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Mismatched donor cell infusion-related syndrome following microtransplant in patients with acute myeloid leukemia

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chinese Medical Journal 2023年第7期136卷 815-821页

作者： Bo cai Xiaoyan Zou Xin Ning Tieqiang Liu Bingxia Li Yaqing Lei Jianhui Qiao Kaixun Hu Yangyang Lei zhiqing Liu Bo Yao Huisheng Ai Yi Wang changlin Yu Mei Guo Department of Hematology The Fifth Medical CenterChinese PLA General HospitalBeijing 100071China

Background:Immunotherapies such as adoptive immune cell infusion and immune-modulating agents are widely used for cancer treatment,and the concomitant symptoms,including cytokine release syndrome(cRS)or immune-related adverse events(irAEs),are frequently ***,clinical manifestations induced by mismatched donor granulocyte colony-stimulating factor mobilized peripheral blood mononuclear cell(GPBMc)infusion in patients receiving microtransplant(MST)have not yet been well ***:We analyzed 88 cycles of mismatched GPBMc infusion in patients with acute myeloid leukemia receiving MST and 54 cycles of chemotherapy without GPBMc infusion as a *** symptoms and their correlation with clinical features,laboratory findings,and clinical response were ***:Fever(58.0%[51/88])and chills(43.2%[38/88])were the significant early-onset symptoms after GPBMc *** possessing less human leukocyte antigen-matching loci with the donor or those with unrelated donors experienced more chills(3[2–5]loci vs.5[3–5]loci,P=0.043 and 66.7%[12/18]vs.37.1%[26/70],P=0.024).On the other hand,those with decreased cD4^(+)/cD8^(+)T-cell ratio developed more fever(0.8[0.7–1.2]vs.1.4[1.1–2.2],P=0.007).Multivariable analysis demonstrated that younger patients experienced more fever(odds ratio[OR]=0.963,95%confidence interval[cI]:0.932–0.995,P=0.022),while patients with younger donors experienced more chills(OR=0.915,95%cI:0.859–0.975,P=0.006).Elevated ultra-sensitive c-reactive protein levels in the absence of cytokine storm were observed following GPBMc infusion,which indicated mild and transient inflammatory *** no predictive value of infusion-related syndrome to leukemia burden change was found,the proportion of host pre-treatment activated T cells was positively correlated with leukemia ***:Mismatched GPBMc infusion in MST induced unique infusion-related symptoms and laboratory changes,which were associated with

关键词： Microtransplant Immunotherapy Adoptive immune cell infusion Adverse events Acute myeloid leukemia

技术进步偏向性变动对全要素生产率增长的影响

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管理学报 2014年第8期11卷 1199-1207页

作者：董直庆陈锐吉林大学数量经济研究中心吉林大学商学院

基于cES生产函数分解全要素生产率增长率,考察技术进步偏向性对要素结构和全要素生产率的作用效应,证明技术进步偏向性变动会通过改变要素结构从而影响全要素生产率增长。数据显示,我国整体经济和东中西部地区技术进步偏向于资本程度逐... 详细信息

基于cES生产函数分解全要素生产率增长率,考察技术进步偏向性对要素结构和全要素生产率的作用效应,证明技术进步偏向性变动会通过改变要素结构从而影响全要素生产率增长。数据显示,我国整体经济和东中西部地区技术进步偏向于资本程度逐年减弱;技术进步偏向性变化趋势提高了全要素生产率增长率,且技术进步偏向性与要素结构适配性逐年增强,并呈现出愈加有利于全要素生产率增长的趋势。

关键词：全要素生产率技术进步偏向性要素结构

Human hematopoietic cells express two forms of thecytokine receptor common γ-chain (γc)

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cell Research 1997年第2期7卷 195-205页

作者： SHI YU FANG MARY HILL ANTON NOVAK zhiqing c.en RUO XIANG WANG cHOONGcHIN LIEW GORDON B. MILLS (Oncology Research, The Toronto Hospital, 200 ElizabcthSt., Toronto, Ontario, canada MSG 2c4Department of Immunology, Holland Laboratoryof American Red cr Oncology Research The Toronto Hospital 200 Elizabeth St. Toronto Ontario Canada M5G 2C4

Recent studies have revealed that the γ-chain of theIL-2 receptor is shared by the receptors for IL-4, IL7, IL-9, IL-13, and IL-15, and it is therefore also referred toas the common γ-chain (γc). Mutations of γc result inX-linked severe combined immunodefic.ency syndrome inhumans, indicating that rye is essential for normal development and function of the immune system. We demonstratethat human hematopoietic cells express two γc transcriptsdiffering in their carboxyl terminal coding region. Onetranscript is the previously reported sequence (γc-long),whereas the newly identified sequence exhibits a deletion of72 nucleotides close to the 3'-end of the open reading frame(γc-short). This alteration predicts a loss of 24 amino acidsincluding a conserved tyrosine residue which is shared byseveral members of the cytokine receptor family. Thepresence of these two distinct forms of rye transcripts wasdemonstrated by sequencing of reversely transcribed andpolymerase chain reaction (RT-PcR) amplified mRNA, restriction digestion of the RT-PcR products, RNAse protection, and Northern blotting from human cell lines andhuman peripheral blood lymphocytes. Furthermore, thetwo variants were present in peripheral blood lymphocytesfrom both female and male donors, which rules out allelicvariants since rye is a single copy gene located on the Xchromosome. A truncation mutant at a site near the observed changes in γc-short has been reported by othersto alter biochemical events activated by cytokines. Thiscombined with the loss of a potential SH2 "docking" sitein γc-short suggests that γc-long and γc-short may link todifferent signaling pathways and may play an importantrole in determining the cellular response to IL-2, IL-4, IL-7, IL-9, IL-13, IL-15.

