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Analysis of Chinese Medical Syndrome Features of Ischemic Stroke Based on Similarity of Symptoms Subgroup

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Chinese Journal of Integrative Medicine 2023年第5期29卷 441-447页

作者： liU Xiao-qing ZHANG Run-shun ZHOU Xue-zhong ZHOU Hong HE Yu-yao HAN Shu ZHANG Jing SHU Zi-xin ZHANG Xue-bin JI Jing-hui zhong Quan ZHANG li-li MOU Zi-jun HE li-yun ZHANG Lun-zhong YANG Jie HU Yan-jie CHEN Zheng-guang li Xiao-zhen TAN Yan YAN Zhan-feng CAO Ke-gang MENG Wei ZHAO He ZHANG Wei zhong li-qun Department of Neurology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing(100700)China Department of Gastroenterology Guanganmen HospitalChina Academy of Chinese Medical SciencesBeijing(100053)China School of Computer and Information Technology and Beijing Key Lab of Traffic Data Analysis and Mining Beijing Jiaotong UniversityBeijing(100044)China Department of Neurology Weifang Hospital of Traditional Chinese MedicineWeifangShandong Province(261041)China Beijing zhong Teng Bai Mai Medical Technology Co.Ltd. Beijing(100027)China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing(100700)China Department of Radiology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing(100700)China School of life Sciences Beijing University of Chinese MedicineBeijing(100029)China Department of Otolaryngology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing(100029)China Department of Psychiatry Massachusetts General HospitalHarvard Medical SchoolBoston(MA 02115)United States

Objective: To derive the Chinese medicine(CM) syndrome classification and subgroup syndrome characteristics of ischemic stroke patients. Methods: By extracting the CM clinical electronic medical records(EMRs) of 7,170 hospitalized patients with ischemic stroke from 2016 to 2018 at Weifang Hospital of Traditional Chinese Medicine, Shandong Province, China, a patient similarity network(PSN) was constructed based on the symptomatic phenotype of the patients. Thereafter the efficient community detection method BGLL was used to identify subgroups of patients. Finally, subgroups with a large number of cases were selected to analyze the specific manifestations of clinical symptoms and CM syndromes in each subgroup. Results: Seven main subgroups of patients with specific symptom characteristics were identified, including M3, M2, M1, M5, M0, M29and M4. M3 and M0 subgroups had prominent posterior circulatory symptoms, while M3 was associated with autonomic disorders, and M4 manifested as anxiety;M2 and M4 had motor and motor coordination disorders;M1 had sensory disorders;M5 had more obvious lung infections;M29 had a disorder of consciousness. The specificity of CM syndromes of each subgroup was as follows. M3, M2, M1, M0, M29 and M4 all had the same syndrome as wind phlegm pattern;M3 and M0 both showed hyperactivity of Gan(liver) yang pattern;M2 and M29 had similar syndromes, which corresponded to intertwined phlegm and blood stasis pattern and phlegm-stasis obstructing meridians pattern, respectively. The manifestations of CM syndromes often appeared in a combination of 2 or more syndrome elements. The most common combination of these 7 subgroups was wind-phlegm. The 7 subgroups of CM syndrome elements were specifically manifested as pathogenic wind, pathogenic phlegm,and deficiency pathogens. Conclusions: There were 7 main symptom similarity-based subgroups in ischemic stroke patients, and their specific characteristics were obvious. The main syndromes were wind phlegm pat

关键词： ischemic stroke patient similarity network subgroup syndrome Chinese medicine

Meta label associated loss for fine-grained visual recognition

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Science China(Information Sciences) 2024年第6期67卷 230-247页

作者： Yanchao li Fu XIAO Hao li qun li Shui YU School of Computer Science Nanjing University of Posts and Telecommunications School of Network Engineering Zhoukou Normal University School of Computer Science University of Technology Sydney

