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Clinical Evaluation of a Vancomycin Dosage Strategy Based on a Serum Trough Concentration Model in Elderly Patients with Severe Pneumonia

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Biomedical and Environmental Sciences 2023年第5期36卷 397-405页

作者： YAN Wei SUN Xiao Yan WANG Meng ZHAO Fei Fan zhou qing tao Department of Respiratory and Critical Care Medicine Peking University Third HospitalBejing 100191China

Objective This study aimed to evaluate the clinical benefits of a vancomycin dosage strategy based on a serum trough concentration model in elderly *** This prospective single-center, open-label, randomized controlled trial categorized 66 elderly patients with severe pneumonia into study and control groups. The control group received vancomycin using a regimen decided by the attending physician. Meanwhile, the study group received individualized vancomycin therapy with a dosing strategy based on a serum trough concentration model. The primary endpoint was the proportion of patients with serum trough concentrations reaching the target *** secondary endpoints were clinical response, vancomycin treatment duration, and vancomycinassociated acute kidney injury(VA-AKI) *** All patients were at least 60 years old(median age = 81 years). The proportion of patients with target trough concentration achievement(≥ 15 mg/L) with the initial vancomycin regimen was significantly higher in the study group compared to the control group(75.8% vs. 42.4%, P = 0.006).Forty-five patients(68.2%) achieved clinical success, the median duration of vancomycin therapy was10.0 days, and VA-AKI occurred in eight patients(12.1%). However, there were no significant differences in these parameters between the two groups. The model for predicting vancomycin trough concentrations was upgraded to: serum trough concentration(mg/L) = 17.194-0.104 × creatinine clearance rate(mL/min) + 0.313 × vancomycin daily dose [mg/(kg·d)].Conclusion A vancomycin dosage strategy based on a serum trough concentration model can improve the proportion of patients achieving target trough concentrations in elderly patients with severe pneumonia.

关键词： Pneumonia Clinical trials Vancomycin Trough concentration Elderly patients

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Influence of the Pre-shock State on the Prognosis of Medical Patients with Sepsis: A Retrospective Cohort Study

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Biomedical and Environmental Sciences 2023年第12期36卷 1152-1161页

作者： ZHANG Lei GAI Xiao Yan LI Xin LIANG Ying WANG Meng ZHAO Fei Fan zhou qing tao SUN Yong Chang Department of Respiratory and Critical Care Medicine Peking University Third HospitalBeijing 100191China Respiratory Intensive Care Unit Zhengzhou Central HospitalZhengzhou 450007HenanChina

Objective To investigate the effects of the pre-shock state on the mortality of patients with *** We enrolled patients with sepsis admitted to the medical intensive care unit of a tertiary care university hospital. These patients were then classified into three groups: sepsis, pre-shock state,and septic shock. The primary outcome was the 28-day mortality rate. The secondary outcomes were the 90-day, 180-day, and 1-year mortality *** A total of 303 patients(groups: sepsis 135 [44.6%]), pre-shock state(93 [30.7%]), and septic shock(75 [24.8%]) completed the 1-year follow-up. The mortality rates at 28 days, 90 days, and 180days and 1 year were significantly higher in the pre-shock state group than those of the sepsis group,but significantly lower than those in the septic shock group, especially among older patients. When compared with the pre-shock state group, the sepsis group had significantly lower mortality risks at 28days, 90 days, and 180 days and 1 year, whereas the sepsis shock group had higher mortality risks at these time *** The mortality rates of patients in the pre-shock state were notably different from those of patients with sepsis or septic shock. The introduction of a modified sepsis severity classification, which includes sepsis, pre-shock state, and septic shock, could offer valuable additional prognostic information.

