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Genome-wide identification and analysis of the regulation wheat DnaJ family genes following wheat yellow mosaic virus infection

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Journal of Integrative Agriculture 2022年第1期21卷 153-169页

作者： liU Ting-ting XU Miao-ze GAO Shi-qi ZHANG Yang HU Yang JIN Peng CAI lin-na CHENG Ye CHEN Jian-ping YANG Jian zhong kai-li State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products/Key Laboratory of Biotechnology in Plant Protection of Ministry of Agriculture and Rural Affairs and Zhejiang Province Institute of Plant VirologyNingbo UniversityNingbo 315211P.R.China Institutes of Biomedical Sciences Fudan UniversityShanghai 200032P.R.China Institute of Forest Health Zhejiang Academy of ForestryHangzhou 310021P.R.China

The co-chaperone DnaJ plays an important role in protein folding and regulation of various physiological activities, and participates in several pathological processes. DnaJ has been extensively studied in many species including humans,drosophila, mushrooms, tomatoes, and Arabidopsis. However, few studies have examined the role of DnaJ in wheat(Triticum aestivum), and the interaction mechanism between TaDnaJs and plant viruses. Here, we identified 236 TaDnaJs and performed a comprehensive genome-wide analysis of conserved domains, gene structure and protein motifs, chromosomal positions and duplication relationships, and cis-acting elements. We grouped these Ta Dna Js according to their domains, and randomly selected six genes from the groups for tissue-specific analysis, and expression profiles analysis under hormone stress, and 17 genes for plant virus infection stress. In qRT-PCR, we found that among the 17 TaDnaJ genes tested, 16 genes were up-regulated after wheat yellow mosaic virus(WYMV) infection, indicating that the TaDnaJ family is involved in plant defense response. Subsequent yeast two-hybrid assays verified the WYMV NIa, NIb and 7 KD proteins interacted with TaDJC(TraesCS7 A02 G506000), which had the most significant changes in gene expression levels after WYMV *** into the molecular mechanisms of Ta Dna J-mediated stress tolerance and sensitivity could inform different strategies designed to improve crop resistance to abiotic and biotic stress. This study provides a basis for future investigation of the TaDnaJ family and plant defense mechanisms.

关键词： TaDnaJ WYMV wheat genome-wide expression hormone biotic stress HSP40

Exploring the performance of large language models on hepatitis B infection-related questions:A comparative study

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World Journal of Gastroenterology 2025年第3期31卷 103-112页

作者： Yu li Chen-kai Huang Yi Hu Xiao-Dong Zhou Cong He Jia-Wei zhong Department of Gastroenterology Jiangxi Provincial Key Laboratory of Digestive DiseasesJiangxi Clinical Research Center for GastroenterologyDigestive Disease HospitalThe First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina HuanKui Academy Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Patients with hepatitis B virus(HBV)infection require chronic and personalized care to improve *** language models(LLMs)can potentially provide medical information for *** To examine the performance of three LLMs,ChatGPT-3.5,ChatGPT-4.0,and Google Gemini,in answering HBV-related *** LLMs’responses to HBV-related questions were independently graded by two medical professionals using a four-point accuracy scale,and disagreements were resolved by a third *** question was run three times using three *** was assessed via the Gunning Fog index and Flesch-Kincaid grade *** Overall,all three LLM chatbots achieved high average accuracy scores for subjective questions(ChatGPT-3.5:3.50;ChatGPT-4.0:3.69;Google Gemini:3.53,out of a maximum score of 4).With respect to objective questions,ChatGPT-4.0 achieved an 80.8%accuracy rate,compared with 62.9%for ChatGPT-3.5 and 73.1%for Google *** the six domains,ChatGPT-4.0 performed better in terms of diagnosis,whereas Google Gemini demonstrated excellent clinical ***,in the readability analysis,the mean Gunning Fog index and Flesch-Kincaid grade level scores of the three LLM chatbots were significantly higher than the standard level eight,far exceeding the reading level of the normal *** Our results highlight the potential of LLMs,especially ChatGPT-4.0,for delivering responses to HBV-related *** may be an adjunctive informational tool for patients and physicians to improve ***,current LLMs should not replace personalized treatment recommendations from physicians in the management of HBV infection.

关键词： ChatGPT-3.5 ChatGPT-4.0 Google Gemini Hepatitis B infection Accuracy

An effective discrete invasive weed optimization algorithm for multi-AGVs dispatching problem in a matrix production workshop

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An effective discrete invasive weed optimization algorithm f...

