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Surface Modification With Zinc and Zn-Ni Alloy Compositionally Modulated Multilayer Coatings

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Journal of Iron and Steel Research International 2006年第4期13卷 61-67页

作者： FEI Jing-yin liANG Guo-zheng XIN wen-li WANG Wei-kang Department of Applied Chemistry Northwestern Polytechnical University Xi＇an 710072 Shaanxi China

Zinc and Zn-Ni alloy compositionally modulated multilayer （CMM） coatings were electrodeposited on to a steel substrate by the successive deposition of zinc and Zn-Ni alloy sublayers from dual baths. The coated samples were evaluated in terms of the surface appearance, surface and cross-sectional morphologies, as well as corrosion resistance. The microstructural characteristics that were examined using the field emission gun scanning electron microscopy （FEGSEM） confirmed the layered structure, grain refinement of the zinc and Zn-Ni alloy CMM coatings, and revealed the existence of microcracks caused by the internal stress in the thick Zn-Ni alloy sublayers. The corrosion resistance that was evaluated by means of the salt spray test shows that the zinc and Zn-Ni alloy CMM coatings were more corrosion-resistant than the monolithic coatings of zinc or Zn-Ni alloy of the same thickness. The possible reasons for the better protective performance of Zn-Ni/Zn CMM coatings were given on the basis of the analysis on the micrographic features of zinc and Zn-Ni alloy CMM eoatings after the corrosion test. A probable corrosion mechanism of zinc and Zn-Ni alloy CMM coatings was also proposed.

关键词： electrodeposition compositionally modulated multilayer coating Zn-Ni alloy corrosion resistance

Determination of Tetracyclines and Their Epimers in Agricultural Soil Fertilized with Swine Manure by Ultra-High-Performance liquid Chromatography Tandem Mass Spectrometry

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Journal of Integrative Agriculture 2012年第7期11卷 1189-1198页

作者： zheng wen-li ZHANG li-fang ZHANG Ke-yu WANG Xiao-yang XUE Fei-qun Key Laboratory of Veterinary Drug Safety Evaluation and Residues Research Shanghai Veterinary Research InstituteChinese Academy of Agricultural SciencesMinhang 200241P.R.China

A rapid, sensitive and specific ultra-high-performance liquid chromatography tandem mass spectrometry （UPLC-MS） method was developed for the analysis of tetracycline antibiotics, including tetracycline （TC）, oxytetracycline （OTC）, chlortetracycline （CTC） and their 4-epimers （4-epiTCs） in agricultural soil fertilized with swine manure. Soil samples were extracted and cleaned-up with 10 mL EDTA-McIlvaine buffer solution （pH 4.0）, then cleaned-up and pre-concentrated using the Oasis MAX cartridge and then eluted with 1 mL solution by mixing formic acid, methanol and water at a ratio of 2：15：83 （v/v/v）. The purified samples were separated by an ACQUITY UPLC BEH C18 column using acetonitrile and water containing 0.1% formic acid mobile phase and detected by a single quadrupole MS. The limits of detection for the soil extraction method （LODsoil） ranged from 0.6-2.5 lag kg-~ with recoveries from 23.3-159.2%. Finally, the method was applied to an agricultural field in an area with intensive pig-fattening farming. Tetracyclines were detected in soil from 2.8 to 42.4 μg kg-1 soil. These results demonstrate that soil from swine farms can become severely contaminated with tetracycline antibiotics and their metabolites.

关键词： tetracyclines epimers ultra performance liquid chromatography soil solid phase extraction

Spectrum-Effect Relationship Between High Performance liquid Chromatography Fingerprints and Anticoccidial Activities of a Compound Chinese Medicine

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Journal of Integrative Agriculture 2014年第5期13卷 1082-1089页

作者： XIAO Sui FEI Chen-zhong ZHANG li-fang zheng wen-li ZHANG Ke-yu XUE Fei-qun Key Laboratory of Veterinary Drug Safety Evaluation and Residues Research Shanghai Veterinary Research Institute Chinese Academy of Agricultural Sciences

Quality control and screening of active substances in traditional Chinese medicines have been performed using fingerprint analysis. The spectrum-effect relationship between chromatography fingerprints and efficacy of herbal drugs is considered as a potentially useful method for determining active ingredients in complex mixtures. The study was designed to develop a method for determining the bioactive components of a compound Chinese medicine called Tiefeng based on spectrum-effect relationships between high-performance liquid chromatography （HPLC） fingerprints and anticoccidial activities. Four peaks of the established HPLC fingerprint indicate the main bioactive components of this medicine. In addition, pharrnacodynamic atlas was defined and used to assess the anticoccidial activity of Tiefeng from different sources for the first time. We found that the level of anticoccidial activity of Tiefeng was consistent with the degree of similarity between the pharmacodynamic atlas and chromatogram of any sample. Furthermore, effect of this medicine was related with the main active constituents, along with the origin and the harvesting time.

