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A novel mechanism of inhibiting in-stent restenosis with arsenic trioxide drug-eluting stent: Enhancing contractile phenotype of vascular smooth muscle cells via YAP pathway

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Bioactive Materials 2021年第2期6卷 375-385页

作者： Yinping Zhao Guangchao Zang tieying Yin Xiaoyi Ma Lifeng zhou Lingjuan Wu Richard Daniel Yunbing Wang Juhui Qiu Guixue Wang Laboratory of Tissue and Cell Biology Lab Teaching&Management CenterChongqing Medical UniversityChongqing400016China Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqing400030China Beijing Amsinomed Medical Co. LtdBeijing100021China Medical School Newcastle UniversityNewcastle Upon TyneNE24AXUK National Engineering Research Center for Biomaterials Sichuan UniversityChengdu610065China

Objective:Arsenic trioxide(ATO or As2O3)has beneficial effects on suppressing neointimal hyperplasia and restenosis,but the mechanism is still *** goal of this study is to further understand the mechanism of ATO's inhibitory effect on vascular smooth muscle cells(VSMCs).Methods and results:Through in vitro cell culture and in vivo stent implanting into the carotid arteries of rabbit,a synthetic-to-contractile phenotypic transition was induced and the proliferation of VSMCs was inhibited by ATO.F-actin filaments were clustered and the elasticity modulus was increased within the phenotypic modulation of VSMCs induced by ATO in ***,Yes-associated protein(YAP)nuclear translocation was inhibited by ATO both in vivo and in *** was found that ROCK inhibitor or YAP inactivator could partially mask the phenotype modulation of ATO on ***:The interaction of YAP with the ROCK pathway through ATO seems to mediate the contractile phenotype of *** provides an indication of the clinical therapeutic mechanism for the beneficial bioactive effect of ATO-drug eluting stent(AES)on in-stent restenosis(ISR).

关键词： Arsenic trioxide(ATO) Bioactive Yes-associated protein(YAP) In-stent restenosis(ISR)

Surface protonation and oxygen evolution activity of epitaxial La(1-x)SrxCoO3 thin films

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Science China(Physics,Mechanics & Astronomy) 2020年第9期63卷 77-82页

作者： XiaoShuo Wang Liang zhou MengXin Li Yi Luo tieying Yang TianLi Wu XiaoLong Li Kui-Juan Jin Er-Jia Guo LiFen Wang XueDong Bai WeiFeng Zhang HaiZhong Guo Henan Key Laboratory of Photovoltaic Materials School of Physics and ElectronicsHenan UniversityKaifeng 475004China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China Shanghai Synchrotron Radiation Facility(SSRF) Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201204China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Collaborative Innovation Center of Light Manipulations and Applications Shandong Normal UniversityJinan 250358China

As an alternative electrode material,transition metal oxides are promising candidates due to multivalent nature and oxygen vacancies present in the structure with facilitate redox *** aim of this study is to explore the intrinsic mechanism of oxygen evolution reaction(OER)using two-dimensional thin film La1-xSrxCoO3 electrode as a ***,we report a planar two-dimensional model La1-xSrxCoO3 electrode grown on a Nb-SrTiO3 single-crystal substrate via pulsed laser *** two-dimensional La1-xSrxCoO3 films offer different oxygen evolution activities at different pH electrolyte *** mechanisms behind the variations of the oxygen evolution activity were discussed after comparing the oxygen evolution activity before and after treatments of the electrodes and measurements by various test *** results of this study offer a promising,low-cost electrode material for the efficient OER and a sustainable production of hydrogen fuel.

关键词： oxygen evolution reaction La1-xSrxCoO3 thin films lattice oxygen protonation

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自适应学习在护理教育中的应用进展

中华护理教育 2024年第7期21卷 892-896页

作者：刘于高丽佳张文艳于明峰文佳祺曾铁英华中科技大学同济医学院附属同济医院武汉市430030

自适应学习是人工智能赋能教育的重要形式,不断受到护理教育者的关注。该文概述了自适应学习的定义、特征,并对自适应学习在护理教育中的应用现况、自适应学习系统的构建与运行、效果评价进行综述,总结自适应学习在护理教育领域中应用... 详细信息

