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Nano Research 2024年第7期17卷 6342-6352页

作者： Xinyang Li Binbin Ding Jing Li Di Han Hao Chen Jia Tan Qi Meng pan zheng Ping’an Ma Jun Lin State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

Chemodynamic therapy(CDT),an inventive approach to cancer treatment,exploits innate chemical processes to trigger cell death through the generation of reactive oxygen species(ROS).While offering advantages over conventional treatments,the optimization of CDT efficacy presents challenges stemming from suboptimal catalytic efficiency and the counteractive ROS scavenging effect of intracellular glutathione(GSH).In this study,we aim to address this dual challenge by delving into the role of copper valence states in *** the unique attributes of copper-based nanoparticles,especially zero-valent copper nanoparticles(CuPd NPs),we aim to enhance the therapeutic potential of *** experiments reveal that zero-valent CuPd NPs outperform divalent copper nanoparticles(Ox-CuPd NPs)by displaying superior catalytic performance and sustaining ROS generation through a dual approach integrating peroxidase-like(POD-like)activity and Cu+***,zero-valent NPs exhibit enhanced GSH depletion compared to their divalent counterparts,thereby intensifying CDT and inducing ferroptosis,ultimately resulting in high-efficiency tumor growth *** findings reveal the impact of valences on CDT,providing novel insights for the optimization and design of CDT agents.

关键词： CuPd nanoparticle ferroptosis chemodynamic therapy valance tailoring tumor therapy

Recovering from prolonged cardiac arrest induced by electric shock:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2248-2253页

作者： Jian Zhang Yan-Ru Qiao Ya-Dong Yang Guo-zheng pan Chong-Qing Lv Department of General Surgery Shengli Oilfield Central HospitalDongying 257000Shandong ProvinceChina Department of Emergency Medicine Shengli Oilfield Central HospitalDongying 257000Shandong ProvinceChina

BACKGROUND Cardiac arrest(CA)induced by electric shock is a rare occurrence,particularly in cases of prolonged ***,there is limited literature on similar incidents,and we present a relevant case *** SUMMARY A 27-year-old Asian male man,experiencing respiratory CA due to electric shock,was successfully restored to sinus rhythm after 50 min of cardiopulmonary resuscitation and 8 electrical defibrillation *** the subsequent stages,the patient received multiple organ function protection measures,leading to a successful recovery and eventual discharge from the *** Prolonging resuscitation time can enhance the chances of survival for patients,this study provide valuable insights into the management of electric shock-induced CA.

关键词： Electric shock Cardiac arrest Prolonged cardiopulmonary resuscitation Cerebral resuscitation Case report

Exploring the multicomponent synergy mechanism of Zuogui Wan(左归丸) on postmenopausal osteoporosis by a systems pharmacology strategy

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Journal of Traditional Chinese Medicine 2024年第3期44卷 489-495页

作者： FENG Yanchen LIU Yali DANG Xue LIN Zixuan ZHANG Yunke CHE Zhiying LI Xiang pan Xiaolong LIU Feixiang zheng pan Traditional Chinese Medicine (Zhong Jing) School Henan University of Chinese Medicine Hospital of Encephalopathy the First Affiliated Hospital of Henan University of Chinese Medicine State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesthe First Affiliated HospitalZhejiang University School of MedicineResearch Units of Infectious Disease and MicroecologyChinese Academy of Medical Sciences

