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模拟长期微重力对大鼠耳蜗基底膜p120-catenin表达的影响

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中华耳科学杂志 2024年第1期22卷 136-140页

作者：朱莹蕾王刚周莹王磊范博雅韩浩伦李保卫孙喆喆吴继华吴玮北京大学解放军306医院教学医院北京100101 中国人民解放军战略支援部队特色医学中心耳鼻喉科国家环境保护环境感官应激与健康重点实验室中国人民解放军战略支援部队特色医学中心病理科

目的观察模拟长期微重力对大鼠听功能的影响,探讨耳蜗黏附连接蛋白p120-catenin(p120ctn)在耳蜗基底膜表达情况及模拟微重力对其产生的影响。方法选取健康雄性SD大鼠48只,随机分为模拟微重力组和对照组,每组24只;模拟微重力组和对照组... 详细信息

目的观察模拟长期微重力对大鼠听功能的影响,探讨耳蜗黏附连接蛋白p120-catenin(p120ctn)在耳蜗基底膜表达情况及模拟微重力对其产生的影响。方法选取健康雄性SD大鼠48只,随机分为模拟微重力组和对照组,每组24只;模拟微重力组和对照组又根据暴露时间分别随机分为1 d、1周、8周、12周组,每组6只12耳。在暴露前(B0)、暴露结束后即刻(P0)进行双耳畸变产物耳声发射(distortion product otoacoustic emission,DPOAE)和听性脑干反应(auditory brainstem response,ABR)阈值检测,并于P0测听结束后处死每组大鼠并分离双侧耳蜗,进行免疫组化染色。结果各组DPOAE引出率比较,差异无统计学意义(P>0.05),ABR阈值随暴露时间的增加而升高,模拟微重力1周组、模拟微重力8周组、模拟微重力12周组P0时ABR阈值较B0时升高,差异有统计学意义(P<0.05)。模拟微重力8周组、模拟微重力12周组基底膜上p120ctn阳性表达较对照组显著增高,差异有统计学意义(P<0.05)。结论模拟微重力会导致大鼠听功能损伤,耳蜗基底膜上p120ctn表达随暴露时间的延长而增加,中长期微重力导致听功能下降可能与基底膜p120ctn的表达增加有关。

关键词：微重力听性脑干反应黏附连接蛋白 p120-catenin

Divergent responses of runoff to climate change in the upper basins of the Third Pole dominated by westerlies and monsoon

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Science China Earth Sciences 2024年第8期67卷 2592-2614页

作者： Qikai sun Fengge SU He sun State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China

The diverse climates,distribution of snow and glaciers,and geographic locations directly affect the runoff response to climate change in the upper basins of the Third *** present,a comprehensive analysis of runoff variations and their distinct responses to climate change in the westerlies-and monsoon-dominated upper basins is still *** study comprehensively analyzed annual runoff variations in westerlies-dominated basins(the upper basins of the Aksu(UAKS),Syr Darya(USRD),Yarkant(UYK),Hotan(UHT),Amu Darya(UAMD),and Indus(UI))and monsoon-dominated basins(the upper basins of the Yangtze(UYA),Yellow(UYE),Lancang(ULC),Nujiang(UNJ),and Yarlung Zangbo(UYZ))of the Third Pole from 1961 *** multi-source meteorological data and large-scale circulation factors,this study investigated the divergent responses of runoff in the upper basins to climate change,and explored the large-scale circulation mechanisms underlying runoff variations in these upper *** results showed that:(1)The annual runoff in the majority of upper basins(except for the UYE and UYZ)exhibited an increasing trend,and the annual runoff in the UAKS,UYK,and UI showed a significant increasing trend from1961 to *** annual runoff in the upper basins of the Third Pole changed abruptly from decreasing to increasing between the 1980s and 2000s,with the exception of the UYE.(2)The runoff in the monsoon-dominated upper basins has been controlled primarily by changes in precipitation over the past 55 *** contrast,the runoff in the westerlies-dominated upper basins exhibited three distinct long-term responses to climate change:temperature-dominated(UYK and UHT),precipitation-dominated(USRD and UAMD),and the combined influence of precipitation and temperature(UAKS and UI).Since the 1960s,the sensitivity of runoff to warm season temperature changes in the most westerlies-dominated upper basins has decreased,while the response of runoff to precipitation changes has intensified.(3)The stud

关键词： Upper basins of the Third Pole Climate change Westerlies and monsoon Runoff variations Large-scale circulation factors

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New perspectives on deep carbon cycling

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Science China Earth Sciences 2024年第8期67卷 2411-2422页

作者： Weidong sun Center of Deep Sea Research Key Laboratory of Ocean Observation and ForecastingInstitute of OceanologyChinese Academy of SciencesQingdao 266071China Laoshan Laboratory Qingdao 266237China University of Chinese Academy of Sciences Beijing 100049China