关键词： IL-2 receptor γ-chain cytokine receptor common γ-chain IL-2 receptor cytokine receptors RNA splicing

新型细菌卟吩类衍生物的合成及抗肿瘤活性研究

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中国现代应用药学 2023年第21期40卷 2964-2971页

作者：吕志卿陈贞亮浙江海正药业股份有限公司浙江台州318000

目的设计、合成新型细菌卟吩类衍生物,并研究其抗肿瘤效果。方法以细菌卟吩类化合物为原料,经还原、溴化后与2-[4-(羟甲基)苯氧基]乙酸甲酯进行醚化,随后水解得到目标化合物。采用NcI-H460 BALB/c裸鼠移植瘤模型,检测药物在组织中的分布... 详细信息

目的设计、合成新型细菌卟吩类衍生物,并研究其抗肿瘤效果。方法以细菌卟吩类化合物为原料,经还原、溴化后与2-[4-(羟甲基)苯氧基]乙酸甲酯进行醚化,随后水解得到目标化合物。采用NcI-H460 BALB/c裸鼠移植瘤模型,检测药物在组织中的分布,利用光动力治疗法对目标化合物的抗肿瘤效果进行了研究。结果合成了1个全新结构的细菌卟吩类衍生物,结构经^(1)H-NMR、^(13)c-NMR、MS和UV确证,目标化合物具有较好的组织分布性,对肿瘤细胞的生长具有较好的抑制作用。结论细菌卟吩类衍生物结构中引入亲水性基团后,组织选择性及抗肿瘤效果得到了改善,值得深入研究。

关键词：细菌卟吩合成光动力治疗抗肿瘤

Pilot test of polymer microsphere alternate surfactant flood(PMAS)with mixtures of anionic-cationic surfactants under harsh conditions in a sandstone reservoir

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Petroleum Research 2023年第3期8卷 291-300页

作者： Yingc.eng Li Jun Jin zhiqing Su Weidong Zhang Xinning Bao Baolun Niu changhua Yang Xinyue Wu Xiaodong Zhai Li Zhang Rong Guo Yong Meng Xiujuan He Zhiqin Shen Hui Zhang Ou Sha Sinopec Shanghai Research Institute of Petrochemical Technology ShanghaiChina Sinopec Zhongyuan Oil Field company PuyangChina Xi'an Petroleum University Xi'anChina

The first pilot test of polyacrylamide microsphere alternate surfactant flood(PMAS)with mixtures of anionic-cationic surfactants(Sa/c)was carried out for a high-temperature,high-salinity,and highhardness sandstone reservoir to demonstrate the potential of this novel technique to improve oil recovery.A critical micelle concentration(cMc)of 4.82 mg/L,an ultralow interfacial tension(IFT)of 8104 mN/m,and a high oil solubilization of 22 were *** and dynamic adsorptions of Sa/c on natural core containing 15 wt%clay were reduced to about 2.20 and 0.30 mg/g-core,respectively,with the addition of adsorption inhibitor(AI).Since June 2014,the pilot test of PMAS was carried out in a Sinopec reservoir with a temperature of 87c,a salinity of 260,393 mg/L,and a hardness of 6,401 mg/*** cycles of alternative injection of 0.0125 PV Sa/c with a concentration of 0.1%and 0.0125 PV polyacrylamide microsphere with a concentration of 0.2%were conducted at an injection rate of 0.1 PV/yr,for a total of 0.3 PV chemical *** a result,the net daily oil production increased from 0 t to 6.5 t,and the water cut decreased from 96.3%to 93.8%,leading to an ultimate improved oil recovery of 6.3%original oil-in-place.

