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中心城区城市公园的儿童友好性分析及其规划应对——以武汉市沙湖公园为例

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湖北大学学报（自然科学版） 2025年第1期47卷 43-51页

作者：邓付东刘润周晓芳胡志豪湖北大学资源环境学院湖北武汉430062 区域开发与环境响应湖北省重点实验室湖北武汉430062

以儿童友好为导向规划建设出能够充分保障儿童权益和诉求的儿童友好型城市公园,对于促进儿童健康成长、推动儿童友好型城市建设具有重要意义。依据“儿童友好”导向理论体系,采用非参与式观察方法对武汉市沙湖公园开展实地调研,结果表明... 详细信息

以儿童友好为导向规划建设出能够充分保障儿童权益和诉求的儿童友好型城市公园,对于促进儿童健康成长、推动儿童友好型城市建设具有重要意义。依据“儿童友好”导向理论体系,采用非参与式观察方法对武汉市沙湖公园开展实地调研,结果表明,沙湖公园在自然友好度、人文友好度方面有待提升。然后基于马斯洛需求层次理论,提出儿童友好导向下沙湖公园规划与建设的具体策略。

关键词：儿童友好城市公园沙湖公园马斯洛需求层次理论

Spatial heterogeneity and source apportionment of soil metal(loid)s in an abandoned lead/zinc smelter

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Journal of Environmental Sciences 2023年第5期127卷 519-529页

作者： Yunxia Zhang Tianshuang Li Zhaohui Guo huimin Xie zhihao hu Hongzhen Ran Changzhou Li Zhichao Jiang Institute of Environmental Engineering School of Metallurgy and EnvironmentCentral South UniversityChangsha 410083China

Metal smelting have brought severe metal(loid)s contamination to the *** distribution and pollution source analysis for soil metal(loid)s in an abandoned lead/zinc smelter were *** results showed that soil was contaminated heavily withmetal(loid)*** mean of lead(Pb),arsenic(As),cadmium(Cd),mercury(Hg)and antimony(Sb)content in topsoil is 9.7,8.2,5.0,2.3,and 1.2 times higher than the risk screening value for soil contamination of development land of China(GB36600-2018),*** ismainly enriched in the 0–6mdepth of site soil while As and Pbmainly deposited in the 0–*** spatial distribution of soil metal(loid)s is significantly correlated with the pollution source in the different functional areas of ***,Hg,Sb,Pb and copper(Cu)were mainly distributed in pyrometallurgical area,while Cd,thallium(Tl)and zinc(Zn)was mainly existed in both hydrometallurgical area and raw material storage *** metal(loid)s pollution sources in the abandoned smelter are mainly contributed to the anthropogenic sources,accounting for 84.5%.Specifically,Pb,Tl,As,Hg,Sb and Cumainly from atmospheric deposition(55.9%),Cd and Zn mainly from surface runoff(28.6%),While nickel(Ni)mainly comes from parent material(15.5%).The results clarified the spatial distribution and their sources in different functional areas of the smelter,providing a new thought for the risk prevention and control of metal(loid)s in polluted site soil.

关键词： Smelting industry Site soil Metal(loid)s Spatial heterogeneity Source apportionment

Regulation of pathological blood-brain barrier for intracranial enhanced drug delivery and anti-glioblastoma therapeutics

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Oncology Research 2021年第5期29卷 351-363页

作者： KAI WANG FENGTIAN ZHANG CHANGLONG WEN ZHIhuA huANG zhihao hu YUWEN ZHANG FUQIANG hu LIJUAN WEN Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education Gannan Medical UniversityGanzhou341000China College of Pharmaceutical Sciences Zhejiang UniversityHangzhou310058China Department of Orthopedics First Affiliated Hospital of Gannan Medical UniversityGanzhou341000China Medical College of Soochow University Suzhou215123China Department of Infectious Diseases Ganzhou People’s HospitalGanzhou341000China Ganzhou Key Laboratory of Neuroinflammation Research Gannan Medical UniversityGanzhou341000China

The blood-brain barrier(BBB)is an essential component in regulating and maintaining the homeostatic microenvironment of the central nervous system(CNS).During the occurrence and development of glioblastoma(GBM),BBB is pathologically destroyed with a marked increase in *** to the obstruction of the BBB,current strategies for GBM therapeutics still obtain a meager success rate and may lead to systemic ***,chemotherapy could promote pathological BBB functional restoration,which results in signiﬁcantly reduced intracerebral transport of therapeutic agents during multiple administrations of GBM and the eventual failure of GBM *** effective delivery of intracerebral drugs still faces severe ***,strategies that regulate the pathological BBB to enhance the transport of therapeutic agents across the barrier may provide new opportunities for the effective and safe treatment of *** article reviews the structure and function of BBB in physiological states,the mechanisms underlying BBB pathological fenestration during the development of GBM,and the therapeutic strategies of GBM based on BBB intervention and medicinal drugs transporting across the BBB.

