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Programmed cell death 1 inhibitor sintilimab plus S-1 and gemcitabine for liver metastatic pancreatic ductal adenocarcinoma

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World Journal of Clinical Oncology 2025年第2期16卷 29-35页

作者： Shi-Qiong Zhou Peng Wan Seng zhang yuan Ren hong-Tao Li qing-Hua Ke Department of Chemoradiotherapy The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly aggressive cancer with poor *** it metastasizes to the liver,treatment options become particularly limited and *** treatment options for liver metastatic PDAC are limited,and chemotherapy alone often proves ***,particularly programmed cell death 1(PD-1)inhibitors like sintilimab,shows potential efficacy for various cancers but has limited reports on *** study compares the efficacy and safety of sintilimab plus S-1 and gemcitabine vs S-1 and gemcitabine alone in liver metastatic *** To explore the feasibility and effectiveness of combined PD-1 inhibitor sintilimab and S-1 and gemcitabine(combination group)vs S-1 and gemcitabine used alone(chemotherapy group)for treating liver metastatic pancreatic *** Eligible patients were those with only liver metastatic PDAC,an Eastern Cooperative Oncology Group performance status of 0-1,adequate organ and marrow functions,and no prior anticancer *** in the combination group received intravenous sintilimab 200 mg every 3 weeks,oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle,and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight cycles or until disease progression,death,or unacceptable *** in the chemotherapy group received oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight *** June 2020 and December 2021,66 participants were enrolled,with 32 receiving the combination treatment and 34 receiving chemotherapy *** The group receiving the combined therapy exhibited a markedly prolonged median overall survival(18.8 months compared to 10.3 months,P<0.05)and progression-free survival(9.6 months vs 5.4 months,P<0.05).compared to the chemotherapy *** incidence of severe adverse events did not differ sign

关键词： Immunotherapy Programmed cell death 1 inhibitor Sintilimab Chemotherapy Metastatic Pancreatic ductal adenocarcinoma

New Complexiton Solutions of (2+1)-Dimensional Nizhnik-Novikov-Veselov Equations

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Communications in Theoretical Physics 2006年第9期46卷 407-414页

作者： zhang yuan-yuan,~+ zheng ying, zhang hong-qing Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, China Department of Applied Mathematics Dalian University of Technology

In this paper, we extend the multiple Riccati equations rational expansion method by introducing a new ansatz. Using this method, many complexiton solutions of the (2+1)-dimensional Nizhnik-Novikov-Veselov equations are obtained which include various combination of hyperbolic and trigonometric periodic function solutions, various combination of hyperbolic and rational function solutions, various combination of trigonometric periodic and rational function solutions, etc. The method can be also used to solve other nonlinear partial differential equations.

关键词： rational expansion method (2+1)-dimensional Nizhnik Novikov-Veselov equations complexiton solutions

Further Extended Jacobi Elliptic Function Rational Expansion Method and New Families of Jacobi Elliptic Function Solutions to （2＋1）-Dimensional Dispersive Long Wave Equation

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Communications in Theoretical Physics 2006年第2期45卷 199-206页

作者： zhang yuan-yuan WANG Qi zhang hong-qing Department of Applied Mathematics Dalian University of Technology Dalian 116024 China

In this paper, a further extended Jacobi elliptic function rationM expansion method is proposed for constructing new forms of exact solutions to nonlinear partial differential equations by making a more general transformation. For illustration, we apply the method to （2＋1）-dimensionM dispersive long wave equation and successfully obtain many new doubly periodic solutions. When the modulus m→1, these sohitions degenerate as soliton solutions. The method can be also applied to other nonlinear partial differential equations.

关键词： doubly periodic solution soliton solution (2+1)-dimensional dispersive long wave equation

New Complexiton Solutions of （2＋1）-Dimensional Nizhnik-Novikov-Veselov Equations

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Communications in Theoretical Physics 2006年第3X期46卷 407-414页

作者： zhang yuan-yuan zheng ying zhang hong-qing Department of Applied Mathematics Dalian University of Technology Dalian 116024 China

In this paper, we extend the multiple Riccati equations rational expansion method by introducing a new ansatz. Using this method, many complexiton solutions of the （2＋ 1 ）-dimensional Nizhnik-Novikov-Veselov equations are obtained which include various combination of hyperbolic and trigonometric periodic function solutions, various combination of hyperbolic and rational function solutions, various combination of trigonometric periodic and rational function solutions, etc. The method can be also used to solve other nonlinear partial differential equations.

