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Polymorphisms of TLR7 and TLR8 associated with risk of asthma and asthma-related phenotypes in a southeastern Chinese Han population

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Journal of Nanjing Medical University 2009年第1期23卷 25-32页

作者： Qian Zhang Fenhong Qian Linfu zhou Guozhen Wei Ying Wang Zhibin Hu guangfu Jin Jianling Bai Kaisheng Yin Department of Respiratory Medicine Affiliated Changzhou No.2 People's Hospital Nanjing Medical University Changzhou 213003 China Department of Respiratory Medicine Affiliated Jiangbing Hospital Jiangsu University Zhenjiang 212001 China Department of Respiratory Medicine First Affiliated Hospital Nanjing Medical University Nanjing 210029 China Department of Genetics Chinese National Human Genome Center at Shanghai Shanghai 201203 China Department of Epidemiology and Biostatistics Cancer Research Center Nanjing Medical University Nanjing 210029 China Department of Epidemiology and Biostatistics School of Public Health Nanjing Medical University Nanjing 210029 China

Objective： To evaluate the effects of polymorphisms in TLR7 and TLRS（as potential candidate genes） on asthma risk and asthma-related phenotypes. Methods： We consecutively recruited 318 unrelated adult asthmatic patients and 352 healthy volunteers from the same area of southeast China. Genotyping of each selected SNP was performed using multiplex PCR in conjunction with tagged array single base extension technology. We conducted case-control and case-only association studies between the selected SNPs in TLR7 and TLR8 and asthma or asthma-related phenotypes. Results： The T allele of rs5935436 SNP in TLR7 was protective from developing asthma in males （adjusted ORs = 0.126, 95% CIs = 0.016-0.995）. The CT/TT genotype of rs5935436 was less frequent in female asthmatics with allergic rhinitis （adjusted ORs = 0.18, 95% CIs = 0.04-0.90）. The homozygote AA of rs3761623 and GG of rs3764880 were positively associated with lower FEV1% and asthma severity in female asthmatics. These results were confirmed by haplotype analysis. Conclusion：TLR7 and TLR8 polymorphisms may play an important role in the pathogenesis of asthma that is gender-dependent. This could be clinically useful, both for identifying patients at risk of asthma and for preventing its occurrence.

关键词： Asthma Atopy Phenotype Polymorphism Toll-like receptors

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β-Cyclodextrin derived full-spectrum fluorescent carbon dots: The formation process investigation and biological applications

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Chinese Chemical Letters 2023年第10期34卷 215-222页

作者： Peide Zhu Wenjing Li Yuqi Zhang Qiang Sun Yi Lin Ailin Qiu Xinyi Chen Yujin zhou guangfu Wu Yifan Li Zhiqiang Yu Quan Xu Dixian Luo Lulu Cai State Key Laboratory of Heavy Oil Processing China University of Petroleum-BeijingBeijing 102249China Department of Laboratory Medicine Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital)Shenzhen 518052China Personalized Drug Therapy Key Laboratory of Sichuan Province Department of PharmacySichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 611731China Department of Laboratory Medicine Dongguan Institute of Clinical Cancer ResearchAffiliated Dongguan HospitalSouthern Medical UniversityDongguan 523018China

Carbon dots(CDs), a new building unit, have been revolutionizing the fields of biomedicine, bioimaging, and optoelectronics with their excellent physical, chemical, and biological properties. However, the difficulty of preparing excitation-dependent full-spectrum fluorescent CDs has seriously hindered their further research in fluorescence emission mechanisms and biomedicine. Here, we report full-spectrum fluorescent CDs that exhibit controlled emission changes from purple(380 nm) to red(613 nm) at room temperature by changing the excitation wavelength, and the excitation dependence was closely related to the regulation of sp2 and sp3 hybrid carbon structures by β-cyclodextrin-related groups. In addition,by regulating the content of β-cyclodextrin, the optimal quantum yields of full-spectrum fluorescent CDs were 8.97%, 8.35%, 7.90%, 9.69% and 17.4% at the excitation wavelengths of 340, 350, 390, 410 and 540 nm,respectively. Due to their excellent biocompatibility and color tunability, full-spectrum fluorescent CDs emitted bright and steady purple, blue, green, yellow, and red fluorescence in MCF-7 cells. Moreover, we optimized the imaging conditions of CDs and mitochondrial-specific dyes;and realized the mitochondrialtargeted co-localization imaging of purple, blue and green fluorescence. After that, we also explored the effect of full-spectrum fluorescent CDs in vivo fluorescence imaging through the intratumorally, subcutaneously, and caudal vein, and found that full-spectrum fluorescent CDs had good fluorescence imaging ability in vivo.

