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High Power Laser Science and Engineering 2024年第3期12卷 1-8页

作者： lian zhou Haipeng Lou Zejiang Deng Xiong Qin Jiayi Pan Yuanfeng Di Chenglin Gu Daping Luo Wenxue Li State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghaiChina Joint Research Center of Light Manipulation Science and Photonic Integrated Chip of East China Normal University and Shandong Normal University East China Normal UniversityShanghaiChina

The mid-infrared optical frequency comb is a powerful tool for gas *** this study,we demonstrate a simple midinfrared dual-comb spectrometer covering 3±4μm in Li Nb O_(3)*** on a low-power fiber laser system,the mid-infrared comb is achieved via intra-pulse difference frequency generation in the Li Nb O_(3)*** construct pre-chirp management before supercontinuum generation to control spatiotemporal alignment for pump and signal *** supercontinuum is directly coupled into a chirped periodically poled Li Nb O_(3)waveguide for the 3±4μm idler generation.A mid-infrared dual-comb spectrometer based on this approach provides a 100 MHz resolution over25 THz *** evaluate the applicability for spectroscopy,we measure the methane spectrum using the dualcomb *** measured results are consistent with the HITRAN database,in which the root mean square of the residual is 3.2%.This proposed method is expected to develop integrated and robust mid-infrared dual-comb spectrometers on chip for sensing.

关键词： difference frequency generation dual-comb spectroscopy mid-infrared gas sensing nonlinear optics

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Flexible piezoelectret film sensor for noncontact mechanical signal capture by multiple transmission media

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Nano Research 2024年第8期17卷 7643-7657页

作者： Xingchen Ma Qianqian Hu lian zhou Xinhao Xiang Yi Qin Ke Zhang Pengfei He Ying Dai Wenxin Niu Xiaoqing Zhang Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology School of Physics Science and EngineeringTongji UniversityShanghai 200092China Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) School of MedicineTongji UniversityShanghai 201619China Department of Rehabilitation Sciences Tongji University School of MedicineShanghai 200092China School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai 200092China

Mechanical signal capture without physical contact has emerged as a highly promising research field and attracted tremendous attention due to its prosperous applications in household medical care,lifestyle monitoring and remote operation,offering users high level of safety,convenience and ***,noncontact sensing is ideal to maximize the immersive user experience in the human–machine interaction(HMI),eliminating interference to human activities and mechanical fatigue to the sensor,***,we report a self-powered flexible sensor integrated with irradiation cross-linked polypropylene(IXPP)piezoelectret film for noncontact sensing,featuring multi-functions to detect mechanical signals transmitted through solid,liquid and gaseous media and would facilitate their versatile practical *** folded-structure configuration of the sensor facilitates the improvement of the noncontact sensing *** solid media,such as the rectangular wooden stick used in this study,the sensor can detect mechanical stimulus exerted at a distance of 100 cm.A system detection sensitivity up to 57 pC/kPa with a low detection limit of 0.6 kPa is achieved at a noncontact distance of 10 *** when partly or completely immersed in water,the sensor effectively traces movement signals of human bodies underwater,demonstrating great advantages for non-inductive aquatic fitness training ***,due to the low acoustic impedance of piezoelectret film,speech recognition through gaseous medium is also *** further introduce application demonstrations of the developed film sensors to monitor exercise postures and physiological signals without direct contact between human body and the sensor,displaying great potential to be incorporated into future smart *** study commendably expands the application scope of piezoelectret materials,which will have profound implications for exploring novel intelligent human–machine interactions.