关键词： Pilot test Mixtures of anionic and cationic surfactant Polyacrylamide microsphere High salinity High temperature

水性3c1B汽车涂装工艺预喷涂层“黑点”研究

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涂料工业 2016年第11期46卷 77-80页

作者：何智卿一汽-大众汽车有限公司佛山分公司广东佛山528237

水性3c1B是一种"三涂一烘"工艺,以"湿碰湿"方式进行预喷涂、色漆和清漆喷涂的集成化汽车涂装工艺,在设备、材料、环保等多方面都具备优势。文中重点介绍了利用显微镜分析水性3c1B汽车涂装工艺预喷涂层"黑点"缺陷的形状及类型。根据缺陷... 详细信息

水性3c1B是一种"三涂一烘"工艺,以"湿碰湿"方式进行预喷涂、色漆和清漆喷涂的集成化汽车涂装工艺,在设备、材料、环保等多方面都具备优势。文中重点介绍了利用显微镜分析水性3c1B汽车涂装工艺预喷涂层"黑点"缺陷的形状及类型。根据缺陷类型从材料、膜厚、喷涂工艺、预烘干工艺等方面分析研究缺陷产生的原因,从而确定各影响因素的主次。针对主次因素提出了多种应对方案,解决了预喷涂层的"黑点"缺陷。

关键词： 3c1B工艺预喷涂层黑点因素

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齐梁时代的音乐观念及乐府诗的创作面貌

江汉论坛 2010年第10期 106-110页

作者：王志清吉首大学文学与新闻传播学院

音乐观念是指一定历史时期的音乐理论表述和在音乐实践活动中体现出来的态度、认识和倾向。齐梁时代音乐理论表述集中于音乐功能论和音乐雅俗论两方面,总体继承了先秦乐教思想和儒家雅正的音乐观念;音乐实践中一方面寻求雅乐的传统依据... 详细信息

音乐观念是指一定历史时期的音乐理论表述和在音乐实践活动中体现出来的态度、认识和倾向。齐梁时代音乐理论表述集中于音乐功能论和音乐雅俗论两方面,总体继承了先秦乐教思想和儒家雅正的音乐观念;音乐实践中一方面寻求雅乐的传统依据,另一方面认可新声俗乐,并追求新声的雅化。齐梁时代雅俗兼容、共存的音乐观念为齐梁乐府诗的创作提供了开放的音乐环境,由此形成齐梁乐府诗全面的繁荣并推动雅乐、俗乐的新变。齐梁音乐实践观念对乐府诗创作的指导意义更为突出。

关键词：齐梁音乐观念雅乐俗乐乐府诗

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半球谐振陀螺在宇宙飞船上的应用

压电与声光 1999年第5期21卷 349-353页

作者：吕志清四川压电与声光技术研究所重庆400060

半球谐振陀螺（ＨＲＧ）作为一种惯性级陀螺经历了曲折的发展历程。９０年代初，美国Ｄｅｌｃｏ公司的ＨＲＧ已达到实用水平并已小批量生产。１９９４年５月，世界上最大的惯性系统制造商之一的利顿公司宣布收购Ｄｅｌｃｏ公司，... 详细信息

半球谐振陀螺（ＨＲＧ）作为一种惯性级陀螺经历了曲折的发展历程。９０年代初，美国Ｄｅｌｃｏ公司的ＨＲＧ已达到实用水平并已小批量生产。１９９４年５月，世界上最大的惯性系统制造商之一的利顿公司宣布收购Ｄｅｌｃｏ公司，在中国研究者心目中打了一个很大的问号。当人们还在猜测这次兼并的内幕的时候，ＨＲＧ已贴上利顿公司的标签，登上了航天应用的舞台。可见，ＨＲＧ具有很强的生命力，可用于航空惯导系统、兵器惯导系统，更是空间任务的最佳选择。文章简述了ＨＲＧ的国内外发展状况和应用前景，对发展ＨＲＧ的目标、技术关键和途径提出了粗浅的看法。

关键词：半球谐振陀螺 HRG 空间任务宇宙飞船

c/Sic在大口径空间望远镜次镜承力筒的应用

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红外与激光工程 2022年第5期51卷 350-355页

作者：崔世程宋志清杨居奎北京空间机电研究所北京100094 先进光学遥感技术北京市重点实验室北京100094

设计并研制了基于c/Sic复合材料的大口径空间望远镜次镜承力筒。首先对c/Sic复合材料的特性以及在空间遥感器领域的应用进行了介绍。其次以某大口径空间望远镜次镜承力筒为例,对不同材料下次镜承力筒的质量、力热性能进行了对比。仿真... 详细信息

设计并研制了基于c/Sic复合材料的大口径空间望远镜次镜承力筒。首先对c/Sic复合材料的特性以及在空间遥感器领域的应用进行了介绍。其次以某大口径空间望远镜次镜承力筒为例,对不同材料下次镜承力筒的质量、力热性能进行了对比。仿真分析表明:设计的c/Sic复合材料次镜承力筒低至32 kg,相比钛合金筒减轻45.5%;基频为204 Hz,满足设计要求;更易于控制热变形对反射镜面形的影响。最终完成了c/Sic复合材料次镜承力筒的研制和主要物理性能的检测,并进行了力学振动试验考核,对振动前后结构的三坐标测量数据进行了比对。结果表明:次镜承力筒组件的基频良好,振动试验前后频漂低于1%,结构的微位移变化量级在微米级。为应用c/Sic开展空间遥感器大尺寸整体成型支撑结构的设计提供有效的参考价值。

关键词：空间望远镜 c/Sic复合材料次镜承力筒