关键词： Carbon dots Multi-emission Fluorescence mechanism Mitochondrial targeting Color tenability Fluorescence imaging

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多学科联合不同内镜下治疗食管异物79例临床分析

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中国医学文摘（耳鼻咽喉科学） 2021年第3期36卷 52-55,F0002页

作者：崔建鹏牟肖梅于伟周广福张芬王晶王春雨徐红梅张庆泉程晓娟烟台芝罘医院山东烟台264000

目的分析我院多学科联合对79例食管异物患者行电子纤维喉镜、硬质食管镜与胃镜治疗的效果。方法回顾性分析山东省烟台芝罘医院2015年1月至2020年12月79例食管异物经不同内镜治疗的病例资料。结果79例食管异物中,50例行电子纤维喉镜下和... 详细信息

目的分析我院多学科联合对79例食管异物患者行电子纤维喉镜、硬质食管镜与胃镜治疗的效果。方法回顾性分析山东省烟台芝罘医院2015年1月至2020年12月79例食管异物经不同内镜治疗的病例资料。结果79例食管异物中,50例行电子纤维喉镜下和硬式食管镜下治疗,29例行胃镜下治疗,硬式食管镜组治疗成功率100%,胃镜组治疗成功率为96.6%,二者比较差异无统计学意义(P>0.05)。结论电子纤维喉镜适合于食管入口的异物部分暴露于下咽的患者、硬式食管镜与胃镜适合于食管入口以下的异物,二者取食管异物成功率均较高,不同的食管异物可以采用不同的内镜治疗。

关键词：食管异物食管镜胃镜

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Magnetism in Carbon Nanoscrolls: Quasi-Half-Metals and Half-Metals in Pristine Hydrocarbons

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Nano Research 2009年第11期2卷 844-850页

作者： Lin Lai Jing Lu Lu Wang guangfu Luo Jing zhou Rui Qin Yu Chen Hong Li Zhengxiang Gao Guangping Li Wai Ning Mei Yutaka Maeda Takeshi Akasaka and Stefano Sanvito State Key Laboratory for Mesoscopic Physics and Department of Physics Peking UniversityBeijing 100871China Department of Physics University of Nebraska at OmahaOmahaNebraska 68182-0266USA SICAS Center Lee HallSUNY OneontaOneontaNY 13820USA Department of Chemistry Tokyo Gakugei UniversityTokyo 184-8501Japan PRESTO Japan Science and Technology Agency4-1-8 Honcho KawagushiSaitamaJapan Center for Tsukuba Advanced Research Alliance University of TsukubaIbaraki 305-8577Japan School of Physics and CRANN Trinity CollegeDublin 2Ireland

A magnetic ground state is revealed for the first time in zigzag-edged carbon nanoscrolls(ZCNSs)from spin-unrestricted density functional theory *** their flat counterpart-zigzag-edged carbon nanoribbons,which are semiconductors with spin-degenerate electronic structure-ZCNSs show a variety of magnetic configurations,namely spin-selective semiconductors,metals,semimetals,quasi-half-metals,and *** the best of our knowledge,this is the first discovery of quasi-half-metals and half-metals in a pure hydrocarbon without resort to an external electric *** addition,we calculated the spin-dependent transportation of the semiconducting ZCNSs with 12 and 20 zigzag chains,and found that they are 13% and 17% at the Fermi level,respectively,suggesting that ZCNS can be an effective spin filter.