关键词： Critical care Mortality Pre-shock state Sepsis Septic shock

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A Discussion on Dealing With Chinese Transfer in English Teaching

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Sino-US English Teaching 2012年第10期9卷 1601-1606页

作者： JIN Zhao-hui zhou qing-yan tao yu University of Shanghai for Science and Technology Shanghai China

Native language transfer is a common phenomenon in foreign language learning and is all the time influencing the learners＇ language. As to us English teachers in China, how to use or avoid the Chinese transfer in students＇ English learning is an issue we need to further explore. The paper, based on the theory of SLA （second language acquisition） and language transfer, discusses this phenomenon, analyzes the factors that cause the transfer, and puts forward some suggestions to deal with the influence of transfer in teaching English as a foreign language Contrastive analysis, with examples, is employed to find the similarities and difficulties in students＇ learning Some of the difficulties can be predicted and positive transfer indeed plays a positive role in language acquisition.

关键词： language transfer positive transfer negative transfer error

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Microsurgical treatment of craniopharyngiomas:report of 284 patients

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Chinese Medical Journal 2006年第19期119卷 1653-1663页

作者： SHI Xiang-en WU Bin zhou Zhong-qing FAN tao ZHANG Yong-li Department of Neurosurgery Brain Science Institute of Beijing Fuxing Hopital Capital Medical University Beijing 100038 China

Background Generally, total surgical removal of craniopharyngioma results in satisfactory outcome with a low recurrence rate, however, the location of the tumor and its adherence to the hypothalamic structures can make the operation difficult. The goal of the present study was to assess the outcome of craniopharyngiomas in 284 patients treated surgically. Methods A total of 284 patients （151 men and 133 women） with craniopharyngioma were treated surgically by our neurosurgeons from January 1996 to March 2006. Among them, 226 （79.6%） patients were adults （15 years of age or older; mean, 35.8 ± 10.6）, 58 （20.4%） were children （14 years of age or younger; mean, 9.1 ± 3.8）. The diameter of the tumors were 2.0-9.0 cm （mean, 36.54± 11.4）. The tumors were classified into the superior （23 patients） and inferior ventricular （261） types according to the location of the tumor relative to the third ventricular floor. For the patients with craniopharyngioma of inferior ventricular type, pterional approach was used in 191 （67.3%） patients, subfrontal approach in 17 （6.0%）, and translamina terminalis through frontobasal interhemispheric approach in 53 08.7%）. For those with the tumors of superior ventricular type, transcallosal approach into the anterior third ventricle was done in 10 （3.5%） patients, and the lamina terminalis approach in 13 （4.6%）. Of the 284 patients, 204 （71.8%） were followed up for 0.5 to 8 years （mean, 2.1 ± 1.8）, including 162 patients received total tumor removal, and 37 underwent subtotal or partial removal. Results Total, subtotal and partial removal of the tumors were achieved in 237 （83.5%）, 34 （12.0%） and 13 （4.5%） patients, respectively. The pituitary stalk was preserved in 176 （62.0%） patients, severed in 52 （18.3%）, and unidentified in 56 （19.7%）. Twelve （4.2%） patients died within one month after the surgery. During the follow-up, 23 （14.1%） patients experienced tumor recurrence 1.0-3.5 years （mean, 1.8± 1.6） after total tumor removal, and 24 （64.9

关键词： craniopharyngioma microsurgery treatment

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美罗培南个体化给药的研究进展

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中国抗生素杂志 2009年第5期34卷 263-266,290页

作者：周庆涛贺蓓北京大学第三医院北京100191

美罗培南作为第二代碳青霉烯类抗生素往往是治疗严重感染的最后选择,其个体化给药的研究近年来备受关注。药代/药效学(PK/PD)参数可用于优化美罗培南给药方案,但美罗培南的体内代谢和消除受多种因素影响,因此需进行群体药代动力学(PPK)... 详细信息

美罗培南作为第二代碳青霉烯类抗生素往往是治疗严重感染的最后选择,其个体化给药的研究近年来备受关注。药代/药效学(PK/PD)参数可用于优化美罗培南给药方案,但美罗培南的体内代谢和消除受多种因素影响,因此需进行群体药代动力学(PPK)研究以更好地表证个体差异。利用PPK模型,结合患者个体资料、病原菌最低抑菌浓度(MIC)和临床药效学参数可实现美罗培南的个体化给药,从而在保证疗效的前提下避免治疗过度。本文就近年来美罗培南个体化给药的研究进展作一综述。

