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Synthesis of Novel 3-Aryl Isoindolinone Derivatives

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Chemical Research in Chinese Universities 2013年第3期29卷 487-494页

作者： HU Chen-ming zheng lian-you PEI Ya-zhong BAI Xu Center for Combinatorial Chemistry and Drug Discovery College of Chemistry and School of Pharmaceutical Sciences Jilin University Changchun 130021 P. R. China

A library of novel 3-aryl isoindolinone derivatives with aromatic amino acid derivative fragments was designed and synthesized. Two synthetic routes were employed to construct 3-aryl isoindolinone ring system for diff... 详细信息

关键词： Molecular library 3-Aryl isoindolinone Aromatic amino acid derivative

求解模糊作业车间调度问题的群体邻域搜索算法

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电子学报 2011年第10期39卷 2454-2458页

作者：郑友莲李元香雷德明湖北大学数学与计算机科学学院湖北武汉430062 武汉大学软件工程国家重点实验室湖北武汉430072 武汉理工大学自动化学院湖北武汉430070

本文提出一种群体邻域搜索算法(Swarm-based Neighborhood Search,SNS),用于最小化模糊作业车间调度问题(Fuzzy Job Shop Scheduling Problem,FJSSP)的模糊makespan.该算法使用基于有序工序的编码,通过锦标赛选择和概率为1的动态调整互... 详细信息

本文提出一种群体邻域搜索算法(Swarm-based Neighborhood Search,SNS),用于最小化模糊作业车间调度问题(Fuzzy Job Shop Scheduling Problem,FJSSP)的模糊makespan.该算法使用基于有序工序的编码,通过锦标赛选择和概率为1的动态调整互换操作更新群体.对调度结果的理论分析表明,模糊makespan能反映解的优劣.理论分析及大量实验证明,SNS具有较强的全局和局部优化能力,以及较快的收敛速度,在求解FJSSP方面具有较强的优势.

关键词：模糊作业车间调度群体邻域搜索互换

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基于密集距离的多目标粒子群优化算法

湖北大学学报（自然科学版） 2008年第2期30卷 141-144,191页

作者：郑友莲樊俊青湖北大学数学与计算机科学学院湖北武汉430062 中国地质大学计算机学院湖北武汉430074

设计出基于密集距离的多目标粒子群优化算法(CMPSO),该算法根据密集距离大小按轮盘赌方式为每个粒子从外部档案选取全局最好位置并采用基于密集距离的方法对外部档案进行维护.将算法应用于3个复杂的测试实例,并与强度Pareto进化算法2等... 详细信息

设计出基于密集距离的多目标粒子群优化算法(CMPSO),该算法根据密集距离大小按轮盘赌方式为每个粒子从外部档案选取全局最好位置并采用基于密集距离的方法对外部档案进行维护.将算法应用于3个复杂的测试实例,并与强度Pareto进化算法2等算法进行比较,计算结果表明CMPSO具有良好的连续优化能力.

关键词：密集距离多目标优化粒子群优化

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多目标粒子群优化算法研究

湖北大学学报（自然科学版） 2008年第4期30卷 351-355页

作者：郑友莲樊俊青湖北大学数学与计算机科学学院湖北武汉430062 中国地质大学计算机学院湖北武汉430074

在过去的十多年,粒子群算法对多目标优化问题的应用研究取得了较大的进展.本文首先描述多目标粒子群优化算法(MOPSO)的基本流程,然后从算法设计与应用等方面回顾MOPSO的研究进展,最后对该算法未来的研究进行了分析和展望.

关键词：多目标优化粒子群优化算法设计

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求解高维多目标调度的新型人工蜂群算法

计算机科学 2020年第7期47卷 186-191页

作者：郑友莲雷德明郑巧仙湖北大学计算机与信息工程学院武汉430062 武汉理工大学自动化学院武汉430070

高维多目标连续优化问题已得到广泛研究,而高维多目标组合优化问题的进展相对较小,虽然人工蜂群(Artificial Bee Colony,ABC)算法已成功应用于多种生产调度问题,但很少被用来求解高维多目标调度问题,而且高维多目标调度自身的研究进展... 详细信息

高维多目标连续优化问题已得到广泛研究,而高维多目标组合优化问题的进展相对较小,虽然人工蜂群(Artificial Bee Colony,ABC)算法已成功应用于多种生产调度问题,但很少被用来求解高维多目标调度问题,而且高维多目标调度自身的研究进展也非常小。针对高维多目标柔性作业车间调度问题,文中提出了一种新型ABC算法以同时优化最大完成时间、总延迟时间、总能耗和机器总负荷。与常规柔性作业车间调度问题不同,上述问题考虑了总能耗,使其成为绿色调度问题。新型ABC具有明显不同于现有ABC算法的新特点,其跟随蜂(onlooker bee)的数量小于引领蜂(employed bee),引领蜂侧重于全局搜索,而跟随蜂只进行局部搜索,通过两类蜜蜂彼此各异的搜索方式来避免算法陷入局部最优。同时,该算法将跟随对象限定为质量较好的部分引领蜂和外部档案成员,其他引领蜂无法成为跟随对象,以避免计算资源浪费在较差解的搜索上,并给出了侦查蜂(scout)新的处理策略。测试实例的仿真实验表明,高维多目标调度问题中非劣解数量占种群规模的比例明显低于高维连续优化问题。将新型ABC与多目标遗传算法和变邻域搜索进行比较,实验结果表明,新型ABC在求解高维多目标调度方面比对比算法更有优势,计算结果更好。

关键词：人工蜂群算法多目标优化调度问题外部档案局部最优

Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients

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Science China Life Sciences 2025年第1期68卷 297-299页

