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Self-adaptive gas flow and phase change behaviors during hydrate exploitation by alternate injection of N_(2) and CO_(2)

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Petroleum Science 2024年第3期21卷 2120-2129页

作者： Bo-Jian Cao Yi-Fei Sun Hong-nan Chen Jin-Rong zhong Ming-Long Wang Ming Wang Chang-Yu Sun Guang-Jin Chen State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China School of Chemistry and Chemical Engineering Changsha University of Science&TechnologyChangsha410114HunanChina

Since hydrate resources play a part of the stratigraphic framework structure in sediments,establishing a safe and economic method for hydrates exploitation remains the primary challenge to this *** the proposed methods,the spontaneous displacement of CH_(4) from hydrate cages by CO_(2) seems to be a perfect mechanism to address gas production and CO_(2) storage,especially in today's strong demand for carbon reduction and replacing clean *** extensive lab researches,in the past decade,injecting a mixture of CO_(2) and small molecule gas has become a key means to enhance displacement efficiency and has great potential for ***,there is a lack of in-depth research on gas flow in the reservoir,while the injected gas always passes through low-saturated hydrate areas with high permeability and then occurs gas channel in a short term,finally resulting in the decreases in gas production efficiency and produced gas ***,we explored a new injection-production mode of alternate injection of N2 and CO_(2) in order to fully coordinate the advantages of N_(2) in enhanced hydrate decomposition and CO_(2) in solid storage and heat *** alternate"taking"and"storing"processes perfectly repair the problem of the gas channel,achieving self-regulation effect of CH_(4) recovery and CO_(2) *** 3-D experimental results show that compared to the mixed gas injection,CH_(4) recovery is increased by>50%and CO_(2) storage is increased by>70%.Additionally,this alternate injection mode presented a better performance in CH_(4) concentration of produced gas and showed outstanding N_(2) utilization ***,we analyzed its self-adaptive gas flow mechanism and proposed an application model of"one injection and multiple production".We look forward to this study accelerating the application of CO_(2)-CH_(4) replacement technology.

关键词： Hydrate Replacement CH_(4)recovery CO_(2)storage Reservoir remediation

Interfacial reaction between AZ91D magnesium alloy melt and mild steel under high temperature

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China Foundry 2024年第2期21卷 159-167页

作者： Jia-hong Dai Jian-yue Zhang Bin Jiang Xiang-jun Xu zhong-tao Jiang Hong-mei Xie Qing-shan Yang Guo-qing Zhang College of Materials Science and Engineering Yangtze Normal UniversityChongqing 408100China National Engineering Research Center for Magnesium Alloys College of Materials Science and EngineeringChongqing UniversityChongqing 400044China Chongqing Jiulongyuan High-tech Industry Group Co. Ltd.Chongqing 400080China Loncin Industry Co. Ltd.Chongqing 400080China Department of Materials Science and Engineering The Ohio State UniversityColumbusOH 43210USA Chongqing Key Laboratory of Materials Surface&Interface Science Chongqing University of Arts and SciencesChongqing 402160China School of Metallurgy and Material Engineering Chongqing University of Science and TechnologyChongqing 401331China

The metallurgical quality control of magnesium(Mg)and Mg alloys in melting process is required to ensure a satisfied mechanical and corrosion performance,while the typical used steel crucible introduces impurities and interfacial interaction during melting ***,a systematic study about impurities diffusion and interfacial interaction between molten Mg and steel is *** the present study,the interfacial reaction between molten AZ91D Mg alloy and mild steel during melting process was investigated with the melting temperatures of 700℃,750℃ and 800℃.The results show that Al(Fe,Mn)intermetallic layer is the intermetallic primarily formed at the interfaces of AZ91D melt and mild ***,Al_(8)(Mn,Fe)5is indexed between Al(Fe,Mn)and ***_(3)C appears between the mild steel and Al(Fe,Mn)at 700℃ and 750℃,but absent at 800℃ due to the increased solubility of carbon in Mg *** is found that the growth of the intermetallic layer is controlled by diffusion mechanism,and Al and Mn are the dominant diffusing species in the whole interfacial reaction *** measuring the thickness of different layers,the growth constant was *** increases from 1.89(±0.03)×10^(-12)m^(2)·s^(-1)at 700℃ to 3.05(±0.05)×10^(-12)m^(2)·s^(-1)at 750℃,and 5.18(±0.05)×10^(-12)m^(2)·s^(-1)at 800℃.Meanwhile,the content of Fe is linearly increased in AZ91D with the increase of holding time at 700℃ and 750℃,while it shows a significantly increment after holding for 8 h at 800℃,indicating holding temperature is more crucial to determine the Fe content of AZ91D than holding time.