关键词： Carbon nanoscrolls quasi-half-metals half-metals graphene spin-selective spin filter

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Identification of A-to-I RNA editing profiles and their clinical relevance in lung adenocarcinoma

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Science China(Life Sciences) 2022年第1期65卷 19-32页

作者： Cheng Wang Mingtao Huang Congcong Chen Yuancheng Li Na Qin Zijian Ma Jingyi Fan Linnan Gong Hui Zeng Liu Yang Xianfeng Xu Jun zhou Juncheng Dai guangfu Jin Zhibin Hu Hongxia Ma Fengwei Tan Hongbing Shen Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personized MedicineNanjing Medical UniversityNanjing 211166China Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Adenosine-to-inosine(A-to-I)RNA editing is a widespread posttranscriptional modification that has been shown to play an important role in ***,we evaluated a total of 19,316 RNA editing sites in the tissues of 80 lung adenocarcinoma(LUAD)patients from our Nanjing Lung Cancer Cohort(NJLCC)and 486 LUAD patients from the TCGA *** global RNA editing level was significantly increased in tumor tissues and was highly heterogeneous across *** high RNA editing level in tumors was attributed to both RNA(ADAR1 expression)and DNA alterations(mutation load).Consensus clustering on RNA editing sites revealed a new molecular subtype(EC3)that was associated with the poorest prognosis of LUAD ***,the new classification was independent of classic molecular subtypes based on gene expression or DNA *** further proposed a simplified model including eight RNA editing sites to accurately distinguish the EC3 subtype in our *** model was further validated in the TCGA dataset and had an area under the curve(AUC)of the receiver operating characteristic curve of 0.93(95%CI:0.91-0.95).In addition,we found that LUAD cell lines with the EC3 subtype were sensitive to four chemotherapy *** findings highlighted the importance of RNA editing events in the tumorigenesis of LUAD and provided insight into the application of RNA editing in the molecular subtyping and clinical treatment of cancer.

关键词： lung adenocarcinoma A-to-I RNA editing cancer molecular type

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基于附加约束的小型涡轮增压器转子模态测试

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中国机械工程 2017年第11期28卷 1274-1278页

作者：宾光富周伟王钢陈文湖南科技大学机械设备健康维护湖南省重点实验室湘潭411201

针对转子模态参数难以有效获取的问题,进行了基于附加约束的小型涡轮增压器转子模态测试研究。以多种材料和零部件组成的某型汽油发动机涡轮增压器转子结构为例,采用有限元法构建了其有限元模型,得到自由边界条件下转子前三阶模态频率... 详细信息

针对转子模态参数难以有效获取的问题,进行了基于附加约束的小型涡轮增压器转子模态测试研究。以多种材料和零部件组成的某型汽油发动机涡轮增压器转子结构为例,采用有限元法构建了其有限元模型,得到自由边界条件下转子前三阶模态频率。然后分别采用卧式悬挂、立式悬挂、海绵垫、硬纸垫四种不同附加约束条件,开展转子的力锤模态测试,通过稳态图识别模态频率,与有限元仿真结果进行对比发现,采用悬挂方式较采用直接固定约束方式的识别值要低,而采用立式悬挂约束方式获得的转子模态测试综合效果最佳。

关键词：模态参数附加约束涡轮增压器转子锤击模态测试稳态图

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A 5'-flanking region polymorphism in toll-like receptor 4 is associated with gastric cancer in a Chinese population

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The Journal of Biomedical Research 2010年第2期24卷 100-106页

作者： Hua Huang Juan Wu guangfu Jin Hanze Zhang Yanbing Ding Zhaolai Hua Yan zhou Yan Xue Yan Lu Zhibin Hu Yaochu Xu Hongbing Shen Department of Epidemiology and Biostatisties Cancer Center Nanjing Medical University Nanjing 210029 Jiangsu China Department of Gastroenterology Yangzhou First People's Hospital. Yangzhou 225009 Jiangsu China Department of Epidemiology Yangzhong Cancer Institute Yangzhong 212200 Jiangsu China Department of Oneology Yixing People 's Hospital Yixing 214200 Jiangsu China

Objective： Inflammation induced by *** colonization in the stomach is related to the development of gastric cancer and the genetic variations of the genes involved in the immune responses modify the host response to the infection. The aim of this study was to evaluate whether polymorphisms in the toll-like receptor 4 （TLR4） gene, a key regulator of both innate and adaptive immunity, were related to the susceptibility to

