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The immunophilin CYCLOPHILIN28 affects PSII-LHCII supercomplex assembly and accumulation in Arabidopsis thaliana

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Journal of Integrative Plant Biology 2022年第4期64卷 915-929页

作者： Weining Zhu Linqing Xu Xiaoxia Yu ying zhong Chinese Education Ministry's Key Laboratory of Western Resources and Modern Biotechnology Key Laboratory of Biotechnology Shaanxi ProvinceCollege of Life SciencesNorthwest UniversityXi'an 710069China

In plant chloroplasts,photosystem II(PSII)complexes,together with light-harvesting complex II(LHCII),form various PSII-LHCII supercomplexes(SCs).This process likely involves immunophilins,but the underlying regulatory mechanisms are ***,by comparing Arabidopsis thaliana mutants lacking the chloroplast lumen-localized immunophilin CYCLOPHILIN28(CYP28)to wildtype and transgenic complemented lines,we determined that CYP28 regulates the assembly and accumulation of PSII-LHCII *** to the wild type,cyp28 plants showed accelerated leaf growth,earlier flowering time,and enhanced accumulation of high molecular weight PSII-LHCII SCs under normal light *** lack of CYP28 also significantly affected the electron transport *** native-polyacrylamide gel electrophoresis analysis revealed more Lhcb6 and less Lhcb4 in M-LHCII-Lhcb4-Lhcb6 complexes in cyp28 versus wild-type ***-prolyl cis/trans isomerase(PPIase)activity assays revealed that CYP28 exhibits weak PPIase activity and that its K113 and E187 residues are critical for this *** analysis suggested that CYP28 may regulate PSIILHCII SC accumulation by altering the configuration of Lhcb6 via its PPIase ***,the Lhcb6-P139 residue is critical for PSII-LHCII SC assembly and ***,our findings suggest that CYP28 likely regulates PSII-LHCII SC assembly and accumulation by altering the configuration of P139 of Lhcb6 via its PPIase activity.

关键词： cyclophilin28 immunophilin peptidyl-prolyl cis/trans isomerase activity photosynthesis PSII-LHCII supercomplexes thylakoid lumen

生酮饮食治疗患儿基线营养状况和主要照顾者对其知晓现况调查研究

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中国实用儿科杂志 2024年第7期39卷 524-529页

作者：龚晓妍卢忠英张赟健郁莉斐周水珍钱甜国家儿童医学中心(上海) 复旦大学附属儿科医院临床营养科上海201102 国家儿童医学中心(上海) 复旦大学附属儿科医院神经内科上海201102

目的调查生酮饮食治疗启动前期患儿基线营养状况和主要照顾者对生酮饮食疗法(ketogenicdiet therapies,KDTs)的知晓现况,为后续有效治疗和长程管理模式的探索提供依据。方法采用前瞻性队列研究设计,纳入2021年7月至2024年1月于复旦大学... 详细信息

目的调查生酮饮食治疗启动前期患儿基线营养状况和主要照顾者对生酮饮食疗法(ketogenicdiet therapies,KDTs)的知晓现况,为后续有效治疗和长程管理模式的探索提供依据。方法采用前瞻性队列研究设计,纳入2021年7月至2024年1月于复旦大学附属儿科医院神经内科接受KDTs患儿及其主要照顾者作为研究对象,患儿完善营养筛查与评估。采用现场调查方式对主要照顾者进行问卷调查,了解患儿日常饮食行为习惯和主要照顾者在启动前期对KDTs知晓情况。结果研究共纳入104例患儿,有效问卷回收率100%。所有患儿均存在营养风险。在针对患儿日常饮食行为习惯的调查中发现,55.3%的患儿存在挑食偏食问题。在启动生酮饮食治疗前期,89.4%的主要照顾者通过神经内科专科就诊知晓患儿可行生酮饮食治疗,25.0%通过微信、网络、书籍知晓,10.6%通过病友群知晓。对于KDTs执行问题,72.1%的主要照顾者担心患儿难以接受此类特殊饮食,28.8%担心无法胜任临床实施流程,22.1%担心自身无法准确掌握生酮饮食治疗团队的教学。对于疗效期待,主要照顾者均期望患儿癫痫发作得到有效控制,79.8%期望治疗的同时能够改善患儿认知行为能力,77.9%期望同时能够减停所有抗癫痫药物。结论启动KDTs的患儿存在中度或高度营养风险,部分患儿存在营养不足或过剩问题。患儿日常存在膳食摄入不均衡的比例较高。主要照顾者对于疗效期待值较高。KDTs团队在常规诊疗过程中需关注患儿营养状况,加大KDTs宣教力度,以保障其能够安全有效实施。

关键词：生酮饮食营养状况主要照顾者现况调查

Monte Carlo study of the neutron ambient dose equivalent at the heavy ion medical machine in Wuwei

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Nuclear Science and Techniques 2022年第9期33卷 111-125页

作者： Sheng-Cong Huang Hui Zhang Kai Bai ying Luo Hai-Jun Mao zhong-ying Dai University of Chinese Academy of Sciences Beijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China