关键词： AZ91D mild steel interface reaction intermetallic growth kinetics

转染野生型p53基因对苯并芘诱导的肺癌细胞生物学特性及其原发性耐药的作用

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中华结核和呼吸杂志 2005年第3期28卷 176-179页

作者：都昌胡徐军钟南山广州医学院附属第一医院广州呼吸疾病研究所 510120

目的　探讨苯并芘的代谢产物反式二羟环氧苯并芘 (BPDE)诱发的p53基因突变,在肺癌发生发展中的作用,及外源性转染野生型p53基因对肺癌细胞原发性耐药的影响。方法　以携带野生型p53基因的缺陷型腺病毒穿梭载体(pshuttle-cmv-p53cDNA),... 详细信息

目的　探讨苯并芘的代谢产物反式二羟环氧苯并芘 (BPDE)诱发的p53基因突变,在肺癌发生发展中的作用,及外源性转染野生型p53基因对肺癌细胞原发性耐药的影响。方法　以携带野生型p53基因的缺陷型腺病毒穿梭载体(pshuttle-cmv-p53cDNA),感染由BPDE诱发p53基因突变的成瘤支气管上皮细胞株,用空载体pshuttle cmv为对照组。通过软琼脂集落形成试验、细胞生长曲线实验、细胞凋亡和体外化疗药物敏感性分析等探讨野生型p53基因的生物学效应。结果　外源野生型p53基因转染的肺癌细胞的集落数为(5.4±0.8)个、转染空载体组为 (22.5±2.5)个、未转染组为(24 5±3 5)个;p53基因转染组细胞克隆形成率为 0.5%、未转染组为 2.5%、转染空载体组为2.3%。p53基因转染组的集落形成率与未转染组和转染空载体组比较差异均具有统计学意义 (U值分别为 3.651和 3.642,P均 0.05)。外源野生型p53基因转染肺癌细胞可诱导其凋亡;同时逆转细胞对表柔比星的耐药。结论　p53基因突变在肺癌的发生、发展及耐药性方面可能具有重要的作用。野生型p53基因替代结合抗肿瘤药物对于提高肿瘤细胞的药物敏感性,克服耐药方面可能有一定的帮助。

关键词：转染野生型p53基因肺癌细胞耐药 p53基因突变原发性诱导结论载体克服

广州市区青少年哮喘和过敏性疾病流行变化趋势调查

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中华医学杂志 2006年第15期86卷 1014-1020页

作者：王红玉郑劲平钟南山广州医学院第一附属医院广州呼吸疾病研究所 510120

目的了解广州市区青少年哮喘、过敏性鼻炎、湿疹的患病率变化趋势.方法按照儿童哮喘及其他过敏性疾病的国际间对比研究（ISAAC）阶段Ⅲ方案,对广州市4个中心城区10所中学的3516名13～14岁青少年进行横断面问卷调查,并将结果与1994～1995... 详细信息