关键词： Blood-brain barrier Physiological Pathological Glioblastoma Intervention

Wind and Snow Impacts on Urban Space Planning:A Multiphase Numerical Simulation

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Journal of Harbin Institute of Technology(New Series) 2023年第5期30卷 12-24页

作者： zhihao hu huizhe Cao Bin Zhang Chein-Chi Chang Biao Li School of Architecture Harbin Institute of TechnologyHarbin150000China Key Laboratory of ColdR egion Urban and Rural human Settlement Environment Science and Technology Ministry of Industry andI nformation TechnologyHarbin Institute of TechnologyHarbin 150000China China Energy Engineering Group Shanxi Electric Power Engineering Co. Ltd.Taiyuan 030001China University of Maryland Baltimore CountyMaryland 21250USA School of Energy Sciencea nd Engineering Harbin Institute of TechnologyHarbin 150006 China

The wind and snow environment outside the planned space plays a key role in the comfort and safety of the human habitat in severe cold regions. Traditional studies of the external environment of human settlements, however, frequently overlook the combined impacts of wind and snow environments. Furthermore, in urban meteorological studies, it is impossible to accurately assess the wind and snow environment in specific areas or locations. In this study, a refined Computational Fluid Dynamics(CFD) multiphase flow numerical method was used to simulate a planning space's wind and snow environment. The study classified the Snowstorm Weather Grade(SWG) by incorporating the Snowstorm Weather Index(SWI) to generate calculation results of the wind environment and snow environment. In particular, 150 measurement points in the planning space were chosen for analysis and evaluation of their wind and snow environments. The results demonstrated that the SWI index can effectively correlate to the wind and snow environment calculation results. In addition, the graph of SWI showed that 55% of the measurement points had a moderate wind and snow grade SWI, which exceeds the average grade for the entire region. The practical application shows that the wind and snow environment assessment indexes and technical methods developed in this paper can be successfully applied to wind and snow environment studies in other cold cities.

关键词： urban planning planning space cold region wind and snow environment numerical simulation of multiple flows

High performance wide frequency band triboelectric nanogenerator based on multilayer wave superstructure for harvesting vibration energy

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Nano Research 2023年第5期16卷 6933-6939页

作者： Song Tang Wenxuan Chang Gui Li Jianfeng Sun Yan Du Xindan hui Qian Tang zhihao hu Jiaqi Li Jie Chen Wencong He Hengyu Guo School of Physics Chongqing UniversityChongqing 400044China College of Physics and Electronic Engineering Chongqing Normal UniversityChongqing 400047China

Efficiently converting the random vibration energy widely existed in human activities and natural environments into electricity is significant to the local power supply of sensor nodes in the internet of ***,the conversion efficiency of energy harvester is relatively low due to the limitation of device’s intrinsic *** this work,a multi-layered,wavy super-structuredtriboelectric nanogenerator(SS-TENG)is designed,whose output performances can be greatly promoted by combining the charge excitation *** steel sheet acts not only as an electrode but also as a supporter for the overall frame of SSTENG,which effectively improves the space utilization rate and results in a volume charge density up to 129 mC·m^(−3).In addition,the resonant frequency width of the SS-TENG can be widened by changing the parameters of the *** demonstration,the SS-TENG can sustainably drive two temperature and humidity sensors in parallel by harvesting vibration *** work may provide an effective strategy for harvesting vibration energy and broadening frequency response.

关键词： charge excitation superstructure vibration energy volume charge density resonant frequency

Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies

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Acta Pharmaceutica Sinica B 2024年第2期14卷 533-578页

作者： Xiaopeng Peng zhihao hu Limei Zeng Meizhu Zhang Congcong Xu Benyan Lu Chengpeng Tao Weiming Chen Wen Hou Kui Cheng huichang Bi Wanyi Pan Jianjun Chen College of Pharmacy Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of EducationGannan Medical UniversityGanzhou 314000China College of Basic Medicine Gannan Medical UniversityGanzhou 314000China Guangdong Provincial Key Laboratory of New Drug Screening NMPA Key Laboratory for Research and Evaluation of Drug MetabolismSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China

Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators(e.g., inhibitors). However, epigenetic inhibitors have faced multiple challenges,including limited clinical efficacy, toxicities, lack of subtype selectivity, and drug resistance. As a result,the design of new epigenetic modulators(e.g., degraders) such as PROTACs, molecular glue, and hydrophobic tagging(Hy T) degraders has garnered significant attention from both academia and pharmaceutical industry, and numerous epigenetic degraders have been discovered in the past decade. In this review,we aim to provide an in-depth illustration of new degrading strategies(2017-2023) targeting epigenetic proteins for cancer therapy, focusing on the rational design, pharmacodynamics, pharmacokinetics, clinical status, and crystal structure information of these degraders. Importantly, we also provide deep insights into the potential challenges and corresponding remedies of this approach to drug design and development. Overall, we hope this review will offer a better mechanistic understanding and serve as a useful guide for the development of emerging epigenetic-targeting degraders.