Recently, intensive attempts have been made to design robust models for fine-grained visual recognition, most notably are the impressive gains for training with noisy labels by incorporating a reweighting strategy into a meta-learning framework. However, it is limited to up or downweighting the contribution of an instance for label reweighting approaches in the learning process. To solve this issue, a novel noise-tolerant method with auxiliary web data is proposed. Specifically, first, the associations made from embeddings of well-labeled data with those of web data and back at the same class are measured. Next, its association probability is employed as a weighting fusion strategy into angular margin-based loss, which makes the trained model robust to noisy datasets. To reduce the influence of the gap between the well-labeled and noisy web data, a bridge schema is proposed via the corresponding loss that encourages the learned embeddings to be coherent. Lastly, the formulation is encapsulated into the meta-learning framework, which can reduce the overfitting of models and learn the network parameters to be noise-tolerant. Extensive experiments are performed on benchmark datasets, and the results clearly show the superiority of the proposed method over existing state-of-the-art approaches.

关键词： label associated loss weighting noisy samples fine-grained visual recognition noise-tolerant learning meta-learning

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Data-driven active vibration control for helicopter with trailing-edge flaps using adaptive dynamic programming

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Chinese Journal of Aeronautics 2024年第6期37卷 151-166页

作者： Yu CHEN qun ZONG Xiuyun ZHANG Jinna li School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China School of Information and Control Engineering Liaoning Petrochemical UniversityFushun 113001China

The helicopter Trailing-Edge Flaps(TEFs)technology is one of the recent hot topics in morphing wing *** employing controlled deflection,TEFs can effectively reduce the vibration level of ***,designing specific vibration reduction control methods for the helicopters equipped with trailing-edge flaps is of significant practical *** paper studies the optimal control problem for helicopter-vibration systems with TEFs under the framework of adaptive dynamic programming combined with Reinforcement Learning(RL).Time-delay and disturbances,caused by complexity of helicopter dynamics,inevitably deteriorate the control performance of vibration *** solve this problem,a zero-sum game formulation with a linear quadratic form for reducing vibration of helicopter systems is presented with a virtual *** this context,an off-policy reinforcement learning algorithm is developed to determine the optimal control *** algorithm utilizes only vertical vibration load data to achieve a policy that reduces vibration,attains Nash equilibrium,and addresses disturbances while compensating for time-delay without knowledge of the dynamics of the helicopter *** effectiveness of the proposed method is demonstrated in a virtual platform.

关键词： Active control Adaptive dynamic program-ming Helicopter rotor Vibration control Zero-sum game

Stabilizing High-Nickel Cathodes via Interfacial Hydrogen Bonding Effects Using a Hydrofluoric Acid-Scavenging Separator

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Engineering 2024年第8期39卷 117-126页

作者： Shijie zhong liwei Dong Botao Yuan Yueyao Dong qun li Yuanpeng Ji Yuanpeng liu Jiecai Han Weidong He National Key Laboratory of Science and Technology on Advanced Composites in Special Environments &Center for Composite Materials and StructuresHarbin Institute of TechnologyHarbin 150080China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China Chongqing Research Institute Harbin Institute of TechnologyChongqing 401151China School of Mechanical Engineering Chengdu UniversityChengdu 610106China

Nickel-rich layered li transition metal oxides are the most promising cathode materials for high-energydensity li-ion ***,they exhibit rapid capacity degradation induced by transition metal dissolution and structural reconstruction,which are associated with hydrofluoric acid(HF)generation from lithium hexafluorophosphate *** potential for thermal runaway during the working process poses another *** are promising components to alleviate the aforementioned ***,an ultrathin double-layered separator with a 10 lm polyimide(PI)basement and a 2 lm polyvinylidene difluoride(PVDF)coating layer is designed and fabricated by combining a nonsolvent induced phase inversion process and coating *** PI skeleton provides good stability against potential thermal shrinkage,and the strong PI-PVDF bonding endows the composite separator with robust structural integrity;these characteristics jointly contribute to the extraordinary mechanical tolerance of the separator at elevated ***,unique HF-scavenging effects are achieved with the formation of-CO…H-F hydrogen bonds for the abundant HF coordination sites provided by the imide ring;hence,the layered Ni-rich cathodes are protected from HF attack,which ultimately reduces transition metal dissolution and facilitates long-term cyclability of the Ni-rich ***||NCM811 batteries(where“NCM”indicates liNi_(x)Co_(y)Mn_(1-x-y)O_(2))with the proposed composite separator exhibit a 90.6%capacity retention after 400 cycles at room temperature and remain sustainable at 60℃with a 91.4%capacity retention after 200 *** adopting a new perspective on separators,this study presents a feasible and promising strategy for suppressing capacity degradation and enabling the safe operation of Ni-rich cathode materials.

