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Mercury in leaf litter in typical suburban and urban broadleaf forests in China

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Journal of Environmental Sciences 2011年第12期23卷 2042-2048页

作者： Zhenchuan Niu Xiaoshan Zhang Zhangwei wang zhijia Ci Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

To study the role of leaf litter in the mercury （Hg） cycle in suburban broadleaf forests and the distribution of Hg in urban forests, we collected leaf litter and soil from suburban evergreen and deciduous broadleaf forests and from urban forests in Beijing. The Hg concentrations in leaf litter from the suburban forests varied from 8.3 to 205.0 ng/g, with an average （avg） of （49.7 ± 36.9） ng/g. The average Hg concentration in evergreen broadleaf forest leaf litter （50.8 ± 39.4） ng/g was higher than that in deciduous broadleaf forest leaf litter （25.8 ± 10.1） ng/g. The estimated Hg fluxes of leaf litter in suburban evergreen and deciduous broadleaf forests were 179.0 and 83.7 mg/（ha·yr）, respectively. The Hg concentration in organic horizons （O horizons）（（263.1 ± 237.2） ng/g） was higher than that in eluvial horizons （A horizons）（（83.9 ± 52.0） ng/g）. These results indicated that leaf litterfall plays an important role in transporting atmospheric mercury to soil in suburban forests. For urban forests in Beijing, the Hg concentrations in leaf litter ranged from 8.8–119.0 （avg 28.1 ± 16.6） ng/g, with higher concentrations at urban sites than at suburban sites for each tree. The Hg concentrations in surface soil in Beijing were 32.0–25300.0 ng/g and increased from suburban sites to urban sites, with the highest value from Jingshan （JS） Park at the centre of Beijing. Therefore, the distribution of Hg in Beijing urban forests appeared to be strongly influenced by anthropogenic activities.

关键词： mercury broadleaf forests leaf litter soil flux

Antibody-drug conjugates:Recent advances in payloads

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Acta Pharmaceutica Sinica B 2023年第10期13卷 4025-4059页

作者： zhijia wang Hanxuan Li Lantu Gou Wei Li Yuxi wang Department of Pulmonary and Critical Care Medicine Targeted Tracer Research and Development LaboratoryInstitute of Respiratory HealthFrontiers Science Center for Disease-related Molecular NetworkNational Clinical Research Center for GeriatricsState Key Laboratory of BiotherapyPrecision Medicine Key Laboratory of Sichuan Province&Precision Medicine Research CenterWest China HospitalSichuan UniversityChengdu 610041China Frontiers Medical Center Tianfu Jincheng LaboratoryChengdu 610212China Department of Pharmaceutical Sciences College of PharmacyUniversity of Tennessee Health Science CenterMemphisTN 38163USA

Antibody-drug conjugates(ADCs),which combine the advantages of monoclonal antibodies with precise targeting and payloads with efficient killing,show great clinical therapeutic *** ADCs’payloads play a key role in determining the efficacy of ADC drugs and thus have attracted great attention in the *** ideal ADC payload should possess sufficient toxicity,low immunogenicity,high stability,and modifiable functional *** ADC payloads include tubulin inhibitors and DNA damaging agents,with tubulin inhibitors accounting for more than half of the ADC drugs in clinical ***,due to clinical limitations of traditional ADC payloads,such as inadequate efficacy and the development of acquired drug resistance,novel highly efficient payloads with diverse targets and reduced side effects are being *** perspective summarizes the recent research advances of traditional and novel ADC payloads with main focuses on the structure-activity relationship studies,co-crystal structures,and designing strategies,and further discusses the future research directions of ADC *** review also aims to provide valuable references and future directions for the development of novel ADC payloads that will have high efficacy,low toxicity,adequate stability,and abilities to overcome drug resistance.

关键词： Antibody‒drug conjugates Dual payloads Tubulin inhibitors DNA damaging agents PROTACs RNA targeting agents

Chemiluminescence:From mechanism to applications in biological imaging and therapy

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Aggregate 2021年第6期2卷 43-59页

作者： zhijia wang Jiaguo Huang Jingsheng Huang Bingran Yu Kanyi Pu Fu-Jian Xu Laboratory of Biomedical Materials and Key Lab of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical Technology Ministry of Education)Beijing University of Chemical TechnologyBeijingP.R.China School of Chemical and Biomedical Engineering Nanyang Technological UniversitySingapore Division of Chemistry and Biological Chemistry School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore

Chemiluminescence(CL)is an emission phenomenon induced by chemical *** from the photoluminescence,CL is free from external excitation source,which is expected to show great advantages such as higher signal-to-background ratio(SBR)in bioimaging,and deeper tissue penetration in photodynamic therapy(PDT).This review introduces the theoretical aspects of CL mechanism,such as classification,energy consideration and chemiexcited/photoexcited *** of CL in bioimaging is *** particular,the approaches to modulate the brightness and the wavelength of CL are summarized,which are two fundamental parameters in ***,the application of CL in PDT is *** potential challenges and perspectives of CL in bioimaging and therapy are also discussed.

