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HIV-1 Subtype Diversity and Factors Affecting Drug Resistance among Patients with Virologic Failure in Antiretroviral Therapy in Hainan Province,China,2014–2020

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Biomedical and Environmental Sciences 2023年第9期36卷 800-813页

作者： YU De E XU Yu Jun LI Mu YANG Yuan LIANG Hua Yue zhong shan mei QIN Cai LAN Ya Nan LI Da Wei YU Ji Peng PANG Yuan QIN Xue Qiu LIANG Hao ZHU Kao Kao YE Li LIANG Bing Yu Guangxi Key Laboratory of AIDS Prevention and Treatment School of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina International School of Public Health and One Health Hainan Medical UniversityHaikou 571199HainanChina Prevention and Treatment Department the Fifth People's Hospital of Hainan Province&Affiliated Dermatology Hospital of Hainan Medical UniversityHaikou 570102HainanChina Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Life Sciences InstituteGuangxi Medical UniversityNanning 530021GuangxiChina Oncology Medical College Guangxi Medical UniversityNanning 530021GuangxiChina The First Clinical Medical College Guangxi Medical UniversityNanning 530021GuangxiChinaGuangxi Key Laboratory of AIDS Prevention and TreatmentSchool of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina

Objective This study aimed to determine the HIV-1 subtype distribution and HIV drug resistance(HIVDR)in patients with ART failure from 2014 to 2020 in Hainan,*** A 7-year cross-sectional study was conducted among HIV/AIDS patients with ART failure in *** used online subtyping tools and the maximum likelihood phylogenetic tree to confirm the HIV subtypes with pol *** resistance mutations(DRMs)were analyzed using the Stanford University HIV Drug Resistance *** A total of 307 HIV-infected patients with ART failure were included,and 241 available pol sequences were *** 241 patients,CRF01_AE accounted for 68.88%,followed by CRF07_BC(17.00%)and eight other subtypes(14.12%).The overall prevalence of HIVDR was 61.41%,and the HIVDR against non-nucleoside reverse transcriptase inhibitors(NNRTIs),nucleotide reverse transcriptase inhibitors(NRTIs),and protease inhibitors(PIs)were 59.75%,45.64%,and 2.49%,*** patients,hypoimmunity or opportunistic infections in individuals,and samples from 2017 to 2020 increased the odd ratios of ***,HIVDR was less likely to affect female *** common DRMs to NNRTIs were K103N(21.99%)and Y181C(20.33%),and M184V(28.21%)and K65R(19.09%)were the main DRMs against *** The present study highlights the HIV-1 subtype diversity in Hainan and the importance of HIVDR surveillance over a long period.

关键词： HIV-1 subtypes Antiretroviral therapy Virological failure Drug resistance

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Cultivating College Students' Cultural Confidence in English Teaching in the Context of New Liberal Arts

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海外英语 2021年第9期 277-278,280页

作者：肖艳君钟善美 Hunan Institute of Technology Hengyang 421002China

Cultural confidence represents a fundamental and profound force that sustains the development of a country and a na-tion. It is also a prerequisite for college students' growth and development. Given phenomena such as college students' alienationfrom Chinese culture and"Chinese culture aphasia", this paper tries to analyze the reasons behind it. It then states the significanceand ways of helping college students build up cultural confidence through English teaching in the context of new liberal arts.

关键词： cultural confidence college students new liberal arts

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坛紫菜多糖对两种突变剂诱导的大蒜根尖细胞损伤的保护作用（英文）

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现代食品科技 2017年第3期33卷 40-46页

作者：张忠山王晓梅刘重斌湖州师范学院生命科学学院浙江湖州313000

研究发现从红藻坛紫菜中提取的多糖具有优异的抗氧化活性。本文研究了坛紫菜多糖及其硫酸衍生物对两种突变剂环磷酰胺和丝裂霉素C诱导的大蒜根尖细胞微核率、有丝分裂指数和染色体畸变率的影响作用,以及抗脂质过氧化作用。结果表明,两... 详细信息