作者： Junbin Zhou Rongli Wei Guanghan Fan zhengxing lian Xuanyu Zhang Linsong Tang Zhetuo Qi Haiyang Xie Shusen zheng Qiang Wei Xiao Xu Department of Hepatobiliary and Pancreatic Surgery People's Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui University NHFPC Key Laboratory of Combined Multi-Organ Transplantation Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People's Hospital Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of Medicine Department of Urology The Second Affiliated HospitalZhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan (Hangzhou) Hospital Hangzhou Medical College Zhejiang University School of Medicine

Dear Editor, Liver transplantation(LT) is the only curative therapy for patients with endstage liver disease(He et al., 2023; Ling et al., 2022). Post-transplant hypertriglyceridemia(PTHT), which has an incidence of up to 32.8% in 6 months after LT, is one of the major post-transplant complications(Toshima et al., 2020).

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Activatable chemiluminescence probe based on four-arm PEGconjugated-pyropheophorbide-a for in vivo autofluorescence-free imaging of peroxynitrite

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Science China Chemistry 2025年

作者： Jianmei Ke Lei Ding Ronggui lian Cheng zheng Wenjun Li Aixian zheng Yupeng Sun Ming Wu Yongyi Zeng Xiaolong Liu Maochun Hong Xiaolong Zhang The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical University Ganjiang Innovation Academy Chinese Academy of Sciences School of Rare Earths University of Science and Technology of China College of Chemistry Fuzhou University State Key Laboratory of Structure Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Peroxynitrite（ONOO-） is a highly reactive nitrogen species that plays pivotal roles in cell signal transduction and physiological or pathological progresses. However, commonly used ONOO-optical imaging probes are still hampered by high background/autofluorescence（fluorescence probe）, short emission wavelength, or poor selectivity in the case of chemiluminescence. Herein,we report a facile method to prepare an activatable chemiluminescence probe（PPA-PEG） with good biocompatibility and functionality for in vivo autofluorescence-free imaging of ONOO-. The PPA-PEG consists of pyropheophorbide-a（PPA）, a typical deep red photosensitizer that acts as both the recognition and signaling element, and 4-arm poly（ethylene glycol）(4-arm PEG), which improves the biosafety and water solubility of probe. These components can self-assemble into nanoparticles（namely PPA-PEG nanoprobe） in aqueous solution. The PPA-PEG nanoprobe showed an ultra-low chemiluminescence signal before interacting with ONOO-, but exhibited good selectivity, high sensitivity and a fast response toward ONOO-. The PPAPEG was successfully applied to image cellular ONOO-changes, as well as the endogenous ONOO-changes in inflammation models and subcutaneous or orthotopic hepatocellular carcinoma（HCC） tumors models in living mice. In vitro and in vivo studies verified the good detection and imaging capabilities of PPA-PEG for peroxynitrite, demonstrating suitable tissue penetration and a high signal-to-background ratio（SBR）. Thus, our nanoprobe can serve as a valuable activatable chemiluminescence imaging tool for studying important peroxynitrite-related chemical and biological applications.

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彩色图像分割算法研究与费歇算法应用

海军航空工程学院学报 2008年第4期23卷 436-438页

作者：郑友莲樊俊青湖北大学数学与计算机科学学院武汉430062 中国地质大学计算机学院武汉430074

图像分割是图像分析和模式识别需要解决的首要问题和经典难题。彩色图像比灰度图像具有更多的视觉信息，因而受到了越来越多的重视。文中对各种彩色图像分割方法进行了系统论述，分析了各种方法的优缺点，重点介绍了费歇算法。该算法能... 详细信息

图像分割是图像分析和模式识别需要解决的首要问题和经典难题。彩色图像比灰度图像具有更多的视觉信息，因而受到了越来越多的重视。文中对各种彩色图像分割方法进行了系统论述，分析了各种方法的优缺点，重点介绍了费歇算法。该算法能有效地对彩色图像进行分割，在工业实践中取得了比较好的效果。

关键词：彩色图像分割数学形态学模糊技术费歇算法

Photo‑Energized MoS_(2)/CNT Cathode for High‑Performance Li–CO_(2)Batteries in a Wide‑Temperature Range

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Nano-Micro Letters 2025年第1期17卷 160-175页

作者： Tingsong Hu Wenyi lian Kang Hu Qiuju Li Xueliang Cui Tengyu Yao Laifa Shen Jiangsu Key Laboratory of Materials and Technologies for Energy Storage College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Li–CO_(2) batteries are considered promising energy storage systems in extreme environments such as Mars;however,severe performance degradation will occur at a subzero temperature owning to the sluggish reaction ***,a photo-energized strategy adopting sustainable solar energy in wide working temperature range Li–CO_(2) battery was achieved with a binder-free MoS_(2)/carbon nanotube(CNT)photo-electrode as *** unique layered structure and excellent photoelectric properties of MoS_(2) facilitate the abundant generation and rapid transfer of photo-excited carriers,which accelerate the CO_(2) reduction and Li_(2)CO_(3) decomposition upon *** illuminated battery at room temperature exhibited high discharge voltage of 2.95 V and mitigated charge voltage of 3.27 V,attaining superior energy efficiency of 90.2%and excellent cycling stability of over 120 *** at an extremely low temperature of−30℃,the battery with same electrolyte can still deliver a small polarization of 0.45 V by the photoelectric and photothermal synergistic mechanism of MoS_(2)/CNT *** work demonstrates the promising potential of the photo-energized wide working temperature range Li–CO_(2) battery in addressing the obstacle of charge overpotential and energy efficiency.

关键词： Li-CO_(2)batteries Photo-energized Wide operation-temperature Kinetics MoS_(2)