关键词： chemiluminescence imaging molecular probes photodynamic therapy

A metal ions-mediated natural small molecules carrier-free injectable hydrogel achieving laser-mediated photo-Fenton-like anticancer therapy by synergy apoptosis/cuproptosis/anti-inflammation

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Bioactive Materials 2023年第11期29卷 98-115页

作者： Wenmin Pi Linying Wu Jihui Lu Xiaoyu Lin Xuemei Huang zhijia wang Zhihua Yuan Hailing Qiu Jianglan Zhang Haimin Lei Penglong wang School of Chinese Pharmacy Beijing University of Chinese MedicineBeijing102488China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China

Tumor microenvironment (TME) plays an important role in the tumorigenesis, proliferation, invasion and metastasis. Thereby developing synergistic anticancer strategies with multiple mechanisms are urgent. Copper is widely used in the treatment of tumor chemodynamic therapy (CDT) due to its excellent laser-mediated photo- Fenton-like reaction. Additionally, copper can induce cell death through cuproptosis, which is a new modality different from the known death mechanisms and has great promise in tumor treatment. Herein, we report a natural small molecules carrier-free injectable hydrogel (NCTD Gel) consisted of Cu2+-mediated self-assembled glycyrrhizic acid (GA) and norcantharidin (NCTD), which are mainly governed by coordination and hydrogen bonds. Under 808 nm laser irradiation, NCTD Gel can produce reactive oxygen species (ROS), consume glutathione (GSH) and overcome hypoxia in TME, leading to synergistically regulate TME via apoptosis, cuproptosis and anti-inflammation. In addition, NCTD Gel’s CDT display high selectivity and good biocompatibility as it relies on the weak acidity and H2O2 overexpression of TME. Notably, NCTD Gel’s components are originated from clinical agents and its preparation process is easy, green and economical, without any excipients. This study provides a new carrier-free hydrogel synergistic antitumor strategy, which has a good prospect in industrial production and clinical transformation.

关键词： Natural small molecular ternary carrier-free hydrogel Tumor microenvironment Cuproptosis Laser-mediated photo-fenton-like reaction

Novel thieno[2,3-b]quinoline-procaine hybrid molecules:A new class of allosteric SHP-1 activators evolved from PTP1B inhibitors

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Chinese Chemical Letters 2023年第8期34卷 213-218页

作者： Lei Xu Xuyang Mu Minmin Liu zhijia wang Chao Shen Qianwen Mu Bo Feng Yechun Xu Tingjun Hou Lixin Gao Haini Jiang Jia Li Yubo Zhou Wenlong wang School of Life Sciences and Health Engineering Jiangnan UniversityWuxi 214122China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshan 528400China School of Chemical and Material Engineering Jiangnan UniversityWuxi 214122China Innovation Institute for Artificial Intelligence in Medicine College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

Small molecule activators could equally provide powerful tools as inhibitors do for interrogating cellular signal ***,targeted protein activation is chemically *** activators against Src homology region 2 domain-containing phosphatase-1(SHP-1)to block STAT3 pathway represents a promising strategy for DLBCL *** we reported a new class of thieno[2,3-b]quinolineprocaine hybrid molecules as SHP-1 allosteric *** representative hybrid compound 3b displayed SHP-1 activating effect with EC50 of 5.48±0.28μmol/*** investigations confirmed that 3b allosterically interacted with SHP-1,switched it from close to open conformation,blocked SHP-1/p-STAT3 pathway,induced apoptosis and inhibited ABC-DLBCL cell proliferation in vitro,and delayed tumor growth in the xenograft model of ***,this work offered a novel paradigm to develop SHP-1 allosteric activators through chemical space evolution of PTPs inhibitors,and firstly validated the therapeutic strategy that directly activating SHP-1 alone could be a potential therapy against ABC-DLBCL via blocking STAT3 pathway.