研究发现从红藻坛紫菜中提取的多糖具有优异的抗氧化活性。本文研究了坛紫菜多糖及其硫酸衍生物对两种突变剂环磷酰胺和丝裂霉素C诱导的大蒜根尖细胞微核率、有丝分裂指数和染色体畸变率的影响作用,以及抗脂质过氧化作用。结果表明,两种多糖均表现出明显地抑制微核和染色体畸变作用,明显地提高有丝分裂指数。其影响作用具有明显的剂量依赖性。当多糖浓度为100 mg/L时,多糖表现出最大抑制效应或增强效应。同时,硫酸化衍生物表现出比原料多糖更优异的抗细胞内脂质过氧化作用。分析表明坛紫菜多糖表现出的抗突变作用与抗脂质过氧化作用具有一定关系。同时也表明硫酸基对于抗突变作用的间接影响。结果显示坛紫菜多糖具有成为抗突变活性物质的潜力。

关键词：坛紫菜多糖大蒜根尖环磷酰胺丝裂霉素-C

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浒苔多糖脂质体的制备及其抗肿瘤活性研究

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粮食与油脂 2016年第10期29卷 82-84页

作者：张忠山王晓梅刘重斌荆楚理工学院药物合成与优化湖北省重点实验室湖北荆门448000 湖州师范学院生命科学学院浙江湖州313000

采用薄膜超声分散法制备了浒苔多糖脂质体,通过正交试验确定了最佳制备条件为脂药比20∶1(g/g)、膜材比3∶1(g/g)、载药温度35℃。浒苔多糖脂质体体外释放速度缓慢,48 h后基本释放完全。体外抗肿瘤试验表明,浒苔多糖脂质体表现出比原料... 详细信息

采用薄膜超声分散法制备了浒苔多糖脂质体,通过正交试验确定了最佳制备条件为脂药比20∶1(g/g)、膜材比3∶1(g/g)、载药温度35℃。浒苔多糖脂质体体外释放速度缓慢,48 h后基本释放完全。体外抗肿瘤试验表明,浒苔多糖脂质体表现出比原料更好的缓释作用和抑制人肝癌HepG2细胞增殖作用。

关键词：浒苔多糖脂质体肝癌细胞

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个性化护理干预对肺癌患者生活质量的影响

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中国医药导刊 2016年第11期18卷 1171-1172页

作者：钟珊龚小梅武海燕湖南省肿瘤医院长沙410013 山东省广饶县中医院肿瘤科广饶257300

目的:探讨个性化护理对晚期肺癌患者生活质量的影响。方法:96例肺癌晚期患者随机分为对照组和试验组,各48例,两组均给予医院常规护理,实验组再由护理人员给予个性化护理干预。采用生活质量核心量表(QLQ-C30)测量两组患者入院后第10天的... 详细信息

目的:探讨个性化护理对晚期肺癌患者生活质量的影响。方法:96例肺癌晚期患者随机分为对照组和试验组,各48例,两组均给予医院常规护理,实验组再由护理人员给予个性化护理干预。采用生活质量核心量表(QLQ-C30)测量两组患者入院后第10天的生活质量。结果:经个性化护理干预后,试验组生活质量明显高于对照组,P<0.05。结论:个性化护理可有效提高晚期肺癌患者的生活质量,改善患者生活状态。

关键词：肺癌个性化护理生活质量

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对体育概念嫁接广州楼盘的理性思考

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南京体育学院学报（社会科学版） 2003年第1期17卷 39-41页

作者：万翠琳李建军张三梅广州体育学院研究生部广东广州510075

随着经济的发展和人们生活水平的提高 ,人们更注重自身健康。“健康是福”、“花钱买健康”的观念已深入人心。广州各房地产开发商也应大势而行 ,在楼盘开发经营中纷纷引入体育概念。因此 ,对体育概念嫁接广州楼盘这一现象和趋势进行理... 详细信息

