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Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li hong zhou Zhihao Ren Cheng Xu Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

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Leukemia stem cells： the root of chronic myeloid leukemia

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Protein & Cell 2015年第6期6卷 403-412页

作者： hong zhou Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education Department of Hematology Zhejiang University Hangzhou 310009 China Cancer Institute Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

Chronic myeloid leukemia （CML） is a clonal myeloprolif- erative disorder characterized by a chromosome translocation that generates the Bcr-Abl oncogene en- coding a constitutive kinase activity. Despite remarkable success in controlling CML at chronic phase by Bcr-Abl tyrosine kinase inhibitors （TKIs）, a significant proportion of CML patients treated with TKIs develop drug resis- tance due to the inability of TKIs to kill leukemia stem cells （LSCs） that are responsible for initiation, drug re- sistance, and relapse of CML. Therefore, there is an ur- gent need for more potent and safer therapies against leukemia stem cells for curing CML. A number of LSC- associated targets and corresponding signaling path- ways, including CaMKII-y, a critical molecular switch for co-activating mu｜tipte LSC-associated signaling path- ways, have been identified over the past decades and various small inhibitors targeting LSC are also under development. Increasing evidence shows that leukemia stem cells are the root of CML and targeting LSC may offer a curable treatment option for CML patients. This review summarizes the molecular biology of LSC and its- associated targets, and the potential clinical application in chronic myeloid leukemia.

关键词： chronic myeloid leukemia (CML) leukemiastem cells (LSCs) tyrosine kinase inhibitors (TKIs),CaMKII-~ molecular switch

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Weak Coupling in ^(143)Nd

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Chinese Physics Letters 2000年第4期17卷 264-266页

作者： zhou Xiao-hong Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000 E.Ideguchi T.KishidaM.Ishihara RIKENHirosawa 2-1WakoSaitama 351-01Japan H.Tsuchida Y.GonoT.MorikawaM.ShibataH.WatanabeM.MiyakeT.TsutsumiS.MotomuraS.Mitarai Department of Physics Kyushu UniversityHakozaki 6-10-1Fukuoka 812Japan

The high-spin states of ^(143)Nd have been studied in the ^(130)Te(^(18)O, 5n)^(143)Nd reaction at a beam energy of 80 MeV using techniques of in-beam γ-ray spectroscopy. Measurements of γ - γ - t coincidences, γ-ray angular distributions, and γ-ray linearpolarizations were performed. A level scheme of 143Nd with spin and parity assignments up to 53/2^(+) is proposed. While a weak coupling model can explain the level structure up to the J^(π)=39/2^(-)state,this model can not reproduce the higher-lying states. Additionally, a new low-lying non-yrast level sequence in ^(143)Nd was observed in the present work, which can be well described by the weak coupling of an i_(13/2) neutron to the ^(142)Nd core nucleus.

关键词： spectroscopy coupling

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Scalable fabrication of Bi_(2)O_(2)Se polycrystalline thin film for near-infrared optoelectronic devices applications

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Chinese Physics B 2021年第10期30卷 470-475页

作者： Bin Liu hong zhou School of Physics and Electronics Hunan UniversityChangsha 410082China

We present a controlled,stepwise formation of layered semiconductor Bi_(2)O_(2)Se thin films prepared via the vapour process by annealing topological insulator Bi_(2)Se3 thin films in low oxygen atmosphere for different *** based on Bi_(2)O_(2)Se thin film show a responsivity of 1.7×10^(4) A/W at a wavelength of 980 ***-effect transistors based on Bi_(2)O_(2)Se thin film exhibit n-type behavior and present a high electron mobility of 17 cm^(2)/V·*** addition,the electrical properties of the devices after 4 months keeping in the air shows little change,implying outstanding air-stability of our Bi_(2)O_(2)Se thin *** the obtained results,it is evident that low oxygen annealing is a surprisingly effective method to fabricate Bi_(2)O_(2)Se thin films for integrated optoelectronic applications.