关键词： herb medicine fingerprint anticoccidial index spectrum-effect relationship

Fluorescence Properties of Porphyrin Dimers Incorporating an Anhydride linker

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Chemical Research in Chinese Universities 2006年第6期22卷 684-687页

作者： FA Huan-bao YIN Wei zheng wen-qi li Di SHAN Ning WANG Xing-qiao College of Chemistry Jilin University Changchun 130023 P. R. China

A preliminary study on a novel free base porphyrin dimer and a zinc prophyrin dimer by comparing their fluorescence properties with those of the corresponding monomers is presented. The fluorescence intensity of the free base dimer is five times higher than that of the monomer, but the fluorescence intensity of the zinc porphyrin dimer is nearly similar to that of the zinc porphyrin monomer. The emission spectra show that energy transfer occurs between the two units.

关键词： Porphyrin dimer Zinc dimer Fluorescence property

An efficient TILliNG platform for cultivated tobacco

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Journal of Integrative Plant Biology 2020年第2期62卷 165-180页

作者： Yu-Long Gao Xue-Feng Yao wen-zheng li Zhong-Bang Song Bing-Wu Wang Yu-Ping Wu Jun-li Shi Guan-Shan liu Yong-Ping li Chun-Ming liu Key Laboratory of Tobacco Biotechnological Breeding National Tobacco Genetic Engineering Research CenterYunnan Academy of Tobacco Agricultural SciencesKunming 650021China Key Laboratory of Plant Molecular Physiology Institute of Botanythe Chinese Academy of SciencesBeijing 100093China The University of Chinese Academy of Sciences Beijing 100049China Tobacco Research Institute the Chinese Agriculture Academy of SciencesQingdao 266101China Institute of Crop Sciences the Chinese Academy of Agricultural SciencesBeijing 100081China

Targeting-induced local lesions in genomes(TILliNG)is a powerful reverse-genetics tool that enables high-throughput screening of genomic variations in *** TILliNG has been developed for many diploid plants,the technology has been used in very few polyploid species due to their genomic ***,we established an efficient capillary electrophoresis-based TILliNG platform for allotetraploid cultivated tobacco(Nicotiana tabacum L.)using an ethyl methanesulfonate(EMS)-mutagenized population of 1,536 *** optimized the procedures for endonuclease preparation,leaf tissue sampling,DNA extraction,normalization,pooling,PCR amplification,heteroduplex formation,and capillary *** a test screen using seven target genes with eight PCR fragments,we obtained 118 *** mutation density was estimated to be approximately one mutation per 106kb on *** analyses showed that mutations in two heavy metal transporter genes,HMA2S and HMA4T,led to reduced accumulation of cadmium and zinc,which was confirmed independently using CRISPR/Cas9 to generate knockout *** results demonstrate that this powerful TILliNG platform(available at http://***)can be used in tobacco to facilitate functional genomics applications.

关键词： An efficient TILliNG platform cultivated tobacco HMA

Insulin/PI3K/AKt Signaling Pathway Mediates Cardiac Hypertrophy in FKBP12.6 Deficient Male Mice

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生物物理学报 2009年第S1期25卷 206-207页

作者： zheng Chen, zheng-zheng li, wen-Xuan Yin, Guangju Ji Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101

Male mice deficient in FKBP12.6 display cardiac hypertrophy, but the underlying mechanism is still unclear. Here we report that the cardiac hypertrophy is a physiological response

关键词： AKT, insulin cardiac hypertrophy male FKBP12.6 null mice

Extremely Narrow Sb Delta-Doped Epitaxial Layer Characterized by X-Ray Reflectivity

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Chinese Physics Letters 1997年第9期14卷 686-689页

作者： JIANG Zui-min XIU li-song JIANG Xiao-ming zheng wen-li LU Xue-kun ZHU Hai-jun ZHANG Xiang-jiu WANG Xun Fudan T.D.Lee Physics Laboratory Surface Physics Laboratoryfudan UniversityShanghai 200433 Synchrotron Radiation Laboratory Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100039 Surface Physics Laboratory Fudan UniversityShanghai 200433

An Sb delta doping layer in silicon is grown at the temperature of 300℃ by silicon molecular beam epitaxy and characterized by the small angle x-ray reflectivity measurement using synchrotron radiation *** oscillations of the reflectivity caused by dopant Sb at Q as large as 14.5 are *** of this curve as a whole shows that the total amount of dopant Sb is 0.15 monolayer and is restricted to two atomic *** extremely narrow Sb delta doping structure without Sb segregation is thus obtained at the growth temperature of 300℃ as verified by the experiment.