关键词： rational expansion method (2+1)-dimensional Nizhnik-Novikov-Veselov equations complexiton solutions

Negatons, Positons, and Complexiton Solutions of Higher Order for a Non-isospectral KdV Equation

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Communications in Theoretical Physics 2007年第3X期48卷 411-414页

作者： zhang yuan-yuan WANG Qi zhang hong-qing Department of Applied Mathematics Dalian University of Technology Dalian 116024 China

In this paper, negatons, positons, and complexiton solutions of higher order for a non-isospectral KdV equation, the KdV equation with loss and non-uniformity terms are obtained through the bilinear Baicklund transfor... 详细信息

关键词： bilinear Backlund transformation negatons positons complexiton solutions

Homogeneity analysis of Y-bearing 12Cr ferritic/martensitic steel fabricated by vacuum induction melting and casting

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Journal of Iron and Steel Research International 2020年第8期27卷 940-951页

作者： Wei-wei Guo Xiao-xin zhang ying-xue Chen Zhi-yuan hong qing-zhi Yan Institute of Nuclear Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China Advanced Energy Research Center Shenzhen UniversityShenzhen 518060GuangdongChina Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhen 518060GuangdongChina

Advanced oxide metallurgy technique was adopted to produce 100-kg Y-bearing 12Cr ferritic/martensitic steel via vacuum induction melting and casting route. Subsequently, nine specimens at top, middle and bottom regions of the sheet were char-acterized to evaluate the homogeneity of chemical composition, microstructure and mechanical properties. The small vibra-tion of hardness (200–220 HBW), ultimate tensile strength (672–678 MPa), yield strength (468–480 MPa), total elongation (26.2%–30.5%) and Charpy energy at room temperature (98–133 J) and at ??40 ℃ (12–40 J) demonstrated that mechanical properties’ homogeneity of Y-bearing steel was acceptable although slight Y segregation and inhomogeneous microstructure occurred at the bottom. Furthermore, the effect of Y content on microstructure characteristics and mechanical properties was explained and the comparison of failure mechanism for the dual-phase steel between tensile test (i.e., quasi-static loading) and Charpy test (i.e., dynamic loading) was discussed in detail.

关键词： Y-bearing ferritic/martensitic steel Casting Homogeneity Chemical composition Microstructure characteristics Mechanical property

Mechanical behavior of entangled metallic wire materials-polyurethane interpenetrating composites

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Defence Technology（防务技术） 2023年第2期20卷 120-136页

作者： Xiao-yuan zheng Zhi-ying Ren hong-bai Bai zhang-bin Wu You-song Guo College of Mechanical Engineering and Automation Fuzhou UniversityFuzhou350116China Institute of Metal Rubber&Vibration Noise Fuzhou UniversityFuzhou350116China Gongbang Vibration Control Technology Co. LtdJiangsuJiangyin214431China

Composite materials exhibit the impressive mechanical properties of high damping and stiffness,which cannot be attained by employing conventional single *** these lines,a novel material architecture is presented in this work in order to fabricate composites with enhanced mechanical *** specifically,entangled metallic wire materials were used as the active matrix,whereas polyurethane was employed as the reinforcement *** a result,an entangled metallic wire material-polyurethane composite with high damping and stiffness was prepared by enforcing the vacuum infiltration *** top of that,the mechanical properties(loss factor,energy consumption,and average stiffness)of the proposed composite materials were characterized by performing dynamic tests,and its fatigue characteristics were verified by the micro-interface bonding,as well as the macro-damage *** impact of the density,preloading spacing,loading amplitude,and exciting frequency on the mechanical properties of the composites were also thoroughly *** extracted results indicate that the mechanical properties of the composites were significantly enhanced than those of the pure materials due to the introduction of interface ***,the average stiffness of the composites was about 10 times the respective value of the entangled metallic wire ***,a rise in the loading period leads to some failure between the composite interfaces,which reduces the stiffness property but enhances the damping dissipation ***,a comprehensive dynamic mechanical model of the composites was established,while it was experimentally *** proposed composites possess higher damping features,i.e.,stiffness characteristics,and maintain better fatigue characteristics,which can broaden the application range of the *** addition,we provide a theoretical and experimental framework for the research and applications in the field of metal ma