关键词： Epigenetic Degrader PROTAC Molecularglue Hydrophobic tagging

In Vitro Antioxidant Activity of Hot Water Extracts from 7 Different Sources of Ganoderma Lucidum

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Medicinal Plant 2017年第4期8卷 62-65,71页

作者： Jian NIE Shuilian YANG Meihua MO zhihao hu College of Food Science of South China Agricultural University Lingnan Institute of Technology

[Objectives] To study the in vitro antioxidant activity of hot water extracts from 7 different sources of Ganoderma lucidum mushroom.[Methods] The in vitro antioxidant activity of hot water extracts from 7 different sources of G. lucidum was studied from total reducing capacity,scavenging of hydroxyl free radical( ·OH),superoxide anion( O_2^(2-)·),and DPPH free radical.[Results]Under the same concentration,hot water extracts wild G. lucidum in Maoer Mountain showed the strongest reducing capacity with the absorbency being 2. 48,the highest scavenging capacity of hydroxyl free radical( · OH) with the scavenging rate being 99. 46%,and the strongest scavenging ability of DPPH free radical with its scavenging rate being 96. 62%. The ability of scavenging superoxide anion free radical( O_2^(2-)·) ranked the third.[Conclusions]The hot water extracts from Maoer Mountain wild G. lucidum showed the highest antioxidant ability in three aspects,indicating that Maoer Mountain wild G. lucidum has high development potential.

关键词： Ganoderma lucidum Antioxidant Hot water extract

国债管理:财政政策与货币政策协调配合的关键点

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学术前沿 2024年第3期 65-73页

作者：胡志浩中国社会科学院大学应用经济学院

国债兼具财政和金融功能,是财政政策与货币政策互动最为频繁活跃的领域,而货币政策的立场和操作也会直接影响赤字融资的来源与成本。因此,国债管理是两大政策协调配合的关键切入点。鉴于财政政策与货币政策配合的国际经验,针对我国政策... 详细信息

国债兼具财政和金融功能,是财政政策与货币政策互动最为频繁活跃的领域,而货币政策的立场和操作也会直接影响赤字融资的来源与成本。因此,国债管理是两大政策协调配合的关键切入点。鉴于财政政策与货币政策配合的国际经验,针对我国政策协调配合中面临的挑战,我国应根据经济形势适时调整宏观政策调控机制;推动央行开展公开市场买卖国债;稳步推进国债市场的国际化建设;完善债务约束机制,科学设置债务上限;优化国库现金与央行流动性管理;积极发挥财政部在债务管理与国债市场建设中的主导作用,建立统一高效的政府债券市场;协同健全国债收益率曲线,共同推动曲线深入应用;进一步加强以国债为基础的金融市场流动性机制安排;在更高层面确立财政政策与货币政策的协调机制;保持两大政策部门更为畅通的信息交流。

关键词：财政政策货币政策政策协调配合国债管理

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如何认识当前全球自由贸易的制约因素

学术前沿 2018年第20期 29-37页

作者：胡志浩中国社会科学院金融研究所

特朗普自就职以来,试图通过单边行动来改变现有贸易体系并重构全球价值链,这已经对全球自由贸易形成巨大挑战。从全球自由贸易的历史中可以看出,自由贸易总是在规则主导国能明显获益时才被积极推动。而当前全球经济结构调整的压力,美国... 详细信息

特朗普自就职以来,试图通过单边行动来改变现有贸易体系并重构全球价值链,这已经对全球自由贸易形成巨大挑战。从全球自由贸易的历史中可以看出,自由贸易总是在规则主导国能明显获益时才被积极推动。而当前全球经济结构调整的压力,美国国内经济社会矛盾的压力,甚至是美国自身对于霸权地位的担忧,都已促使美国国内的新孤立主义再次抬头。这种趋势虽然并不会让WTO多边体系马上瓦解,但全球很有可能进入一个贸易领域的"牙买加体系"。面对困境,中国应该理性看待中美贸易摩擦,提倡正确的义利观,积极拓展区域和双边经贸协商,并将国内改革和对外开放有机协调起来。

关键词：自由贸易多边体系孤立主义