关键词： dopant reflectivity doping

Pharmacokinetics of oral ethanamizuril solution in chickens

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Journal of Integrative Agriculture 2018年第12期17卷 2783-2789页

作者： CHENG Pei-pei HU Xing-xing WANG Chun-mei liU Ying-chun WANG Mi ZHANG Ke-yu FEI Chen-zhong ZHANG li-fang WANG Xiao-yang zheng wen-li XUE Fei-qun Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics Ministry of Agriculture and Rural Affairs/Shanghai Veterinary Research Institute Chinese Academy of Agricultural Sciences

Ethanamizuril(EZL) is a novel triazine anticoccidial compound that has high anticoccidial activity in chickens. In order to treat coccidiosis rationally in poultry, a detection method was developed for ethanamizuril in broiler plasma, and then the pharmacokinetics studies were performed in broilers after oral administration of different dose levels. Ethanamizuril was administered as single oral doses at low(0.67 mg kgBW), medium(1.33 mg kgBW) and high(6.67 mg kgBW) levels in which the medium dose was that recommended in clinics. Plasma concentrations of ethanamizuril were determined using ultra-high performance liquid chromatography and the data were analyzed with a non-compartmental model. Peak plasma concentrations of ethanamizuril were(2.16±0.57),(3.91±0.71), and(23.71±5.02) mg Lat(5.17±1.80),(4.60±2.12), and(4.60±2.12) h, respectively. The terminal elimination half-lives(t) for ethanamizuril were(10.84±2.59),(10.66±2.47), and(13.34±3.10) h after oral administration at low, medium and high doses, respectively. The areas under the concentrationtime curve(AUC)) were(37.68±6.87),(73.19±9.18), and(485.76±125.10) mg Lh with mean residence times(MRT) of(14.79±3.03),(15.57±3.69), and(20.22±4.01) h at the 3 dosages, respectively. Ethanamizuril was absorbed rapidly and eliminated slowly. A comparison across the dose range indicated that the time to reach peak plasma concentration(T) values were similar while peak plasma concentration(C) and AUCwere positively correlated with increasing dosages. This study of the pharmacokinetics of an ethanamizuril solution in chickens provides a theoretical basis for the rational use in the clinic.

关键词： ethanamizuril solution coccidiosis pharmacokinetics chickens

Effects of epidermal growth factor on sperm content and motility of rats with surgically induced varicoceles

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Asian Journal of Andrology 2006年第6期8卷 713-717页

作者： Dong Cheng Xin-Min zheng Shi-wen li Zhi-Wei Yang li-Quan Hu Research Center of Urology and Andrology Zhongnan Hospital Wuhan University Wuhan 430071 China

Aim： To investigate the effect of epidermal growth factor （EGF） on the sperm content and motility of the varicocelized rats. Methods： Forty-eight male Wistar rats were randomly divided into five groups. Experimental varicocele was induced by partial ligation of the left renal vein in the varicocele, the varicocele repair, the varicocele with EGF and the varicocele repair with EGF groups, whereas the control group only received a sham induction of varicocele. Surgical repair of varicocele was performed 4 months later in the varicocele repair and varicocele repair with EGF groups. EGF administration was performed daily by s.c. injection in the varicocele with EGF and varicocele repair with EGF groups at the dose of 10 μg/（kg·day） from the next day of the second surgery. One month later, all animals were killed and bilateral cauda epididymal sperm counts and motility were evaluated. Results： The mean sperm count and percentage of motile spermatozoa were significantly higher bilaterally in the varicocele with EGF group than in the varicocele group （P 〈 0.05）. They were also significantly higher bilaterally in the varicocele repair with EGF group than in the varicocele repair and the varicocele with EGF groups （P 〈 0.05）. Conclusion： EGF can improve bilateral epididymal sperm content and motility of the rat with surgically induced varicocele. The administration of EGF in combination with surgical repair is more effective than surgical repair or EGF administration alone. EGF might be useful for the treatment of infertility induced by varicocele.

关键词： epidermal growth factor varicocele infertility rats therapy