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Effects of PM_(2.5)and Its Components on Disease Severity in Patients with Schizophrenia and the Mediating Role of Thyroid Hormones

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Environment & Health 2024年第5期2卷 290-300页

作者： Jintao Liu Rong Song Xuanxuan Li Li Liu Ning Wei Jiajun Yuan Weizhuo Yi Rubing Pan Jian Cheng Xulai Zhang hong su Department of Epidemiology and Health Statistics School of Public HealthAnhui Medical UniversityHefeiAnhui 230032China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province HefeiAnhui 230032China Center for Big Data and Population Health of IHM HefeiAnhui 230032China Anhui Mental Health Center(Affiliated Psychological Hospital of Anhui Medical University) HefeiAnhui 230032China

Studies have indicated the different effects of PM_(2.5)components on human ***,specific components that influence the severity of disease in schizophrenia patients and their underlying mechanisms remain ***,a repeated measures study for schizophrenia was constructed based on Anhui Mental Health *** collected information,including demographics and thyroid hormones(TH)levels,on repeat admissions of schizophrenia patients during 2017−2020,assessing their illness severity by positive and negative symptom scales(PANSS).Concentrations from the nearest component monitoring station in the 3 months before admission were assigned as the participant’s exposure *** assessed the effects of PM_(2.5)components individually and in combination on schizophrenia and explored the mediating role of *** indicated that benzo[a]pyrene,sulfate,nitrate,chloride,ammonia,cadmium,chromium,lead,selenium,and thallium exposure were associated with increased PANSS scores,with more significant results observed in *** exposure to PM_(2.5)components was found to be associated with increased PANSS scores and decreased free triiodothyronine(FT3).Mediation analysis suggested that the reduction in FT3 might mediate the association between the PM_(2.5)components and PANSS *** findings emphasize the impacts of PM_(2.5)components on schizophrenia and the potential value of focusing on changes in THs.

关键词： PM_(2.5)components Schizophrenia Thyroid hormones Mediation analysis

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Refiector Deformation Measurement and Correction Methodology of Large Antenna Based on Phased Array Feed

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Research in Astronomy and Astrophysics 2024年第3期24卷 297-308页

作者： Zan Wang De-Qing Kong hong-Bo Zhang Yan su Xin-Ying Zhu Cong-Si Wang Yu-Chen Liu Key Laboratory of Lunar and Deep Space Exploration National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Electronic Equipment Structure Design Ministry of EducationXidian UniversityXi'an 710071China

To solve the problem of time-consuming measurement and correction of large antennas’reflector deformation,a new microwave holography methodology based on a Phased Array Feed(PAF)is *** from the known expression of receiving signals in microwave holography,the theory of PAF holography is derived through Geometrical *** deformation,as well as pointing deviation and subreflector offset,can be calculated out by applying the derived equations.A measurement and correction system based on PAF holography is depicted,and two kinds of measurement methods are *** proposed measurement methodology is verified by numerical simulation,and its measurement error is *** results indicate that our proposed methodology is feasible,especially for Cassegrain antennas.

关键词： telescopes-methods analytical--methods numerical

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Alterations in Serum Lipids and Lipoproteins Induced by Neoadjuvant Chemotherapy in Patients with Osteosarcoma around the Knee Joint:A Retrospective Analysis

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Current Medical Science 2024年第4期44卷 741-747页

作者： su-guo WANG Yong-gang WANG Guo-wei QIAN Li-na TANG Xin ZHOU Dong-dong CHENG Chen-liang ZHOU Qing-cheng YANG Zan SHEN Gao-zhong HUANG hong-tao LI Department of General Medicine Shenzhen Third People's HospitalShenzhen 518112China Department of VIP Clinic Shanghai Jiao Tong University Afiliated Sixth People's HospitalShanghai 200233China Department of Oncology Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China Cancer Research Institute of Jilin University the First Hospital of Jilin UniversityChangchun 130021China Department of Orthopedics Shanghai Jiao Tong University Afiliated Sixth People's HospitalShanghai 200233China