关键词： thin films Bi_(2)Se_(3) vapor-phase deposition photodetector Bi_(2)O_(2)Se

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STABILITY OF EQUILIBRIA OF NEMATIC LIQUID CRYSTALLINE POLYMERS

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Acta Mathematica Scientia 2011年第6期31卷 2289-2304页

作者： hong zhou hongyun Wang Department of Applied MathematicsNaval Postgraduate School Monterey CA 93943 USA Department of Applied Mathematics and StatisticsUniversity of California Santa Cruz CA 95064 USA

We provide an analytical study on the stability of equilibria of rigid rodlike nematic liquid crystalline polymers （LCPs） governed by the Smoluchowski equation with the Maier-Saupe intermolecular potential. We simplify the expression of the free energy of an orientational distribution function of rodlike LCP molecules by properly selecting a coordinate system and then investigate its stability with respect to perturbations of orientational probability density. By computing the Hessian matrix explicitly, we are able to prove the hysteresis phenomenon of nematic LCPs： when the normalized polymer concentration b is below a critical value b＊（6.T314863965）, the only equilibrium state is isotropic and it is stable; when b＊〈 b 〈 15/2, two anisotropic （prolate） equilibrium states occur together with a stable isotropic equilibrium state. Here the more aligned prolate state is stable whereas the less aligned prolate state is unstable. When b 〉 15/2, there are three equilibrium states： a stable prolate state, an unstable isotropie state and an unstable oblate state.

关键词： equilibria stability nematic liquid crystalline polymers hysteresis phenomenon

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Dynamical Feedback between Synoptic Eddy and Low-Frequency Flow as Simulated by BCC_CSM1.1(m)

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Advances in Atmospheric Sciences 2017年第11期34卷 1316-1332页

作者： Fang zhou hong-Li REN Laboratory for Climate Studies National Climate CenterChina Meteorological Administrationbeijing 100081china CMA-NJU Joint Laboratory for Climate Prediction Studies School of Atmospheric SciencesNanjing Universitynanjing 210093china Department of Atmospheric Science School of Environmental StudiesChina University of Geosciencewuhan 430074china

Since the interaction between atmospheric synoptic eddy （SE）（2-8 days） activity and low-frequency （LF）（monthly） flow （referred to as SELF） plays an essential role in generating and maintaining dominant climate modes, an evaluation of the performance of BCC_CSMI.I（m） in simulating the SE feedback onto the LF flow is given in this paper. The model captures well the major spatial features of climatological eddy vorticity forcing, eddy-induced growth rate, and patterns of SELF feedback for the climate modes with large magnitudes in cold seasons and small magnitudes in warm seasons for both the Northern and Southern Hemisphere. As in observations, the eddy-induced growth rate and SELF feedback patterns in the model also show positive SE feedback. Overall, the relationships between SE and LF flow show that BCC_CSM1. l（m） satisfactorily captures the basic features of positive SE feedback, which demonstrates the simulation skill of the model for LF variability. Specifically, such an evaluation can help to find model biases of BCC_CSM1.1 （m） in simulating SE feedback, which will provide a reference for the model＇s application.

关键词： model evaluation synoptic eddy feedback simulation eddy vorticity forcing eddy-induced growth rate patternsof synoptic eddy feedback

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Structure and Mechanical Properties of Ni-P-Nano Al_2O_3 Composite Coatings Synthesized by Electroless Plating

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Journal of Iron and Steel Research International 2008年第1期15卷 65-69页

作者： zhou Guang-hong DING hong-yan zhou Fei ZHANG Yue Department of Mechanical Engineering Huaiyin Institute of Technology Huai＇an 223001 Jiangsu China Institute of Bio-inspired Structure and Surface Engineering Academy of Frontier Science Nanjing University of Aeronautics and Astronautics Nanjing 210016 Jiangsu China

Ni-P-nano Al2O3 composite coatings were deposited by electroless plating,and their microstructures were observed by SEM（scanning electron microscope）.The microhardness and the wear resistance of the Ni-P-nano Al2O3 composite coatings were measured using microhardness tester and block-on-ring tribometer,respectively,and the comparison with those of Ni-P coatings or Ni-P-micro Al2O3 coating was *** influences of aging temperature on their hardness and wear resistance were *** results showed that the nano Al2O3 particles were distributed uniformly in the Ni-P-Al2O3 *** three kinds of Ni-P based coatings,the hardness and wear resistance of Ni-P-nano Al2O3 coatings were largest,and the maximum values could be obtained at 400 ℃.This indicated that the precipitation of nano Al2O3 particles would improve the hardness and wear resistance of the Ni-P coatings.