关键词： noncontact sensing piezoelectret multiple transmission media mechanical signal capture

A Problem Not to Be Ignored: The Influencing Factors of Mobile Phone Addiction and Its Influence on Sleep Quality

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Health 2024年第5期16卷 459-469页

作者： Zihan Ji lian zhou Department of Occupational Medicine and Environmental Health School of Public Health of Nanjing Medical University Nanjing China Institute of Environment and Health Jiangsu Center for Disease Control and Prevention (Jiangsu Institute of Public Health) Nanjing China

Background and Objective: With the popularity and widespread use of mobile phones, the effects of mobile phone dependence and addiction on individuals’ physical and mental health have attracted more and more attention. The present study aims to analyze the current state of mobile phone addiction and its impact on sleep quality within the population, while also exploring the influence of related factors on sleep quality. Ultimately, this research will provide a scientific foundation for targeted intervention measures and strategies. Methods: A total of 253 permanent residents in Nanjing were randomly selected as study subjects. The Mobile Phone Addiction Index (MPAI) and Pittsburgh Sleep Quality Index (PSQI) were used to evaluate the degree of smartphone addiction and sleep quality of the study subjects. Body mass index (BMI) was measured according to standardized procedures. Independent sample t-test, Chi-square test, rank sum test and multiple linear regression were used to analyze the correlation between mobile phone addiction and sleep quality, and P Results: 117 people (46.2%) were addicted to mobile phones. Chi-square test showed that the rate of mobile phone addiction in drinking group was significantly higher than that in non-drinking group (P P P P P P P P P P Conclusion: Mobile phone addiction may lead to shorter sleep duration and reduce sleep efficiency. The withdrawal of mobile phone addiction may have a negative impact on sleep quality. According to the characteristics of the population, appropriate comprehensive intervention measures should be taken to build an effective evaluation system, so as to reduce the impact of mobile phone addiction and withdrawal problems on sleep and improve sleep quality.

关键词： Mobile Phone Addiction Influencing Factors Withdrawal Sleep Quality

RsaL is a self-regulatory switch that controls alternative biosynthesis of two AHL-type quorum sensing signals in Pseudomonas aeruginosa PA1201

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mLife 2024年第1期3卷 74-86页

作者： Ya-Wen He Zi-Jing Jin Ying Cui Kai Song Bo Chen lian zhou State Key Laboratory of Microbial Metabolism Joint International Research Laboratory of Metabolic and Developmental SciencesSJTU-NLBP Joint R&D Centre for Biopesticides and BiofertilizersSchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghaiChina Zhiyuan Innovative Research Centre Student Innovation CentreZhiyuan CollegeShanghai Jiao Tong UniversityShanghaiChina

Pseudomonas aeruginosa is a ubiquitous and metabolically versatile microorganism naturally found in soil and *** is also an opportunistic pathogen in plants,insects,animals,and *** response to increasing cell density,*** uses two acylhomoserine lactone(AHL)quorum-sensing(QS)signals(i.e.,N-3-oxo-dodecanoyl homoserine lactone[3-oxo-C12-HSL]and Nbutanoyl-homoserine lactone[C4-HsL]),which regulate the expression of hundreds of ***,how the biosynthesis of these two QS signals is coordinated remains *** studied the regulation of these two QS signals in the rhizosphere strain ***1201 sequentially produced 3-oxo-C12-HSL and C4-HSL at the early and late growth stages,*** highest 3-oxo-C12-HSL-dependent elastase activity was observed at the early stage,while the highest C4-HSL-dependent rhamnolipid production was observed at the late *** atypical regulator RsaL played a pivotal role in coordinating 3-oxo-C12-HSL and C4-HSL biosynthesis and QS-associated *** repressed las/transcription by binding the-10 and-35 boxes of the lasl *** contrast,RsaL activated rhll transcription by binding the region encoding the 5'-untranslated region of the rhll ***,RsaL repressed its own expression by binding a nucleotide motif located in the-35 box of the rsaL ***,RsaL acts as a molecular switch that coordinates the sequential biosynthesis of AHL QS signals and differential virulence in ***,C4-HSL activation by RsaL was independent of the Las and Pseudomonas quinolone signal(PQS)QS signaling ***,we propose a new model of the QS regulatory network in PA1201,in which RsaL represents a superior player acting at the top of the hierarchy.

