Identification of R...

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华东六省一市生物化学与分子生物学会2003年学术交流会

作者： Jiansong Sheng Shuo Yang Lei Xu Chunhua Wu Xuefei Wu Min Yin Yi Yu jiawei zhou(Key Laboratory of Proteomics institute of Biochemistry and Cell Biology shanghai institutes for biological sciences chinese academy of sciences shanghai 200031 P.R.China)

Bystin is one of important molecules at the time of implantation. It binds direcily to trophinin and tastin to forma cell adhesion molecular complex that potentially mediates an initiate attachmen

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Molecular Cloning of Rat Bystin Gene and Identification of Reactive Astrocytes in the Adult Brain Following Injury

Molecular Cloning of Rat Bystin Gene and Identification of R...

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华东六省一市生物化学与分子生物学会2003年学术交流会

作者： Jiansong Sheng, Shuo Yang, Lei Xu, Chunhua Wu, Xuefei Wu, Min Yin, Yi Yu, jiawei zhou (Key Laboratory of Proteomics, institute of Biochemistry and Cell Biology, shanghai institutes for biological sciences, chinese academy of sciences, shanghai, 200031, P.R.China)

Bystin is one of important molecules at the time of implantation. It binds direcily to trophinin and tastin to forma cell adhesion molecular complex that potentially mediates an initiate attachment of the blastocyst to uterine epithe-lial cells and the attachment can be enhanced in the presence of cytokeratins-8 and -18. However, the presence ofbystin has not been reported in CNS previously. Here, we provide evidence demonstrating that bystin may be in-volved in the pathogenesis of Parkinson’s disease. We cloned the bystin cDNA from the substantia nigra (SN) of 6-hydroxydoamine (6-OHDA) -lesioned *** bystin cDNA clone consists of 1421 nucleotides encoding 324 aminoacids. The rat bystin has 21 a. a. extrude in itS N-terminal compared with existing human bystin gene. The rest of

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