Formation of arsenic−copper-containing particles and their sulfation decomposition mechanism in copper smelting flue gas

第40届中国控制会议

作者： zhong-kai li Hong-Yan Sang Xu-Jin Zhang Jun-Qing li Heng-Wei Guo School of Computer Science Liaocheng University

Automatic guided vehicles dispatching problem（AGVDP） has important applications in matrix production *** this paper, we present a mathematical model for the AGVDP. Then, a new violating time decreasing method is designed to reduce the transportation cost. An effective discrete invasive weed optimization algorithm（DIWO） is proposed. In the proposed DIWO algorithm, a nearest-neighbor-based heuristic is used to generate initial population with high quality, a local search is applied to enhance the local search capability. A comprehensive calculation campaign based on 110 benchmark examples from actual factory is carried out in this paper. The comparative evaluations show that the proposed DIWO algorithm has much better performance than other algorithms.

关键词： automatic guided vehicle dispatching invasive weed optimization

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Transactions of Nonferrous Metals Society of China 2021年第7期31卷 2153-2164页

作者： Wen-ming YAO Xiao-bo MIN Qing-zhu li kai-zhong li Yun-yan WANG Qing-wei WANG Hui liU Sheng-li QU Zhun-qin DONG Chao QU Tao CHEN Chao SONG School of Metallurgy and Environment Central South UniversityChangsha 410083China National Engineering Research Center for Control&Treatment of Heavy Metal Pollution Central South UniversityChangsha 410083China Shandong Humon Smelting Co. Ltd.Yantai 264109China Yantai Humon Group Co. Ltd.Yantai 264100China

The heat recovery steam generator(HRSG)of copper smelting generates a large number of arsenic−coppercontaining particles,and the in-situ separation of arsenic and copper is of importance for cutting off environmental risk and realizing resource *** formation of arsenic−copper-containing particles was simulated,the method of in-situ decomposition of arsenic−copper-containing particles by pyrite was proposed,and the decomposition mechanism was *** was found that particles with high arsenic content were formed in the simulated HRSG,and copper arsenate was liable for the high arsenic *** promoted the sulfation of copper,leading to the in-situ decomposition of copper *** this process,gaseous arsenic was released,and thus the separation of arsenic and copper was realized.

关键词： copper smelting flue gas particles sulfation decomposition copper arsenate pyrite

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论布尔加科夫对余华“当代性”写作的影响

汉江师范学院学报 2018年第5期38卷 42-47页

作者：钟凯丽浙江师范大学人文学院浙江金华321004

在余华的写作道路中,外国文学对其创作的影响是不容忽视的。其中布尔加科夫对余华书写当代社会产生了重要影响。余华在阅读布尔加科夫的《大师和玛格丽特》时产生了独特的阅读体会,布尔加科夫对待现实的态度及其作品中表现的文学的现实... 详细信息

在余华的写作道路中,外国文学对其创作的影响是不容忽视的。其中布尔加科夫对余华书写当代社会产生了重要影响。余华在阅读布尔加科夫的《大师和玛格丽特》时产生了独特的阅读体会,布尔加科夫对待现实的态度及其作品中表现的文学的现实都引起了余华的关注。在《兄弟》和《第七天》的狂欢化书写、荒诞书写和对彼岸世界的书写中,我们都能看到布尔加科夫对余华的影响。但在借鉴的同时,余华又结合中国传统文化和社会环境及其对文学现实的独特理解有所创造。

关键词：余华布尔加科夫当代现实

Crust and uppermost mantle structure of the Ailaoshan-Red River fault from receiver function analysis

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Science China Earth Sciences 2006年第10期49卷 1043-1052页

作者： XU Mingjie1, WANG liangshu1, liU Jianhua2, zhong kai1, li Hua1, HU Dezhao1 & XU Zhen1 1. Department of Earth Sciences, Nanjing University, Nanjing 210093, China 2. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China 1. Department of Earth Sciences Nanjing University Nanjing 210093 China 2. Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China

S-wave velocity structure beneath the Ailaoshan-Red River fault was obtained from receiver functions by using teleseismic body wave records of broadband digital seismic stations. The average crustal thickness, Vp/Vs ratio and Poisson’s ratio were also estimated. The results indicate that the interface of crust and mantle beneath the Ailaoshan-Red River fault is not a sharp velocity discontinuity but a characteristic transition zone. The velocity increases relatively fast at the depth of Moho and then increases slowly in the uppermost mantle. The average crustal thickness across the fault is 36―37 km on the southwest side and 40―42 km on the northeast side, indicating that the fault cuts the crust. The relatively high Poisson’s ratio (0.26―0.28) of the crust implies a high content of mafic materials in the lower crust. Moreover, the lower crust with low velocity could be an ideal position for decoupling between the crust and upper mantle.