自适应学习是人工智能赋能教育的重要形式,不断受到护理教育者的关注。该文概述了自适应学习的定义、特征,并对自适应学习在护理教育中的应用现况、自适应学习系统的构建与运行、效果评价进行综述,总结自适应学习在护理教育领域中应用的挑战与建议,为护理教育的改革与发展提供参考。

关键词：教育护理综述自适应学习

恶性梗阻性黄疸PTCD带管病人出院经历的质性研究

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循证护理 2024年第9期10卷 1606-1610页

作者：栾佳斌李恋王骞曾铁英华中科技大学同济医学院附属同济医院湖北430030

目的:基于“以家庭为中心”的理论,探讨恶性梗阻性黄疸经皮肝穿刺胆管引流术(PTCD)带管病人出院经历的体验,为制定相应的护理支持方案提供依据。方法:采用现象学研究方法,选取2022年6月—12月在武汉市某三级甲等综合医院胆胰外科住院的1... 详细信息

目的:基于“以家庭为中心”的理论,探讨恶性梗阻性黄疸经皮肝穿刺胆管引流术(PTCD)带管病人出院经历的体验,为制定相应的护理支持方案提供依据。方法:采用现象学研究方法,选取2022年6月—12月在武汉市某三级甲等综合医院胆胰外科住院的13例携带PTCD引流管出院的病人,对其进行半结构访谈,应用Colaizzi 7步分析法对资料进行分析、归纳及提炼主题。结果:遵循“以家庭为中心”的理论,提炼出恶性梗阻性黄疸病人出院准备期、出院接受期、出院后期带管出院体验的3个主题。结论:恶性梗阻性黄疸PTCD带管病人出院照护体验动态变化,医护人员应有针对性地给予心理支持,强调家庭的参与感,增强家庭照护的延续性。

关键词：以家庭为中心恶性梗阻性黄疸带管出院质性研究护理

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Statistical models for intensity and phase fluctuation of laser light in a turbulent medium

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Chinese Science Bulletin 2011年第15期56卷 1539-1542页

作者： WANG HongXing LIU Min WANG Qian ZHANG tieying LIU XiGuo Department of Electronic and Information Engineering Navy Aeronautical and Astronautical University Yantai 264001 China

The probability density function of irradiance fluctuations in a turbulent atmosphere remains an open topic of *** is generally considered that the speckle field has an elliptical-Gaussian speckle distribution,but because of its complexity there is still no exact analytical *** introducing the concept of random fluctuation intensity and using an equiprobability density ellipse,exact models of the random fluctuation intensity and its phase are *** theoretical analysis and numerical simulation,it is concluded that the random fluctuation intensity and its corresponding phase are independent only under the circular-Gaussian approximation.

关键词：波动强度相位波动统计模型湍流介质概率密度函数激光随机波动高斯近似

中性粒细胞/淋巴细胞比值在慢性阻塞性肺疾病急性加重中的研究进展

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国际呼吸杂志 2024年第9期44卷 1102-1106页

作者：杨瑞英郭岩斐孙铁英北京医院呼吸与危重症医学科国家老年医学中心中国医学科学院老年医学研究所北京

慢性阻塞性肺疾病是一种异质性肺部病变, 表现为持续性、进行性加重的气流受限。在我国, 慢性阻塞性肺疾病患病率高, 疾病负担重, 急性加重是患者的首要死亡因素。目前慢性阻塞性肺疾病急性加重的诊断主要依靠症状的加重, 尚缺乏客观有... 详细信息

慢性阻塞性肺疾病是一种异质性肺部病变, 表现为持续性、进行性加重的气流受限。在我国, 慢性阻塞性肺疾病患病率高, 疾病负担重, 急性加重是患者的首要死亡因素。目前慢性阻塞性肺疾病急性加重的诊断主要依靠症状的加重, 尚缺乏客观有效的生物标志物用以指导诊断和评估。中性粒细胞/淋巴细胞比值作为一种新兴的生物标志物, 因其简单便捷、可重复性高的特点, 近年来备受关注。本文就中性粒细胞/淋巴细胞比值在慢性阻塞性肺疾病急性加重的风险预测、发病诱因、治疗预后及并发症方面的研究进展作简要综述。