关键词： N-3-oxo-dodecanoyl homoserine lactone N-butanoyl-homoserine lactone Pseudomonas aeruginosa quorum sensing RsaL

Low-noise compact fiber laser based on nonlinear polarization evolution in an all-polarization-maintaining figure-8 cavity

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Chinese Optics Letters 2024年第7期22卷 47-52页

作者： lian zhou Daping Luo Gehui Xie Shiping Xiong Haipeng Lou Zilin Zhao Yuanfeng Di Chenglin Gu Wenxue Li State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200062China

We demonstrate an all-polarization-maintaining(APM)fiber mode-locked laser based on nonlinear polarization evolution(NPE).A well-designed Sagnac fiber loop is employed to establish the nonlinear polarization evolution process in a polarization beam splitter(PBS)figure-8 fiber *** loss curves are calculated to verify the saturable absorption characteristic of this NPE-based APM ***,we simulate the pulse propagation process in the cavity to demonstrate the pulse mode-locked ***,we also design a realizable compact scheme to further reduce noise disturbances,achieving a 101-fs mode-locked pulse train with a 0.3-mrad integrated phase noise and a 0.006%integrated relative intensity noise(RIN).This figure-8 fiber laser provides a new scheme for compacting low-noise compact APM fiber lasers based on the NPE mode-locked mechanism.

关键词： ultrafast laser fiber laser polarization-maintaining

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Paeoniflorin ameliorates chronic colitis via the DR3 signaling pathway in group 3 innate lymphoid cells

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Journal of Pharmaceutical Analysis 2024年第6期14卷 889-901页

作者： Shaowei Huang Xueqian Xie Bo Xu Zengfeng Pan Junjie liang Meiling Zhang Simin Pan Xiaojing Wang Meng Zhao Qing Wang Jinyan Chen Yanyang Li lian zhou Xia Luo School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine510006China School of Basic Medicine Guangzhou University of Chinese Medicine510006China First Clinical Medical College Guangzhou University of Chinese Medicine510000China

Inhibiting the death receptor 3(DR3)signaling pathway in group 3 innate lymphoid cells(ILC3s)presents a promising approach for promoting mucosal repair in individuals with ulcerative colitis(UC).Paeoniflorin,a prominent component of Paeonia lactiflora Pall.,has demonstrated the ability to restore barrier function in UC mice,but the precise mechanism remains *** this study,we aimed to delve into whether paeoniflorin may promote intestinal mucosal repair in chronic colitis by inhibiting DR3 signaling in ILC3s.C57BL/6 mice were subjected to random allocation into 7 distinct groups,namely the control group,the 2%dextran sodium sulfate(DSS)group,the paeoniflorin groups(25,50,and 100 mg/kg),the anti-tumor necrosis factor-like ligand 1A(anti-TL1A)antibody group,and the IgG *** detected the expression of DR3 signaling pathway proteins and the proportion of ILC3s in the mouse colon using Western blot and flow cytometry,***,DR3-overexpressing MNK-3 cells and 2%DSS-induced Rag1^(-/-)mice were used for *** results showed that paeoniflorin alleviated DSS-induced chronic colitis and repaired the intestinal mucosal ***,paeoniflorin inhibited the DR3 signaling pathway in ILC3s and regulated the content of cytokines(interleukin-17A,granulocyte-macrophage colony stimulating factor,and interleukin-22).Alternatively,paeoniflorin directly inhibited the DR3 signaling pathway in ILC3s to repair mucosal damage independently of the adaptive immune *** additionally confirmed that paeoniflorin-conditioned medium(CM)restored the expression of tight junctions in Caco-2 cells via *** conclusion,paeoniflorin ameliorates chronic colitis by enhancing the intestinal barrier in an ILC3-dependent manner,and its mechanism is associated with the inhibition of the DR3 signaling pathway.