目的了解广州市区青少年哮喘、过敏性鼻炎、湿疹的患病率变化趋势.方法按照儿童哮喘及其他过敏性疾病的国际间对比研究（ISAAC）阶段Ⅲ方案,对广州市4个中心城区10所中学的3516名13～14岁青少年进行横断面问卷调查,并将结果与1994～1995年ISAAC阶段Ⅰ作对比.结果书面问卷中,近12个月喘息和运动后喘息症状的患病率,分别由阶段I的3.4%和17.4%上升为阶段Ⅲ的4.8%和23.4%（P〈0.01）,而医生诊断哮喘的患病率（阶段Ⅰ为3.9%,阶段Ⅲ为4.6%）在两阶段间比较差异无统计学意义.录像问卷中,阶段Ⅲ的近12个月休息时喘息和运动后喘息患病率分别为3.8%和11.3%,也高于阶段Ⅰ的2.0%和6.9%（均P〈0.01）.无感冒时有鼻炎和鼻结膜炎症状的近12个月患病率,分别由阶段Ⅰ的39.5%和8.7%上升为阶段Ⅲ的45.5%和11.1%（均P〈0.01）;同时,医生诊断为季节性花粉过敏和过敏性鼻炎的患病率,分别由阶段Ⅰ的2.9%和17.4%上升为阶段Ⅲ的4.1%和22.7%（均P〈0.05）.近12个月湿疹症状的患病率,由阶段Ⅰ的1.3%上升为阶段Ⅲ的2.2%（P〈0.01）,而医生诊断湿疹的患病率,两阶段间比较差异无统计学意义（P＞0.05）.男性哮喘、过敏性鼻炎、湿疹的近12个月症状及医生诊断患病率上升的幅度均较女性明显.结论广州市13～14岁青少年哮喘及过敏性鼻炎、湿疹患病率均较7年前高,且以男性上升明显.

关键词：呼吸道疾病过敏症湿疹青少年哮喘

Mechanisms of vacuolar phosphate efflux supporting soybean root hair growth in response to phosphate deficiency

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Journal of Integrative Plant Biology 2024年第9期66卷 1983-1999页

作者： zhong shan Yanli Chu Guangfang Sun Rui Chen Jun Yan Qiwei He Yingna Liu Bin Wang Mingda Luan Wenzhi Lan School of Life Sciences Nanjing UniversityNanjing 210023China Institute of Future Agriculture Northwest A&F UniversityYangling 712100China

Phosphorus is an essential macronutrient for plant growth and *** response to phosphate(Pi)deficiency,plants rapidly produce a substitutive amount of root hairs;however,the mechanisms underlying Pi supply for root hair growth remain ***,we observed that soybean(Glycine max)plants maintain a consistent level of Pi within root hairs even under external Pi *** therefore investigated the role of vacuole-stored Pi,a major Pi reservoir in plant cells,in supporting root hair growth under Pi-deficient *** findings indicated that two vacuolar Pi efflux(VPE)transporters,GmVPE1 and GmVPE2,remobilize vacuolar stored Pi to sustain cytosolic Pi content in root hair *** analysis showed that double mutants of GmVPE1 and GmVPE2 exhibited reduced root hair growth under low Pi ***,GmVPE1 and GmVPE2 were highly expressed in root hairs,with their expression levels significantly upregulated by low Pi *** analysis revealed that GmRSL2(ROOT HAIR DEFECTIVE 6-like 2),a transcription factor involved in root hair morphogenesis,directly binds to the promoter regions of GmVPE1 and GmVPE2,and promotes their expressions under low Pi ***,mutants lacking both GmRSL2 and its homolog GmRSL3 exhibited impaired root hair growth under low Pi stress,which was rescued by overexpressing either GmVPE1 or *** together,our study has identified a module comprising vacuolar Pi exporters and transcription factors responsible for remobilizing vacuolar Pi to support root hair growth in response to Pi deficiency in soybean.