The use of carbon-ion radiotherapy(CIRT)is gradually *** to the generation of high-energy secondary neutrons during CIRT,its use presents new challenges in radiation ***,secondary neutron dose distributions must be explored and evaluated under clinical scenarios based on different treatment ***,neutron dose and energy spectrum measurements are often *** can be primarily attributed to the inherent limitations of most neutron detectors,such as their unsuitability for spectral measurements and inaccurate responses to neutrons with energies above 20 *** calculation methods based on probabilistic statistical theory are fast and convenient for neutron dose *** this study,external secondary neutron doses at the heavy ion medical machine in Wuwei,which is equipped with a passive beam delivery system,were calculated using the Monte Carlo *** dependence of neutron doses on various treatment parameters(incident carbon-ion beam energy,spatial location,field size,and spread-out Bragg peak(SOBP)width)was ***,the feasibility of applying an analytical model to predict the ambient dose equivalent was *** the combination involving an energy of 400 MeV=u and SOBP width of 6 cm,the ambient dose equivalent per therapeutic dose(H=D)at the isocenter was 79.87 mSv=Gy:The H=D value decreased rapidly with increasing spatial distance and slightly with increasing aperture size and SOBP *** H=D values derived from the Monte Carlo simulations were in good agreement with the results reported in the *** analytical model could be used to quickly predict the H=D value along the incidence direction of the beam with an error of less than 20%.Thus,our study contributes to the understanding of the relationship between neutron radiation and treatment configuration parameters,which establishes a basis for predicting non-therapeutic radiation doses in CIRT.

关键词： Carbon-ion radiotherapy Passive beam delivery Secondary neutrons Monte Carlo method

肠道微生物定植抗性影响B族链球菌定植的研究进展

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中国抗生素杂志 2024年第8期49卷 851-859页

作者：朱靓欧阳谭亮李云鹤钟樱薛云新王岱分子疫苗学和分子诊断学国家重点实验室厦门大学厦门361102

B族链球菌(group B Streptococcus, GBS)可导致孕妇早产、宫内感染和新生儿化脓性脑膜炎、败血症和肺炎等多种疾病甚至死亡。美国疾病预防控制中心指南建议所有孕产妇在孕35~37周应进行GBS筛查,对检测阳性的孕产妇进行产时抗生素预防。... 详细信息

B族链球菌(group B Streptococcus, GBS)可导致孕妇早产、宫内感染和新生儿化脓性脑膜炎、败血症和肺炎等多种疾病甚至死亡。美国疾病预防控制中心指南建议所有孕产妇在孕35~37周应进行GBS筛查,对检测阳性的孕产妇进行产时抗生素预防。使用抗生素会对人体产生副作用且无法预防GBS迟发性感染,随着细菌抗生素耐药逐年严重,探索成本更低、更有效的预防GBS定植感染措施尤为重要。GBS是一种可通过食物传播的人畜共患病病原体,研究其在肠道中的定植至关重要。肠道内共生细菌可通过肠道定植抗性机制抑制肠道病原体的定植和扩张,减少肠道GBS逆行性感染生殖道的风险,具有成为防治GBS的一级预防措施的潜力。本文着重探讨肠道定植抗性对GBS定植感染的影响,以及基于此的益生菌应用。

关键词： GBS 抗生素耐药肠道定植抗性益生菌

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子宫内膜微生物群的组成及研究进展

国际妇产科学杂志 2024年第5期51卷 481-485页

作者：钟晓盈刘海元(审校) 中国医学科学院北京协和医学院北京协和医院妇产科国家妇产疾病临床医学研究中心100730

近年来,子宫内膜微生物群的研究逐渐受到重视,不同比例的菌群组成与生殖系统疾病及病理性妊娠的发生密切相关。子宫内膜微生物群的组成尚未完全明确,许多研究秉持子宫内膜中以乳杆菌为主导微生物的观点,但因各个研究标本采集及分析方法... 详细信息

近年来,子宫内膜微生物群的研究逐渐受到重视,不同比例的菌群组成与生殖系统疾病及病理性妊娠的发生密切相关。子宫内膜微生物群的组成尚未完全明确,许多研究秉持子宫内膜中以乳杆菌为主导微生物的观点,但因各个研究标本采集及分析方法的不同,对该理论仍存在争议。16S rRNA测序技术是目前子宫内膜微生物群最常用的研究方法,同时亦有利用不同组学技术的研究报道。子宫内膜容受性是胚胎成功植入的关键,子宫内膜中乳杆菌的优势可能与生殖预后改善有关。慢性子宫内膜炎(chronic endometritis,CE)已被证实与不孕、复发性流产及反复种植失败有关。目前尚未证实子宫内膜微生物失衡与CE的相关性,但有研究发现CE患者的乳杆菌比例下降,提示子宫内膜微生物与CE可能具有一定相关性。本文综述子宫内膜微生物组成的不同研究结果及研究方法,并总结近年子宫内膜微生物对于子宫内膜容受性及CE的影响及作用。