关键词： Paeoniflorin Ulcerative colitis Intestinal mucosal barrier DR3 signaling pathway Group 3 innate lymphoid cells

Biomarkers associated with immune-related adverse events induced by immune checkpoint inhibitors

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World Journal of Clinical Oncology 2024年第8期15卷 1002-1020页

作者： An-Jie Guo Qing-Yuan Deng Pan Dong lian zhou Lei Shi School of Life Sciences Chongqing UniversityChongqing 400044China Head and Neck Cancer Center Chongqing University Cancer HospitalChongqing 400000China

Immune checkpoint inhibitors(ICIs)constitute a pivotal class of immunotherapeutic drugs in cancer ***,their widespread clinical application has led to a notable surge in immune-related adverse events(irAEs),significantly affecting the efficacy and survival rates of patients undergoing ICI *** conventional hematological and imaging tests are adept at detecting organ-specific toxicities,distinguishing adverse reactions from those induced by viruses,bacteria,or immune diseases remains a formidable ***,there exists an urgent imperative for reliable biomarkers capable of accurately predicting or diagnosing ***,a thorough review of existing studies on irAEs biomarkers is *** review commences by providing a succinct over-view of major irAEs,followed by a comprehensive summary of irAEs biomarkers across various ***,we delve into innovative methodologies such as machine learning,single-cell RNA sequencing,multiomics analysis,and gut microbiota profiling to identify novel,robust biomarkers that can facilitate precise irAEs diagnosis or ***,this review furnishes a concise exposition of irAEs mechanisms to augment understanding of irAEs prediction,diagnosis,and treatment strategies.

关键词： Immunotherapy Immune checkpoint inhibitors Immune-related adverse events Biomarkers Cancers

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水稻低温发芽力的研究进展与展望

中国稻米 2024年第5期30卷 41-48页

作者：周旭杨梯丰刘祖培周炼华南农业大学农学院广州510640 广东省农业科学院水稻研究所/广东省水稻育种新技术重点实验室/广东省水稻工程实验室广州510640

低温萌发力是水稻适应极端天气、特别是水稻直播生产不可或缺的一个重要性状。本文综述了近年来关于水稻低温萌发力的鉴定方法、生理机制、分子克隆和遗传育种等方面的研究进展,提出了研究趋势与展望。在水稻低温萌发力鉴定方面,多采用1... 详细信息

低温萌发力是水稻适应极端天气、特别是水稻直播生产不可或缺的一个重要性状。本文综述了近年来关于水稻低温萌发力的鉴定方法、生理机制、分子克隆和遗传育种等方面的研究进展,提出了研究趋势与展望。在水稻低温萌发力鉴定方面,多采用13℃~15℃试验温度、低温萌发第10 d的萌发率为评价指标。利用图位克隆和全基因组关联分析(GWAS)等技术手段已鉴定的水稻低温萌发力相关QTL超过100个,但实现目的基因克隆的仅4个,关于分子机制方面的研究极少。当前水稻低温萌发力强的品种主要是从育成品种中筛选而来。水稻低温萌发生理机理和分子机理的研究将有助于提高低温萌发鉴定及其育种应用。

关键词：水稻低温萌发鉴定方法分子克隆遗传育种

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Continuous age-and sex-specific reference ranges of liver enzymes in Chinese children and application in pediatric non-alcoholic fatty liver disease

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World Journal of Pediatrics 2024年第9期20卷 949-956页

作者： Zhao-Yuan Wu Si-Wei Chi Liu-Jian Ouyang Xiao-Qin Xu Jing-Nan Chen Bing-Han Jin Rahim Ullah Xue-lian zhou Ke Huang Guan-Ping Dong Zhe-Ming Li Ying Shen Jie Shao Yan Ni Jun-Fen Fu Qiang Shu Wei Wu Department of Endocrinology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child Health3333 Binsheng RoadHangzhou310051China Department of Data and Information Children’s HospitalZhejiang University School of MedicineHangzhouChina Department of Child Health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouChina Department of Thoracic&Cardiovascular Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children’s Regional Medical Center3333 Binsheng RoadHangzhou310051China