关键词： mineral deficiency remobilization root remodeling transcriptional regulation

Veno-venous extracorporeal membrane oxygenation for patient with a history of open cholecystectomy and acute respiratory distress syndrome caused by coinfection of avian influenza A (H7N9) and Epstein-Barr virus

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Chinese Medical Journal 2019年第11期132卷 1363-1364页

作者： Yong Yuan Wen-Da Guan Hai-Ming Jiang Jian-Wei Li Bin-Fei Li Wei-Jia Wang Zi-Feng Yang Rong-Chang Chen nan-shan zhong Yun-Ceng Weng Department of Emergency Sun Yat-Sen University Affiliated Zhongshan Hospital Sun Yat-Sen University Zhongshan Guangdong 528403 China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory Health the First Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong 510120 China

To the Editor:Most patients infected with avian influenza A (H7N9) rapidly develop progressive pneumonia and acute respiratory distress syndrome (ARDS), a heterogeneous disorder that is refractory to conventional mechanical ventilation. Most H7N9 patients also have underlying disease such as chronic obstructive pulmonary disease, hypertension, diabetes mellitus, and heart diseases, and are more susceptible to coinfections. For these patients with such serious complications, extracorporeal membrane oxygenation (ECMO) support can be adopted as a feasible life-saving therapy Here, we present our successful experience with ECMO utilized in a patient with ARDS and also with H 7N9 and Epstein-Barr virus (EBV) infection.

关键词： Most people are infected with avian influenza A (H7N9) diabetes mellitus avian influenza

Mohnarin 2009年度报告:广东地区细菌耐药监测

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中国临床药理学杂志 2011年第7期27卷 551-556,560页

作者：卓超苏丹虹钟南山广州医学院呼吸疾病国家重点实验室广州510120

目的了解2009年广东地区细菌耐药性监测网所属22所医院临床分离株的耐药情况。方法用纸片扩散法(KB法)对26004株临床分离株作药敏试验。结果 26004株细菌中,革兰阳性菌占35.7%;革兰阴性菌占64.3%。耐甲氧西林金葡菌(MRSA)和耐甲氧西林... 详细信息

目的了解2009年广东地区细菌耐药性监测网所属22所医院临床分离株的耐药情况。方法用纸片扩散法(KB法)对26004株临床分离株作药敏试验。结果 26004株细菌中,革兰阳性菌占35.7%;革兰阴性菌占64.3%。耐甲氧西林金葡菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)的检出率分别为58.8%和53.6%。未发现万古霉素中介株(VISA)或耐药株(VRSA)。肺炎链球菌(非脑膜炎分离株)对青霉素耐药率为2.4%。肠杆菌科细菌对碳青霉烯类保持最低耐药性。在大肠埃希菌和克雷伯菌属中,产ESBLs菌的检出率分别为47.7%和42.6%;二甲医院大肠埃希菌ESBL发生率(52.8%)高于三甲医院(45.0%)(χ2=18.2,P<0.01)。对铜绿假单胞菌耐药率最低的依次是美洛培南(16.5%)、头孢哌酮/舒巴坦(16.9%)和哌拉西林/他唑巴坦(19.0%)。对不动杆菌属耐药率最低的依次是头孢哌酮/舒巴坦(11.2%)、米诺环素(18.2%)和亚胺培南(24.3%)。与2007年本地资料相比,不动杆菌属对亚胺培南的耐药率已由7.1%增加至24.7%,其余菌种耐药性相对稳定。结论不动杆菌属对碳青霉烯类耐药问题日趋严峻。

关键词：细菌耐药性抗菌药细菌药敏试验

Investigation of gravity influence on EOR and CO_(2) geological storage based on pore-scale simulation

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Petroleum Science 2024年第2期21卷 987-1001页

作者： Yong-Mao Hao Gui-Cheng Wu Zong-Fa Li zhong-Hui Wu Yong-Quan Sun Ran Liu Xing-Xing Li Bo-Xin Pang nan Li Key Laboratory of Unconventional Oil&Gas Development(China University of Petroleum(East China)) Ministry of EducationQingdao266580ShandongChina School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina School of Petroleum Engineering Yangtze UniversityWuhan430100HubeiChina Dongsheng Jinggong Petroleum Development Group Co. LtdShengli Oilfield CompanySINOPECDongying257001ShandongChina