随着经济的发展和人们生活水平的提高 ,人们更注重自身健康。“健康是福”、“花钱买健康”的观念已深入人心。广州各房地产开发商也应大势而行 ,在楼盘开发经营中纷纷引入体育概念。因此 ,对体育概念嫁接广州楼盘这一现象和趋势进行理性的分析和思考 ,为体育概念成功嫁接广州楼盘提出一些思路与对策都具有极为重要的现实意义。

关键词：体育概念楼盘开发经典品牌人文环境广州市楼盘经营房地产业

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Engineering morphologies of cobalt oxide/phosphate-carbon nanohybrids for high-efficiency electrochemical water oxidation and reduction

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Journal of Energy Chemistry 2021年第1期30卷 139-146,I0005页

作者： shan-shan Xu Xian-Wei Lv Yan-mei Zhao Tie-Zhen Ren zhong-Yong Yuan Hebei Provincial Key Laboratory of Green Chemical Technology&High Efficient Energy Saving School of Chemical Engineering and TechnologyHebei University of TechnologyTianjin 300130China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) School of Materials Science and EngineeringNankai UniversityTianjin 300350China State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering Ningxia UniversityYinchuan 750021NingxiaChina

Active non-noble metal catalysts plays a decisive role for water electrolysis,however,the rational design and development of cost-efficient electrocatalysts with Pt/IrO2-like activity is still a challenging ***,a facile one-step electrodeposition route in deep eutectic solvents(DESs) is developed for morphology-controllable synthesis of cobalt oxide/phosphate-carbon nano hybrids on nickel foam(CoPO@C/NF).A series of CoPO@C/NF nanostructures including cubes,octahedrons,microspheres and nanoflowers are synthesized,which show promising electrocatalytic properties toward oxygen and hydrogen evolution reactions(OER/HER).Such surface self-organized microstructure with accessible active sites make a significant contribution to the enhanced electrochemical activity,and hybridizing cobalt oxide with cobalt pyrophosphates and carbon can result in enhanced OER performance through synergistic *** all nanostructures,the obtained microspherical CoPO@C/NF-3 catalyst exhibits excellent catalytic activities for OER and HER in 1.0 M KOH,affording an anodic current density of 10 mA cm^(-2) at overpotentials of 293 mV for OER and 93 mV for HER,with good long-time *** work offers a practical route for engineering the high-performance electrocatalysts towards efficient energy conversion and storage devices.

关键词： Cobalt-based electrocatalysts Oxygen evolution reaction Hydrogen evolution reaction Deep eutectic solvents Electrodeposition

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Numerical investigation of hydro-morphodynamic characteristics of a cascading failure of landslide dams

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Journal of Mountain Science 2024年第6期21卷 1868-1885页

作者： zhong Qiming CHEN Lingchun mei Shengyao shan Yibo WU Hao ZHAO Kunpeng Department of Geotechnical Engineering Nanjing Hydraulic Research InstituteNanjing 210024China National Key Laboratory of Water Disaster Prevention Nanjing 210098China Key Laboratory of Reservoir and Dam Safety of the Ministry of Water Resources Nanjing 210029China

A cascading failure of landslide dams caused by strong earthquakes or torrential rains in mountainous river valleys can pose great threats to people’s lives,properties,and *** this study,based on the three-dimensional Reynoldsaveraged Navier-Stokes equations(RANS),the renormalization group(RNG)k-εturbulence model,suspended and bed load transport equations,and the instability discriminant formula of dam breach side slope,and the explicit finite volume method(FVM),a detailed numerical simulation model for calculating the hydro-morphodynamic characteristics of cascading dam breach process has been *** developed numerical model can simulate the breach hydrograph and the dam breach morphology evolution during the cascading failure process of landslide dams.A model test of the breaches of two cascading landslide dams has been used as the validation *** comparison of the calculated and measured results indicates that the breach hydrograph and the breach morphology evolution process of the upstream and downstream dams are generally consistent with each other,and the relative errors of the key breaching parameters,i.e.,the peak breach flow and the time to peak of each dam,are less than±5%.Further,the comparison of the breach hydrographs of the upstream and downstream dams shows that there is an amplification effect of the breach flood on the cascading landslide dam *** key parameters,i.e.,the distance between the upstream and the downstream dams,the river channel slope,and the downstream dam height,have been used to study the flood amplification *** parameter sensitivity analyses show that the peak breach flow at the downstream dam decreases with increasing distance between the upstream and the downstream dams,and the downstream dam ***,the peak breach flow at the downstream dam first increases and then decreases with steepening of the river channel *** the flood caused by the upstream dam failure flows to the