Background Alanine aminotransferase(ALT)is widely used to screen patients with hepatic ***,the current reference ranges(<50 U/L)were developed by laboratories and have not been validated in populations with a large number of healthy *** This study collected venous blood and anthropometric data from a total of 13,287 healthy children aged 3 months to 18 years who underwent routine physical examinations in the Department of Pediatric *** applied the least mean square algorithm to establish age-and sex-related reference percentiles of serum levels of *** validation,we recruited 4276 children and adolescents with obesity/overweight who underwent evaluation and metabolic tests in the *** receiver operating characteristic curves,we determined age-and sex-specific upper limit percentiles of liver enzymes for fatty liver *** This study revealed a significant correlation between serum transaminase levels and age and sex(P<0.01).These transaminase levels exhibited age-and sex-specific *** individuals in the non-alcoholic fatty liver disease(NAFLD)cohort,elevated ALT levels displayed a positive association with clinical markers of disease severity,including homeostatic model assessment of insulin resistance,waist-hip ratio,and serum uric acid levels(P<0.01).According to the receiver operating characteristic curves,ALT levels at the 92.58th percentile for boys and the 92.07th percentile for girls yielded the highest accuracy and *** This study provides age-and sex-specific reference ranges for ALT,aspartate aminotransferase,andγ-glutamyltransferase in Chinese children and adolescents,making it the largest population study to ***,the study establishes a precise upper limit for ALT levels,facilitating their use in NAFLD screening.

关键词： Alanine aminotransferase Childhood Fatty liver diseases

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光学遥感图像的小样本目标检测

遥感学报 2024年第7期28卷 1693-1701页

作者：周莲何楚汪鼎文郭子琪武汉大学计算机学院武汉430072 武汉大学电子信息学院武汉430072

对遥感图像进行目标检测,具有广阔的应用前景。针对小样本背景下遥感图像目标检测任务存在特征提取不足、定位困难和分类易混淆的问题,本文提出了一种基于协同注意力模块和对比学习分支的小样本目标检测算法。首先,对训练样本进行数据... 详细信息

对遥感图像进行目标检测,具有广阔的应用前景。针对小样本背景下遥感图像目标检测任务存在特征提取不足、定位困难和分类易混淆的问题,本文提出了一种基于协同注意力模块和对比学习分支的小样本目标检测算法。首先,对训练样本进行数据增强操作,以扩充数据集规模;其次,提出了一种协同注意力模块,包括设计的背景衰减注意力和空间感知注意力,利用遥感图像丰富的背景与目标特征信息,指导网络关注与目标定位相关的重点信息,从而便于RPN网络生成更好的区域建议框,减少遗漏目标的概率,提升模型对小样本类别的定位性能;然后,设计了一种对比学习分支。基于设计的对比损失函数,通过联合训练策略,在训练时从特征学习逐步过渡到分类器学习,提高了分类的准确率;最后,设计出一种基于微调的迁移学习范式的小样本目标检测模型,分为基础训练阶段和微调阶段,在基础训练阶段借助充足的基类样本训练模型学习类无关的参数,在微调阶段使用制作的小样本数据集帮助目标检测模型适应特定类别目标,提升其检测性能。此外,本文以两阶段微调方法TFA(Two-stage Fine-tuning Approach)为基准,通过在遥感数据集NWPU VHR-10和DIOR上验证本文提出算法的有效性,结果显示本文算法在NWPU VHR-10和DIOR数据集上与其他基准算法相比,平均精度均有大幅提升。

关键词：目标检测小样本学习遥感图像注意力机制对比学习

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