关键词： Entangled metallic wire material Composites materials Damping property Stiffness Fatigue characteristics

Recycling of High Ferrous Bauxite Reducing Slag for Synthesis of CaAl_2Si_2O_8-Al_2O_3-CaAl_(12)O_(19) Composite

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Journal of Iron and Steel Research International 2016年第12期23卷 1255-1261页

作者： ying-yi zhang yuan-hong QI Zong-shu ZOU College of Materials Science and Engineering Chongqing University State Key Laboratory of Advanced Steel Processes and Products Central Iron and Steel Research Institute School of Metallurgy Northeastern University

CaAl2 Si2 O8- Al2 O3- CaAl12 O19）（CAS2- Al2 O3 -CA6 ） composite was synthesized through reaction sintering alumina and bauxite reducing slag. The CAS2-Al2 O3-CA5 composite was mainly composed of α-Al2O3 , CAS2 , and CA6. Gehlenite （Ca2 Al2 SiO7 , C2 AS） phase was effectively transformed to CASe and CA6 through high-temperature reaction sintering under weak oxidizing atmosphere at 1400 ℃for 4 h. SEM （scanning electron microscopy） and EDS （energy dispersive spectroscopy） analysis indicated that black and needle-shaped Al2O3, rhombic or irregular polygonal shaped FeAl2O4 , and glassy phase Ca2 Al2 SiO7 disappeared after the reaction sintering. The light gray and flaky hexagon crystals of CaAl12 O19 （10 μm） and the grainy particles of Al2O3 （2-7 μm） were observed in the CASe-Al2 O3-CA6 composite. The gray crystals of CASe act as the binding phase and are distributed around CA6 and Al2O3. CAS2-Al2O3-CA6 composite exhibits high refractoriness and service temperature, which are 1 650 ℃ and 1 450 ℃, respectively. Reaction sintering of alumina and bauxite reducing slag is a feasible method for the synthesis of CAS2-Al2 O3-CA6 composite.

关键词： calcium hexaluminate composite reaction sintering bauxite reducing slag phase transformation

Cross-linked Polyamides Prepared through Direct Bulk Michael Addition and Polycondensation from 1,6-Hexanediamine and Methyl Acrylate

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Chinese Journal of Polymer Science 2020年第2期38卷 143-150,I0006页

作者： Sheng-qing Yang Jin-Nan Zhao Jing-Bo Zhao Zhi-yuan zhang Jun-ying zhang Key Laboratory of Carbon Fiber and Functional Polymers(Beijing University of Chemical Technology) Ministry of Education/College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China

Cross-linked polyamides(c PAs)were prepared through direct bulk Michael addition and subsequent *** mixed hexanediamine multi-esters(HDAMEs)were generated through the Michael addition of 1,6-hexanediamine(HDA)and methyl acrylate(MA)at50℃ with different HDA/MA molar *** polycondensation of HDAMEs then proceeded at 150 or 170℃ in flasks to obtain viscous fluids,and curing was continued in tetrafluoroethylene molds to obtain c PA *** Michael addition was monitored on the basis of FTIR and ESI-MS *** c PA films were characterized by DSC,TGA,dynamic mechanical analysis,and tensile *** directly prepared c PAs exhibited Tg of 1–39℃,tensile strength of up to 45 MPa,and strain at break from 18%to 40%.The c PAs with high tensile strength and good toughness were successfully synthesized through the direct bulk Michael addition from HDA and MA followed with polycondensation.

关键词： Michael addition Polycondensation Mechanical properties