关键词： composite coating nano Al2O aging treatment mechanical property

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Coseismic displacement estimate of the 2013 M_S7.0 Lushan, China earthquake based on the simulation of near-fault displacement field

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Earthquake Science 2016年第6期29卷 327-335页

作者： hong zhou Institute of Geophysics China Earthquake Administration

Usually, GPS observation provides direct evidence to estimate coseismic displacement. However, GPS stations are scattered, sparse and cannot provide a detailed distribution of coseismic displacement. Strong ground motion records share the same disadvantages as GPS in estimating coseismic displacement. Estimations from InSAR data can provide displacement distributions; however, the resolution of such methods is limited by the analysis techniques. The paper focuses on estimating the coseismic displacement of the Ms7.0 Lushan earthquake on April 20, 2013 using a simulation of the wave field based on the elastic wave equation instead of a quasi-static equation. First, the media and source models were con- structed by comparing the simulated velocity and the record velocity of the ground motion. Then simulated static displacements were compared with GPS records. Their agreement validates our results. Careful analysis of the distribution of simulated coseismic displacements near the fault reveals more details of the ground motion. For example, an uplift appears on the hanging wall of the fault, rotation is associated with the horizontal displacement, the fault strike and earthquake epicenter provide the main control on motion near the faults, and the motion on the hanging wall is stronger than that on the footwall. These results reveal additional characteristics of the ground motion of the Lushan earthquake.

关键词： Lushan earthquake. Coseismic displacementSimulation of the wave field . Spectral element method

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Review on the study of topographic effect on seismic ground motion

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Earthquake Science 2018年第2期31卷 110-116页

作者： hong zhou Institute of Geophysics China Earthquake Administration Beijing 100081 China

Topographic effect study is a very important research topic in seismology, seismic engineering,earthquake engineering, engineering earthquake construction and engineering seismology. This paper focuses on its present development status. Post-earthquake investigation has found that the existence of topography caused more serious earthquake damage. The actual seismographs also recorded the topographic amplification effect of 6 to 7 times and even more than 10 times. Numerical simulation is an important technique to study topographic effect, which complements the lack of observed records. However researches on 3-D topographic effect are not enough and need to be studied deeper. To find the main influence factors and the quantitative relationship between topography and ground motion are required very urgently. Obviously the achievements not only can be applied in the earthquake resistant design, but also can provide the quantitative pre-earthquake disaster prediction and quantitative post-earthquake disaster evaluation.

关键词： topographic effect to earthquakes numerical simulation of ground motion quantitative mathematical model

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Method for uncertain multi-attribute decisionmaking with preference information in the form of interval numbers complementary judgment matrix

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Journal of Systems Engineering and Electronics 2007年第2期18卷 265-269页

作者： zhou hong'an Liu Sanyang Fang Xiangrong Dept. of Applied Mathematics Xidian Univ. Xi'an 710071 P. R. China Dept. of Mathematics Shanxi Univ. of Technology Hanzhong 723000 P. R. China Dept. of Electronics and Information Xi'an Inst. of Posts and Telecommunication Xi'an 710061 P. R. China.

The uncertain multi-attribute decision-making problems because of the information about attribute weights being known partly, and the decision maker＇s preference information on alternatives taking the form of interval numbers complementary to the judgment matrix, are investigated. First, the decision-making information, based on the subjective uncertain complementary preference matrix on alternatives is made uniform by using a translation function, and then an objective programming model is established. The attribute weights are obtained by solving the model, thus the overall values of the alternatives are gained by using the additive weighting method. Second, the alternatives are ranked, by using the continuous ordered weighted averaging （C-OWA） operator. A new approach to the uncertain multi-attribute decision-making problems, with uncertain preference information on alternatives is proposed. It is characterized by simple operations and can be easily implemented on a computer. Finally, a practical example is illustrated to show the feasibility and availability of the developed method.

关键词： Uncertain multi-attribute decision-making Objective programming, Weight, C-OWA operator, Priority.

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