The proto-atmosphere serves as a crucial starting point for the carbon *** based on atmospheric data from Mars and Venus suggest that Earth's proto-atmosphere contained>110 bar of CO_(2)and>2.6 bar of *** protoatmosphere had over 1000 bar of water vapor during the magma ocean stage,assuming the proto-ocean had a volume of two oceans of *** this stage both water and carbon dioxide were in a supercritical state at the magma-atmosphere *** serpentinization reactions occurred due to rock-water interaction,producing abundant ***,nitrogen is reduced to ammonia,and carbon dioxide to methane,forming carbonate *** proto-atmosphere dominated by methane,ammonia,and hydrogen formed a significant amount of amino acids through *** process is essential not only to the origin of life,but also to the early carbon-nitrogen cycle on *** the Hadean eon,a large amount of CO_(2)was sequestered as carbonate and organic ***,it mainly entered the deep mantle through mantle overturn or *** the mantle transition zone,carbonate undergoes“Redox freezing”,where carbonate is reduced to diamond through oxidation of ferrous iron in the *** the lower mantle,Fe^(2+)undergoes disproportionation reactions,forming Fe^(3+)and metallic *** these,Fe^(3+)mainly resides in bridgmanite,thereby increasing the oxygen fugacity of the lower mantle,while metallic iron falls to the Earth's *** distribution of carbon in the mantle is crucial for deep carbon *** density curves of diamond and mantle peridotite melt intersect at the bottom of the mantle transition zone(about 660 km).This density crossover leads to the accumulation of diamond during the magma ocean *** materials such as subducting slabs enter the lower mantle,compensatory upwelling of lower mantle material *** enters the upper mantle,decomposes,releasing Fe^(3+)ions and oxidizes diamond

关键词： Carbon cycling Proto-atmosphere Amino acids Subduction initiation Passive margin subduction Atmospheric carbon dioxide

Fossil Equidae in the Linxia Basin with Biostratigraphic and Paleozoogeographic Significance

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 1-9页

作者： sun Boyang Key Laboratory of Vertebrate Evolution and Human Origins of the Chinese Academy of Sciences Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China

The Linxia Basin is characterized by an abundance of Cenozoic sediments,that contain exceptionally rich fossil *** are abundant in the Linxia Basin,the fossil record of equids in this region including 16 species that represent 10 *** comparison to other classic late Cenozoic areas in China,the Linxia Basin stands out,because the fauna and chronological data accompanying Linxia equids render them remarkably useful for *** anchitheriines in the region,such as Anchitherium and Sinohippus,represent early equids that appeared in the late stages of the middle and late Miocene,*** the equines,most species of Chinese hipparions have been identified in the Linxia Basin and some species of the genera Hipparion and Hippotherium have FAD records for ***,Equus eisenmannae is one of the earliest known species of Equus in the Old World and is well-represented at the Longdan *** species with precise geohistorical distributions can serve as standards for high-resolution chronological units within this *** at the eastern margin of the Tibetan Plateau and subject to considerable uplift,the Linxia Basin has served as a biogeographic transition area for equids throughout the late Cenozoic.

关键词： Equidae Cenozoic biostratigraphy paleozoogeography Linxia Basin

Achieving simultaneously high conversion and high selectivity for light olefins directly producing from syngas

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Science China Chemistry 2024年第3期67卷 753-754页

作者： Yuhan sun Shanxi Research Institute Huairou Research LaboratoryTaiyuan 030032China Institute of Carbon Neutrality ShanghaiTech UniversityShanghai 201210China

The activity and selectivity are two primary indexes of a successful catalyst for chemical reactions. However,achieving a high activity and a high selectivity simultaneously is a long-standing challenge in catalysis, the socalled activity-selectivity trade-off. In the article recently published in Science, a research team led by Prof.

关键词： selectivity simultaneous catalysis

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国际注册多导睡眠技师发展现状

护理研究 2023年第7期37卷 1213-1217页

作者：刘红丹孙喆喆王鑫吴玮中国人民解放军战略支援部队特色医学中心北京100101 国家环境保护环境感官应激与健康重点实验室

对国际注册多导睡眠技师的起源与发展、教育水平、技术能力、注册认证要求、实践范围、角色定位及对病人、护士及从业者的影响进行综述,分析国际注册多导睡眠技师在我国发展遇到的挑战,旨在为我国睡眠技师的发展提供参考。

关键词：注册多导睡眠技师护士多导睡眠监测综述

ONE-PARAMETER FINITE DIFFERENCE METHODS AND THEIR ACCELERATED SCHEMES FOR SPACE-FRACTIONAL SINE-GORDON EQUATIONS WITH DISTRIBUTED DELAY

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Journal of Computational Mathematics 2024年第3期42卷 705-734页