关键词： receiver function, Ailaoshan-Red River fault, velocity structure, Poisson's ratio, crust and upper mantle.

MoDnm1 Dynamin Mediating Peroxisomal and Mitochondrial Fission in Complex with MoFis1 and MoMdv1 is Important for Development of Functional Appressorium in Magnaporthe oryzae

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MoDnm1 Dynamin Mediating Peroxisomal and Mitochondrial Fissi...

中国植物病理学会2016年学术年会

作者： zhong kai-li li Xiao LE Xin-yi KONG Xiang-yi ZHANG Hai-feng ZHENG Xiao-bo WANG Ping ZHANG Zheng-guang College of Plant Protection/Key Laboratory of Integrated Management of Crop Diseases and Pests Ministry of EducationNanjing Agricultural University Department of Pediatrics Louisiana State University Health Sciences CenterNew Orleans

Dynamins are large superfamily GTPase proteins that are involved in various cellularprocesses including budding of transport vesicles,division of organelles,cytokinesis,and pathogen ***,we characterized several dynamin-related proteins from the rice blast fungus Magnaporthe *** found that MoDnm1 is required for normal functions,including vegetative growth,conidiogenesis,and full *** addition,we found that MoDnm1 co-localizes with peroxisomes and mitochondria,which is consistent with the conserved role of dynamin ***,MoDnm1-dependent peroxisomal and mitochondrial fission involves the functions of the mitochondrial fission protein MoFisl and the WD-40 repeat protein *** two proteins display similar functions as well as cellular localizations to MoDnml,and are required for full *** studies showed that MoDnm1,MoFisl and MoMdvl are in complex to regulate peroxisomal and mitochondrial *** is required for not only pexophagy and mitophagy progression but also appresorium function and host *** summary,our studies provide insights into how dynamin-related proteins interact with their partners to mediate peroxisomal and mitochondrial function and how such regulatory events may link to differentiation and pathogenicity in the rice blast fungus ***.

关键词： Peroxisome Mitochondria Fission Pexophagy Mitophagy Autophagy Pathogenicity

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复发性和难治性霍奇金淋巴瘤的治疗

白血病．淋巴瘤 2008年第1期17卷 -页

作者：仲凯励张伟京解放军三○七医院肿瘤二科北京100071

复发性和难治性霍奇金淋巴瘤(HL)目前是治疗的难点.根据再次分期的结果和临床特点,可以采用挽救性放疗、新的化疗方案等手段,但对部分患者仍不能达到满意的疗效.新的化疗方案,包括吉西他滨、长春瑞滨等以及有新的作用机制的药物,如硼替... 详细信息

复发性和难治性霍奇金淋巴瘤(HL)目前是治疗的难点.根据再次分期的结果和临床特点,可以采用挽救性放疗、新的化疗方案等手段,但对部分患者仍不能达到满意的疗效.新的化疗方案,包括吉西他滨、长春瑞滨等以及有新的作用机制的药物,如硼替佐米等已初见成效.大剂量化疗配合自体干细胞移植能够明显提高疗效,已经作为难治性或1年内复发的HL的常规治疗.靶向药物如利妥昔单抗对于HL,尤其是结节性淋巴细胞为主型的HL患者疗效明确.

关键词：霍奇金淋巴瘤复发性难治性治疗

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周立波小说中的风景与抒情

西安文理学院学报（社会科学版） 2018年第2期21卷 11-15页

作者：钟凯丽浙江师范大学人文学院浙江金华321004

周立波的小说以风格清新秀丽、乡土气息浓郁见长,小说中的风景与抒情更是别具一格。"十七年文学"时期,政治与文学抒情呈现出紧张的关系,周立波却在特定政治环境的压力下形成了独树一帜的抒情风格。从抒情传统、湖湘风光和作家个人的浪... 详细信息

周立波的小说以风格清新秀丽、乡土气息浓郁见长,小说中的风景与抒情更是别具一格。"十七年文学"时期,政治与文学抒情呈现出紧张的关系,周立波却在特定政治环境的压力下形成了独树一帜的抒情风格。从抒情传统、湖湘风光和作家个人的浪漫情怀三个方面出发,尝试寻找周立波小说中独特的风景与抒情产生的原因,并对作家在特定时期如何处理文艺与政治的关系做了思考。

关键词：周立波风景抒情