Objective To investigate the serum lipid profiles of patients with localized osteosarcoma around the knee joint before and after neoadjuvant *** After retrospectively screening the data of 742 patients between January 2007 and July 2020,50 patients aged 13 to 39 years with Enneking stage II disease were included in the *** lipid levels,including total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),lipoprotein-α[Lp(a)],and apolipoprotein A1,B,and E(ApoA1,ApoB,and ApoE),and clinicopathological characteristics were collected before and after neoadjuvant *** The mean levels of TC,TG,and ApoB were significantly increased following neoadjuvant chemotherapy(16%,38%,and 20%,respectively,*** values;Psurvival(DFS)was observed in patients with decreased TG and increased LDL-C following chemotherapy,although this difference was not statistically significant(P=0.23 and P=0.24,respectively).Conclusion Significant elevations in serum lipids were observed after neoadjuvant chemotherapy in patients with localized *** was no prognostic significance of pretreatment serum lipid levels on histologic response to neoadjuvant *** scale of increase in serum Lp(a)might have a potential prognostic role in *** with increased LDL-C or reduced TG after chemotherapy seem to exhibit a trend toward favorable DFS.

关键词： osteosarcoma neoadjuvant chemotherapy serum lipids

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节选类略读课文教学的“整读”设计与实施

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教学与管理 2024年第23期 45-48页

作者：吴素红江苏省滨海县第二实验小学

节选类略读课文教学既要完成一般略读课文的教学目标,又要推进整本书阅读。实现二者兼顾,就需要针对“只教单篇”“先教单篇,再教整本”的现状,提出“整读”的观点。即在整本书阅读视域下,采取自上而下的“整本”统摄“单篇”的整体策... 详细信息

节选类略读课文教学既要完成一般略读课文的教学目标,又要推进整本书阅读。实现二者兼顾,就需要针对“只教单篇”“先教单篇,再教整本”的现状,提出“整读”的观点。即在整本书阅读视域下,采取自上而下的“整本”统摄“单篇”的整体策略和自下而上的“单篇”溯源“整本”的整合策略。让学生在“整本”中理解“单篇”,在“单篇”中管窥“整本”,并尝试从评价节点、评价内容、评价工具、评价主体四个方面构建整本书阅读视域下节选类略读课文教学评价框架。

关键词：小学语文整本书阅读节选类略读课文

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Omadacycline in the treatment of scrub typhus:Three case reports

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World Journal of Clinical Cases 2024年第25期12卷 5832-5838页

作者： Xue-Mei Lang Yun Qiu Ya-Juan Jia hong sun su-Min Gao hong-Mei Zhao Department of Emergency Medicine The Affiliated Huaian No.1 People's Hospital of Nanjing Medical UniversityHuai’an 223000Jiangsu ProvinceChina

BACKGROUND Scrub typhus is a naturally occurring acute infectious disease that is primarily transmitted through the bites of chiggers or larval mites infected by Orientia tsutsugamushi(***).Omadacycline,a novel tetracycline,exhibits potent antibacterial efficacy against both typical bacteria and atypical ***,omadacycline application in the treatment of scrub typhus remains *** suMMARY In the present work,we report several cases of scrub typhus,with the main clinical symptoms being fever,the formation of eschars or ulcers,local or systemic lymphadenopathy,headache,myalgia and *** samples were collected before omadacycline was administered,and *** infection was confirmed through targeted next-generation sequencing(tNGS).After two days of treatment,the patients’symptoms,including fever,were alleviated,with no adverse drug *** tNGS is an effective method for diagnosing scrub *** can be considered an alternative option for antiinfective therapy in patients with *** infections.