关键词：肺疾病, 慢性阻塞性中性粒细胞/淋巴细胞比值急性加重

Effect of intraplaque angiogenesis to atherosclerotic rupture-prone plaque induced by high shear stress in rabbit model

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Regenerative Biomaterials 2017年第4期4卷 215-222页

作者： Juhui Qiu Daoxi Lei Jianjun Hu tieying Yin Kang Zhang Donghong Yu Guixue Wang Department of Bio-engineering Key Laboratory for Biorheological Science and Technology of Ministry of EducationState and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqing 400044China

Atherosclerotic prone-rupture plaque is mainly localized in the region of the entrance to the stenosiswith high shear stress and the reasons are largely unknown. Our hypothesis is that such a distributionof cells in atherosclerotic plaque may depend on the angiogenesis. Silastic collars inducedregions of high shear stress (20.6865.27 dynes/cm2) in the upstream flow and low shear stress(12.2561.28 dynes/cm2) in the downstream flow in carotid arteries. Compared with the low shearstress region, plaques in the high shear stress region showed more intraplaque haemorrhaging,less collagen and higher apoptotic rates of vascular smooth muscle cells;endothelial cells (ECs) inthe high shear stress region were characterized with integrity and high endothelial nitric oxidesynthase (eNOS) expression (1570.36345.5% vs 172.9649.9%). The number of intraplaque microvesselsis very high in the high shear stress region (1561.8 n/mm2 vs 3.560.4 n/mm2), and themicrovessels in the plaque show ECs were abnormal, with membrane blebs, intracytoplasmic vacuolesand leukocyte infiltration. Our current study reveals that the integrity of the endothelium andthe vulnerability of atherosclerotic plaques are simultaneously localized in high shear stress regions,and we provide evidence for the first time that microvessels in the intraplaque maybe responsiblefor rupture-prone plaque formation in the high shear stress region.

关键词： angiogenesis atherosclerosis shear stress prone-rupture plaque

老年髋部骨折患者术后谵妄快速识别及早期预防的研究进展

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中华现代护理杂志 2024年第6期30卷 713-718页

作者：张鸿儒史根芽史铁英李连红大连医科大学附属第一医院护理部大连116000

老年髋部骨折患者术后谵妄发生率高,严重影响患者的预后。快速识别与早期预防术后谵妄对改善老年髋部骨折患者预后至关重要。本文从老年髋部骨折患者术后谵妄的概述、分型、危险因素、快速筛查工具的选择以及干预策略等方面进行综述,以... 详细信息

老年髋部骨折患者术后谵妄发生率高,严重影响患者的预后。快速识别与早期预防术后谵妄对改善老年髋部骨折患者预后至关重要。本文从老年髋部骨折患者术后谵妄的概述、分型、危险因素、快速筛查工具的选择以及干预策略等方面进行综述,以期对老年髋部骨折患者术后谵妄的管理提供借鉴与参考。

关键词：综述老年人髋部骨折术后谵妄快速识别危险因素早期预防

Best fit算法在三峡船闸调度中的应用

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华中科技大学学报（自然科学版） 2005年第7期33卷 38-40页

作者：周剑陈铁英华中科技大学系统工程研究所湖北武汉430074

为了最大限度地发挥三峡区段的通航能力,建立了一种适用于三峡永久船闸的决策支持系统.研究了决策支持系统中的关键问题———船舶入闸编排算法,基于三峡通航的实际情况,如船型复杂多变,中小船舶抢道入闸等,建立了解决问题所需的数学模... 详细信息

为了最大限度地发挥三峡区段的通航能力,建立了一种适用于三峡永久船闸的决策支持系统.研究了决策支持系统中的关键问题———船舶入闸编排算法,基于三峡通航的实际情况,如船型复杂多变,中小船舶抢道入闸等,建立了解决问题所需的数学模型.以经典的bestfit算法为基础,考虑到各种实际情况,设计了带匹配权值的bestfit算法,通过多次测试确定了估价函数,较好地解决了闸室面积利用率和船只优先级别之间的矛盾.实验表明算法适用于三峡永久船闸的编排调度,效果不错.

关键词：三峡永久船闸决策系统调度决策编排算法 best fit算法