Gravity assistance is a critical factor influencing CO_(2)-Oil mixing and miscible flow during EOR and CO_(2)geological *** on the Navier-Stokes equation,component mass conservation equation,and fluid property-composition relationship,a mathematical model for pore-scale CO_(2) injection in oilsaturated porous media was developed in this *** model can reflect the effects of gravity assistance,component diffusion,fluid density variation,and velocity change on EOR and CO_(2) *** nonhomogeneous porous media,the gravity influence and large density difference help to minimize the velocity difference between the main flow path and the surrounding area,thus improving the oil recovery and CO_(2) *** CO_(2) injection angles and oil-CO_(2) density differences can increase the oil recovery by 22.6% and 4.2%,respectively,and increase CO_(2) storage by 37.9% and 4.7%,*** diffusion facilitates the transportation of the oil components from the low-velocity region to the main flow path,thereby reducing the oil/CO_(2) concentration difference within the porous *** diffusion can increase oil recovery and CO_(2) storage by 5.7% and 6.9%,*** addition,combined with the component diffusion,a low CO_(2) injection rate creates a more uniform spatial distribution of the oil/CO_(2) component,resulting in increases of 9.5% oil recovery and 15.7% CO_(2) storage,*** study provides theoretical support for improving the geological CO_(2) storage and EOR processes.

关键词： Gravity Flow simulation CO_(2)-oil mixing Enhanced oil recovery(EOR) Geological storage

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2007年广州地区耐药性监测分析

中华检验医学杂志 2009年第4期32卷 397-402页

作者：卓超苏丹虹钟南山呼吸疾病国家重点实验室广州医学院第一附属医院 510120

目的了解广州地区2007年细菌耐药性监测协作组所属15所医院临床分离株的耐药情况，明确广州地区的耐药特点。方法采用纸片扩散法（KB法）和美国临床和实验室标准协会（CISI）2008年的判断标准对18500株临床分离株作药敏试验。结果18500... 详细信息

目的了解广州地区2007年细菌耐药性监测协作组所属15所医院临床分离株的耐药情况，明确广州地区的耐药特点。方法采用纸片扩散法（KB法）和美国临床和实验室标准协会（CISI）2008年的判断标准对18500株临床分离株作药敏试验。结果18500株细菌中革兰阳性菌占31．6％，革兰阴性菌占68．4％，其中非发酵菌占革兰阴性菌45．7％。耐甲氧西林金葡菌（MRSA）和耐甲氧西林凝固酶阴性葡萄球菌（MRCNS）的检出率分别为55．9％和75．9％。按照2008年CLSI标准，所有肺炎链球菌都对青霉素敏感。在大肠埃希菌和克雷伯菌属中产ESBLs菌的检出率分别为43．8％和39．8％，对大肠埃希菌和克雷伯菌属ESBL产生菌的耐药率最低的药物分别是美罗培南、亚胺培南、头孢哌酮／舒巴坦和哌拉西彬他唑巴坦，耐药率为0—14．1％。铜绿假单胞菌对头孢哌酮／舒巴坦、哌拉西林／他唑巴坦和美罗培南的耐药率最低，分别为20．4％、24．4％和25．4％，但3者敏感率相比，由高到低分别为：哌拉西彬他唑巴坦（75．4％）、美罗培南（72．4％）和头孢哌酮／舒巴坦（63．2％）。不动杆菌属对头孢哌酮／舒巴坦和美罗培南的耐药率分别为2．6％和5．1％。出现少数铜绿假单胞菌（5．5％）和鲍曼不动杆菌（1．5％）的泛耐药株。痰标本来源的铜绿假单胞菌和鲍曼不动杆菌对大多抗菌药物的耐药性都高于血液标本来源菌。结论非发酵菌分离率上升，细菌耐药性持续增加，出现泛耐药的铜绿假单胞菌和鲍曼不动杆菌。加强地区性细菌耐药性监测，对于正确合理选用抗菌药和控制细菌耐药性产生十分重要。

关键词：细菌耐药性抗菌药细菌药敏试验