关键词： toll-like receptor 4 polymorphisms susceptibility gastric cancer

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A DC Grid Benchmark Model for Studies of Interconnection of Power Systems

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CSEE Journal of Power and Energy Systems 2015年第4期1卷 101-109页

作者： Ting An Xiaoxin zhou Congda Han Yanan Wu Zhiyuan He Hui Pang guangfu Tang Smart Grid Research Institute(SGRI)of State Grid Corporation of China(SGCC) Beijing 102211China China Electric Power Research Institute(CEPRI) Beijing 100192China

Reducing carbon emissions in the power sector is critical for transitioning to a sustainable and low-carbon *** carbon efficiency of demand side response(DSR)in the power system is an important step towards realizing potential environmental *** emission factor(MEF)is an effective tool for estimating incremental changes in carbon emissions as a result of a change in ***,estimation methods currently used for evaluating MEF can be improved upon,specifically,by factoring in the ramp-rate constraint of generators in the fuel cost based merit order *** this paper is described a new method for MEF assessment under ramp-rate constraints;the method is then compared with two conventional estimations in a British power *** fuel price scenarios are used to conduct a sensitivity analysis of MEFs to fuel *** are drawn that can pave the way for future improvements in estimating MEF in power systems.

关键词： Carbon emission fuel prices scenarios marginal emissions factor ramp-rate constraint sensitivity analysis

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直流换流阀阻尼电阻脉冲功率试验方法研究

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电网技术 2013年第1期37卷 89-93页

作者：周万迪高冲汤广福中国电力科学研究院北京市昌平区102206

阻尼电阻作为直流换流阀的核心部件之一,其电气性能也直接决定了换流阀的可靠性。分析了阻尼电阻在换流阀实际运行中经受的电气应力以及产生的功率损耗。在此基础上,采用等效模拟的思想研究了对阻尼电阻稳态和暂态脉冲功率进行试验的方... 详细信息

阻尼电阻作为直流换流阀的核心部件之一,其电气性能也直接决定了换流阀的可靠性。分析了阻尼电阻在换流阀实际运行中经受的电气应力以及产生的功率损耗。在此基础上,采用等效模拟的思想研究了对阻尼电阻稳态和暂态脉冲功率进行试验的方法。结合试验方法,提出了基于重频充电原理的试验电路拓扑,阐述了试验电路的工作方式,并进行了电路仿真波形的分析,最后用所研制样机验证了设计的合理性。

关键词：直流换流阀阻尼电阻脉冲功率重频充电

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“建筑技能大师工作室”赋能乡村振兴模式实践探索

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高等建筑教育 2024年第5期33卷 119-126页

作者：周彝馨华南农业大学水利与土木工程学院广东广州510642

“技能大师工作室”建设是新时期人才培养的重要措施之一。德国包豪斯工作坊教学模式存在的主要问题,影响了其可持续发展,而高校的“建筑技能大师工作室”针对“工作坊”的不可持续性问题,提出了多方面的改进意见,成为包豪斯工作坊2.0... 详细信息

“技能大师工作室”建设是新时期人才培养的重要措施之一。德国包豪斯工作坊教学模式存在的主要问题,影响了其可持续发展,而高校的“建筑技能大师工作室”针对“工作坊”的不可持续性问题,提出了多方面的改进意见,成为包豪斯工作坊2.0模式。以华南农业大学“广府古建筑技能大师工作室”为案例,结合该工作室在乡村振兴领域的研究实践,探索“建筑技能大师工作室”与乡村振兴相互促进的特色之路。工作室在包豪斯“工作坊”体系的基础上改进,突出自身的优势和特点,贯彻教学、科研、实践“三位一体”的教学理念。运用“以行促学,学科融合,扎根乡建”的教学方法,与教学体系高度结合,促进建立特色教学体系;开拓本校建筑学专业多学科交叉的新研究领域;通过不断实践培养熟悉乡村振兴的创新型人才。教学达到了学科发展、人才培养、回馈社会的教学效果,建立起高校学科与外部系统的联系,培养多学科交叉型人才,学院式研究与科普公益工作相结合。

关键词：乡村振兴建筑技能大师工作室工作坊2.0模式以行促学学科融合系统性思维

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