关键词：美罗培南群体药代动力学个体化给药

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Chronic obstructive pulmonary disease assessment test score correlated with dyspnea score in a large sample of Chinese patients

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Chinese Medical Journal 2013年第1期126卷 11-15页

作者： zhou qing-tao MEI Jing-jing HE Bei HUANG Shao-guang SHI Yi WEN Fu-qiang ZHAO Ming-wu Department of Respiratory Medicine Peking University ThirdHospital Beijing 100191 China Department of Respiratory Medicine Ruijin Hospital ShanghaiJiaotong University School of Medicine Shanghai 200025 China Department of Respiratory Medicine Nanjing General Hospital ofNanjing Military Command Nanjing Jiangsu 210002 China Department of Respiratory Medicine West China HospitalSichuan University Chengdu S ichuan 610041 China

Background The chronic obstructive pulmonary disease assessment test （CAT） is an easy to use health-related quality of life questionnaire, the modified Medical Research Council （mMRC） dyspnea scale is a classic dyspnea scale which is widely used, while the correlation between them is still not clear. This study investigated the use of the Chinese translation of CAT in chronic obstructive pulmonary disease patients and its correlation with the mMRC dyspnea scale. Methods The multicenter cross-sectional study was conducted in 329 hospitals throughout China from March 1 to April 30, 2010. Chronic obstructive pulmonary disease patients completed both the assessment test and the dyspnea scale during a single study visit. Results Six thousand, four hundred and thirty-seven patients were evaluated; 74.9% were male and the mean age was （64.9±10.0） years. Median test scores in dyspnea grades 0 to 4 were 14, 16, 22, 26 and 32, respectively; these differences were statistically significant. The CAT score was moderately correlated with mMRC dyspnea grade （r=0.579, P 〈0.001）. There was no significant difference in mean CAT score between males and females, and patients of high and low socioeconomic status. Primary analysis suggested that CAT scores were higher in older patients （〉65 years） than in younger patients （〈65 years） and increased with duration of formal education, but these findings were repudiated by further analysis of subgroups according to mMRC dyspnea grade. Conclusions There was no obvious confounding factor influencing use of the CAT in Chinese patients. CAT scores were moderately correlated with the mMRC dyspnea scale.

关键词： chronic obstructive pulmonary disease dyspnea quality of life questionnaire

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伴胸部受累的淋巴瘤25例临床分析

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中华内科杂志 2009年第10期48卷 846-849页

作者：周庆涛朱红贺蓓北京大学第三医院呼吸科 100191

目的分析伴胸部受累的淋巴瘤的临床特点与诊断方法，以提高其诊断率。方法回顾性分析2000—2007年北京大学第三医院确诊的有胸肺病变的淋巴瘤患者25例，收集患者确诊前的症状、体征、实验室检查结果、影像学资料、确诊方法和病理诊断。... 详细信息