关键词： Cascading landslide dams Cascading dam failure process Detailed numerical simulation model Flood amplification effect Parameter sensitivity analyses

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Learning a graph-based classifier for fault localization

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Science China(Information Sciences) 2020年第6期63卷 195-216页

作者： Hao zhong Hong mei Department of Computer Science and Engineering Shanghai Jiao Tong University

Because software emerged, locating software faults has been intensively researched, culminating in various approaches and tools that have been applied in real development. Despite the success of these developments, improved tools are still demanded by programmers. Meanwhile, some programmers are reluctant to use any tools when locating faults in their development. The state-of-the-art situation can be naturally improved by learning how programmers locate faults. The rapid development of open-source software has accumulated many bug fixes. A bug fix is a specific type of comments containing a set of buggy files and their corresponding fixed files, which reveal how programmers repair bugs. Feasibly, an automatic model can learn fault locations from bug fixes, but prior attempts to achieve this vision have been prevented by various technical challenges. For example, most bug fixes are not compilable after checking out, which hinders analyzing bug fixes by most advanced static/dynamic tools. This paper proposes an approach called ClaFa that trains a graph-based fault classifier from bug fixes. ClaFa is built on a recent partial-code tool called Grapa, which enables the analysis of partial programs by the complete code tool called WALA. Once Grapa has built a program dependency graph from a bug fix, ClaFa compares the graph from the buggy code with the graph from the fixed code, locates the buggy nodes, and extracts the various graph features of the buggy and clean nodes. Based on the extraction result, ClaFa trains a classifier that combines Adaboost and decision tree learning. The trained ClaFa can predict whether a node of a program dependency graph is buggy or *** evaluate ClaFa on thousands of buggy files collected from four open-source projects: Aries, Mahout,Derby, and Cassandra. The f-scores of ClaFa achieves are approximately 80% on all projects.

关键词： fault classifier partial code analysis bug fix analysis

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Dissolution and diffusion of TiO_2 in the CaO-Al_2O_3-SiO_2 slag

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International Journal of Minerals,Metallurgy and Materials 2014年第4期21卷 345-352页

作者： zhong-shan Ren Xiao-jun Hu Xin-mei Hou Xiang-xin Xue Kuo-chih Chou State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing School of Metallurgical and Ecological Engineering University of Science and Technology Beijing School of Materials and Metallurgy Northeastern University

The dissolution of TiO2 in the CaO-Al2O3-SiO2 slag under static conditions was studied in the temperature range from 1643 K to 1703 K. After TiO2 dissolved, the microstructure of the interface between TiO2 and the slag was observed by scanning electron microscopy, and the concentration profiles of Ti4＋and other ions across the TiO2/slag interfaces were analyzed by energy-dispersive X-ray spectroscopy. On the basis of these results, the dissolution behavior of TiO2 was evaluated, and the diffusivity of Ti4＋in the bulk slag was estimated. Ac-cording to the Stokes-Einstein relation, the viscosity calculated by a previously reported model gave a diffusivity of Ti4＋ions greater than that estimated by the concentration profiles of Ti4＋ions. The mechanism of TiO2 dissolution in the CaO-Al2O3-SiO2 slag is discussed in de-tail.

关键词： slags titanium dioxide dissolution diffusion interface

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