关键词： Nickel-rich cathodes Composite separator HF scavenging Transition metal dissolution Long-term cyclability

Two ABCI family transporters,OsABCI15 and OsABCI16,are involved in grain-filling in rice

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Journal of Genetics and Genomics 2024年第5期51卷 492-506页

作者： Bin Ma Xiubiao Cao Xiaoyuan li zhong Bian Qi-Qi Zhang Zijun Fang Jiyun liu qun li Qiaoquan liu lin Zhang Zuhua He Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/zhongshan Biological Breeding Laboratory/Key Laboratory of Plant Functional Genomics of the Ministry of Education/Jiangsu Key Laboratory of Crop Genetics and Physiology Agricultural College of Yangzhou UniversityYangzhouJiangsu 225009China Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops Jiangsu Key Laboratory of Crop Genetics and PhysiologyYangzhou UniversityYangzhouJiangsu 225009China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology&EcologyChinese Academy of SciencesShanghai 200032China Institute of Biotechnology Hangzhou Academy of Agricultural SciencesHangzhouZhejiang 310024China Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education Yangzhou UniversityYangzhouJiangsu 225009China

Seed development is critical for plant reproduction and crop yield,with panicle seed-setting rate,grain-filling,and grain weight being key seed characteristics for yield ***,few genes are known to regulate grain ***,we identify two adenosine triphosphate(ATP)-binding cassette(ABC)I-type transporter genes,OsABCI15 and OsABCI16,involved in rice *** genes are highly expressed in developing seeds,and their proteins are localized to the plasma membrane and ***,knockout of OsABCI15 and OsABCI16 results in a significant reduction in seed-setting rate,caused predominantly by the severe empty pericarp phenotype,which differs from the previously reported low seed-setting phenotype resulting from failed *** analysis indicates that OsABCI15 and OsABCI16 participate in ion homeostasis and likely export ions between filial tissues and maternal tissues during grain ***,overexpression of OsABCI15 and OsABCI16 enhances the seed-setting rate and grain yield in transgenic plants and decreases ion accumulation in brown ***,the OsABCI15/16 orthologues in maize exhibit a similar role in kernel development,as demonstrated by their disruption in transgenic ***,ourﬁndings reveal the important roles of two ABC transporters in cereal grain filling,highlighting their value in crop yield improvement.

关键词： ABC transporters Rice Grain filling Ion homeostasis Grain yield

Hot versus cold subduction initiation

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National Science Review 2024年第2期11卷 101-102页

作者： zhong-Hai li Key Laboratory of Computational Geodynamics College of Earth and Planetary SciencesUniversity of Chinese Academy of Sciences

In the framework of plate tectonics, subduction initiation(SI) indicates the birth of a plate convergent boundary, which is a key point of plate tectonics and Wilson's cycle; however, its dynamic process is not well c... 详细信息

关键词： DRIVEN CRUST

Revisiting aluminum current collector in lithium-ion batteries:Corrosion and countermeasures

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Journal of Energy Chemistry 2024年第2期89卷 610-634,I0014页

作者： Shanglin Yang Jinyan zhong Songmei li Bin li Key Laboratory of Aerospace Advanced Materials and Performance of Ministry of Education School of Materials Science&EngineeringBeihang UniversityBeijing 100191China