目的分析伴胸部受累的淋巴瘤的临床特点与诊断方法，以提高其诊断率。方法回顾性分析2000—2007年北京大学第三医院确诊的有胸肺病变的淋巴瘤患者25例，收集患者确诊前的症状、体征、实验室检查结果、影像学资料、确诊方法和病理诊断。结果25例患者中位年龄46岁，发热（13例）、6个月内体重减轻10％以上（11例）、咳嗽（10例）、气短（9例）、浅表淋巴结无痛性肿大（16例）是最常见的临床表现。72．7％的患者ESR增快；81％的患者血清乳酸脱氢酶（LDH）升高。25例患者中纵隔肺门淋巴结肿大者16例；影像学显示肺受累15例，包括斑片或实变表现、团块、多发结节、弥漫磨玻璃影、粟粒样病变；另外胸腔积液10例，心包积液4例，胸壁肿物2例；上述表现中有2种以上同时存在的患者18例。胸膜受累患者的胸腔积液外观呈黄色浑浊、血性或乳糜性，黏蛋白试验均阳性，比重1．031，白细胞6．72×10^9／L，淋巴细胞86％，中性粒细胞14％，蛋白31．4g／L，LDH 296 U／L，腺苷脱氨酶（ADA）67．4 U／L。外科手术活检确诊16例，其中浅表淋巴结活检确诊12例；超声或CT引导穿刺活检确诊5例；骨髓穿刺确诊1例；胸腔镜胸膜活检和纵隔镜纵隔肿物活检确诊各1例；经支气管镜黏膜活检确诊1例，而接受支气管镜气道黏膜活检和（或）经支气管肺活检（TBLB）确诊共8例。病理诊断除1例霍奇金淋巴瘤外，其余24例均为非霍奇金淋巴瘤。结论伴胸部受累的淋巴瘤患者临床表现缺乏特异性，同时存在浅表或纵隔淋巴结肿大较为多见，血清学检查、胸腔积液性质和影像学检查亦有一定特点。浅表淋巴结手术活检是确诊淋巴瘤简便易行的方法；微创活检方法如超声或CT引导下浅表肿物、胸膜、肺、肝、脾、深部淋巴结活检及胸腔镜和纵隔镜胸膜、肺、纵隔病变活检亦具有较好的诊断价值，而经支气管镜获取气道黏膜和肺组织确诊率低。

关键词：淋巴瘤胸部诊断临床分析

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Differential diagnosis of coronavirus disease 2019 from pneumonias caused by other etiologies in a fever clinic in Beijing

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Chinese Medical Journal 2020年第20期133卷 2504-2506页

作者： Ying Liang Jing-Jin Liang qing-tao zhou Xiao-Guang Li Fei Lin Zhong-Hua Deng Bi-Ying Zhang Lu Li Xiao-Hua Wang Hong Zhu qing-Bian Ma Xiao-Mei Tong Jie Xu Yong-Chang Sun Department of Respiratory and Critical Care Medicine Peking University Third HospitalBeijing 100191China Department of Infectious Diseases Peking University Third HospitalBeijing 100191China Department of Radiology Peking University Third HospitalBeijing 100191China Emergency Department Peking University Third HospitalBeijing 100191China Department of Pediatrics Peking University Third HospitalBeijing 100191China

Coronavirus disease 2019(COVID-19)is an acute respiratory infectious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).111 Fever clinics in general hospitals were requested to reinforce surveillance of this highly contagious *** with body temperatures≥37.3℃ were asked to firstly visit fever clinics,where a triage strategy was implemented,and probable or possible cases were identified by experts or expert panels,and samples were sent for quick viral detection.

关键词： acute diagnosis fever

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Preparation of FeCoNi medium entropy alloy from Fe^(3+)-Co^(2+)-Ni^(2+)solution system

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 92-101页

作者： Zongyou Cheng qing Zhao Mengjie tao Jijun Du Xingxi Huang Chengjun Liu Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education) Shenyang 110819China

In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical *** controlling reasonable elemental composition and processing parameters,the medium entropy alloys can exhibit similar properties to high entropy alloys and have lower *** this paper,a FeCoNi medium entropy alloy precursor was prepared via sol-gel and coprecipitation methods,respectively,and FeCoNi medium entropy alloys were prepared by carbothermal and hydrogen *** phases and magnetic properties of FeCoNi medium entropy alloy were *** showed that FeCoNi medium entropy alloy was produced by carbothermal and hydrogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy alloy prepared by carbothermal *** alloy prepared by hydrogen reduction was uniform and showed a relatively high ***,the hydrogen reduction product exhibited better saturation magnetization and lower coercivity.

关键词： medium entropy alloy sol-gel co-precipitation carbothermal hydrogen reduction

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Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-qing Qiao Guo Hui Bojing Sun Dongfang Hou Meidi Wang Xueqian Wu tao Wu Dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect

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