关键词： Omadacycline Scrub typhus Orientia tsutsugamushi Targeted nextgeneration sequencing Eschar Case report

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Layered oxide cathodes for sodium-ion batteries:microstructure design,local chemistry and structural unit

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Science China Chemistry 2024年第1期67卷 191-213页

作者： Ling-Yi Kong Han-Xiao Liu Yan-Fang Zhu Jia-Yang Li Yu su hong-Wei Li Hai-Yan Hu Yi-Feng Liu Ming-Jing Yang Zhuang-Chun Jian Xin-Bei Jia Shu-Lei Chou Yao Xiao Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China

Because of the low price and abundant reserves of sodium compared with lithium,the research of sodium-ion batteries(SIBs)in the field of large-scale energy storage has returned to the research *** oxides distinguish themselves from the mains cathode materials of SIBs owing to their advantages such as high specific capacity,simple synthesis route,and environmental ***,the commercial development of the layered oxides is limited by sluggish kinetics,complex phase transition and poor air *** on the research ideas from macro-to micro-scale,this review systematically summarizes the current optimization strategies of sodium-ion layered oxide cathodes(SLOC)from different dimensions:microstructure design,local chemistry regulation and structural unit *** the dimension of microstructure design,the various structures such as the microspheres,nanoplates,nanowires and exposed active facets are prepared to improve the slow kinetics and electrochemical ***,from the view of local chemistry regulation by chemical element substitution,the intrinsic electron/ion properties of SLOC have been enhanced to strengthen the structural ***,the optimization idea of endeavors to regulate the physical and chemical properties of cathode materials essentially is put forward from the dimension of structural unit *** opinions and strategies proposed in this review will provide some inspirations for the design of new SLOC in the future.

关键词： sodium-ion batteries layered oxide cathodes microstructure design local chemistry structural unit

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Two different mutational types of familial gastrointestinal stromal tumors:Two case reports

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 4028-4036页

作者： Xiao-Ke Wang Lu-Fan Shen Xin Yang He su Tao Wu Peng-Xian Tao hong-Ying Lv Tong-Han Yao Lin Yi Yuan-Hui Gu The First School of Clinical Medical Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina School of Traditional Chinese and Western Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Department of General surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal(GI)tract,and cases of GISTs tend to be of the disseminated type,with a global incidence of 10 to 15 cases/million each *** rarer familial GISTs,which often represent a population,differ in screening,diagnosis,and *** GISTs include primary familial GISTs with predominantly KIT/PDGFRA mutations and wild-type ***,whether the same genetic family has different phenotypes has not been *** suMMARY We report two cases of rare GISTs in the same family:A male patient with the V561D mutation in exon 12 of the PDGFRA gene,who has been taking the targeted drug imatinib since undergoing surgery,and a female patient diagnosed with wild-type GIST,who has been taking imatinib for 3 years since undergoing *** favorable prognosis of these patients during the 7-year follow-up period validates the accuracy of our treatment strategy,and we have refined the entire process of diagnosis and treatment of familial GISTs in order to better manage this rare familial *** Different mutation types of familial GISTs in the same family are very rare,thus it is very important to make the correct diagnosis and treatment strategies according to the results of molecular detection for the management of familial GISTs.

关键词： Gastrointestinal stromal tumor Familial gastrointestinal stromal tumor Wild-type gastrointestinal stromal tumors PDGFRA Imatinib Treatment Case report

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Cellular angiofibroma arising from the rectocutaneous fistula in an adult: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1778-1784页

作者： Hao-En Chen Yu-Yang Lu Ruei-Yu su hong-Hau Wang Chao-Yang Chen Je-Ming Hu Jung-Cheng Kang Kuan-Hsun Lin Ta-Wei Pu Department of surgery Taichung Armed Forces General HospitalTaichung 411Taiwan Department of surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pediatrics Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 105Taiwan Department of Pathology and Laboratory Medicine Taoyuan Armed Forces General HospitalTaoyuan 32551Taiwan Department of Radiology Tri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105Taiwan Division of Colon and Rectal surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal surgery Department of SurgeryTaiwan Adventist HospitalTaipei 105Taiwan Division of Thoracic surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal surgery Department of SurgeryTri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105Taiwan