关键词： Activator PTPs Inhibitor Thieno[2,3-b]quinoline derivatives Diffuse large B-cell lymphoma

学术史中的话语演变与谱系构建——清代公羊学史与庄存与

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学术月刊 2018年第3期50卷 139-150页

作者：王鸷嘉北京大学历史学系

目前对清代学术史的普遍认知中，以公羊学为核心的“今文学”在治学方法等多方面同乾嘉学术存在鸿沟，且存在以庄存与为始祖的独立传承谱系。然而，清代公羊学奠基人刘逢禄自述学术渊源，却并不承认其春秋学源于外祖庄存与。考察刘氏对... 详细信息

目前对清代学术史的普遍认知中，以公羊学为核心的“今文学”在治学方法等多方面同乾嘉学术存在鸿沟，且存在以庄存与为始祖的独立传承谱系。然而，清代公羊学奠基人刘逢禄自述学术渊源，却并不承认其春秋学源于外祖庄存与。考察刘氏对《公羊春秋》相关研究著作，其中的治学立场与具体观点同庄存与《春秋正辞》迥然有别。在此观察的基础上，考察19世纪以来学术史的论述，发现“庄-刘”一脉学术谱系的构建中以魏源为代表的“今文”学者人为推动的因素。随着西汉今文派影响的扩大，这一论述被不断地强化并成为目前的主流认识。这是学术话语变迁显著影响学术虫叙述的绝佳之例。

关键词：庄存与刘逢禄魏源公羊学今文学

碳排放权交易政策对企业绿色技术创新的影响--基于工具变量和三重差分的检验

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科学学与科学技术管理 2023年第5期44卷 15-33页

作者：李创王智佳王丽萍集美大学工商管理学院福建厦门361021 河南理工大学工商管理学院河南焦作454000 集美大学财经学院福建厦门361021

碳排放权交易政策能否激发企业绿色技术创新,对实现环境绩效和经济绩效的双赢至关重要。运用准自然实验研究法,考察了碳排放权交易试点政策对企业绿色技术创新的激励机制。研究发现:(1)在基准回归基础上,运用工具变量克服内生性问题、... 详细信息

碳排放权交易政策能否激发企业绿色技术创新,对实现环境绩效和经济绩效的双赢至关重要。运用准自然实验研究法,考察了碳排放权交易试点政策对企业绿色技术创新的激励机制。研究发现:(1)在基准回归基础上,运用工具变量克服内生性问题、三重差分方法剔除其他政策影响以及一系列稳健性检验后,碳排放权交易政策仍能显著激发企业绿色技术创新,包括高质量绿色技术创新和低质量绿色技术创新。(2)进一步研究表明,宏观市场需求、中观行业竞争和微观企业内部控制等因素均能强化碳排放权交易试点政策的创新激励作用。(3)从企业所有制类型来看,相较于非国有企业,国有企业对碳排放权交易试点政策更加敏感;从资源禀赋来看,在资源禀赋短缺地区,碳排放权交易试点政策对企业绿色技术创新的激励更显著。

关键词：碳排放权交易绿色技术创新工具变量三重差分安慰剂检验

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试论国家境外武力反恐的合法性

法学杂志 2016年第9期37卷 46-54页

作者：李寿平王志佳北京理工大学法学院北京100081

国家实施境外武力反恐主要有安理会授权实施境外武力反恐、以自卫为名实施境外武力反恐、经他国邀请实施境外武力反恐、单边主义实施境外武力反恐等四种情形。在现行国际法下,经安理会授权实施境外武力反恐和经他国邀请实施境外武力反... 详细信息

国家实施境外武力反恐主要有安理会授权实施境外武力反恐、以自卫为名实施境外武力反恐、经他国邀请实施境外武力反恐、单边主义实施境外武力反恐等四种情形。在现行国际法下,经安理会授权实施境外武力反恐和经他国邀请实施境外武力反恐的合法性明显,但以自卫为名实施境外武力反恐合法性存疑,采取单边行动实施境外武力反恐更是缺乏法律依据。因此,要在联合国框架下建立和完善安理会主导的境外武力反恐国际法律制度,明确危害国际和平与安全情势的界定标准,完善安理会授权使用武力机制,明确境外武力反恐的对象以及需要遵循的适当性原则。

关键词：武力反恐自卫权单边主义合法性

Removal of a foreign body by a flexible bronchoscope in children

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Removal of a foreign body by a flexible bronchoscope in chil...