OBJECTIVE: To explore the multi-component synergistic mechanism of Zuogui Wan(左归丸, ZGW) in treating postmenopausal osteoporosis(PMOP). METHODS: The main components and target genes of ZGW were screened via the Traditional Chinese Medicine Systems Pharmacology(TCMSP). In addition, the target gene sets of PMOP were derived from the Gene Cards and Online Mendelian Inheritance in Man databases. The search tool for recurring instances of neighbouring genes(STRING) 11.0 software was used to analyze the interaction among intersecting genes. Cytoscape 3.6.1 software and the Matthews correlation coefficient(MCC) algorithm were used to screen the core genes. Fifty Sprague-Dawley female rats were randomly divided into the sham-operated(Sham) group and the four ovariectomized(OVX) subgroups. Rats subjected to Sham or OVX were administered with the vehicle(OVX, 1 m L water/100 g weight), 17β-estradiol(E2, 50 μg·kg-1·d-1), and lyophilized powder of ZGW at a low dose of 2.3(ZGW-L) and high dose of 4.6(ZGW-H) g·kg-1·d-1 for three months. The bone density and bone strength were assessed using dual-energy X-ray and three-point bending tests, respectively. Furthermore, enzyme-linked immunosorbent assay, Hematoxylin-eosin staining, and western blot analysis were used to determine the potential pharmacological mechanisms of action of ZGW in PMOP. RESULTS: A total of 117 active compounds of ZGW were screened from the TCMSP. Furthermore, 108 intersecting genes of drugs and diseases were identified. Using STRING software and the MCC algorithm, ten core genes, including C-X-C chemokine living 8(CXCL8), C-C chemokine receptor type 2(CCR2), alpha-2a active receptor(ADRA2A), melatonin receptor type 1B(MTNR1B), and amyloid-beta A4 protein(APP), were identified. The anti-osteoporosis regulation network of ZGW was constructed using the Cytoscape software. The animal experiments demonstrated that ZGW groups significantly reduced the serum levels of β-C-terminal telopeptide of type I collagen(β-CTX

关键词： Zuogui Wan network pharmacology osteoporosis, postmenopausal

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Comparative transcriptomic analysis reveals the molecular changes of acute pancreatitis in experimental models

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World Journal of Gastroenterology 2024年第14期30卷 2038-2058页

作者： pan zheng Xue-Yang Li Xiao-Yu Yang Huan Wang Ling Ding Cong He Jian-Hua Wan Hua-Jing Ke Nong-Hua Lu Nian-Shuang Li Yin Zhu Department of Gastroenterology Digestive Disease HospitalThe First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Acute pancreatitis(AP)encompasses a spectrum of pancreatic inflammatory conditions,ranging from mild inflammation to severe pancreatic necrosis and multisystem organ *** the challenges associated with obtaining human pancreatic samples,research on AP predominantly relies on animal *** this study,we aimed to elucidate the fundamental molecular mechanisms underlying AP using various AP *** To investigate the shared molecular changes underlying the development of AP across varying severity *** AP was induced in animal models through treatment with caerulein alone or in combination with lipopolysaccharide(LPS).Additionally,using Ptf1αto drive the specific expression of the hM3 promoter in pancreatic acinar cells transgenic C57BL/6J-hM3/Ptf1α(cre)mice were administered Clozapine N-oxide to induce ***,we conducted RNA sequencing of pancreatic tissues and validated the expression of significantly different genes using the Gene Expression Omnibus(GEO)*** Caerulein-induced AP showed severe inflammation and edema,which were exacerbated when combined with LPS and accompanied by partial pancreatic tissue *** with the control group,RNA sequencing analysis revealed 880 significantly differentially expressed genes in the caerulein model and 885 in the caerulein combined with the LPS *** Encyclopedia of Genes and Genomes enrichment analysis and Gene Set Enrichment Analysis indicated substantial enrichment of the TLR and NOD-like receptor signaling pathway,TLR signaling pathway,and NF-κB signaling pathway,alongside elevated levels of apoptosis-related pathways,such as apoptosis,P53 pathway,and phagosome *** significantly elevated genes in the TLR and NOD-like receptor signaling pathways,as well as in the apoptosis pathway,were validated through quantitative real-time PCR experiments in animal *** from the GEO database revealed that only MYD88 concurred in both mouse panc

关键词： Acute pancreatitis RNA-sequencing Experimental acute pancreatitis models Inflammatory Apoptosis TLR and NOD-like signaling pathways

关于小儿脾胃疾病相关方剂配伍规律的文献研究

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中华中医药学刊 2024年第6期42卷 244-247页

作者：孙世杰郑攀河南中医药大学仲景学院河南郑州450046

目的运用数据挖掘方法对近年来关于小儿脾胃疾病的相关研究进行研究分析,以揭示治疗小儿脾胃疾病的选方用药及其方剂配伍规律。方法通过文献检索从中国知网数据库查找近两年来治疗小儿脾胃疾病的相关文献,筛选符合纳入标准的文献运用... 详细信息