BACKGROUND Rectocutaneous fistulae are *** infection originates within the anal glands and subsequently extends into adjacent regions,ultimately resulting in fistula *** angiofibroma(CAF),also known as an angiomy ofibroblastoma-like tumor,is a rare benign soft tissue neoplasm predominantly observed in the scrotum,perineum,and inguinal area in males and in the vulva in *** describe the first documented case CAF that developed within a rectocutaneous fistula and manifested as a perineal *** suMMARY In the outpatient setting,a 52-year-old male patient presented with a 2-year history of a growing perineal mass,accompanied by throbbing pain and minor scrotal *** examination revealed a soft,well-defined,non-tender mass at the left buttock that extended towards the perineum,without a visible *** initial assessment identified a soft tissue tumor,and the laboratory data were within normal *** and pelvic computed tomography(CT)revealed swelling of the abscess cavity that was linked to a rectal cutaneous fistula,with a track-like lesion measuring 6 cm×0.7 cm in the left perineal region and attached to the left *** examination found no significant inner orifices.A left medial gluteal incision revealed a thick-walled mass,which was excised along with the extending tract,and curettage was *** examination confirmed CAF *** patient achieved total resolution during follow-up assessments and did not require additional *** CT imaging supports perineal lesion diagnosis and *** angiofibromas,even with a cutaneous fistula,can be excised transperineally.

关键词： Angiofibroma Perineal mass Rectocutaneous fistula Anorectal fistula Anal fistula Case report

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A Systematic Review of the Definition,Measurement,and Associated Factors of Pandemic Fatigue

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China CDC weekly 2024年第36期6卷 924-933,I0007页

作者： Ruohan Chen Qi Tan Bowen su Shuqi Wang Zhanwei Du WHO Collaborating Center for Infectious Disease Epidemiology and Control School of Public HealthLKS Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Laboratory of Data Discovery for Health Limited Hong Kong Science ParkHong Kong Special Administrative RegionChina Nanjing Tech University Nanjing CityJiangsu ProvinceChina School of Cybersecurity Northwestern Polytechnical UniversityXi’an CityShaanxi ProvinceChina.

The rapid emergence and widespread transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have prompted governments worldwide to enact policies and measures to manage the virus’s *** interventions have substantially contributed to controlling disease ***,they have also significantly disrupted daily life,leading to increased public fatigue and resistance to sustained control measures,a phenomenon known as pandemic *** develop a comprehensive understanding of pandemic fatigue,this review systematically explores the concept and identifies quantitative indicators for measuring *** reviewed studies on pandemic fatigue across various countries,summarized the contributing factors,and analyzed its impact on personal protective *** findings indicate that the enforcement of health measures significantly influences the onset of pandemic fatigue,while individual perceptions of risk can negatively affect personal protective behaviors,creating a feedback loop with increasing *** results underscore the importance of considering the current severity of the pandemic and individual decisionmaking processes in the implementation of *** our understanding of pandemic fatigue is essential for developing effective policy responses in preparation for future potential epidemics.

关键词： fatigue protective prompt

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自然禀赋决定城市规模:中国经验与启示

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经济体制改革 2024年第2期 50-56页

作者：苏红键中国社会科学院农村发展研究所北京100732

随着中国城镇化快速推进,城镇体系不断调整,明确城市规模决定因素具有重要的理论和现实意义。利用1985~2020年中国城市数据检验城市规模的自然禀赋决定论,研究发现:东部沿海虚拟变量与城市规模和城市增长显著正相关,改革开放释放了其区... 详细信息

随着中国城镇化快速推进,城镇体系不断调整,明确城市规模决定因素具有重要的理论和现实意义。利用1985~2020年中国城市数据检验城市规模的自然禀赋决定论,研究发现:东部沿海虚拟变量与城市规模和城市增长显著正相关,改革开放释放了其区位优势;以一月平均最低气温衡量的气候舒适度与城市增长显著正相关,人们倾向于向冬季温暖的地方迁移;地形起伏度与城市规模显著负相关;资源型城市虚拟变量与城市规模和城市增长显著负相关;较高的行政等级或政策支持能够强化自然禀赋的优势,但较难扭转自然禀赋的劣势。据此,应尊重城市和区域发展规律,因地制宜促进城市发展,积极优化各类城市功能,加强区际、城际合作,推动各地区共同富裕。

关键词：自然禀赋城市规模城市增长气候舒适度城市行政等级

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