With the large-scale service of lithium-ion batteries(liBs),their failures have attracted significant *** the decay of active materials is the primary cause for liB failures,the degradation of auxiliary materials,such as current collector corrosion,should not be ***,it is necessary to conduct a comprehensive review in this *** this review,from the perspectives of electrochemistry and materials,we systematically summarize the corrosion behavior of aluminum cathode current collector and propose corresponding ***,the corrosion type is clarified based on the properties of passivation layers in different organic electrolyte ***,a thoroughgoing analysis is presented to examine the impact of various factors on aluminum corrosion,including lithium salts,organic solvents,water impurities,and operating ***,strategies for electrolyte and protection layer employed to suppress corrosion are discussed in *** and most importantly,we provide insights and recommendations to prevent corrosion of current collectors,facilitate the development of advanced current collectors and the implementation of next-generation high-voltage stable liBs.

关键词： lithium-ion battery Aluminum current collector Corrosion Electrochemical performance Electrolyte Protective layer

An Electrochemical Perspective of Aqueous Zinc Metal Anode

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Nano-Micro Letters 2024年第1期16卷 274-312页

作者： Huibo Yan Songmei li Jinyan zhong Bin li School of Materials Science and Engineering Beihang UniversityBeijing 100191People’s Republic of China

Based on the attributes of nonflammability,environmental benignity,and cost-effectiveness of aqueous electrolytes,as well as the favorable compatibility of zinc metal with them,aqueous zinc ions batteries(AZIBs)become the leading energy storage candidate to meet the requirements of safety and low ***,aqueous electrolytes,acting as a double-edged sword,also play a negative role by directly or indirectly causing various parasitic reactions at the zinc anode *** reactions include hydrogen evolution reaction,passivation,and dendrites,resulting in poor Coulombic efficiency and short lifespan of AZIBs.A comprehensive review of aqueous electrolytes chemistry,zinc chemistry,mechanism and chemistry of parasitic reactions,and their relationship is ***,the understanding of strategies for suppressing parasitic reactions from an electrochemical perspective is not profound *** this review,firstly,the chemistry of electrolytes,zinc anodes,and parasitic reactions and their relationship in AZIBs are deeply ***,the strategies for suppressing parasitic reactions from the perspective of enhancing the inherent thermodynamic stability of electrolytes and anodes,and lowering the dynamics of parasitic reactions at Zn/electrolyte interfaces are ***,the perspectives on the future development direction of aqueous electrolytes,zinc anodes,and Zn/electrolyte interfaces are presented.

关键词： Aqueous zinc ions batteries Parasitic reactions Aqueous electrolyte Zinc anode

Torque limit-based Inertial Control Method Based on Delayed Support for Primary Frequency Control of Wind Turbines

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 561-570页

作者： Wei Gu Zaiyu Chen qun li Minghui Yin Qiang li Yun Zou School of Automation Nanjing University of Science and TechnologyNanjing 210094China State Grid Jiangsu Electric Power Co. Ltd.Research InstituteNanjing 211103China

To avoid the secondary frequency dip caused by the steep drop of the electrical power of wind turbines(WTs)at the end of frequency support stage,the torque limit-based iner-tial control(TliC)method sets the power reference as a linear function of rotor speed,rather than the step form for the step-wise inertial ***,the compensation effect on the frequency nadir(FN)caused by the load surge is weakened as the TliC power is no longer in the step ***,the maximum point of the frequency response component(FRC)contributed by TliC occurs earlier than the minimum point of FRC corresponding to the load surge,so that the FN cannot be adequately ***,this paper first investigates the relation between the peak and nadir times of FRCs stimulated by the TliC and load *** this basis,with the compensation principle of matching the peak and nadir times of FRCs,the improved TliC method based on delayed support is ***,the effectiveness of the proposed method is validated via the experiments on the test bench of wind-integrated power system.

关键词： Wind turbine frequency response component torque limit inertial control delayed support