目的运用数据挖掘方法对近年来关于小儿脾胃疾病的相关研究进行研究分析,以揭示治疗小儿脾胃疾病的选方用药及其方剂配伍规律。方法通过文献检索从中国知网数据库查找近两年来治疗小儿脾胃疾病的相关文献,筛选符合纳入标准的文献运用频次分析、关联规则分析、因子分析等数据挖掘方法进行数据分析。结果小儿脾胃疾病主要证型分布有脾胃虚弱、脾胃湿热、脾胃虚寒、乳食积滞。主要选用方剂频次使用前五的依次为四君子汤、参苓白术散、藿香正气散、异功散、保和丸。主要用药有白术、甘草、茯苓、陈皮、半夏、山楂、薏苡仁、桔梗、神曲、藿香、山药、厚朴、白扁豆、麦芽、大腹皮、砂仁、白芷、鸡内金、黄芪、人参。方剂配伍高频药对有白术—茯苓、白术—山楂、山楂—鸡内金、陈皮—白术、白术—人参,半夏—厚朴、山药—薏苡仁、藿香—茯苓、砂仁—鸡内金、山药—茯苓、陈皮—山楂。使用因子分析发现高频药组有茯苓—人参—白术—甘草,山药—薏苡仁—山楂—神曲—麦芽,陈皮—半夏—厚朴—砂仁—鸡内金。结论临床关于小儿脾胃疾病的治疗主要从脾胃虚弱、脾胃湿热、脾胃虚寒、乳食积滞几大证型辨证论治,遣方用药则以补虚、化湿、消食为主,多运用补气剂、祛湿剂以及消食剂加减以治之,以达补益脾胃功能,健脾助运、燥湿和胃、消食化积之效。

关键词：数据挖掘小儿脾胃疾病中药配伍规律

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剪切增稠液增强高发泡率废纸缓冲材料的制备及性能

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材料导报 2024年第1期38卷 278-287页

作者：张斌陶文轩裴爽任子铭潘政苟进胜北京林业大学材料科学与技术学院木材科学与工程北京市重点实验室北京100083 中国林业科学院林产化学工业研究所南京210042

随着经济的快速增长和人们环保意识的不断增强,植物纤维类环保型发泡缓冲材料逐渐成为研究热点。为改善植物纤维发泡材料发泡率低、缓冲吸能效果差等问题,本研究设计半密闭型发泡模具,成功制备了具有高发泡率和优异吸能性的废纸缓冲材... 详细信息

随着经济的快速增长和人们环保意识的不断增强,植物纤维类环保型发泡缓冲材料逐渐成为研究热点。为改善植物纤维发泡材料发泡率低、缓冲吸能效果差等问题,本研究设计半密闭型发泡模具,成功制备了具有高发泡率和优异吸能性的废纸缓冲材料并对制备工艺进行了优化。结果表明:使用质量分数为0.5%的氢氧化钠溶液预处理废纸浆,不仅可以有效去除废纸中的杂质,而且能在不降低纤维长度的情况下对废纸纤维进行适当改性,有利于提高废纸缓冲材料的发泡率和整体性能。以正交优化试验研究原料配比对废纸缓冲材料性能的影响,并据此确定了最优配方。通过设计全新半密闭型发泡模具,成功制备高发泡率的废纸缓冲材料,其膨胀率相较传统制备方式提高了3~4倍。本研究首次引入剪切增稠液(STF)增强废纸纤维,考察了STF含量对废纸缓冲材料力学性能、发泡倍率和回弹性能的影响,分析了STF对废纸缓冲材料的增强机理。结果表明:STF能够提高单根废纸纤维的强度并增强纤维之间的连结,从而提升缓冲材料吸能性,且随着STF含量的增加,材料的吸能性逐渐增强,发泡率逐渐降低,当STF含量为10%(质量分数,下同)时,STF增强废纸缓冲材料的综合性能达到最优。

关键词：废纸纤维剪切增稠液缓冲包装材料高发泡率

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基于视觉注意力的图文跨模态情感分析

计算机工程与设计 2024年第2期45卷 601-607页

作者：王法玉郝攀征天津理工大学智能计算及软件新技术天津市重点实验室天津300384

针对单模态情感分析无法完全捕获情感信息的问题,提出一种图像和文本跨模态情感分析模型(BERT-VistaNet),该模型没有直接使用视觉信息作为特征,而是利用视觉信息作为对齐方式,使用注意力机制指出文本中重要的句子,得到基于视觉注意力的... 详细信息

