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Experimental study on moving boundaries of fluid flow in porous media

Chinese Science Bulletin 2008年第16期53卷 2438-2445页

作者： zhou hongwei zhang yaheng li aimin qiu dayong Institute of Rock Mechanics and Fractals China University of Mining and Technology Beijing 100083 China

Researches on the boundary shape of fluid flow in porous media play an important role in engineering practices, such as petroleum exploitation, nuclear waste disposal and groundwater contamination. In this paper, six types of artificial porous samples (emery jade) with different porosities are manufactured. With the background of slow flow in porous media, laboratory experiments are carried out by observing the movement of five types of fluids with different dynamic viscosities in various types of porous media. A digital video recorder is employed to record the complete process of the fluid flow in the porous media. Based on the digital photos of the moving boundaries of fluid flow in porous media, the average displacement and fractal dimension of the moving boundary are estimated for different combinations of porosity and dynamic viscosity. Moreover, the evolution behavior of the average velocity and fractal dimension of the moving boundary with time is known. The statistical relations of the average velocity, the fractal dimension of the moving boundary and the porosity of porous media and the dynamic vis- cosity of fluids are proposed in this paper. It is shown that the front shape of the moving boundary of fluid flow in porous media is an integrated result of the porosity of porous media and the dynamic viscosity of fluids.

关键词：多孔渗水介质流程移动边界石油

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Precise nanomedicine for intelligent therapy of cancer

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Science China Chemistry 2018年第12期61卷 1503-1552页

作者： Huabing Chen Zhanjun Gu hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang liu Suping li Tianyu li Zhuang liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng zhang Yanbing Zhao Weihong Tan Xi zhang Yuliang Zhao State Key Laboratoiy of Radiation Medicine and Protection Jiangsu Key Laboratoiy of Neuropsychiatric Diseases College of Pharmaceutical Sciences Soochow University Suzhou 215123 China Key Laboratoiy of Biomedical Polymers of Ministry of Education Department of Chemistiy Wuhan University Wuhan 430072 China Laboratoiy of Molecular Imaging and Nanomedicine National Institute of Biomedical Imaging and Bioengineering National Institutes of Health Bethesda MD 20892 USA Molecular Science and Biomedicine Laboratoiy State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistiy and Chemical Engineering Aptamer Engineering Center of Hunan Province Hunan University Changsha 410082 China Jiangsu Key Laboratoiy for Carbon-Based Functional Materials & Devices Institute of Functional Nano & Soft Materials Soochow University Suzhou 215123 China Department of Polymer Science and Engineering College cf Chemistry and Chemical Engineering Nanjing University Nanjing 210093 China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China Department of Chemistiy Tsinghua University Beijing 100084 China National Engineering Research Center for Nanomedicine College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China Department of Chemistiy and Department of Physiology and Functional Genomics Center for Research at Bio/nano Interface Health Cancer Center UF Genetics Institute and McKnight Brain Institute University of Florida Gainesville FL 32611-7200 USA institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China CAS Key Laboratoiy for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China Key Labo

Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.

关键词： nanomedicine nanoparticles cancer therapy cancer imaging intelligent therapy

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