作者： Tao sun Chengjian Zhang Haiwei sun School of Mathematics and Statistics Huazhong University of Science and TechnologyWuhan 430074China Hubei Key Laboratory of Engineering Modeling and Scientific Computing Huazhong University of Science and TechnologyWuhan 430074China Department of Mathematics University of MacaoMacaoChina

This paper deals with numerical methods for solving one-dimensional(1D)and twodimensional(2D)initial-boundary value problems(IBVPs)of space-fractional sine-Gordon equations(SGEs)with distributed *** 1D problems,we construct a kind of oneparameter finite difference(OPFD)*** is shown that,under a suitable condition,the proposed method is convergent with second order accuracy both in time and *** implementation,the preconditioned conjugate gradient(PCG)method with the Strang circulant preconditioner is carried out to improve the computational efficiency of the OPFD *** 2D problems,we develop another kind of OPFD *** such a method,two classes of accelerated schemes are suggested,one is alternative direction implicit(ADI)scheme and the other is ADI-PCG *** particular,we prove that ADI scheme can arrive at second-order accuracy in time and *** some numerical experiments,the computational effectiveness and accuracy of the methods are further ***,for the suggested methods,a numerical comparison in computational efficiency is presented.

关键词： Fractional sine-Gordon equation with distributed delay One-parameter finite difference methods Convergence analysis ADI scheme PCG method

Dominant woody plant species recognition with a hierarchical model based on multimodal geospatial data for subtropical forests

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Journal of Forestry Research 2024年第3期35卷 111-130页

作者： Xin Chen Yujun sun State Forestry&Grassland Administration Key Laboratory of Forest Resources&Environmental Management Beijing Forestry UniversityBeijing 100083People's Republic of China

Since the launch of the Google Earth Engine(GEE)cloud platform in 2010,it has been widely used,leading to a wealth of valuable ***,the potential of GEE for forest resource management has not been fully *** extract dominant woody plant species,GEE combined Sen-tinel-1(S1)and Sentinel-2(S2)data with the addition of the National Forest Resources Inventory(NFRI)and topographic data,resulting in a 10 m resolution multimodal geospatial dataset for subtropical forests in southeast *** and texture features,red-edge bands,and vegetation indices of S1 and S2 data were computed.A hierarchical model obtained information on forest distribution and area and the dominant woody plant *** results suggest that combining data sources from the S1 winter and S2 yearly ranges enhances accuracy in forest distribution and area extraction compared to using either data source ***,for dominant woody species recognition,using S1 winter and S2 data across all four seasons was *** terrain factors and removing spatial correlation from NFRI sample points further improved the recognition *** optimal forest extraction achieved an overall accuracy(OA)of 97.4%and a maplevel image classification efficacy(MICE)of 96.7%.OA and MICE were 83.6%and 80.7%for dominant species extraction,*** high accuracy and efficacy values indicate that the hierarchical recognition model based on multimodal remote sensing data performed extremely well for extracting information about dominant woody plant *** the results using the GEE application allows for an intuitive display of forest and species distribution,offering significant convenience for forest resource monitoring.

关键词： Google Earth Engine Sentinel Forest resource inventory data Dominant woody plant species Subtropics Model performance

The Functional Redundancy of Neddylation E2s and E3s in Modulating the Fitness of Regulatory T Cells

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Research 2024年第2期2023卷 373-387页

作者： Di Wu Yi sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Zhejang Provincial Clinical Research Center for Cancer Zhejang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences Zhejang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is necessary for activation of Cullin-RING ligases(CRLs),which degrade various immune regulatory *** recent study showed that while depletion of neddylation E2-E3 pair Ube2f-Sag in regulatory T(T_(reg))cells had no obvious phenotype,the same depletion of either Ube2m or Rbx1 caused inflammation disorders with different *** these E2s or E3s compensate each other in functional regulations of T_(reg)cells is,however,previously *** this report,we generated Foxp3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Foxp3^(Cre);Rbx1^(fl/fl);Sag^(fl/fl)double-null mice by simultaneous deletion of both neddylation E2s or E3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe autoimmune phenotypes than did Ube2m-null mice,indicating that Ube2m markedly compensates Ube2f in T_(reg)*** minor worsened autoimmune phenotypes seen at the very early stage in Rbx1&Sag double-null than Rbx1-null mice is likely due to already severe phenotypes of the later,indicating a minor compensation of Rbx1 for *** RNA profiling-based analyses revealed that up-and down-regulations of few signaling pathways in T_(reg)cells are associated with the severity of autoimmune ***,severer inflammation phenotypes seen in mice with double E3-null than with double E2-null T_(reg)cells indicate a neddylation-independent mechanism of 2 E3s,also known to serve as the RING component of CRLs in regulation of T_(reg)cell fitness.

关键词： Foxp3 inflammation markedly