关键词：微生物群子宫内膜子宫内膜微生物群子宫内膜容受性慢性子宫内膜炎

Accelerometer error estimation and compensation for three-axis gyro-stabilized camera mount based on proportional multiple-integral observer

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Science China(Technological Sciences) 2014年第12期57卷 2387-2395页

作者： LI Shu Sheng zhong Mai ying ZHAO Yan School of Instrument Science & Opto-engineering Beihang University

This paper deals with the problem of accelerometer error estimation and compensation for a three-axis gyro-stabilized camera mount. In a dynamic environment, the aircraft motion acceleration affects the accelerome ：er output and causes a degradation of attitude steady accuracy. In order to improve control accuracy, this paper proposes a proportional multiple-integral observer- based control strategy to estimate and compensate the accelerometer error. The basic idea of this paper is to approximate the error property by using a q-order polynomial function and extend the error and its derivatives as augmented states. Then a proportional multiple-integral observer is developed to estimate the error, with which the relationship between the error and the imbalance torque is formulated. The estimated value is compared to an angle threshold, the result of which is used to compen- sate the accelerometer output. Through static and vehicle-mounted experiments, it is demonstrated that compared with the tra- ditional method, the proposed method can improve the attitude steady accuracy effectively.

关键词： three-axis gyro-stabilized camera mount accelerometer error estimation and compensation proportional multiple-integralobserver imbalance torque

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圆碟形水下滑翔机耐压壳体的优化设计

舰船科学技术 2024年第7期46卷 65-73页

作者：熊仲营刘越尧陶品华李向辉江苏科技大学船舶与海洋工程学院江苏镇江212100

圆碟形水下滑翔机是一种新型的水下滑翔机,耐压壳体则是滑翔机的重要组件。本文主要研究在不同水深下机身直径、机身高度与机身表面饱和度对耐压壳体表面变形与压力分布情况的影响。通过有限元分析表明在100~300 m水深范围内应减小机身... 详细信息

圆碟形水下滑翔机是一种新型的水下滑翔机,耐压壳体则是滑翔机的重要组件。本文主要研究在不同水深下机身直径、机身高度与机身表面饱和度对耐压壳体表面变形与压力分布情况的影响。通过有限元分析表明在100~300 m水深范围内应减小机身直径,从而降低机身的最大变形量和最大应力。随着机身高度的增加,最大变形量和最大应力的变化规律是先减后增,且随着工作水深的增加,这种趋势越发明显。对于不同机身表面饱和度的圆碟型水下滑翔机,其外壳的最大变形和最大应力分布规律并不统一,机身饱和度较低的圆碟形滑翔机的综合性能较优。本文分析结果可为圆碟形滑翔机在不同深度下的外形设计提供参考。

关键词：圆碟形水下滑翔机耐压壳体优化设计应力分析

Effects of the cosmological constant on chaos in an FRW scalar field universe

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Research in Astronomy and Astrophysics 2009年第11期9卷 1185-1191页

作者： Da-Zhu Ma Xin Wu Shuang-ying zhong Department of Physics Nanchang University Nanchang 330031 China Department of Physics Hubei University for Nationalities Enshi 445000 China

The dependence of chaos on two parameters of the cosmological constant and the self-interacting coefficient in the imaginary phase space for a closed Friedman- Robertson-Walker （FRW） universe with a conformally coupled scalar field, as the full understanding of the dependence in real phase space, is investigated numerically. It is found that Poincar6 plots for the two parameters less than 1 are almost the same as those in the absence of the cosmological constant and self-interacting terms. For energies below the energy threshold of 0.5 for the imaginary problem in which there are no cosmological constant and self-interacting terms, an abrupt transition to chaos occurs when at least one of the two parameters is 1. However, the strength of the chaos does not increase for energies larger than the threshold. For other situations of the two parameters larger than 1, chaos is weaker, and even disappears as the two parameters increase.

关键词： cosmology cosmological parameters -- methods numerical

Determination of inorganic anions in ethyl acetate by in-line hollow fiber membrane extraction with ion chromatography

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Chinese Chemical Letters 2009年第12期20卷 1498-1501页

作者： Zhen Zhen Hu ying ying zhong Yun Chang Fan Yan Zhu Department of Chemistry Xixi Campus Zhejiang University Hangzhou 310028 China

In this work, a novel hollow fiber membrane extractor was set up to extract inorganic anions from ethyl acetate using deionized water. Inorganic anions in slightly soluble organic solvents can be determined by the in-line hollow fiber membrane extractor coupled with ion chromatography at first time. Different aspects of the extraction procedure such as magnetic stirring speed, extraction flow rate and extraction time were optimized to achieve high extraction efficiency and good separation results. Satisfactory linear range, limits of detection and good repeatability were obtained. The procedure was applied to analyze inorganic anions in two commercial ethyl acetate samples.

关键词： Inorganic anions Ethyl acetate In-line hollow fiber membrane extraction Ion chromatography