针对单模态情感分析无法完全捕获情感信息的问题,提出一种图像和文本跨模态情感分析模型(BERT-VistaNet),该模型没有直接使用视觉信息作为特征,而是利用视觉信息作为对齐方式,使用注意力机制指出文本中重要的句子,得到基于视觉注意力的文档表示。对于视觉注意力无法完全覆盖的文本内容,使用BERT模型对文本进行情感分析,得到基于文本的文档表示,将特征进行融合应用于情感分类任务。在Yelp公开餐厅数据集上,该模型相比基线模型TFN-aVGG,准确率提高了43%,相比VistaNet模型准确率提高了1.4%。

关键词：情感分析视觉注意力机制跨模态深度学习特征融合预训练模型双向门控单元

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关于钻探技术在矿山地质勘探中的应用研究

世界有色金属 2024年第5期 166-168页

作者：潘政国安徽省煤田地质局第三勘探队安徽宿州234000

钻探技术在矿山地质勘探中的应用十分重要,可以为工程师和勘探人员提供丰富的地质信息,包括地层构造、岩石性质、矿产储量和地下水资源等方面的数据,进而为矿山勘探、资源评估、工程建设和环境管理提供基础支持。随着技术的不断发展,钻... 详细信息

钻探技术在矿山地质勘探中的应用十分重要,可以为工程师和勘探人员提供丰富的地质信息,包括地层构造、岩石性质、矿产储量和地下水资源等方面的数据,进而为矿山勘探、资源评估、工程建设和环境管理提供基础支持。随着技术的不断发展,钻探技术将进一步完善,为矿山地质勘探提供更加精确、高效和可持续的解决方案。本文旨在探讨钻探技术在矿山地质勘探中的应用研究,并对其未来的发展趋势进行展望,为矿山地质勘探领域的研究和实践提供参考和启示。

关键词：钻探技术矿山地质勘探应用策略

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GB/T 40701-2021《动车组驱动齿轮箱润滑油》国家标准的研究分析

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润滑油 2024年第1期39卷 54-60页

作者：潘正华中国石化润滑油有限公司华南分公司广东广州510620

高速列车动车组具有更加复杂、苛刻的摩擦磨损问题。随着我国高速铁路的迅速发展,特别是高速动车组齿轮箱技术的快速发展,对齿轮箱润滑油的性能提出了更高要求。为解决当前国内外动车组驱动齿轮箱润滑油没有统一标准的问题,为动车组驱... 详细信息

高速列车动车组具有更加复杂、苛刻的摩擦磨损问题。随着我国高速铁路的迅速发展,特别是高速动车组齿轮箱技术的快速发展,对齿轮箱润滑油的性能提出了更高要求。为解决当前国内外动车组驱动齿轮箱润滑油没有统一标准的问题,为动车组驱动齿轮箱提供性能可靠的润滑油,确保高速动车组的安全行驶,我国制定了GB/T 40701-2021《动车组驱动齿轮箱润滑油》国家标准,并于2022年5月1日开始正式实施。文章对GB/T 40701-2021《动车组驱动齿轮箱润滑油》国家标准的具体技术要求进行了研究分析。GB/T 40701-2021《动车组驱动齿轮箱润滑油》国家标准的制定和实施,对实现我国高速动车组技术的全面自主化具有重要意义。

关键词：动车组齿轮箱润滑油标准

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抗战时期山西妇女教育赋权历程与经验启示

西部学刊 2024年第5期 17-20页

作者：吴菲潘铮东北师范大学外国语学院长春130024 中北大学人文社会科学学院三晋国际文化传播基地太原030051 深圳市标准技术研究院深圳518000

抗战时期,中国共产党以红色革命文化为精神内核和价值支撑,采用学校教育与社会教育相结合的方式对广大山西妇女进行教育赋权,呈现出与民族救亡、革命文化传播、妇女解放、劳动生产相结合的特点,实现了最初的扫盲和政治动员的设想,使广... 详细信息

抗战时期,中国共产党以红色革命文化为精神内核和价值支撑,采用学校教育与社会教育相结合的方式对广大山西妇女进行教育赋权,呈现出与民族救亡、革命文化传播、妇女解放、劳动生产相结合的特点,实现了最初的扫盲和政治动员的设想,使广大山西妇女成为支持前线作战和后方建设的重要力量,并完成了对农村社会整体价值观念的改造和重塑。新时代应继续坚持中国共产党领导核心,坚持教育与就业的机会平等与群众路线,为广大妇女特别是乡村女性“赋权增能”。

关键词：抗战时期山西社会性别妇女教育教育赋权